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Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism

World Journal of Hepatology 2024年第2期16卷 264-278页

作者： Hao Ouyang Hui Miao Zhen Li Duan Wu si-cheng gao Yao-Yao Dai Xiao-Di gao Hai-Sheng Chai Wei-Ye Hu Jun-Feng Zhu Department of Liver Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 201203China

BACKGROUND Liver fibrosis is a formidable global medical challenge,with no effective clinical treatment currently *** granule(YHG)is a proprietary Chinese medicine comprising Scutellariae Radix and Lonicerae Japonicae *** is frequently used for upper respiratory tract infections,pharyngitis,as well as acute and chronic *** To investigate the potential of YHG in alleviating carbon tetrachloride(CCl4)-induced liver fibrosis in *** To induce a hepatic fibrosis model in mice,this study involved intraperitoneal injections of 2 mL/kg of CCl4 twice a week for 4 ***,liver fibrosis mice in the low dose of YHG(0.4 g/kg)and high dose of YHG(0.8 g/kg)groups were orally administered YHG once a day for 4 *** alanine/aspartate aminotransferase(ALT/AST)activity and liver hydroxyproline content were *** red and Masson's trichrome staining assay were *** polymerase chain reaction,western-blot and enzyme-linked immunosorbent assay were *** glutathione content,superoxide dismutase activity level,reactive oxygen species and protein carbonylation amount were *** The administration of YHG ameliorated hepatocellular injury in CCl4-treated mice,as reflected by decreased serum ALT/AST activity and improved liver histological *** also attenuated liver fibrosis,evident through reduced liver hydroxyproline content,improvements in sirius red and Masson's trichrome staining,and lowered serum hyaluronic acid ***,YHG hindered the activation of hepatic stellate cells(HSCs)and ameliorated oxidative stress injury and inflammation in liver from CCl4-treated *** prompted the nuclear accumulation of nuclear factor erythroid 2-related factor 2(Nrf2)and upregulated the expression of Nrf2-dependent downstream antioxidant *** addition,YHG promoted mitochondrial biogenesis in liver from CCl4-treated mice,as demonstrated by increased liver adenosine triphosphate content,

关键词： Yinhuang granule Liver fibrosis Hepatic stellate cells Oxidative injury Nuclear factor erythroid 2-related factor 2 Inflammation

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Energy-efficient buffer and service rate allocation in manufacturing systems using hybrid machine learning and evolutionary algorithms

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Advances in Manufacturing 2024年第2期12卷 227-251页

作者： si-Xiao gao Hui Liu Jun Ota Key Laboratory of Traffic Safety on Track of Ministry of Education Institute of Artificial Intelligence and Robotics(IAIR)School of Traffic and Transportation EngineeringCentral South UniversityChangsha410075People’s Republic of China Research into Artifacts Center for Engineering School of EngineeringThe University of TokyoTokyoJapan

Currently,simultaneous buffer and service rate allocation is a topic of interest in the optimization of manufacturing *** allocation problems have been solved previously to satisfy economic requirements;however,owing to the progress of green manufacturing,energy conservation and environmental protection have become increasingly ***,an energy-efficient approach is developed to maximize the throughput and minimize the energy consumption of manufacturing systems,subject to the total buffer capacity,total service rate,and predefined energy *** energy-efficient approach integrates the simulated annealing-non-dominated sorting genetic algorithm-II with the honey badger algorithm-histogram-based gradient boosting regression *** former algorithm searches for Pareto-optimal solutions of sufficient *** latter algorithm builds prediction models to rapidly calculate the throughput,energy consumption,and energy *** examples show that the proposed hybrid approach can achieve a better solution quality compared with previously reported ***,the prediction models can rapidly evaluate manufacturing systems with sufficient *** study benefits the multi-objective optimization of green manufacturing systems.

关键词： Energy-efficient allocation Multi-objective optimization Energy efficiency Energy consumption Machine learning

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On the global smooth solutions of 3D incompressible Hall-MHD equations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 319-327页

作者： YUE gao-cheng SUN Wen-da School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The present paper is devoted to the well-posedness issue for the 3D incompressible Hall-MHD system obtained from kinetic models. Our analysis strongly relies on the use of the Fourier analysis. We establish the global existence of smooth solutions for a class of large initial data, this result implies the initial velocity and magnetic field can be arbitrarily large.

关键词： 3D Hall-MHD well-posedness Fourier analysis

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Determination of the Pile Drivability Using Random Forest Optimized by Particle Swarm Optimization and Bayesian Optimizer

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 871-892页

作者： Shengdong cheng Juncheng gao Hongning Qi State Key Laboratory of Eco-Hydraulics in Northwest Arid Region Xi’an University of TechnologyXi’an710048China School of Resources and Safety Engineering Central South UniversityChangsha410083China

Driven piles are used in many geological environments as a practical and convenient structural ***,the determination of the drivability of piles is actually of great importance in complex geotechnical *** methods of predicting pile drivability often rely on simplified physicalmodels or empirical formulas,whichmay lack accuracy or applicability in complex geological ***,this study presents a practical machine learning approach,namely a Random Forest(RF)optimized by Bayesian Optimization(BO)and Particle Swarm Optimization(PSO),which not only enhances prediction accuracy but also better adapts to varying geological environments to predict the drivability parameters of piles(i.e.,maximumcompressive stress,maximum tensile stress,and blow per foot).In addition,support vector regression,extreme gradient boosting,k nearest neighbor,and decision tree are also used and applied for comparison *** order to train and test these models,among the 4072 datasets collected with 17model inputs,3258 datasets were randomly selected for training,and the remaining 814 datasets were used for model ***,the results of these models were compared and evaluated using two performance indices,i.e.,the root mean square error(RMSE)and the coefficient of determination(R2).The results indicate that the optimized RF model achieved lower RMSE than other prediction models in predicting the three parameters,specifically 0.044,0.438,and 0.146;and higher R2 values than other implemented techniques,specifically 0.966,0.884,and *** addition,the sensitivity and uncertainty of the optimized RF model were analyzed using Sobol sensitivity analysis and Monte Carlo(MC)*** can be concluded that the optimized RF model could be used to predict the performance of the pile,and it may provide a useful reference for solving some problems under similar engineering conditions.

关键词： Random forest regression model pile drivability Bayesian optimization particle swarm optimization

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REDH:A database of RNA editome in hematopoietic differentiation and malignancy

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Chinese Medical Journal 2024年第3期137卷 283-293页

作者： Jiayue Xu Jiahuan He Jiabin Yang Fengjiao Wang Yue Huo Yuehong Guo Yanmin si Yufeng gao Fang Wang Hui cheng Tao cheng Jia Yu Xiaoshuang Wang Yanni Ma State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry and Molecular Biology Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Institute of Blood Transfusion Chinese Academy of Medical SciencesChengduSichuan 610052China

Background:The conversion of adenosine(A)to inosine(I)through deamination is the prevailing form of RNA editing,impacting numerous nuclear and cytoplasmic transcripts across various eukaryotic *** of high-confidence RNA editing sites have been identified and integrated into various RNA databases,providing a convenient platform for the rapid identification of key drivers of cancer and potential therapeutic ***,the available database for integration of RNA editing in hematopoietic cells and hematopoietic malignancies is still ***:We downloaded RNA sequencing(RNA-seq)data of 29 leukemia patients and 19 healthy donors from National Center for Biotechnology Information(NCBI)Gene Expression Omnibus(GEO)database,and RNA-seq data of 12 mouse hematopoietic cell populations obtained from our previous research were also *** performed sequence alignment,identified RNA editing sites,and obtained characteristic editing sites related to normal hematopoietic development and abnormal editing sites associated with hematologic ***:We established a new database,"REDH",represents RNA editome in hematopoietic differentiation and *** is a curated database of associations between RNA editome and *** integrates 30,796 editing sites from 12 murine adult hematopoietic cell populations and systematically characterizes more than 400,000 edited events in malignant hematopoietic samples from 48 cohorts(human).Through the Differentiation,Disease,Enrichment,and knowledge modules,each A-to-I editing site is systematically integrated,including its distribution throughout the genome,its clinical information(human sample),and functional editing sites under physiological and pathological ***,REDH compares the similarities and differences of editing sites between different hematologic malignancies and healthy ***:REDH is accessible at http://***/.This user-friendly database

关键词： RNA editing Hematopoietic differentiation Hematopoietic malignancy Database management systems

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Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

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Chinese Journal of Polymer Science 2024年第8期42卷 1067-1076页

作者： Chun-Peng Zhang si-Jia gao Ying Luo Lei Zou Yong-Jun Zhang State Key Laboratory of Separation Membranes and Membrane Processes School of Material Science and EngineeringTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membranes and Membrane Processes School of Pharmaceutical SciencesTiangong UniversityTianjin 300387China Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Institute of Hepatobiliary DiseaseNankai University Affiliated Third Center HospitalTianjin 300170China Cangzhou Institute of Tiangong University Cangzhou 061000China

Glucose-sensitive membrane has potential application in self-regulating insulin *** acid(PBA)is a well-known glucose ***,most PBA-based glucose-sensitive materials are expansion-type,which are not suitable as chemical valves in membrane pores for self-regulating insulin *** to a new glucose-sensitive mechanism,we synthesized PBA-based contraction-type glucose-sensitive liner polymer and ***,a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane *** adjusting the chain length and chain density,the glucose-sensitivity of the membrane was *** membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine *** membrane also has good stability,anti-fouling and biocom *** has potential application in selfregulating insulin release.

关键词： Phenylboronic acid Glucose-sensitive Membrane Surface grafting Insulin

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Mechanical behavior and failure mechanisms of rock bolts subjected to static-dynamic loads

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International Journal of Mining Science and Technology 2024年第3期34卷 281-288页

作者： Hongpu Kang Guiyang Yuan Linpo si Fuqiang gao Jinfu Lou Jinghe Yang Shuangyong Dong CCTEG Coal Mining Research InstituteBeijing 100013China State Key Laboratory of Intelligent Coal Mining and Strata Control Beijing 100013China

This study explores the effects of dynamic and static loading on rock bolt performance a key factor in maintaining the structural safety of coal mine roadways susceptible to coal *** a housemade load frame to simulate various failure scenarios,pretension-impact-pull tests on rock bolts were conducted to scrutinize their dynamic responses under varied static load conditions and their failure traits under combined *** experimental results denote that with increased impact energy,maximum and average impact loads on rock bolts escalate significantly under pretension,initiating plastic deformation beyond a certain *** minor reductions in the yield load due to impactinduced damage,pretension aids in constraining post-impact deformation rate and fluctuation degree of rock ***,impact-induced plastic deformation causes internal microstructure dislocation,fortifying the stiffness of the rock bolt support *** magnitude of this fortification is directly related to the plastic deformation induced by the *** findings provide crucial guidance for designing rock bolt support in coal mine roadway excavation,emphasizing the necessity to consider both static and dynamic loads for improved safety and efficiency.

关键词： Rock bolt Pretension Static and dynamic load Impact

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Cascaded four-wave mixing all-optical wavelength converter based on highly nonlinear fiber deposited graphene oxide

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Journal of Materials Science & Technology 2024年第4期171卷 10-15页

作者： Yuanhongliu gao Xiaoyu Chen Tonglei cheng Fang Wang Xin Yan College of Information Science and Engineering State Key Laboratory of Synthetical Automation for Process IndustriesNortheastern UniversityShenyang 110819China

The all-optical wavelength conversion using cascaded four-wave mixing(FWM)phenomena with graphene oxide(GO)and a highly nonlinear fiber(HNLF)device is demonstrated *** has a strong third-order nonlinear effect and is an excellent nonlinear optical material for nonlinear optical wavelength *** group velocity matching of pump and signal,HNLF,and GO amplification promote the cascaded nonlinear frequency mixing *** the experimental and analytical results,the maximum spacing between signal and pump is 21 nm,and specifically,the order of cascaded FWM light increases from order 1 to order 2 with increasing GO,and the first-order FWM conversion effi-ciency increases to a maximum of−14.5 *** the best of our knowledge,this is the first time that cascaded FWM-based all-optical wavelength conversion in HNLF-GO with wide wavelength selectivity is investigated with combined pump and signal *** findings not only provide an effective method for achieving all-optical wavelength conversion in cascaded FWM but also offer the possibility of fabricating high-performance nonlinear optical devices.

关键词： Four-wave mixing Graphene oxide Highly nonlinear fiber Optical wavelength conversion

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Laboratory and field evaluation of a low-cost optical particle sizer

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Journal of Environmental Sciences 2024年第8期142卷 215-225页

作者： Mingzhen Tang Yicheng Shen Yanzhen Ge Jian gao Chong Wang Liqing Wu Shuchun si State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Jinan Grid-Based Supervision Center of Ecological and Environmental Protection Jinan 250100China Tai’an Ecological Environment Protection Control Center Tai’an 271000China School of Physics Shandong UniversityJinan 250013China

Low-cost sensors are widely used to collect high-spatial-resolution particulate matter data that traditional reference monitoring devices *** addition to the mass concentration,the number concentration and size distribution are also fundamental in determining the origin and hazard level of particulate ***,low-cost optical sensors have been improved to establish optical particle sizers(OPSs).In this study,a low-cost OPS,the Nova SDS029,is introduced,and it is evaluated in comparison to two reference instruments—the GRIMM 11-D and the Tsi *** first tested the sizing accuracy using polystyrene latex ***,we assessed the mass and number size distribution accuracy in three application scenarios:indoor smoking,ambient air quality,and mobile *** evaluations suggest that the low-cost SDS029 rivals research-grade optical sizers in many *** example,(1)the particle diameters obtained with the SDS029 are close to the reference instruments(usuallysible particle size distribution can be obtained in an easy and cost-efficient *** believe that low-cost OPSs will increasingly be used to map the sources and risk levels of particles at the city scale.

关键词： Optical particle sizer Particle size distribution Low-cost sensor Evaluation Field application

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Parallel System Based Quantitative Assessment and Self-evolution for Artificial Intelligence of Active Power Corrective Control

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 13-28页

作者： Tianyun Zhang Jun Zhang Feiyue Wang Peidong Xu Tianlu gao Haoran Zhang Ruiqi si School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072HubeiChina State Key Laboratory for Management and Control of Complex System Institute of AutomationChinese Academy of SciencesBeijing 100190China

In artificial intelligence(AI)based-complex power system management and control technology,one of the urgent tasks is to evaluate AI intelligence and invent a way of autonomous intelligence ***,there is,currently,nearly no standard technical framework for objective and quantitative intelligence *** this article,based on a parallel system framework,a method is established to objectively and quantitatively assess the intelligence level of an AI agent for active power corrective control of modern power systems,by resorting to human intelligence evaluation *** this basis,this article puts forward an AI self-evolution method based on intelligence assessment through embedding a quantitative intelligence assessment method into automated reinforcement learning(AutoRL)systems.A parallel system based quantitative assessment and self-evolution(PLASE)system for power grid corrective control AI is thereby constructed,taking Bayesian Optimization as the measure of AI evolution to fulfill autonomous evolution of AI under guidance of their intelligence assessment *** results exemplified in the power grid corrective control AI agent show the PLASE system can reliably and quantitatively assess the intelligence level of the power grid corrective control agent,and it could promote evolution of the power grid corrective control agent under guidance of intelligence assessment results,effectively,as well as intuitively improving its intelligence level through selfevolution.

关键词： AI quantitative intelligence assessment and self-evolution automated reinforcement learning Bayesian optimization corrective control parallel system

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