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Combination of propofol and dezocine to improve safety and efficacy of anesthesia for gastroscopy and colonoscopy in adults: A randomized, double-blind, controlled trial

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World Journal of Clinical Cases 2019年第20期7卷 3237-3246页

作者： Xue-Ting Li Chao-Qun Ma si-hua qi Li-Min Zhang Department of Anaesthesiology The Fourth Affiliated HospitalHarbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Neurosurgery Harbin 242 HospitalHarbin 150066Heilongjiang ProvinceChina

BACKGROUND Gastroscopy and colonoscopy are important and common endoscopic methods for the diagnosis and treatment of gastrointestinal and colorectal ***,endoscopy is usually associated with adverse reactions such as nervousness,nausea,vomiting,choking cough,and *** discomfort,such as vomiting,coughing,or body movement,may lead to aggravation of a preexisting condition or even interruption of examination or treatment,especially in some critically ill patients with physiological dysfunction(e.g.,cardiovascular or respiratory disease).The optimal methods for inducing analgesia and sedation in endoscopy are areas of ongoing debate;nevertheless,determining an appropriate regimen of sedation and analgesia is *** To evaluate the effects of propofol combined with dezocine,sufentanil,or fentanyl in painless gastroscopy and *** Four hundred patients were randomly assigned to one of four groups for anesthesia:intravenous dezocine,sufentanil,fentanyl,or *** was administered intravenously for induction and maintenance of *** The dosage of propofol in the dezocine group was significantly lower than those in other groups(Psive,immobile patient whose airway requires maintenance to a fully recovered patient)after eye opening in the dezocine group were significantly higher than those in other groups(Psignificantly lower than those in other groups(Psignificantly more stable at various time points(before dosing,disappearance of eyelash reflex,and wakeup)than those in other groups(Psignificantly lower than those in other groups(P<0.01).Additi

关键词： Anesthesia Dezocine Propofol Gastroscopy Colonoscopy

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Sap Flow of Populus euphratica in a Desert Riparian Forest in an Extreme Arid Region During the Growing Season

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Journal of Integrative Plant Biology 2007年第4期49卷 425-436页

作者： Jian-hua si qi Feng Xiao-You Zhang Zong-qiang Chang Yong-Hong Su Hai-Yang Xi Cold and Arid Region Environmental and Engineering Research Institute the Chinese Academy of Sciences Alashan Desert Eco-hydrology Experimental Research Station Lanzhou 730000 China

In the present study, the heat pulse technique was applied to investigate the stem sap flow of Populus euphratica in a desert riparian forest in an extreme arid region from April to October 2003 and from May to October 2004. The experimental sites were in qidaoqiao （101 °10′ E, 41°59′ N） and Bayantaolai farm （101°14′ E, 42°01′ N） in Ejina county, in the low reaches of the Heihe River, China. The results indicated that the diurnal change in the velocity of sap flow showed minor fluctuations. At night, the rising of sap flow could be observed in the main tree species because of root pressure. During the growing season, the maximum average velocity was observed in July, followed by August, and the same velocity was observed in September and May; the minimum velocity was observed in October. The transpiration from June to August during the growing season accounted for approximately 70% of the annual total transpiration. The sap flow velocity of P. euphratica trees of different ages could be arranged in the order： 15 yr 〉 25 yr 〉 50 yr. Sap flow velocity was closely related to changes in micrometeorological factors, with average sap flow velocity showing a significant linear correlation with net radiation, air temperature and relative humidity.

关键词： desert riparian forest extreme arid region heat-pulse technique Populus euphratica sap flow velocity.

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硫肽类抗生素诺卡沙星I的结构改造研究进展

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药物生物技术 2020年第2期27卷 177-181页

作者：花私齐赵玲吴旭日中国药科大学生命科学与技术学院化学生物学研究室江苏南京211198

诺卡氏菌Nocardia *** 202099合成的次级代谢产物诺卡沙星Ⅰ是一种杀菌活性超强,作用靶点和机制新颖的硫肽类抗生素。多年来,诺卡沙星Ⅰ以及其类似物或衍生物一直是新型抗生素开发的热点目标化合物。但是,水溶性差是诺卡沙星Ⅰ成药的关... 详细信息

诺卡氏菌Nocardia *** 202099合成的次级代谢产物诺卡沙星Ⅰ是一种杀菌活性超强,作用靶点和机制新颖的硫肽类抗生素。多年来,诺卡沙星Ⅰ以及其类似物或衍生物一直是新型抗生素开发的热点目标化合物。但是,水溶性差是诺卡沙星Ⅰ成药的关键限制因素。为解决水溶性差的难题,科学家们采取了化学半合成、生物转化以及物理转化的方法对诺卡沙星Ⅰ的结构进行改造,以期增加其水溶性,提高成药性。本文将对诺卡沙星Ⅰ的结构改造进行概述,为水溶性差的抗生素的成药研究提供参考。

关键词：诺卡沙星Ⅰ 诺卡沙星类似物结构改造水溶性生物转化化学半合成

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十二烷基羟丙基磺基甜菜碱对产膜表皮葡萄球菌粘附作用的影响

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日用化学工业 2017年第9期47卷 497-501页

作者：段强军花私齐官妍安徽中医药大学安徽合肥230038 中国药科大学江苏南京211198

通过表面活性剂十二烷基羟丙基磺基甜菜碱(DSB)对表皮葡萄球菌生物被膜菌粘附的抑制作用研究,为抗由表皮葡萄球菌生物被膜菌引起的相关感染提供新的探索方向和治疗途径。以万古霉素为阳性对照,利用XTT减低法评价DSB对表皮葡萄球菌初始... 详细信息

通过表面活性剂十二烷基羟丙基磺基甜菜碱(DSB)对表皮葡萄球菌生物被膜菌粘附的抑制作用研究,为抗由表皮葡萄球菌生物被膜菌引起的相关感染提供新的探索方向和治疗途径。以万古霉素为阳性对照,利用XTT减低法评价DSB对表皮葡萄球菌初始粘附的影响。发现质量浓度为64 mg/L的DSB对表皮葡萄球菌初始粘附有显著的抑制作用;用质量浓度为512,256和128 mg/L的DSB对实验材料预处理后,对表皮葡萄球菌初始粘附的抑制作用明显。结果表明,DSB对表皮葡萄球菌形成生物被膜的初始粘附过程具有显著的抑制作用。

关键词：表面活性剂十二烷基羟丙基磺基甜菜碱粘附表皮葡萄球菌生物被膜

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一种适用于卫星电视直播的用户区域化管理方法

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通信技术 2020年第8期53卷 1959-1964页

作者：赵欢司华奇李宗元东方红卫星移动通信有限公司重庆401120 老挝亚太卫星有限公司老挝万象01000

卫星电视直播(DTH)与传统数字有线或地面广播电视相比,一大优势在于其广阔的覆盖面积与价格低廉的用户接收终端。对于国土面积与人口都相对较少的广大第三世界国家,DTH的成功运营往往依赖于多个不同国家或地区的业务开展。而出于国家政... 详细信息

卫星电视直播(DTH)与传统数字有线或地面广播电视相比,一大优势在于其广阔的覆盖面积与价格低廉的用户接收终端。对于国土面积与人口都相对较少的广大第三世界国家,DTH的成功运营往往依赖于多个不同国家或地区的业务开展。而出于国家政治与宣传层面考虑,或基于各国语言文化传统,各国受众对电视节目的收视偏好,尤其是节目排序等直观感受,往往都会有不同需求。传统的DVB-si标准难以实现多个不同地区的区域化管理。提出了一种适用于DTH电视直播的区域化管理规则,通过DTH前端系统与用户终端配合,可实现DTH节目排序与增值业务的区域化管理,较好地解决这一问题,经实践具有一定的商业价值。

关键词：卫星电视直播区域化管理节目排序增值业务

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EDTA-enhanced phytoremediation of lead contaminated soil by Bidens maximowicziana

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Journal of Environmental Sciences 2007年第12期19卷 1496-1499页

作者： WANG Hong-qi LU si-jin LI hua YAO Zhi-hua College of Water Sciences Beijing Normal University Beijing 100875 China.

Phytoremediation is a potential cleanup technology for the removal of heavy metals from contaminated soils. Bidens is a new Pb hyperaccumulator, which not only has remarkable tolerance to Pb but also extraordinary accumulation capacity for Pb. The maximum Pb concentration was 1509.3 mg/kg in roots and 2164.7 mg/kg in overground tissues. The Pb distribution order in the B. was： leaf 〉 stem 〉 root. The effect of amendments on phytoremediation was also studied. The mobility of soil Pb and the Pb concentrations in plants were both increased by EDTA application. Compared with CK （control check）, EDTA application promoted translocation of Pb to overground parts of the plant. The Pb concentrations in overground parts of plants was increased from 24.23-680.56 mg/kg to 29.07-1905.57 mg/kg. This research demonstrated that B. maximowicziana appeared to be suitable for phytoremediation of Pb contaminated soil, especially, combination with EDTA.

关键词： phytoremediation Bidens maximowicziana lead amendment EDTA

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Isolation and characterization of gasoline-degrading bacteria from gas station leaking-contaminated soils

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Journal of Environmental Sciences 2006年第5期18卷 969-972页

作者： LU si-jin WANG Hong-qi YAO Zhi-hua College of Water Sciences Beijing Normal University Beijing 100875 China

The effects of culture conditions in vitro and biosurfactant detection were studied on bacterial strains capable of degrading gasoline from contaminated soils near gas station. The main results were summarized as follows. Three bacteria （strains Q10, Q14 and Q18） that were considered as efficiently degrading strains were isolated and identified as Pseudomonas sp., Flavobaeterium sp. and Rhodococcus sp., respectively. The optimal growth conditions of three bacteria including pH, temperature and the concentration of gasoline were similar. The reduction in surface tension was observed with all the three bacteria, indicating the production of biosurfactant compounds. The value of surface tension reduced by the three strains Q10, Q14 and Q18 was 32.6 mN.m, 12.4 mN. m and 21.9 mN.m, respectively. Strain Q10 could be considered as a potential biosurfactant producer. Gasoline, diesel oil, benzene, toluene, ethylbenzene and xylene （BTEX） could easily be degraded by the three isolates. The consortium was more effective than the individual cultures in degrading added gasoline, diesel oil, and BTEX. These results indicate that these strains have great potential for in situ remediation of soils contaminated by gas station leaking.

关键词： gasolene BTEX bacteria biosurfactant consortium

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Expert consensus on the perioperative management of patients with sepsis

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World Journal of Emergency Medicine 2015年第4期6卷 245-260页

作者： Jun-ping Chen Xiang-ming Fang Xiao-ju Jin Rong-tian Kang Ke-xuan Liu Jin-bao Li Yan Luo Zhi-jie Lu Chang-hong Miao Han-xiang Ma Wei Mei Yang-wen Ou si-hua qi Zai-sheng qin Guo-gang Tian An-shi Wu Dong-xin Wang Tian Yu Yong-hao Yu Jing Zhao Ming-zhang Zuo Shi-hai Zhang Department of Anesthesiology Ningbo Number 2 Hospital Department of Anesthesiology First Affiliated HospitalSchool of MedicineZhejiang University Department of Anesthesiology and Critical Care Medicine Yijishan HospitalWannan Medical College Department of Anesthesiology Second Hospital of Hebei Medical University Department of Anesthesiology First Affiliated HospitalSun Yat-sen University Department of Anesthesiology and Intensive Care Medicine Changhai HospitalSecond Military Medical University Department of Anesthesiology Ruijin HospitalSchool of MedicineShanghai Jiaotong University Department of Anesthesiology and Intensive Care Medicine Eastern Hepatobiliary Surgery HospitalSecond Military Medical University Department of Anesthesiology Fudan University Shanghai Cancer CenterShanghai Medical CollegeFudan University Department of Anesthesiology General Hospital of Ningxia Medical University Department of Anesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Anesthesiology Third Xiangya HospitalCentral South University Department of Anesthesiology Fourth Affiliated HospitalHarbin Medical University Department of Anesthesiology Nanfang HospitalSouthern Medical University Department of Anesthesiology People's Hospital of Sanya Department of Anesthesiology Beijing Chaoyang HospitalCapital Medical University Department of Anesthesiology and Surgical Intensive Care Peking University First Hospital Department of Anesthesiology Affiliated Hospital of Zunyi Medical College Department of Anesthesiology Tianjin Medical University General Hospitaland Tianjin Research Institute of Anesthesiology Department of Anesthesiology Peking Union Medical College HospitalChinese Academy of Medical Sciences Department of Anesthesiology Beijing Hospital Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

INTRODUCTION Sepsis is defined as an infection associated with systemic manifestations of inflammation, which has become the most common complication in the perioperative period caused by severe burn/trauma and major surgical operation.[1,2] The incidence of sepsis in adults is estimated to be 149–240/100 000 per year, and that of severe sepsis and septic shock is 56–91/100 000 per year. In the last decade, the short-term mortality of sepsis has declined to around 20% in developed countries partly due to the international Surviving Sepsis Campaign （SSC）, while the mortality remains very high （50%–80%） in 1–5 years after discharge from hospitals.[3–7] Thus, sepsis and its subsequent severe sepsis and septic shock are currently major issues in the field of medical and health care.

关键词： Expert consensus perioperative management patients with sepsis

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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The design and processing of SONG library

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Nuclear Science and Techniques 2016年第4期27卷 96-103页

作者： hua Bei Jin-Kun Zhao qi-Chang Chen Sheng-Yi si Shanghai Nuclear Engineering Research and Design Institute Shanghai 200233 China

Multi-group cross section library is the basic condition for lattice calculation, which provides the necessary nuclear data parameters. The multi-functional lattice code SONG(si et al. in Nucl Power Eng 35:111–115,2014. doi:10.13832/***.2014.S2.0112; Chen et al. in Nucl Power Eng 35:127–130, 2014. doi:10.13832/***.2014.S2.0127) is developed to adapt to the research demands of different types of new reactors, especially the fourth generation(GEN-IV) reactors(Cerullo and Lomonaco in Nucl Fuel Cycle Sci Eng, 2012. doi:10.1533/9780857096388.3.333; Giorgio et al. in Energy Policy61:1503–1520, 2013. doi:10.1016/***.2013.06.101).The corresponding multi-group cross section library of SONG(SONGLIB) is well designed with much effort considering the next generation reactors' new feature in material, spectrum, burnup depth, etc. Therefore, the burnup chain(Maria and Jaakko in Nucl Sci Eng164:140–150, 2010. doi:10.13182/NSE09-14), energy group structure(Tholakele et al. in Ann Nucl Energy80:279–292, 2015. doi:10.1016/***.2015.01.038),and reaction path should be specially considered. The library SONGLIB is processed with the Evaluated Nuclear Data File(ENDF), nuclide data auxiliary processing code NJOYBAT(si et al. 2014), and library management code MANLIB(si et al. 2014). A series of verification work of SONGLIB is then carried out, and the calculated results are satisfied.

关键词：设计歌曲库核动力工程多群截面库音乐计算结果关键词核燃料循环

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