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Efficient C-N coupling in electrocatalytic urea generation on copper carbonate hydroxide electrocatalysts

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Journal of Energy Chemistry 2024年第6期93卷 289-298,I0008页

作者： Yinuo Wang Yian Wang Qinglan Zhao Hongming xu Shangqian Zhu Fei Yang Ernest P.Delmo Xiaoyi Qiu chi Song Juhee Jang Tiehuai Li Ping Gao MDanny Gu Minhua Shao Advanced Materials Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400GuangdongChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Materials Science and Engineering Southern University of Science and Technology of Chin11088 Xueyuan BoulevardShenzhen 518055GuangdongChina Energy Institute and Chinese National Engineering Research Center for Control&Treatment of Heavy Metal PollutionThe Hong Kong University of Science and TechnologyKowloonHong KongChina Department of Chemistry City University of Hong KongTat Chee AvenueKowloonHong KongChina

Urea generation through electrochemical CO_(2) and NO_(3)~-co-reduction reaction(CO_(2)NO_(3)RR)is still limited by either the low selectivity or yield rate of ***,we report copper carbonate hydroxide(Cu_2(OH)_2CO_(3))as an efficient CO_(2)NO_(3)RR electrocatalyst with an impressive urea Faradaic efficiency of45.2%±2.1%and a high yield rate of 1564.5±145.2μg h~(-1)mg_(cat)~(-1).More importantly,H_(2) evolution is fully inhibited on this electrocatalyst over a wide potential range between-0.3 and-0.8 V versus reversible hydrogen *** thermodynamic simulation reveals that the first C-N coupling follows a unique pathway on Cu_2(OH)_2CO_(3) by combining the two intermediates,~*COOH and~**** work demonstrates that high selectivity and yield rate of urea can be simultaneously achieved on simple Cu-based electrocatalysts in CO_(2)NO_(3)RR,and provide guidance for rational design of more advanced catalysts.

关键词： Copper carbonate hydroxide Co-reduction Urea generation C-N coupling DFT calculation

Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating siRT1-PGC-1αin Mice

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Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： LI Xiao Hong LIU Yu Mei SHAN Hui TAN Jin Feng ZHOU Jian SONG Yuan Jin LI si Qi LIU Chen xu Dong Qun YU Li LI Wan Wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina Weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of siRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and siRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,siRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the siRT1-PGC-1α *** SAL can activate siRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis siRT1-PGC-1α

一九二二年中共领导的浦东日华纱厂罢工——以与上海华界当局的关系为中心

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中共党史研究 2024年第3期 67-76页

作者：徐迟同济大学马克思主义学院博士后流动站

1922年浦东日华纱厂的三次罢工,是由成立初期的中国共产党领导,兼具经济、政治双重斗争目标的工人运动。罢工期间,浦东纺织工会在中国劳动组合书记部领导下,多次与上海华界当局及日华纱厂厂方进行交涉和谈判。三次罢工声震沪上,浦东纺... 详细信息

1922年浦东日华纱厂的三次罢工,是由成立初期的中国共产党领导,兼具经济、政治双重斗争目标的工人运动。罢工期间,浦东纺织工会在中国劳动组合书记部领导下,多次与上海华界当局及日华纱厂厂方进行交涉和谈判。三次罢工声震沪上,浦东纺织工会亦在一段时期内获得小范围发展,与中共对上海华界当局内部非制度性因素的认识与利用是分不开的,具体体现在华界当局治理体系尚不健全、官员依据人情社会的行为逻辑处置罢工,以及地方社会政治生态复杂、政令不能统一这三个方面。

关键词：日华纱厂中国劳动组合书记部工人运动浦东纺织工会

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Skeletal interoception in osteoarthritis

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Bone Research 2024年第2期12卷 241-254页

作者： Dinglong Yang Jiawen xu Ke xu Peng xu Department of Joint Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054China Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengdu 610041China

The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the *** its various forms,skeletal interoception specifically regulates the metabolic homeostasis of ***(OA)is a complex joint disorder involving cartilage,subchondral bone,and *** subchondral bone undergoes continuous remodeling to adapt to dynamic joint *** findings highlight that skeletal interoception mediated by aberrant mechanical loads contributes to pathological remodeling of the subchondral bone,resulting in subchondral bone sclerosis in *** skeletal interoception is also a potential mechanism for chronic synovial inflammation in *** this review,we offer a general overview of interoception,specifically skeletal interoception,subchondral bone microenviroment and the aberrant subchondral *** also discuss the role of skeletal interoception in abnormal subchondral bone remodeling and synovial inflammation in OA,as well as the potential prospects and challenges in exploring novel OA therapies that target skeletal interoception.

关键词： homeostasis inflammation releasing

Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression

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Research 2024年第3期6卷 561-574页

作者： Suzhen Yang Lin Zhou Tianming Zhao Hanlong Zhu Tingting Luo Kang Jiang Xiaoxiao Shi Chunyan Chen Han Zhang si Zhao Xiaoping Zou Yuzheng Zhuge Fangyu Wang Lei Wang Mingzuo Jiang Bing xu Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China. Department of Gastroenterology and Hepatology the Affiliated Jinling Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China School of Medicine Northwest UniversityShaanxiXi’an710069China. Department of Gastroenterology Nanjing Drum Tower HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeJiangsuNanjing210008China.

Persistent hepatic cellular metabolic stress and liver inflammatory stimuli are key signatures of nonalcoholic steatohepatitis(NASH).DDX3X is a vital molecule involved in cell fate decisions in both pro-survival stress granule(SG)and pro-death NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome assembly in response to stress ***,the role of DDX3X in NASH remains *** characterized the cell type-specific roles of DDX3X in *** liver tissues from NASH patients and normal control subjects were collected to assess DDX3X expression and *** steatohepatitis models were constructed by feeding macrophage-specific DDX3X knockout(DDX3^(XΔMφ)),hepatocyte-specific DDX3X knockout(DDX3X^(Δhep)),and wild-type control(DDX3X^(fl/fl))mice a high-fat and high-cholesterol(HFHC)diet,a methionine-and choline-deficient(MCD)diet,and a high-fat/high-iron/high-fructose/high-cholesterol,low-methionine,and choline-deficient(HFHIHFHC-MCD)*** study demonstrated that DDX3X was predominantly expressed in macrophages and hepatocytes in control liver tissues,and its expression was down-regulated in patients or mice with *** to DDX3X^(fl/fl) littermates,DDX3^(XΔMφ)mice showed improved liver histology in nutritional steatohepatitis *** of macrophage DDX3X inhibited NLRP3 inflammasome-mediated pyroptosis,causing anti-inflammatory M2 polarization and alleviating hepatocyte steatohepatitic ***3X^(Δhep) mice developed marked steatohepatitis in multiple nutritional steatohepatitis models compared to DDX3X^(fl/fl) ***3X-deleted hepatocytes showed impaired SG assembly,leading to increased sensitivity and intolerance to metabolic stimulation and resultant *** conclusion,DDX3X plays opposite roles in different cell types during the progression of NASH.A better understanding of the cell-specific differences in the crosstalk between SG formation and NLRP3 activation is crucial for developing pr

关键词： NLRP3 impaired inhibited

Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways

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Genes & Diseases 2024年第1期11卷 64-66页

作者： Ying Li Lingli Ding Yage Zhang Bingyu Zhou Gene chi Wai Man Min Wang Jinglan Li Yamei Liu Weiping Lin Haibin Wang sien Lin Liangliang xu Key Laboratory of Orthopaedics&Traumatology Lingnan Medical Research CenterThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong SAR 999077China Departments of Diagnostics of Traditional chinese Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Orthopaedic Research Lab Affiliated Hospital of Guangdong Medical UniversityGuangdong Medical UniversityZhanjiangGuangdong 524001China

Fractures have an extraordinarily negative impact on individuals'quality of life and functional *** or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MSCs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new *** use of MSCs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion.

关键词： PI3K/Akt HIF1α healing

Depositional process of hyperpycnal flow deposits:A case study on Lower Cretaceous Sangyuan outcrop in the Luanping Basin,Northeast china

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china Geology 2024年第3期7卷 505-516页

作者： De-zhi Yan Ru-kai Zhu Hao Shou Zhao-hui xu Wei-hong Liu si-cheng Zhu Zhi-cheng Lei Jing-ya Zhang Chang Liu Yi Cai Huai-min xu Research Institute of Petroleum Exploration and Development PetroChinaBeijing 100083China National Energy Tight Oil and Gas R&D Center Beijing 100083China Petrochina Key Laboratory of Oil and Gas Reservoir Beijing 100083China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Jiangxi Engineering Laboratory on Radioactive Geoscience and Big Data Technology Department of Information and EngineeringEast China University of TechnologyNanchang 330013China

Sedimentary process research is of great significance for understanding the distribution and characteristics of *** the detailed observation and measurement of the Sangyuan outcrop in Luanping Basin,this paper studies the depositional process of the hyperpycnal flow deposits,and divides their depositional process into three phases,namely,acceleration,erosion and *** the acceleration phase,hyperpycnal flow begins to enter the basin nearby,and then speeds up *** developed in the acceleration phase are *** addition,the original deposits become unstable and are taken away by hyperpycnal flows under the eroding *** a result,there are a lot of mixture of red mud pebbles outside the basin and gray mud pebbles within the *** the erosion phase,the reverse deposits are eroded and become thinner or even ***,no reverse grading characteristic is found in the proximal major channel that is closer to the source,but it is still preserved in the middle branch channel that is far from the *** entering the deceleration phase,normally grading deposits appear and cover previous *** final deposits in the basin are *** are reverse,and others are *** are superimposed with each other under the action of hyperpycnal *** analysis of the Sangyuan outcrop demonstrates the sedimentary process and distribution of hyperpycnites,and reasonably explain the sedimentary characteristics of *** is helpful to the prediction of oil and gas exploration targets in gravity flow deposits.

关键词： Hyperpycnal flow Sedimentary characteristics Depositional process Gravity flow deposit Hyperpycnite Red mud pebble Gray mud pebble Oil and gas exploration engineering Luanping Basin

High-precision X-ray polarimeter based on channel-cut crystals

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Nuclear Science and Techniques 2024年第3期35卷 30-39页

作者： Shang-Yu si Zhong-Liang Li Wen-Hong Jia Lian xue Hong-Xin Luo Jian-Cai xu Bai-Fei Shen Lin-Gang Zhang Liang-Liang Ji Yu-Xin Leng Ren-Zhong Tai Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China

We report on using synthetic silicon for a high-precision X-ray polarimeter comprising a polarizer and an analyzer,each based on a monolithic channel-cut crystal used at multiple Brewster reflections with a Bragg angle very close to 45°.Experiments were performed at the BL09B bending magnet beamline of the Shanghai Synchrotron Radiation Facility using a si(800)crystal at an X-ray energy of 12.914 keV.A polarization purity of 8.4×10^(-9)was *** result is encouraging,as the measured polarization purity is the best-reported value for the bending magnet ***,this is the firstly systematic study on the hard X-ray polarimeter in china,which is crucial for exploring new physics,such as verifying vacuum birefringence.

关键词： X-ray polarimeter Vacuum birefringence Synchrotron radiation Channel-cut crystal

Malware Evasion Attacks Against IoT and Other Devices: An Empirical Study

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Tsinghua Science and Technology 2024年第1期29卷 127-142页

作者： Yan xu Deqiang Li Qianmu Li Shouhuai xu School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Computer Science University of Colorado Colorado SpringsColorado SpringsCO 80918USA

The Internet of Things(loT)has grown rapidly due to artificial intelligence driven edge *** enabling many new functions,edge computing devices expand the vulnerability surface and have become the target of malware ***,attackers have used advanced techniques to evade defenses by transforming their malware into functionality-preserving *** systematically analyze such evasion attacks and conduct a large-scale empirical study in this paper to evaluate their impact on *** specifically,we focus on two forms of evasion attacks:obfuscation and adversarial *** the best of our knowledge,this paper is the first to investigate and contrast the two families of evasion attacks *** apply 10 obfuscation attacks and 9 adversarial attacks to 2870 malware *** obtained findings are as follows.(1)Commercial Off-The-Shelf(COTS)malware detectors are vulnerable to evasion attacks.(2)Adversarial attacks affect COTS malware detectors slightly more effectively than obfuscated malware examples.(3)Code similarity detection approaches can be affected by obfuscated examples and are barely affected by adversarial attacks.(4)These attacks can preserve the functionality of original malware examples.

关键词： Android malware obfuscation adversarial examples