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Chinese Chemical Letters 2024年第8期35卷 187-200页

作者： si ha Jiacheng Zhu Hua Xiang Guoshun Luo State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 211198China

Small molecule inhibitors have dominated the pharmaceutical landscape for a long time as the primary therapeutic paradigm targeting pathogenic ***,their efficacy heavily relies on the amino acid composition and spatial constitution of proteins,rendering them susceptible to drug resistance and failing to target undruggable *** recent years,the advent of targeted protein degradation(TPD)technology has captured substantial attention from both industry and *** an event-driven mode,TPD offers a novel approach to eliminate pathogenic proteins by promoting their degrada-tion,thus circumventing the limitations associated with traditional small molecule ***-bic tag tethering degrader(HyTTD)technology represents one such TPD approach that is currently in the burgeoning *** employ endogenous protein degradation systems to induce the degrada-tion of target proteins through the proteasome pathway,which displays significant potential for medical *** this review,we provide a comprehensive overview of the development history and the reported mechanism of action of ***,we delve into the physiological roles,structure-activity re-lationships,and medical implications of HyTTDs targeting various disease-associated ***,we propose insights into the challenges that necessitate resolution for the successful development of HyTTDs,with the ultimate goal of initiating a new age of clinical treatment leveraging the immense po-tential of HyTTDs.

关键词： Targeted protein degradation(TPD) Hydrophobic tag Degrader Hydrophobic tag tethering degrader(HyTTD) Targeted therapy

Nitrogen addition increased resistance of resident plant community to Solidago canadensis invasion by altering allelopathic effect

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Journal of Plant Ecology 2024年第2期17卷 110-121页

作者： Jing-Fang Cai Kai Sun Lin Li si-ha a Yi-Luan Shen Hong-Li Li School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China The Key Laboratory of EcologicalProtection in the Yellow River Basin of National Forestry and Grassland Administration Beijing Forestry UniversityBeijing 100083China

Allelopathy plays an important role in the interaction between invasive and resident *** nitrogen(N)deposition has become a global problem,but it is unclear whether N enrichment affects the interaction between invasive and resident plants by affecting their ***,we performed a greenhouse experiment in which the resident plant community was grown under two levels of invasion by ***(invasion *** invasion)and fully crossed with two levels of allelopathy(with or without adding activated carbon)and two levels of N addition(with or without).The resident plant communities were constructed with eight herbaceous species that often co-occur with *** results showed that both allelopathy of *** and the resident plants had obvious positive effects on their own *** addition had more obvious positive effects on the resident plants under invasion than those that were not ***,N addition also altered the allelopathy of resident ***,N addition improved the allelopathy of resident plants when they were invaded but decreased the allelopathy of resident plants when they grew *** nitrogen addition had no obvious effect on ***,it reduced the allelopathy of *** results suggest that N addition could improve the resistance of resident plants to invasion by improving the allelopathy of resident plants and reducing the allelopathy of *** fndings provide a scientifc basis to manage and control the *** invasion.

关键词： allelochemicals biological invasion nutrient input nitrogen addition resident plants Solidago canadensis

Endobronchial metastasis secondary to renal clear cell carcinoma:A case report

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World Journal of Clinical Cases 2024年第23期12卷 5416-5421页

作者： Tian-hao Xie Yan Fu si-Ning ha Qing-Xu Meng Qian Sun Pan Wang Department of General Surgery The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Ophthalmology Baoding First Central HospitalBaoding 071000Hebei ProvinceChina Department of Pathology The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BACKGROUND Endobronchial metastases(EBMs)are tumours that metastasise from a malignant tumour outside the lungs to the central and subsegmental bronchi,and are visible under a *** EBMs are formed by direct invasion or metastasis of intrathoracic malignant tumours,such as lung cancer,oesophageal cancer or mediastinum *** cell carcinoma(RCC),accounting for 2%to 3%of all tumours,is a common malignant tumour of the urinary *** clear cell carcinoma(RCCC)constitutes the predominant pathological subtype of RCC,comprising approximately 70%to 80%of all RCC *** can spread and metastasise through arterial,venous and lymphatic circulation to almost all organs of the ***,lung,bone,liver,brain and local recurrence are the most common metastatic neoplasms of ***,EBM from RCCC has a low complication rate and is often misdiagnosed as primary lung *** SUMMARY A 71-year-old male patient who had undergone radical left nephrectomy 7 years prior due to RCCC was referred to our hospital due to a 1-mo history of productive *** results of an enhanced chest CT scan indicated the presence of a soft tissue nodule in the upper lobe of the left lung,and flexible bronchoscopy revealed a hypervascular lesion in the bronchus of the left lung's superior ***,the patient underwent thoracoscopic left superior lobe wedge resection,and pathology confirmed EBM from the *** EBM from RCCC has a low incidence and no characteristic clinical manifestations in the early *** a bronchial tumour is found in a patient with RCCC,the possibility of bronchial metastatic cancer should be considered.

关键词： Endobronchial metastases Clear renal cell carcinoma Renal cell carcinoma diagnosis Treatment Case report

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改性纳米纤维素对铜离子的吸附

内蒙古石油化工 2024年第2期50卷 19-22页

作者：哈斯梁言呼和浩特民族学院化学与环境学院内蒙古呼和浩特010051

用内蒙古自治区武川县废弃的莜麦秸秆制备纳米改性莜麦秸秆纤维素,分别从吸附剂投加量,吸附时间和溶液pH值对其铜离子吸附性能进行对比研究,HCl-NTA-NOSC投加量在0.1g左右时,吸附率最高,可以达到30%至35%,最佳吸附时间为60分钟、在溶液p... 详细信息

用内蒙古自治区武川县废弃的莜麦秸秆制备纳米改性莜麦秸秆纤维素,分别从吸附剂投加量,吸附时间和溶液pH值对其铜离子吸附性能进行对比研究,HCl-NTA-NOSC投加量在0.1g左右时,吸附率最高,可以达到30%至35%,最佳吸附时间为60分钟、在溶液pH值5左右时吸附效果最好。

关键词：莜麦秸秆改性纤维素铜离子

企业ESG与资本市场表现——来自股票流动性的证据

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科学决策 2024年第4期 42-60页

作者：徐晟哈斯木其尔梁富友沈熙峰中南财经政法大学中国医药健康产业股份有限公司

在经济社会发展绿色化、低碳化态势下,ESG理念在资本市场中的地位日益凸显。文章基于2015—2021年我国A股上市公司数据,研究ESG表现对企业股票流动性的影响。研究发现,ESG表现显著提升了企业股票流动性,该效应在国有企业、大规模企业以... 详细信息

在经济社会发展绿色化、低碳化态势下,ESG理念在资本市场中的地位日益凸显。文章基于2015—2021年我国A股上市公司数据,研究ESG表现对企业股票流动性的影响。研究发现,ESG表现显著提升了企业股票流动性,该效应在国有企业、大规模企业以及市场化程度较高的地区企业中更显著。机制分析表明,企业ESG有利于提升投资者情绪和信息透明度,进而促进股票流动性。进一步研究发现,企业良好ESG表现所带来的股票流动性显著提升了企业价值和企业创新。发掘企业ESG在金融市场的作用效果,为活跃资本市场提供新的经验证据。

关键词： ESG 股票流动性投资者情绪信息透明度文本分析

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How Participatory is Participatory Flood Risk Mapping? Voices from the Flood Prone Dharavi Slum in Mumbai

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International Journal of Disaster Risk Science 2022年第2期13卷 230-248页

作者： Subhajyoti Samaddar ha si Xinyu Jiang Junho Choi Hirokazu Tatano Disaster Prevention Research Institute Kyoto UniversityKyoto 6110011Japan School of Management Wuhan University of TechnologyWuhan 430070China Disaster and Safety Management Soongsil UniversitySeoul 06978South Korea

Participatory flood risk mapping(PFRM) is a well-recognized and widely implemented tool for meaningful community involvement in disaster risk reduction(DRR). The effectiveness of PFRM remains anecdotal. The PFRM exercise has rarely been applied identically in two different places by two different organizations, which produces varied and uncertain outcomes. In the absence of any agreed and comprehensive framework for participatory DRR, existing studies struggle to provide a scientific account of how the structure, design, and process of PFRM ensure the effective participation of local *** study, examines what factors and methods make PFRM an effective participatory DRR tool. In this study,we first identified the process-based criteria of participation. Then we briefly introduced a participatory flood risk mapping exercise conducted in a flood-prone informal settlement in Dharavi, Mumbai. The exercise was carefully designed to meet the process criteria of effective participation. Finally, using qualitative research methods, we evaluated the effectiveness of our PFRM from the local community perspective. The findings show that ensuring community livelihood security and true involvement of marginalized groups, preparing an action plan, and incorporating fun and cultural connotations into the facilitation process are critical components that enhance community participation through PFRM in DRR.

关键词： Dharavi Evaluation Mumbai flood Participatory disaster risk reduction Participatory flood risk mapping Process-based criteria of participation

1970−2021年阿尔金山国家级自然保护区湖泊面积变化研究

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北京师范大学学报（自然科学版） 2024年第4期60卷 541-550页

作者：杨岩岩张国明洪畅严平哈斯董苗王一娇周彦广中国林业科学研究院生态保护与修复研究所北京北京师范大学国家安全与应急管理学院北京北京师范大学环境演变与自然灾害教育部重点实验室北京北京师范大学地表过程与资源生态国家重点实验室北京北京师范大学应急管理部/教育部减灾与应急管理研究院北京北京师范大学地理科学学部北京

以阿尔金山国家级自然保护区内湖泊为研究对象,通过对大比例尺地形图和中高分辨率遥感影像的配准和目视解译,并结合保护区周边4个气象站1970−2021年气温、降水、蒸散量数据,系统分析了区内面积>1 km2湖泊的面积变化及其对气候因子的响应... 详细信息

以阿尔金山国家级自然保护区内湖泊为研究对象,通过对大比例尺地形图和中高分辨率遥感影像的配准和目视解译,并结合保护区周边4个气象站1970−2021年气温、降水、蒸散量数据,系统分析了区内面积>1 km2湖泊的面积变化及其对气候因子的响应.结果表明:1)近51 a保护区的湖泊呈现扩张、稳定和萎缩3种变化趋势,但大部分湖泊处于扩张状态.其中:大型湖泊均呈扩张之势,并以20世纪90年代中期为节点,前期扩展缓慢,后期出现明显扩展增速;中型湖泊面积变化呈现扩张、稳定和萎缩3种趋势;小型湖泊面积变化呈现扩张和萎缩2种趋势;湖泊面积的变化趋势与湖泊自身的规模无关,只与其补给和支出平衡有关.2)沙子湖、小沙子湖是部分河段被沙埋的流经湖,多年湖面积变化较小,湖泊周围沙丘未出现大范围朝湖向移动.3)保护区湖泊的面积与气温和降水呈正相关,与蒸发量呈显著负相关,气温和降水对湖泊面积的影响大于蒸发.保护区内湖泊属降雨和冰川融水补给型湖泊,且冰川融水的补给量大于降水.研究结果有助于了解该地区气候变化控制下水资源演变过程,可作为进一步评估区域气候变化和湖泊变化的依据.

关键词：阿尔金山国家级自然保护区湖泊面积变化特征影响因素

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基于巢式PCR的紫草鉴别引物筛选

药物分析杂志 2024年第5期44卷 756-765页

作者：刘杰谷海媛戴胜云乔菲连超杰郑健加沙尔·斯哈克中国食品药品检定研究院北京102629 沈阳药科大学沈阳110016 伊犁哈萨克自治州检验检测认证研究院伊型835000

目的:基于巢式聚合酶链式反应(PCR)理念设计并筛选出可用于高效扩增与鉴别紫草市场样品真伪的特异性引物。方法:针对新疆紫草的ITS序列和紫草非《中华人民共和国药典》品ITS2序列,利用Primer Premier 5软件进行巢式引物设计;比较ITS2通... 详细信息

目的:基于巢式聚合酶链式反应(PCR)理念设计并筛选出可用于高效扩增与鉴别紫草市场样品真伪的特异性引物。方法:针对新疆紫草的ITS序列和紫草非《中华人民共和国药典》品ITS2序列,利用Primer Premier 5软件进行巢式引物设计;比较ITS2通用引物PCR和巢式PCR对紫草药材基因组DNA的扩增效率;基于巢式引物直接扩增紫草基因组DNA,并进行琼脂糖凝胶电泳检测;基于扩增产物片段长度、变异位点覆盖情况对设计的紫草药材特异性引物进行评价。结果:经过Primer Premier 5软件进行引物设计共选出11对引物进行合成;巢式PCR对紫草药材基因组DNA的扩增效率明显优于ITS2通用引物PCR;基于巢式引物直接扩增紫草基因组DNA琼脂糖凝胶电泳检测的结果明显优于ITS2引物直接扩增紫草基因组DNA,且呈单一条带;确定AE-9S/AE-2A、AE-4S/AE-10A、AE-12S/10A、AE-29S/AE-29A共4对引物适用于紫草正伪品鉴定。结论:在DNA条形码鉴定和巢式PCR技术的基础上,确定了4对可以用于有效区分药材市场中主流的新疆紫草和紫草非《中华人民共和国药典》品的特异性引物,为后续紫草药材及其他中药民族药品种的鉴定方法研究与开发提供了可参考的依据。

关键词：紫草聚合酶链式反应(PCR) 内部转录间隔区2(ITS2) DNA条形码巢式PCR(nPCR)

Multiple well-differentiated retroperitoneal liposarcomas with different patterns of appearance on computed tomography:A case report

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World Journal of Clinical Cases 2021年第7期9卷 1661-1667页

作者： Tian-hao Xie Xiang-Xiang Ren Yan Fu si-Ning ha Li-Tao Liu Xiao-Shi Jin Department of General Surgery Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Ophthalmology Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

BACKGROUND Primary retroperitoneal liposarcoma(PRPLS)is a rare soft tissue tumor with nonspecific clinical symptoms;it has different computed tomography(CT)image features according to pathological *** patients with a single tumor have been previously reported in the *** present an exceptional case of a PRPLS patient with multiple large tumors exhibiting different patterns of appearance on CT and confirmed as atypical lipomatous tumor/welldifferentiated liposarcoma by postoperative *** SUMMARY A 64-year-old man presented with abdominal distension for 1 *** patient was diagnosed with PRPLS based on physical examination,laparotomy,ultrasonography,CT scan,and *** of the tumors were completely resected through surgery and confirmed as atypical lipomatous tumor/welldifferentiated liposarcoma by postoperative *** postoperative course was uneventful without recurrence or metastasis,as demonstrated by abdominalpelvic CT during an 18 mo *** Multiple large Well-differentiated liposarcomas with different patterns of appearance on CT image can occur simultaneously in the same patient,to which more attention should be paid to make an effective differential diagnosis.

关键词： Retroperitoneal liposarcoma Soft tissue tumor Complete resection Recurrence Case report

Research Progress of Polysemous Disambiguation

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Research Progress of Polysemous Disambiguation