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Compatibility with Fructus Ligustri Lucidi Effectively Mitigates Idiosyncratic Liver Injury of Epimedii Folium by Modulating NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 159-170页

作者： Xiao-Mei Zhao Zhi-Xin Wu Yan wang Ying-Jie Xu Ye Xiu Xu Dong Jun-Jie Li Gui-Ji Lv si-hao wang Yu-Rong Li Zhao-Fang Bai Xiao-He Xiao Department of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijingChina Department of Military Patient Management The Fifth Medical Center of PLA General HospitalBeijingChina Department of Hepatology China Military Institute of Chinese Materia The Fifth Medical Center of PLA General HospitalBeijingChina Departmentof Hepatology National Key Laboratory of Kidney DiseasesBeijingChina

Background: Idiosyncratic drug-induced liver injury(IDILI) is a serious side effect of drugs, Epimedii Folium(EF) is unequivocally implicated in idiosyncratic liver injury onset, potentially due to its ability to perturb the NOD-like receptor family pyrin domain containing 3(NLRP3) inflammasome. Fructus Ligustri Lucidi(FLL), a frequently used medicinal combination with EF, has not yet been investigated for its ability to ameliorate EF-associated hepatotoxicity. Aims and Objectives: Study on the mechanism of compatibility of FLL to alleviate liver injury caused by EF. Materials and Methods: Western blot was used to determine the expression of related proteins, ELISA was used to detect the secretion of related inflammatory factors IL-1β, IL-18, IL-6 and TNF-α, liver injury indexes were detected and liver pathological tissue staining was used to evaluate the liver injury. Results: Our results demonstrated that EF exerted a particular augmenting effect on the stimulation of the NLRP3 inflammasome mediated by nigericin or ATP, whereas FLL suppressed the NLRP3 inflammasome stimulation. Furthermore, an equal EF to FLL ratio significantly reduced the stimulatory effects of EF. Moreover, EF has the potential to induce hepatic injury and augment pro-inflammatory cytokine synthesis in rats subjected to LPS. However, when combined with FLL, the detrimental effects of EF were mitigated. Conclusions: FLL possesses the capacity to attenuate EF-associated hepatotoxicity by suppressing EF-triggered NLRP3 inflammasome activation. Thus, FLL holds promise for improving the clinical safety profile of EF, shedding light on the potential of compatibility and detoxification theories in traditional Chinese medicine.

关键词： Epimedii Folium Fructus Ligustri Lucidi idiosyncratic drug-induced liver injury NOD-like receptor family pyrin domain containing 3 inflammasome traditional Chinese medicine

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植被叶片光谱特征对烟煤病胁迫程度的响应模型研究

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光谱学与光谱分析 2017年第9期37卷 2873-2878页

作者：杨兴川罗红霞赵文吉程玉丝王皓飞首都师范大学三维信息获取与应用教育部重点实验室北京100048 首都师范大学资源环境与地理信息系统北京市重点实验室北京100048 西南大学地理科学学院重庆400715

烟煤病是我国南方热带、亚热带地区一种非常普遍的植物病害,对我国农业生产造成巨大危害,对其监测预报是实施有效治理措施的重要基础和依据。为建立以高光谱数据为基础的烟煤病严重程度反演模型,在重庆北碚城区采集50个银木叶片样本,利... 详细信息

烟煤病是我国南方热带、亚热带地区一种非常普遍的植物病害,对我国农业生产造成巨大危害,对其监测预报是实施有效治理措施的重要基础和依据。为建立以高光谱数据为基础的烟煤病严重程度反演模型,在重庆北碚城区采集50个银木叶片样本,利用ASD FieldSpec HandHeld光谱仪获取高光谱数据,通过数码相机和ENVI软件获取叶面积数据,将银木叶片烟煤病面积与整个叶片面积的比例作为烟煤病的严重程度,建立相关性最大波段的烟煤病反演模型,探究烟煤病严重程度与光谱曲线之间可能存在的关系。结果表明:单叶尺度下,健康叶片在560nm波段附近有明显的反射峰,随着烟煤病严重程度增大,反射峰逐渐消失,在可见光与近红外波段,总体上光谱反射率与烟煤病病情严重程度呈负相关性。500~650和720~850nm为烟煤病的光谱敏感波段,其中相关度最大值点为550nm波段,相关系数达到-0.72。在烟煤病严重程度与叶片波段原始光谱信息及多波段组合关系研究中,单叶尺度下785nm波段高光谱参数与烟煤病严重程度建立的回归模型的决定系数(R^2)最大,为0.875。通过模型的显著性检验和预测精度检验,785nm处的光谱反射率建立的二次曲线模型为最优。证明在单叶尺度下,基于785nm波段的二次曲线模型反演烟煤病的效果较为理想。

关键词：烟煤病银木病害监测高光谱响应模型

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LED路灯室外照明特性与室内模拟关系研究

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发光学报 2016年第11期37卷 1422-1427页

作者：李景照阚子雄陈振强朱思祁任豪王巧彬顺德职业技术学院电子与信息工程学院广东佛山528300 暨南大学光电工程研究所广东广州510632 广州市光机电技术研究院广东广州510632

为了检验软件模拟道路照明特性的可行性,从几种不同配光曲线的LED路灯的仿真结果出发,按照规范的方法实测了它们的路面照度。比较发现,同一路面上各点的照度与仿真值之间有着相同的比值。进一步计算发现,两者的照度均匀度相等。这表明... 详细信息

为了检验软件模拟道路照明特性的可行性,从几种不同配光曲线的LED路灯的仿真结果出发,按照规范的方法实测了它们的路面照度。比较发现,同一路面上各点的照度与仿真值之间有着相同的比值。进一步计算发现,两者的照度均匀度相等。这表明仿真软件能比较准确地反映路灯的路面照明效果。另外,还研究了路灯的光衰性能,发现散热性能好的灯具光衰更慢,寿命更长。

关键词： LED路灯道路照明照度均匀度光衰性能

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复杂条件下单改双线隧道拆除扩挖控制爆破技术

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铁道工程学报 2009年第11期26卷 84-88页

作者：胡国伟郝四旺程文斌张俊兵中铁三局集团有限公司太原030001

研究目的:保证宜万线铁路隧道在复杂地质条件下单线改双线施工时,围岩与支护结构体系有良好的稳定性、扩挖效果和施工安全,以取得良好的经济和环境效益。研究结论:(1)采用控制预裂爆破技术,分段分部位拆除二次衬砌支护结构,并对断面实... 详细信息

研究目的:保证宜万线铁路隧道在复杂地质条件下单线改双线施工时,围岩与支护结构体系有良好的稳定性、扩挖效果和施工安全,以取得良好的经济和环境效益。研究结论:(1)采用控制预裂爆破技术,分段分部位拆除二次衬砌支护结构,并对断面实施台阶式和全断面式扩挖光面控制弱爆破,通过控制炸药用量、建立多个临空面、改善传播途径和应用非电毫秒微差起爆网络等一系列技术措施达到了减震目的;(2)对爆破振动进行实时监测,表明:监测的数据结果符合过程和目标控制,取得了很好的效果,实现了宜万地区岩石破碎、岩溶发育、埋深浅等恶劣条件下新建隧道按"先单线成洞,后爆破拆除扩挖成型"顺序下的成功修建。

关键词：宜万铁路浅埋隧道单改双线拆除爆破扩挖爆破

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Prediction of cutting forces in flank milling of parts with non-developable ruled surfaces

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Chinese Journal of Aeronautics 2019年第7期32卷 1788-1796页

作者： Liping wang hao si Liheng GU Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Beijing Beiyi Machine Tool Co.Ltd. Beijing101300China

Predicting the cutting forces required for five-axis flank milling is a challenging task due to the difficulties involved in determining the Undeformed Chip Thickness(UCT) and CutterWorkpiece Engagement(CWE). To solve these problems, this paper presents a new mechanistic cutting force model based on the geometrical analysis of a flank milling process. In the model,the part feature and corresponding cutting location data are taken as input information. The UCT considering cutter runout is calculated according to the instantaneous feed rate of the element cutting edges. A solid-discrete-based method is used to precisely and efficiently identify the CWE between the end mill and the surface being machined. Then, after calibrating the specific force coef-ficients, the mechanistic milling force can be obtained. During the validation process, two practical operations, three-axis flank milling of a vertical surface and five-axis flank milling of a nondevelopable ruled surface, are conducted. Comparisons between predicted and measured cutting forces demonstrate the reliability of the proposed cutting force model.

关键词： Chip thickness Cutting force Five-axis flank milling Machining Ruled surface

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产业匹配视角下的环京产研一体化圈建设策略

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河北学刊 2025年第1期45卷 82-90页

作者：张可云黎思灏中国人民大学应用经济学院

打造环京产研一体化圈层是推动京津冀协同发展的创新举措,需要推动北京市制造业高新技术企业与环京区县的合作。但环京区县存在产业基础薄弱、与北京产业匹配度不高和产业投资联系不强的问题。两地发展差距过大、市郊铁路建设滞后和环... 详细信息

打造环京产研一体化圈层是推动京津冀协同发展的创新举措,需要推动北京市制造业高新技术企业与环京区县的合作。但环京区县存在产业基础薄弱、与北京产业匹配度不高和产业投资联系不强的问题。两地发展差距过大、市郊铁路建设滞后和环京区县营商环境不良是造成上述问题的主要原因。未来应当根据产业匹配度建立对口合作关系,进一步加强市际交通基础设施建设,降低企业营商成本。

关键词：京津冀环京区县产研一体高新技术企业上市公司异地投资

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Feedrate scheduling method for constant peak cutting force in five-axis flank milling process

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Chinese Journal of Aeronautics 2020年第7期33卷 2055-2069页

作者： Liping wang Xing YUAN hao si Feiyu DUAN School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China

It is extremely important to select appropriate feedrates for the stable machining of parts with ruled surface in modern aviation industrial ***,the current studies take too much time to achieve this ***,this paper presents an efficient feedrate optimization method for constant peak cutting force in five-axis flank milling *** solution method of the instantaneous undeformed chip thickness(IUCT)is proposed using least squares theory with the cutter entry angle and feedrate as *** on this method,an explicit analytical expression of the peak cutting force for each cutting point is ***,a feedrate scheduling method is developed to quickly solve the appropriate feedrate under constant peak cutting *** verify the proposed IUCT model,the fitting IUCT is compared with the accuracy data at different ***,some experiments of five-axis flank milling are conducted to demonstrate the effectiveness of the peak force model and the feedrate scheduling *** the surface roughness before and after feedrate scheduling is *** results show that the proposed feedrate scheduling method can quickly adjust the feedrate and ensure constant peak force during *** the same time,the surface quality is kept at a high level.

关键词： Cutter runout Feedrate scheduling Force control Instantaneous undeformed chip thickness Peak cutting force

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Fermi Blazars in the Zwicky Transient Facility Survey:Properties of Large Optical Variations

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Research in Astronomy and Astrophysics 2024年第10期24卷 104-115页

作者： si-si Sun Zhong-Xiang wang Shun-hao Ji Department of Astronomy School of Physics and AstronomyYunnan UniversityKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

We analyze the optical light curve data,obtained with the Zwicky Transient Facility(ZTF)survey,for 47 γ-ray blazars monitored by the Large Area Telescope onboard the Fermi Gamma-ray Space Telescope(Fermi).These 47sources are selected because they are among the Fermi blazars with the largest optical variations in the ZTF *** color-magnitude variation patterns are seen in them,with one being redder-to-stable-when-brighter(RSWB;in 31 sources)and the other being stable when brighter(in 16 sources).The patterns fit with the results recently reported in several similar studies with different ***,we find that the colors in the stable state of the sources share similar values,for which(after being corrected for the Galactic extinction)most sources are in a range of 0.4–*** feature could be intrinsic and may be applied in,for example,study of the intragalactic *** also determine the turning points for the sources showing the RSWB pattern,after which the color changes saturate and become *** find a correlation between optical fluxes and γ-ray fluxes at the turning *** physical implications of the correlation remain to be investigated,probably better with a sample of high-qualityγ-ray flux measurements.

关键词： (galaxies:)BL Lacertae objects:general (galaxies:)quasars:general gamma-rays:galaxies

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新高考背景下深化高中教育教学改革应重视的几个问题

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教学与管理 2025年第1期 12-14页

作者：司晓宏马永昊陕西师范大学教育学部西安710062 陕西省社会科学院西安710061

自2014年新高考改革启动以来,已在全国29个省市逐步推进。调研发现,新高考在实际推进中给普通高中传统的教育、教学和管理带来了诸多压力与挑战,这突出表现为:“选课走班制”在实际推行中存在许多堵点;“学生综合素质评价”面临着评价... 详细信息

自2014年新高考改革启动以来,已在全国29个省市逐步推进。调研发现,新高考在实际推进中给普通高中传统的教育、教学和管理带来了诸多压力与挑战,这突出表现为:“选课走班制”在实际推行中存在许多堵点;“学生综合素质评价”面临着评价标准不一、结果应用受限等困境;“学生生涯规划教育”存在着专业性不强、效果不佳等问题;学生多样化自由选课凸显教师队伍结构性缺编等。针对上述问题,应加强普通高中选课走班制的资源条件支持,健全学生综合素质评价的体制机制,提高学生生涯规划教育的专业性和精准度,积极破解改革所导致的教师结构性缺编问题,以推动和确保新高考改革各项政策有效落地实施。

关键词：新高考改革选课走班制学生综合素质评价生涯规划教育教育教学改革

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Magnetic and thermosensitive luminescent nanocomposites based on Fe_3O_4/siO_2/poly(N-isopropylacrylamide)/lanthanidepolyoxometalates and their controllable luminescence properties

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Journal of Rare Earths 2018年第7期36卷 733-738页

作者： Jun wang si Chen hao Liu Wuke Li College of Chemistry Central China Normal University

Magnetic and temperature-responsive luminescent composites based on poly（N-isopropylacrylamide）,magnetic nanoparticles and Na9[EuW10O36] were fabricated. The composites were investigated by IR, UV,XRD, TGA, SEM and TEM. The prepared nanocomposites exhibit good superparamagnetic property and thermo-responsive switchable luminescence properties. The multifunctional nanocomposites can be separated by external magnetic field. Moreover, the nanocomposites exhibit an appreciable temperature response, and the red luminescence of the nanocomposites in solution can be controlled by the temperature stimuli. The hydrogel emits strong redluminescence in solution at 25 ℃,which can be seen by naked eyes. When the external temperature is 40 ℃, the red luminescence almost disappears in *** is expected that the multifunctional nanoparticles have potential applications in the field of biomedicine.

关键词： Magnetic Lanthanide Luminescence Thermosensitive Controllable Rare carths

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