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Targeting the chromatin structural changes of antitumor immunity

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Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： Nian-nian Li Deng-xing Lun Ningning Gong Gang Meng Xin-ying Du He Wang Xiangxiang Bao Xin-yang Li Ji-wu Song Kewei Hu Lala Li si-ying Li Wenbo Liu Wanping zhu Yunlong Zhang Jikai Li Ting Yao Leming Mou Xiaoqing Han Furong Hao Yongcheng Hu Lin Liu Hongguang zhu Yuyun Wu Bin Liu Weifang People's Hospital WeifangShandong261000China School of Life Sciences Nankai UniversityTianjin300071China Weifang Traditional Chinese Medicine Hospital WeifangShandong261000China Shaanxi Key Laboratory of Sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou Normal University Guiyang550025China School of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and Soft Tissue Oncology Tianjin HospitalTianjin300299China Xinqiao Hospital of Army Military Medical University Chongqing400038China Teda Institute of Biological Sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DNA methylation Histone modification Chemotherapy

基于并环螺芴氧杂蒽类单体的链柔性化蓝光聚合物及其柔性有机发光二极管

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高分子学报 2024年第6期55卷 673-687页

作者：李昊罗曼曼祝守加朱爱云虞梦娜冯全友解令海南京邮电大学信息材料与纳米技术研究院、有机电子与信息显示国家重点实验室、分子系统与有机器件中心南京210023 河南大学柔性电子学院、河南省柔性电子产业技术研究院郑州450046

螺芴氧杂蒽作为一类重要的宽带隙蓝光材料功能砌块,常被用于构筑具有优异光电性能和器件稳定性的聚合物半导体,但螺芴氧杂蒽类聚合物柔性化的构筑却很少被报道.基于此,本文报道了高效合成单螺环/并环螺芴氧杂蒽类单体及其蓝光聚合物,包... 详细信息

螺芴氧杂蒽作为一类重要的宽带隙蓝光材料功能砌块,常被用于构筑具有优异光电性能和器件稳定性的聚合物半导体,但螺芴氧杂蒽类聚合物柔性化的构筑却很少被报道.基于此,本文报道了高效合成单螺环/并环螺芴氧杂蒽类单体及其蓝光聚合物,包括均聚物PC8SFX-Homo、PDSFX-Homo和共聚物PC8SFX-Co、PDSFX-Co,其中并环聚合物(PLQYsol=88.2%,EQEmax=0.52%)无论是发光效率还是柔性器件性能均明显优于单螺环体系(PLQYsol=11.1%,EQEmax=0.17%).且并环聚合物表现出更低的内部应力.同时通过主链柔性化策略引入柔性链段共聚在获得更优柔性的同时能够获得更优异的发光性能和更好的柔性发光二极管器件性能.该工作为构建柔性电子应用的宽带隙深蓝光聚合物及其柔性发光显示器件应用提供了新的思路.

关键词：螺芴氧杂蒽蓝光聚合物链柔性化力学行为柔性有机发光二极管

Geochemical modeling to aid experimental design for multiple isotope tracer studies of coupled dissolution and precipitation reaction kinetics

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Acta Geochimica 2024年第1期43卷 1-15页

作者： Mingkun Chen Peng Lu Yongchen Song Chen zhu Department of Earth and Atmospheric Sciences Indiana UniversityBloomingtonIN 47405USA School of Energy and Power Engineering Dalian University of TechnologyDalian 116024China EXPEC Advanced Research Center Saudi Aramco31311 DhahranSaudi Arabia

It is a challenge to make thorough but efficient experimental designs for the coupled mineral dissolution and precipitation studies in a multi-mineral system, because it is difficult to speculate the best experimental duration, optimal sampling schedule, effects of different experimental conditions, and how to maximize the experimental outputs prior to the actual experiments. Geochemical modeling is an efficient and effective tool to assist the experimental design by virtually running all scenarios of interest for the studied system and predicting the experimental outcomes. Here we demonstrated an example of geochemical modeling assisted experimental design of coupled labradorite dissolution and calcite and clayey mineral precipitation using multiple isotope tracers. In this study, labradorite(plagioclase) was chosen as the reactant because it is both a major component and one of the most reactive minerals in basalt. Following our isotope doping studies of single minerals in the last ten years, initial solutions in the simulations were doped withmultiple isotopes(e.g., Ca and si). Geochemical modeling results show that the use of isotope tracers gives us orders of magnitude more sensitivity than the conventional method based on concentrations and allows us to decouple dissolution and precipitation reactions at near-equilibrium condition. The simulations suggest that the precise unidirectional dissolution rates can inform us which rate laws plagioclase dissolution has followed. Calcite precipitation occurred at near-equilibrium and the multiple isotope tracer experiments would provide near-equilibrium precipitation rates, which was a challenge for the conventional concentration-based experiments. In addition, whether the precipitation of clayey phases is the rate-limiting step in some multi-mineral systems will be revealed. Overall, the modeling results of multimineral reaction kinetics will improve the understanding of the coupled dissolution–precipitation in the mu

关键词： Kinetics Feldspar Isotope doping Near-equilibrium CO_(2)sequestration Basalt

Study of Turing patterns in a si reaction-diffusion propagation system based on network and non-network environments

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International Journal of Biomathematics 2024年第1期17卷 199-225页

作者： Yuxuan Tang Shuling Shen Linhe zhu School of Mathematical Sciences Jiangsu University Zhenjiang212013P.R.China Department of Stomatology Afiliated Hospital of Jiangsu University Zhenjiang 210008P.R.China

The study of rumor propagation dynamics is of great significance to *** news and ensure the authenticity of news *** this paper,a si reaction-diffusion rumor propagation model with nonlinear saturation incidence is ***,through stability analysis,we obtain the conditions for the existence and local stability of the positive equilibrium *** selecting suitable variable as the control parameter,the critical value of Turing bifurcation and the existence theorem of Turing bifurcation are ***,using the above theorem and multi-scale standard analysis,the expression of amplitude equation around Turing bifurcation point is *** analyzing the amplitude equation,different types of Turing pattern are divided such as uniform steady-state mode,hexagonal mode,stripe mode and mixed structure ***,in the numerical simulation part,by observing different patterns corresponding to different values of control variable,the correctness of the theory is ***,the effects of different network structures on patterns are *** results show that there are significant differences in the distribution of users on different network structures.

关键词： Reaction-diffusion system rumor propagation amplitude equation Turing pattern

Study on the treatment of dysphagia after stroke with electromyographic biofeedback intensive training

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World Journal of Clinical Cases 2024年第19期12卷 3725-3733页

作者： Qing-Nan Meng Yue zhu si-Wen Liu Bin Hu De-Jun Chai Chun-Xue Dong Department of Rehabilitation Medicine The Second Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161000Heilongjiang ProvinceChina

BACKGROUND Dysphagia,or swallowing disorder,is a common complication following stroke,significantly impacting patients'quality of *** biofeedback(EMGBF)therapy has emerged as a potential rehabilitation technique to improve swallowing function,but its efficacy in comparison with conventional treatments remains to be further *** To investigate the effects of different treatment intensities of EMGBF on swallowing function and motor speed after *** The participants were divided into three groups,all of which received routine neurological drug therapy and motor function rehabilitation *** the basis of routine swallowing disorder training,the EMGBF group received additional EMGBF training,while the enhanced EMGBF group received two additional training *** weeks before and after treatment,the degree of swallowing disorder was evaluated using the degree of swallowing disorder score(VGF)and the Rosenbek penetration-aspiration scale(PAS).RESULTS Initially,there was no significant difference in VGF and PAS scores among the groups(P>0.05).After four weeks,all groups showed significant improvement in both VGF scores and PAS ***,the standardized swallowing assessment and videofluoroscopic dysphagia scale scores also improved significantly post-treatment,indicating enhanced swallowing function and motor function of the hyoid-bone laryngeal complex,particularly in the intensive EMGBF *** EMGBF training is more effective than traditional swallowing training in improving swallowing function and the movement rate of the hyoid laryngeal complex in patients with post-stroke dysphagia.

关键词： Stroke Swallowing disorder Electromyographic biofeedback therapy Rosenbek penetration-aspiration scale score Swallowing disorder score

Promise and challenges of traditional Chinese medicine,specifically Calculus bovis,in liver cancer treatment

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World Journal of Gastroenterology 2024年第40期30卷 4380-4385页

作者： Ao-Xi Xu Zhi-Feng Zhao Li zhu Yi-Heng Zhang Yan Li Yu-Fan Wei Bo-Ya Zhang Bin Jiang Tian-Ze Gao Meng-si Li Jia-Yu Liu School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Medical School of Chinese People's Liberation Army Medical School of Chinese People's Liberation ArmyBeijing 100853China Department of Hepatobiliary and Pancreative Surgery The First Medical CenterChinese People's Liberation Army General HospitalBeijing 100853China Department of Surgery Mancheng District People's HospitalBaoding 072150Hebei ProvinceChina Department of Neurosurgery First Medical Centre of Chinese People's Liberation Army General HospitalBeijing 100853China

Liver cancer,one of the most common malignancies worldwide,ranks sixth in incidence and third in *** cancer treatment options are diverse,inclu-ding surgical resection,liver transplantation,percutaneous ablation,transarterial chemoembolization,radiotherapy,chemotherapy,targeted therapy,immuno-therapy,and traditional Chinese medicine(TCM).A multidisciplinary team(MDT)is essential to customize treatment plans based on tumor staging,liver function,and performance status(PS),ensuring individualized patient *** decisions require a MDT to tailor strategies based on tumor staging,liver function,and PS,ensuring personalized *** approval of new first-line and second-line drugs and the establishment of standard treatments based on immune checkpoint inhibitors have significantly expanded treatment options for advanced liver cancer,improving overall ***,many patients do not respond effectively to these treatments and ultimately succumb to the *** oncology treatments,while extending patient survival,often come with severe side effects,resistance,and damage to the body,negatively impacting quality of *** et al's study published at World Journal of Gastroenterology rigorously validates the anticancer properties of Calculus bovis,enhancing our understanding of TCM and contributing to new liver cancer treatment *** over 5000 years,TCM has been used in East Asian countries like China to treat various diseases,including liver *** of real-world clinical data suggests that for patients with advanced-stage tumors lacking effective treatments,integrated TCM therapies could provide significant breakthroughs.

关键词： Traditional Chinese medicine Liver cancer Calculus bovis Treatment Promise Challenges

Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng Lin-zhu Lu Qian-Qian Guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

Effect of Cr_(2)O_(3) on properties of CaO-siO_(2)-Fe_(t)O-MgO system and dissolution behavior of lime

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Journal of Iron and Steel Research International 2024年第4期31卷 870-881页

作者： Shan-nan Li Jian-li Li Yue Yu Hang-yu zhu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The productivity of the chrome-containing semi-steel converter smelting process is directly affected by the slag-forming speed during the converter preliminary *** effects of Cr_(2)O_(3) content on the physicochemical properties of the CaO-siO_(2)-Fe_(t)O-MgO system,such as melting temperature,solidification behavior,mineral composition,and lime dissolution rate,were *** results showed that the slag was an amorphous phase at 1500℃.When Cr_(2)O_(3) was added,Ca(Fe,Mg)si_(2)O_(6) and spinel were formed in the *** the increase in Cr_(2)O_(3) content,the amount of spinel precipitation increased,and the dendritic FegO_(4) crystal gradually changed into the granular(Fe,Mg)(Fe,Cr)2O_(4) *** the Cr_(2)O_(3) content increased from O to 2.91 wt.%,the melting temperature of the slag rose,and the melting range of the slag expanded slightly,but the lime dissolution rate did not *** the Cr_(2)O_(3) content further increased to 9.09 wt.%,the melting temperature continued to rise,the melting range rapidly expanded,and the lime dissolution rate decreased.

关键词： Cr_(2)O_(3) Vanadium-titanium magnetite Converter Slag Lime dissolution

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绿色矿山建设碳源/汇与减排增汇研究进展

煤炭学报 2024年第3期49卷 1597-1610页

作者：王金满杨曼刘彪朱秋萍中国地质大学(北京)土地科学技术学院北京100083 自然资源部土地整治重点实验室北京100035

为应对长期以来矿业开采导致的环境问题,绿色矿山理念及配套政策逐步发展。碳达峰碳中和目标导向下,绿色矿山倡导低碳化生产、生态开采等新的发展要求。为探究新时期绿色矿山建设在节能减排目标下的重要方向和关键问题,助力碳中和目标... 详细信息

为应对长期以来矿业开采导致的环境问题,绿色矿山理念及配套政策逐步发展。碳达峰碳中和目标导向下,绿色矿山倡导低碳化生产、生态开采等新的发展要求。为探究新时期绿色矿山建设在节能减排目标下的重要方向和关键问题,助力碳中和目标与绿色矿山建设的协同发展,该研究以绿色矿山、碳源/汇与减排增汇为关键词开展文献计量分析,总结“双碳”目标下绿色矿山建设内涵与要求,分析绿色矿山建设背景下碳源/汇与减排增汇研究进展,梳理矿区碳源与碳汇核算方法,探究绿色矿山减排增汇策略。得出:绿色矿山在理论与应用方面均具有较为丰富的研究及实践成果,具有良好基础以面对新的发展挑战;绿色矿山现存管理方案与考评体系成果完整,整体偏定性和基础推荐性要求;矿山碳足迹核算中,基于生命周期理念、采用排放因子法的核算模式已较为成熟,但在生命周期划分与核算因子选取过程中仍需慎重,注意加强因子的本地化选取;针对减排增汇目标,绿色矿山在策略上需重视能源与技术视角。在“双碳”目标下,当前绿色矿山相关验收标准在减排方面的关注度有待增强,指标体系的定量化程度与执行力有待提高;煤炭矿山的碳足迹核算与减排潜力分析是未来绿色矿山研究的重点之一;矿山减排研究中,由复垦产生的碳源与碳汇核算及矿山全生命周期的减排方案设计需得到更多关注。

关键词：碳达峰与碳中和绿色矿山碳足迹碳源碳汇