检索结果-南通市图书馆

Clausenlanins A and B,Two Leucine-Rich Cyclic Nonapeptides from Clausena lansium

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2017年第4期7卷 307-313页

作者： Shai-Ping Hu Wei-Wu Song si-meng zhao Ning-Hua Tan School of Traditional Chinese Pharmacy and State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 211198JiangsuPeople’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China School of Chemistry&Chemical Engineeing Zhoukou Normal UniversityZhoukou 466001HenanPeople’s Republic of China

Two new cyclic nonapeptides,named clausenlanins A(1)and B(2),were isolated from the roots and rhizomes of Clausena *** structures were elucidated as cyclo-(Gly^(1)-L-Leu^(2)-L-Ile^(3)-L-Leu^(4)-L-Leu^(5)-L-Leu^(6)-L-Leu^(7)-L-Leu^(8)-L-Leu^(9))(1)and cyclo-(Gly^(1)-L-Leu^(2)-L-Val^(3)-L-Leu^(4)-L-Leu^(5)-L-Leu^(6)-L-Leu^(7)-L-Leu^(8)-L-Leu^(9))(2)respectively on the basis of extensive spectroscopic analysis,particularly 2D NMR spectra taken at the temperature of 338 or 303 K and MS.

关键词： Clausena lansium Cyclopeptides Clausenlanin A Clausenlanin B

Rubicordilins A-C, new cytotoxic cyclopeptides from Rubia cordifolia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rubicordilins A-C, new cytotoxic cyclopeptides from Rubia co...

Three new quinone derivatives from Rubia sylvatica

中国化学会第十届全国天然有机化学学术会议

作者： Xiao-Qiang Chen si-meng zhao Guang-Zhi Zeng Ning-Hua Tan State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Key Laboratory of Forest Plant Ecology Ministry of Education Northeast Forestry University University of the Chinese Academy of Sciences

Rubia cordifolia,a traditional Chinese medicine(Chinese name‘Qian cao’)cited in Chinese Pharmacopoeia,has been used for the treatment of hematemesis,epistaxis,menoxenia,metrorrhagia and ***-type cyclopeptides(RAs),quinones,and triterpenoids have been isolated from *** are bicyclic hexapeptides mainly from Rubia species,and

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Three new quinone derivatives from Rubia sylvatica

Plant cyclopeptide RA-V inhibits NF-κB by targeting TAK1

中国化学会第九届全国有机化学学术会议

＜正＞Rubia sylvatica,a substitute of the traditional Chinese medicine ***,has been used for the treatment of hematemesis,epistaxis,menoxenia and contusion in northeast ***-type cyclopeptides,quinones,and triterpenoid...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Plant cyclopeptide RA-V inhibits NF-κB by targeting TAK1

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

中国化学会第十届全国天然有机化学学术会议

作者： Zhe Wang si-meng zhao Guang-Zhi Zeng Chen Wang Li-Juan Chen Ning-Hua Tan State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences University of the Chinese Academy of Sciences State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes of Biological Sciences Chinese Academy of Sciences State Key Laboratory of Biotherapy West China Hospital West China Medical School Sichuan University

The nuclear factor-κB(NF-κB),a ubiquitously expressed proinflammatory transcription factor,plays a crucial role in cell growth,apoptosis and tumorigenesis,and it makes the NF-κB signaling pathway become a novel tar...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu Xuerui Wan meng zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词：

同方期刊数据库

Low-Temperature Fabrication of Stable Black-Phase CsPbI₃ Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

在线全文

学校读者我要写书评

暂无评论

NANO-MICRO LETTERS 2025年第1期17卷 1-14页

作者： zhao, Yingjie Sun, Yicheng Pei, Chaoxin Yin, Xing Li, Xinyi Hao, Yi Zhang, mengru Yuan, meng Zhou, Jinglin Chen, Yu Song, Yanlin Zhengzhou Univ Coll Chem Zhengzhou 450001 Peoples R China Zhengzhou Univ Pingyuan Lab Zhengzhou 450001 Peoples R China Chinese Acad Sci Inst Chem Key Lab Green Printing Beijing 100190 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Key Lab Bioinspired Mat & Interfacial Sci Beijing 100190 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China

Low-temperature fabrication of black-phase CsPbI3 perovskite films is first demonstrated by using diphenylphosphinic chloride additive under 30-50 degrees C, arising from the steric effect and chloride insertion ***-area high-quality all-inorganic perovskite films with fewer defects enhanced crystallographic orientation, and excellent environmental stability is *** record performances are demonstrated for flexible wearable photodetectors with a responsivity of 42.1 A W-1, a detectivity of 1.3 x 1014 Jones, high-fidelity image, photoplethysmography sensor functions, and high mechanical stability. Flexible wearable optoelectronic devices fabricated from organic-inorganic hybrid perovskites significantly accelerate the development of portable energy, biomedicine, and sensing fields, but their poor thermal stability hinders further applications. Conversely, all-inorganic perovskites possess excellent thermal stability, but black-phase all-inorganic perovskite film usually requires high-temperature annealing steps, which increases energy consumption and is not conducive to the fabrication of flexible wearable devices. In this work, an unprecedented low-temperature fabrication of stable black-phase CsPbI3 perovskite films is demonstrated by the in situ hydrolysis reaction of diphenylphosphinic chloride additive. The released diphenyl phosphate and chloride ions during the hydrolysis reaction significantly lower the phase transition temperature and effectively passivate the defects in the perovskite films, yielding high-performance photodetectors with a responsivity of 42.1 A W-1 and a detectivity of 1.3 x 1014 Jones. Furthermore, high-fidelity image and photoplethysmography sensors are demonstrated based on the fabricated flexible wearable photodetectors. This work provides a new perspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

本科生全程导师制的价值意蕴及实践探索

北京科技大学学报（社会科学版） 2025年第1期41卷 32-38页

作者：赵萌北京科技大学北京100083

本科教育在人才培养工作中占据基础地位,如何推动本科教育理念和方式不断变革,谋求本科教育体制机制的创新发展是提升教育质量的关键所在。本科生全程导师制从学生多样化、个性化的需求出发,注重因材施教,逐渐成为提升人才培养质量的关... 详细信息

本科教育在人才培养工作中占据基础地位,如何推动本科教育理念和方式不断变革,谋求本科教育体制机制的创新发展是提升教育质量的关键所在。本科生全程导师制从学生多样化、个性化的需求出发,注重因材施教,逐渐成为提升人才培养质量的关键手段之一,并在教学实践中不断得到创新和优化。文章以北京科技大学近年来推行的本科生全程导师制为例,针对8921名本科生进行在校生满意度调查,分析得出该导师制在思想引导、学术指导以及创业就业等方面充分发挥了教师的积极作用,获得了广大学生的高度认可,由此探索构建符合新时代人才培养需求的本科人才培养新模式。

关键词：本科生全程导师制人才培养学生满意度

维普期刊数据库

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期 233-240页

作者： Peipei Liu Yantong Li meng-Xiang Wu Hao Kang Xiao-Li zhao Lin Xu Linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词：

同方期刊数据库

Outlier detection based on multi-dimensional clustering and local density

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2017年第6期24卷 1299-1306页

作者： SHOU zhao-yu LI meng-ya LI si-min School of Information and Communication Engineering Guilin University of Electronic TechnologyGuilin 541004China

Outlier detection is an important task in data mining. In fact, it is difficult to find the clustering centers in some sophisticated multidimensional datasets and to measure the deviation degree of each potential outlier. In this work, an effective outlier detection method based on multi-dimensional clustering and local density(ODBMCLD) is proposed. ODBMCLD firstly identifies the center objects by the local density peak of data objects, and clusters the whole dataset based on the center objects. Then, outlier objects belonging to different clusters will be marked as candidates of abnormal data. Finally, the top N points among these abnormal candidates are chosen as final anomaly objects with high outlier factors. The feasibility and effectiveness of the method are verified by experiments.

关键词： data mining outlier detection outlier detection method based on multi-dimensional clustering and local density (ODBMCLD) algorithm deviation degree

维普期刊数据库