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Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea

World Journal of Gastroenterology 2021年第5期27卷 391-403页

作者： Yan-Dong Li Bao-Ning Liu si-hai zhao Yong-Li Zhou Liang Bai En-Qi Liu Laboratory Animal Center Xi’an Jiaotong University Health Science CenterXi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Research Institute of Atherosclerotic Disease and Laboratory Animal Center School of MedicineXi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Laboratory Animal Center Institute of Atherosclerotic DiseaseXi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Post-cholecystectomy diarrhea(PCD)frequently occurs in patients following gallbladder *** is part of the post-cholecystectomy(PC)syndrome,and is difficult to *** cholecystectomy,bile enters the duodenum directly,independent of the timing of *** interaction between the bile acids and the intestinal microbes is ***,the occurrence of PCD may be related to the change in ***,little is known about the relationship between the gut microbiota and *** To better understand the role of the gut microbiota in PCD *** Fecal DNA was *** diversity and profiles of the gut microbiota were analyzed by performing high-throughput 16S rRNA gene *** gut microbiota were characterized in a healthy control(HC)group and a PC ***,the PC group was further divided into a PCD group and a postcholecystectomy non-diarrhea group(PCND)according to the patients’clinical *** composition,diversity and richness of microbial communities were determined and *** In the PC and HC groups,720 operational taxonomic units(OTUs)were *** PC group had fewer OTUs than the HC group.β-diversity was decreased in the PC *** indicated decreased microbial diversity in the PC *** taxa with differential abundance between the HC and PC groups were *** the PCD group compared to the PCND group,significant decreases in microbial diversity,Firmicutes/Bacteroidetes ratio,and richness of probiotic microbiota(Bifidobacterium and Lactococcus),and an increase in detrimental microbiota(Prevotella and Sutterella)were ***,a negative correlation was found between Prevotella and *** a Kyoto Encyclopedia of Genes and Genomes functional analysis,it was found that the abundances of gut microbiota involved in lipid metabolism pathways were markedly lower in the PCD group compared to the PCND *** This study demonstrated that gut

关键词： Cholecystectomy Post-cholecystectomy Diarrhea 16S rRNA Microbiota Bifidobacterium

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Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 342-347页

作者： Qi YU En-qi LIU si-hai zhao Ya-feng LI Yan-li WANG Yu-long CHEN Ke-na WEI Bing-qiao HUANG Jian-lin FAN Peng-hui YANG Research Institute of A therosclerotic Disease Xi'an Jiaotong University School of MedicineShaanxi 710061China Laboratory Animal Center Xi'an Jiaotong University School of MedicineShaanxi 710061China Department of Molecular Pathology Interdisciplinary Graduate School of Medicine and EngineeringUniversity of YamanashL Yamanashi 409-3898Japan

Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The lit- erature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB poly- morphism of CETP was found to be associated with CAD in the Chinese population.

关键词： Cholesteryl ester transfer protein Coronary artery disease Polymorphism Chinese population

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Chronic Infusion of Urotensin Ⅱ Promote Diet-Induced Atherosclerosis in Rabbits

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中国动脉硬化杂志 2013年第9期21卷 I0079-I0080页

作者： Ya-Feng Li Yan-Li Wang si-hai zhao Rui-Han Liu Yu-Long Chen Yan Lin Ning-Hong Zhu Liang Bai Jiang-Lin Fan En-Qi Liu Research Institute of Atherosclerotic Disease Xi ' an Jiaotong University Cardiovascular Research Center Xi ' an Shaanxi 710061 China Laboratory Animal Center School of Medicine of Xi'an Jiaotong University Xi ' an Shaanxi 710061 China Department of Molecular Pathology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi 409-3898 Japan

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皮肤浆细胞增多症1例

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北京大学学报（医学版） 2018年第4期50卷 752-754页

作者：张思李文海赵琰蔡林北京大学人民医院皮肤科北京100044

皮肤合并系统性浆细胞增多症（cutaneous and systemic plasmacytosis,CSP）是一种以皮肤或多系统成熟浆细胞浸润为特征的良性疾病,最常累及皮肤、淋巴结、骨髓,发病率较低,亚洲人多见,男性发病率稍高,典型的发病年龄为20～55岁。该病... 详细信息

皮肤合并系统性浆细胞增多症（cutaneous and systemic plasmacytosis,CSP）是一种以皮肤或多系统成熟浆细胞浸润为特征的良性疾病,最常累及皮肤、淋巴结、骨髓,发病率较低,亚洲人多见,男性发病率稍高,典型的发病年龄为20～55岁。该病的特征为浆细胞多克隆增殖,皮肤浆细胞增多症（cutaneous plasmacytosis,CP）仅累及皮肤,较为罕见,皮损常表现为棕红色斑块,局部外用糖皮质激素或他克莫司、长波紫外线照射有一定疗效。北京大学人民医院皮肤科收治1例皮肤浆细胞增多症.

关键词：浆细胞增多症皮肤疾病病例报告

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Oxygen vacancies enriched Ir/WOx catalysts for the directly chem-catalytic conversion of cellulose to ethanol

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Tungsten 2025年第1期7卷 88-99页

作者： Yu-Jing Weng zhao-Ying Ding Ying-Chao Li Yuan-Feng Wu Yuan-Yang Xu Rui Chen Xiao-Lei zhao hai-Yong Wang Da-Lei Zhang Yu-Long Zhang Henan Key Laboratory of Coal Green Conversion and International Joint Laboratory of Coal Clean Utilization College of Chemistry and Chemical Engineering Henan Polytechnic University Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Liaoning Institute of Energy Technology

Tungsten and its oxides are highly versatile catalysts with unique properties that hold great promise for a wide array of applications,including biological pathways and chemical *** chemo-catalysis of cellulose to ethanol presents a promising avenue for ethanol synthesis with the potential for enhanced efficiency compared to conventional methods,offering a sustainable and carbon-neutral alternative to existing petrochemical and biological ***,Ir/WOxcatalysts enriched with oxygen vacancies were meticulously prepared and demonstrated remarkable catalytic performance in converting cellulose to ethanol directly in the presence of tungstic *** catalyst achieved a high ethanol yield of 66.5%under optimal reaction conditions,approaching the theoretical yield limit of traditional ethanol *** results revealed the presence of oxygen defects,Bronsted/Lewis acidity,and Ir nanoclusters on the catalyst surface,working synergistically to facilitate the cascade catalysis of cellulose hydrolysis,sugar retro-aldol condensation reaction,and C2 intermediate hydrodeoxygenation to *** situ Fourier transform infrared spectrometer analysis confirmed the catalyst's ability to enhance the adsorption and activation of ethylene glycol for ethanol *** manipulating subtle structural features,this study offers a fresh perspective on tungsten group catalyst design and underscores the importance of synergistic effects among catalytic sites for the efficient production of ethanol from cellulose.

关键词： Cellulosic ethanol Chem-catalysis Hydrogenolysis Retro-aldol condensation Tungsten

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao Kang Xiao-Li zhao Lin Xu Linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

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白藜芦醇对肝癌细胞基质金属蛋白酶-9表达的影响

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中西医结合学报 2008年第3期6卷 270-273页

作者：余海波潘承恩吴武军赵四海张慧峰西安交通大学医学院第一附属医院肝胆外科陕西西安710061 西安交通大学医学院免疫和病原微生物学教研室陕西西安710061 河南省人民医院重症监护治疗中心河南郑州450003

目的:观察白藜芦醇(resveratrol,Res)对体外人肝癌细胞系SMMC-7721细胞增殖及基质金属蛋白酶-9 (matrix metalloproteinase-9,MMP-9)表达的影响,初步探讨Res抑制肝癌细胞侵袭转移的机制。方法:应用不同浓度的Res分别作用于人肝癌细胞系S... 详细信息

目的:观察白藜芦醇(resveratrol,Res)对体外人肝癌细胞系SMMC-7721细胞增殖及基质金属蛋白酶-9 (matrix metalloproteinase-9,MMP-9)表达的影响,初步探讨Res抑制肝癌细胞侵袭转移的机制。方法:应用不同浓度的Res分别作用于人肝癌细胞系SMMC-7721细胞24、48和72 h,采用甲基噻唑基四唑比色试验(methyl thiazolyl tetrazolium,MTT)观察Res对SMMC-7721细胞增殖的影响;反转录聚合酶链反应(reverse transcription polymerase chain reaction,RT-PCR)检测MMP-9 mRNA的表达;蛋白印迹分析(Western blot analysis)法检测MMP-9蛋白表达情况。结果:Res对SMMC-7721细胞有增殖抑制作用,且呈量效和时效关系;经Res作用后,SMMC-7721细胞MMP-9 mRNA和蛋白表达均明显下降(P<0.05)。结论:Res对肝癌细胞的生长具有抑制作用,且能下调其MMP-9的表达,可能具有抑制肝癌细胞侵袭转移的作用。

关键词：白藜芦醇肝癌基质金属蛋白酶-9

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甘肃不同产地黄管秦艽中无机元素的相关性和主成分分析

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天然产物研究与开发 2016年第9期28卷 1402-1408页

作者：谢敏汪洁张启立李四海陈晖赵磊甘肃中医药大学甘肃省道地药材质量标准化技术研究与推广工程实验室甘肃省中药质量与标准研究重点实验室培育基地甘肃省高校中(藏)药化学与质量研究省级重点实验室兰州730000

以甘肃不同产地黄管秦艽为材料,测定其无机元素含量,分析黄管秦艽中无机元素特征及评价药材质量。采用火焰原子吸收光谱法测定黄管秦艽中无机元素含量,并运用相关性分析和主成分分析对其含量进行分析和评价。结果表明不同产地黄管秦艽... 详细信息

以甘肃不同产地黄管秦艽为材料,测定其无机元素含量,分析黄管秦艽中无机元素特征及评价药材质量。采用火焰原子吸收光谱法测定黄管秦艽中无机元素含量,并运用相关性分析和主成分分析对其含量进行分析和评价。结果表明不同产地黄管秦艽中无机元素Ca、K、Mg、Mo含量较高,部分无机元素之间存在相关性;经主成分分析得到3个主因子,3个主成分的累计方差贡献率为83.20%。从无机元素含量的主成分分析来看,产于卓尼县尼巴乡的黄管秦艽质量最优,本实验可为黄管秦艽的资源开发利用、质量控制以及安全评价提供参考依据。

关键词：黄管秦艽无机元素相关性分析主成分分析

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改良四氧嘧啶制作兔糖尿病模型的实验研究(英文)

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国际眼科杂志 2010年第10期10卷 1848-1850页

作者：孙文涛雷春灵赵四海毕春潮张璐中国陕西省西安市第四医院眼科 710004 西安交通大学医学院中国陕西省西安市710061

目的:通过改变四氧嘧啶给药次数探索改良制作兔糖尿病模型的方法。方法:选取健康大耳白兔36只,体质量为2～2.5kg,注射四氧嘧啶剂量均为150mg/kg,随机分为3组,每组12只,分别为一次给药组(A组),分两次给药组(B组)和分三次给药组(C组)。观... 详细信息

目的:通过改变四氧嘧啶给药次数探索改良制作兔糖尿病模型的方法。方法:选取健康大耳白兔36只,体质量为2～2.5kg,注射四氧嘧啶剂量均为150mg/kg,随机分为3组,每组12只,分别为一次给药组(A组),分两次给药组(B组)和分三次给药组(C组)。观测各组空腹血糖值,计算各组成模率和死亡率。结果:B组兔糖尿病模型成模率显著高于A组(P<0.01),死亡率显著低于A组(P<0.01);C组兔糖尿病模型成模率显著高于B组(P<0.01),死亡率显著低于B组(P<0.01)。结论:四氧嘧啶分次给药能提高制作兔糖尿病模型的成模率,降低死亡率并且可以保持模型的稳定。

关键词：四氧嘧啶糖尿病兔死亡率成模率

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Cu掺杂及缺陷共存对ZnO光催化影响的理论研究

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原子与分子物理学报 2025年第2期42卷 24-32页

作者：张海峰赵晋忠伊思静卢士香山西农业大学基础部太谷030801 北京理工大学化学与化工学院北京100081

采用密度泛函理论研究了Cu掺杂及缺陷共存对ZnO光催化性能的影响.计算时考虑了富O和贫O两种掺杂条件.研究结果表明富O条件有利于Cu的掺杂,贫O条件则产生抑制作用.当Cu掺杂浓度较低时,不论在何种掺杂条件下,Cu的主要掺杂方式均为Cu_(Zn)... 详细信息

采用密度泛函理论研究了Cu掺杂及缺陷共存对ZnO光催化性能的影响.计算时考虑了富O和贫O两种掺杂条件.研究结果表明富O条件有利于Cu的掺杂,贫O条件则产生抑制作用.当Cu掺杂浓度较低时,不论在何种掺杂条件下,Cu的主要掺杂方式均为Cu_(Zn)型.当Cu掺杂浓度较高时,富O条件下以Cu_(Zn)-Cu_(Zn)型掺杂方式为主,贫O条件下Cu_(Zn)-Cu_(Zn)和Cu_(Zn)-Cui这两种掺杂方式都有可能出现.富O条件下Cu掺杂会促进V_(Zn)和O_(i)缺陷的产生,且引入的V_(Zn)和O_(i)缺陷趋向于距离Cu原子最近.Cu掺杂可有效降低ZnO的带隙宽度,且随着掺杂浓度的增加,相应模型的带隙宽度会继续降低.V_(Zn)、O_(i)和V_(O)缺陷共存使相应模型的带隙宽度有所增加.Cu掺杂及V_(Zn)、O_(i)、V_(O)缺陷共存使模型对可见光发生响应,扩展了模型对太阳光的吸收范围.对于Cu掺杂模型,富O条件下Cu_(Zn)-Cu_(Zn)是有利的光催化模型.对于缺陷共存模型,富O条件下Cu_(Zn)-Cu_(Zn)-V_(Zn)是有利的光催化模型,其次是Cu_(Zn)-V_(Zn)和Cu_(Zn)-O_(i),贫O条件下Cu_(Zn)-V_(O)是有利的光催化模型.

关键词： ZnO Cu掺杂缺陷共存密度泛函理论光催化

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