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Metallothionein 1E Alleviates Cadmium-induced Renal Cytotoxicity through Promoting Mitochondrial Functional Recovery

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Biomedical and Environmental Sciences 2024年第1期37卷 117-121页

作者： WEN si Hui LI Lu Bei HUANG Hui Dan xie Ying LUO Lei Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina Department of Occupational Health Changsha Centre for Disease Control and PreventionChangsha 410004HunanChina The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province Hunan Normal University School of MedicineChangsha 410013HunanChina

The pervasive utilization of industrial substances has escalated human exposure to cadmium(Cd),a metal associated with long-term negative health outcomes such as renal dysfunction,neurological disorders,and various cancers^([1]).Once ingested by humans,Cd interacts with cysteine-rich metallothioneins(MTs)which have metal-binding and antioxidant properties and is subsequently transported to the kidney^([2]).

关键词： Renal kidney cadmium

Coupling of the Calculated Freezing and Thawing Front Parameterization in the Earth System Model CAS-ESM

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Advances in Atmospheric Sciences 2023年第9期40卷 1671-1688页

作者： Ruichao LI Jinbo xie Zhenghui xie Binghao JIA Junqiang GAO Peihua QIN Longhuan WANG si CHEN State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 101408China School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044China

The soil freezing and thawing process affects soil physical properties,such as heat conductivity,heat capacity,and hydraulic conductivity in frozen ground regions,and further affects the processes of soil energy,hydrology,and carbon and nitrogen cycles.In this study,the calculation of freezing and thawing front parameterization was implemented into the earth system model of the Chinese Academy of Sciences(CAS-ESM)and its land component,the Common Land Model(CoLM),to investigate the dynamic change of freezing and thawing fronts and their effects.Our results showed that the developed models could reproduce the soil freezing and thawing process and the dynamic change of freezing and thawing fronts.The regionally averaged value of active layer thickness in the permafrost regions was 1.92 m,and the regionally averaged trend value was 0.35 cm yr–1.The regionally averaged value of maximum freezing depth in the seasonally frozen ground regions was 2.15 m,and the regionally averaged trend value was–0.48 cm yr–1.The active layer thickness increased while the maximum freezing depth decreased year by year.These results contribute to a better understanding of the freezing and thawing cycle process.

关键词： frozen ground freezing and thawing fronts maximum freezing depth active layer thickness earth system model CAS-ESM

Facile synthesis and functionalization of fluoranthenes via intramolecular[4+2]annulations between thiophenes and alkynes

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Chinese Chemical Letters 2023年第6期34卷 476-479页

作者： Shoudong xie Weinan Chen si Liu Hao Zong Binbin Ming Gang Zhou Lab of Advanced Materials State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200438China

Fluoranthenes have attracted tremendous attention due to their unique optoelectronic properties and extensive applications.Although several synthetic methodologies have been developed for the preparation of fluoranthene derivatives,it is still unfavorable to functionalize the fluoranthene framework at different positions due to the relatively low selectivity and reactivity.Herein,a catalyst-free intramolecular[4+2]annulation between thiophenes and alkynes is developed towards the synthesis of fluoranthenes.Altogether 20 examples have been demonstrated using this method.Various functional groups can be precisely introduced into the fluoranthene skeleton at different positions by simply tuning the substituents on the thiophenes and alkynes.The conjugation of the fluoranthene can be facilely extended through different directions.Furthermore,the feasibility of this[4+2]annulation reaction is also investigated by density functional theory calculations.Therefore,this protocol provides not only a synthetic methodology towards fluoranthenes with substituents functionalized at different positions,but also an effective pathway to construct large polycyclic aromatic hydrocarbons containing fluoranthene moieties.

关键词： Fluoranthene Annulation Polycyclic aromatic hydrocarbon Catalyst-free S-extrusion

Hydrodynamic Characteristics of the Biplane-Type Otter Board with the Canvas Through Flume−Tank Experiment

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China Ocean Engineering 2022年第6期36卷 911-921页

作者： xie si-jie WU Ru-ke HU Fu-xiang SONG Wei-hua Department of Marine Fisheries Zhejiang Ocean UniversityZhoushan 316022China Key Laboratory of Marine Fishery Equipment and Technology of Zhejiang Zhoushan 316022China Tokyo University of Marine Science and Technology MinatoTokyo 108-8477Japan

Hydrodynamic characteristics of a biplane-type otter board,equipped with nylon canvas of 2 mm in thickness was investigated through flume-tank experiment in this study.A series of predesigned structures with different gap-chord ratios G/c(0.75,0.90,1.05),stagger anglesθ(30°,45°,60°),and proportions of flexible area relative to the whole wing areaƒr(0,55%,65%,75%),at an aspect ratio of 2.0 and a camber ratio of 15%,were experimentally carried out.The results showed the solution referring to the usage of flexible canvas replacing part of rigid structure for the biplane-type otter board was efficient for the trawling in the middle or shallow water area.The improvement of lift and stability for the biplane-type otter board was concluded,and drag of the structure was reduced by 1.9%atƒr=55%.In addition,the coefficient of variation of the lift and drag coefficient at different current velocities were 2.69%and 2.28%,respectively,which was smaller than those at relatively large proportion of the flexible area.Compared with the other tested structures,the frame-type flexible structure with the gap-chord ratio of 0.9 and a stagger angle of 45°and the proportion of the flexible area of 55%,performed best,and its drag was reduced by 5.72%and lift increased by 4.8%,compared with the rigid biplane-type otter board at the angles of attack from 18°to 28°.

关键词： frame-type flexible structure hydrodynamic characteristics proportion of flexible area flume−tank experiment

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我国经济增长质量测度及其动态变化分析

统计与决策 2022年第19期38卷 86-91页

作者：谢思辽宁大学经济学院沈阳110036

文章从经济增长的效率、结构、稳定性、持续性与开放性五个方面来界定经济增长质量,并以此为基础构建经济增长质量评价指标体系。运用全局主成分分析法对我国2002—2018年30个省份经济增长质量及其五个维度进行测度,并分析其动态变化。... 详细信息

文章从经济增长的效率、结构、稳定性、持续性与开放性五个方面来界定经济增长质量,并以此为基础构建经济增长质量评价指标体系。运用全局主成分分析法对我国2002—2018年30个省份经济增长质量及其五个维度进行测度,并分析其动态变化。结果表明:经济增长质量指数呈东、中、西部递减趋势,但近几年中西部地区提质增速较快,将会成为我国经济高质量发展的强力引擎;经济增长质量提升最主要的原因并不是经济效率,而是经济结构与稳定性。经济增长效率与持续性指数整体呈上升趋势,但三大地区持续性指数的差距逐渐增加,将会进一步加剧区域间的不协调不平衡性。经济增长结构指数总体呈先下降后上升的趋势,且上升速度逐渐放缓,经济增长稳定性指数整体呈波动上升趋势。经济增长开放性指数整体呈下降趋势,且三大地区该指数差距逐渐缩小。

关键词：经济增长质量全局主成分分析经济结构区域差距

Study of Unforced Unsteadiness in Centrifugal Pump at Partial Flow Rates

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Journal of Thermal Science 2021年第1期30卷 88-99页

作者： YANG Jun xie Tian LIU Xiaohua si Qiaorui LIU Jun School of Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China Key Laboratory of Fluid and Power Machinery(Xihua University) Ministry of EducationChengdu 610039China Shanghai Key Laboratory of Multiphase Flow and Heat Transfer in Power Engineering Shanghai 200093China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China Research Center of Fluid Machinery Engineering and Technology Jiangsu UniversityZhenjiang 212013China

In order to explore the unforced unsteadiness of centrifugal pumps,a 2-D frequency domain imaging display technology was used to study the development of these unsteady flow structures at partial flow conditions.The results showed that,the unsteady flow field was not only affected by rotor and stator interaction,but also appeared an unforced unsteadiness with fundamental frequency of St≈0.23 around the impeller throat area.Moreover,as the flow rates decreased,this unsteady flow structure gradually weakened and disappeared.When the flow rate was reduced to 0.6 times of design flow rate,another two unforced unsteady flow structures with characteristic frequencies of St≈0.0714 and St≈0.12 began to appear in the same area.Therefore,with the operating condition smaller than design flow rate,the internal flow became more and more complex.In addition to the forced unsteadiness,the unforced unsteadiness which is not connected with the blade passage frequency became more and more obvious.

关键词： centrifugal pumps partial flow conditions pressure pulsations unforced unsteadiness 2-D frequency domain visualization method

Boundary Control for a Class of Reaction-diffusion Systems

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International Journal of Automation and computing 2018年第1期15卷 94-102页

作者： Yuan-Chao si Cheng-Kang xie Na Zhao School of Mathematics and System Science Southwest University School of Mathematics and System Science Guizhou University

Boundary control for a class of partial integro-differential systems with space and time dependent coefficients is consid- ered. A control law is derived via the partial differential equation （PDE） backstepping. The existence of kernel equations is proved. Exponential stability of the closed-loop system is achieved. simulation results are presented through figures.

关键词： Stability reaction-diffusion system boundary control backstepping partial differential equation.

Local structure engineering for active sites in fuel cell electrocatalysts

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Science China Chemistry 2020年第11期63卷 1543-1556页

作者： Han Cheng Renjie Gui si Liu Yi xie Changzheng Wu Hefei National Laboratory for Physical Science at the Microscale CAS Centre for Excellence in NanoscienceCollaborative Innovation Centre of Chemistry for Energy Materials(iChEM)CAS Key Laboratory of Mechanical Behavior and Design of MaterialsUniversity of Science and Technology of ChinaHefei 230026China Institute of Energy Hefei Comprehensive National Science CenterHefei 230026China

In this review,we surveyed the significance of local structure engineering on electrocatalysts and electrodes for the performance of oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs).Both on precious metal catalysts(PMC)and non-precious metal catalysts(NPMC),the main methods to modulate local structure of active sites have been summarized.By change of atomic coordination,modulation of bonding distortion and synergy effect from hierarchical structure,local structure engineering has influence on the intrinsic activity and stability of electrocatalysts.Moreover,we emphasized the intimate correlation between lyophobicity of electrocatalysts and membrane electrodes by local structure engineering.Our review aimed to inspire the exploration of advanced electrocatalysts and mechanism study for PEMFCs based on local structure engineering.

关键词： local structure engineering proton exchange membrane fuel cells oxygen reduction reaction active sites

Efficacy and safety of decitabine combined with low-dose cytarabine, aclarubicin, and granulocyte colony-stimulating factor compared with standard therapy in acute myeloid leukemia patients with TP53 mutation

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Chinese Medical Journal 2021年第12期134卷 1477-1479页

作者： si-si Chen Qian Sun Lan Cao Wen-Zhong Wu Yue xie Chun Qiao Jian-yong Li si-Xuan Qian Ming Hong Department of Hematology The Affiliated Yixing Hospital of Jiangsu UniversityWuxiJiangsu 214200China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China Pukou CLL Center Pukou division of Jiangsu Province HospitalNanjingJiangsu 211899China

Tumor suppressor gene P53(TP53)is a critical tumor suppressor gene.The mutant p53 protein enhances the activity,invasion and metastasis of tumor cells.Acute myeloid leukemia(AML)patients with TP53 mutations respond poorly to conventional chemotherapy and have poor clinical outcomes.We previously conducted a multi-center phase II clinical trial(No.ChiCTRONC-11001700)in elderly AML patients with decitabine,low-dose cytarabine,aclarubicin,and granulocyte colony-stimulating factor(G-CSF)(DCAG regimen),which showed an overall response rate(ORR)of 82.4%and a complete remission(CR)rate of 64.7%.[1]Given this satisfactory effect of DCAG regimen,the present study has been designed to compare the efficacy and safety of DCAG regimen with standard therapy in AML patients with TP53 mutations.

关键词： TP53 patients stimulating