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Chinese Chemical Letters 2000年第1期11卷 19-20页

作者： si jia xue Jin Shan ZOU Hai jian YANG (Department of Chemistry, Central China Normal University, Wuhan 430079) Cent China Normal Univ Dept Chem Wuhan 430079 Peoples R China

Fifteen N'-(substituted pyrimidin-2-y1)-N-substituted phenoxyacetyl thioureas were synthesized and tested for biological activities. All of them are new compounds and their structures were confirmed by IR. IHNMR. MS and elemental analysis. Some of the target compounds showed excellent inhibitory activities against root and stalk of dicotyledon plant (such as radish). and selective on monoctyledon plant (such as rice).

关键词： 4-Nitrophenoxyacetyl thiourea 2,4-dichlorophenoxyacetyl thiourea synthesis 2-chlorophenoxyacetyl thiourea 2-amino pyrimidine herbicidal activity

Synthesis and Biological Activity of N-[N'-(4,5,6-Trisubstitued pyrimidin-2-yl)acetylureido] Benzoic Sulfimide Derivatives

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Chinese Chemical Letters 2000年第7期11卷 581-582页

作者： Tao WANG si jia xue Hai jian YANG(Department of Chemistry ,Central China University, Wuhan 430079 Department of Chemistry,Yichun College,Yichun 336000) Cent China Univ Dept Chem Wuhan 430079 Peoples R China Yichun Coll Dept Chem Yichun 336000 Peoples R China

Fourteen N'- (4,5,6-Trisubstitued pyrimidin-2-y1) -2-chloroacetylureas and fourteen N-[N'- (4,5,6-trisubstitued pyrimidin-2-yl) acetylureido] benzoic sulfimide derivatives were synthesized. Among them twenty-seven are new compounds and their structures have been confirmed by 1HNMR, IR, MS and elemental analysis. The preliminary biological tests showed that some of the target compounds have excellent inhibitory activities against barnyard grass and rape, and the others have a good regulating activity for plant growth.

关键词： Benzoic sulfimide 2-amino-pyrimidine biological activity synthesis

Synthesis and Herbicidal Activity of 2-Benzoyliminopyrimido[3,2-b]-1 2,4-Thiadiazolines

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Chinese Chemical Letters 1998年第8期9卷 721-722页

作者： si jia xue Dong Yun TAN Chang You SUN(Department of Chemistry, Central China Normal University, Wuhan 430079)(Wuhan Food Industry College, Wuhan 430022) Wuhan Food Ind Coll Wuhan 430022 Peoples R China Cent China Normal Univ Dept Chem Wuhan 430079 Peoples R China

A series of 2-benzoyliminopyrimido[3,2-b]-1,2,4-thiadiazolines were synthesized and tested for herbicidal effects. All of them are new compounds and their structures were confirmed by (HNMR)-H-1, IR, MS. The prelimina... 详细信息

关键词： pyrimido[3,2-b]-1,2,4-thiadiazoline herbicidal activity synthesis

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煤矿自动化系统的几点分析

煤 2010年第2期19卷 60-62页

作者：贾思学双鸭山矿业集团公司新安煤矿黑龙江双鸭山155100

煤矿自动化可大幅度提高煤矿生产效率,提高生产设备的可靠性和安全性,节约能源和人力资源等。文章主要介绍了煤矿自动化实现的目标与前提,系统构架的接入层、控制层和信息层。

关键词：煤矿自动化系统构架

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia xue Yi Liu Ran Zheng Ying Chen jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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云贵高原隆升研究进展

云南地理环境研究 2017年第3期29卷 23-29,40页

作者：陈思宇王嘉学云南师范大学旅游与地理科学学院云南昆明650500

从云贵高原隆升时代及幅度、云贵高原隆升的证据及其与青藏高原隆升的关系3个方面回顾并梳理了云贵高原隆升的研究现状及进展,已有研究成果表明:云贵高原经历了多阶段、掀斜式、同步异幅的隆升过程,但隆升时代范围跨度大、精度低,且成... 详细信息

从云贵高原隆升时代及幅度、云贵高原隆升的证据及其与青藏高原隆升的关系3个方面回顾并梳理了云贵高原隆升的研究现状及进展,已有研究成果表明:云贵高原经历了多阶段、掀斜式、同步异幅的隆升过程,但隆升时代范围跨度大、精度低,且成果主要集中在新生代以来。利用云贵高原广泛分布的夷平面和古风化壳、河流阶地、层状洞穴、古生物、古土壤、高原周围盆地的沉积速率等证据,应用和创新定年技术提高云贵高原隆升的时间分辨率,同时,加强云贵高原与周边环境演变的关系研究应是今后努力的方向。

关键词：云贵高原隆升青藏高原环境演变

基于CiteSpace的国内外土壤污染治理研究进展和发展动态分析

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现代化工 2024年第9期44卷 17-23页

作者：司佳雪董鑫张晓晴任大军张淑琴武汉科技大学资源与环境工程学院湖北武汉430081 冶金矿产资源高效利用与造块湖北省重点实验室湖北武汉430081

为全面了解国内外土壤污染防治的研究趋势和热点,利用CiteSpace可视化软件分析了近20年土壤污染治理研究相关文献的发文量、发文国家、发文机构、高被引文献和关键词等。结果表明,中英文发文量呈稳定增长趋势,中国于2010年发文量超过美... 详细信息

为全面了解国内外土壤污染防治的研究趋势和热点,利用CiteSpace可视化软件分析了近20年土壤污染治理研究相关文献的发文量、发文国家、发文机构、高被引文献和关键词等。结果表明,中英文发文量呈稳定增长趋势,中国于2010年发文量超过美国而成为该领域发文量最多的国家;中国科学院是发文量最多的机构,但国内机构间的合作较为稀疏;当前土壤污染治理中热点污染物主要侧重于重金属、多环芳烃、石油污染物和农药方面,修复技术则聚焦于生物修复和植物修复方面;学者们近几年更关注土壤污染的来源解析和健康风险评估等;结合基因组学的生物修复、生物炭钝化等高效绿色修复技术是当下和未来土壤污染修复的研究重点。

关键词：土壤污染生物修复生物炭 CiteSpace 文献计量学

高效液相色谱-四级杆飞行时间串联质谱(HPLC-Q-TOF-MS)确定鲩鱼中的主要含N化合物

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现代食品科技 2016年第11期32卷 293-302页

作者：张友胜黄佳思刘学铭程镜蓉陈智毅张业辉广东省农业科学院蚕业与农产品加工研究所农业部功能食品重点实验室广东省农产品加工重点实验室广东广州510610

采用高效液相色谱一四极杆飞行时间串联质谱(HPLC-Q-TOF-MS)对鲩鱼肉甲醇提取液中的主要含N类化合物进行推导和解析。利用正与负离子两种扫描方式,并依据高分辨质谱提供的准分子离子峰和碎片离子的精确分子质量信息,确证有关物质及其特... 详细信息

采用高效液相色谱一四极杆飞行时间串联质谱(HPLC-Q-TOF-MS)对鲩鱼肉甲醇提取液中的主要含N类化合物进行推导和解析。利用正与负离子两种扫描方式,并依据高分辨质谱提供的准分子离子峰和碎片离子的精确分子质量信息,确证有关物质及其特征碎片离子的分子组成,再通过结合chemspider数据库,最终确定鲩鱼肉中的33种含N类化合物组分,并对每个组分的主要碎片数据进行推导与解析。结果显示33种含N类化合物组分中包括11种氨基酸(α-氨基酸8种),12种胺类化合物,8种酰胺类化合物和2种杂环N类化合物。因此,采用HPLC-Q-TOF-MS和质谱质解规律,可推导出鲜活原料中的单体化合物结构,提高其化学成分的鉴定与分析效率。这也有利于鲜活原料保藏过程中活性成分与新化合物的鉴别与演变推导。

关键词：高效液相色谱-四级杆飞行时间串联质谱(HPLC-Q-TOF MS) 鲩鱼化学组分碎片离子

Synthesis and Biological Activities of α-Amino Acylamines Derivatives Containing Furan and Pyridine Ring

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Chemical Research in Chinese Universities 2009年第6期25卷 846-850页

作者： XU Yan~ xue si-jia Department of Chemistry Shanghai Normal University Shanghai 200234 P R. China

In order to find better herbicidal activity and fungicidal activity of a-amino acid derivatives, we introduced furan rings and pyridyl groups to seven different a-amino acids to form a series of 14 novel a-amino acylamines derivatives via dicyclohexylcarbodiimide/4-dimethylaminopyridine（DCC/DMAP） coupling method. The structures of all the compounds prepared were confirmed by IR, LC/MS, IH NMR, and elemental analysis. The herbicidal and fungicidal results show that some compounds containing glycine and valine substrate have good activities.

关键词： Amino acid Furan ring Pyridyl group Herbicidal and fungicidal activity

Crystal Structure and Biological Activities of (R)-N′-[2-(4-Methoxy-6-chloro)-pyrimidinyl]-N-[3-methyl-2-(4-chlorophenyl)butyryl]-urea

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Chinese Journal of Structural Chemistry 2006年第8期25卷 903-908页

作者： LI Jing-Zhi xue si-jia LIU Guo-Hua Department of Chemistry College of Life and Environmental Science Shanghai Normal University Shanghai 200234 China

The title compound （R）-N′-[2-（4-methoxy-6-chloro）-pyrimidyl]-N-[3-methyl-2-（4- chlorophenyl）butyryl]-urea has been synthesized, and its crystal structure and biological behaviors were studied. Crystallographic data： C17H18C12N4O3, Mr = 397.25, monoclinic, space group P21/c, a = 12.331（2）, b = 14.025（3）, c = 23.085（5） A, β = 99.607（4）°, Z = 8, V = 3936.2（13） A3, Dc = 1.341 g/cm^3, F（000） = 1648, R = 0.0718, wR = 0.1585 and/t（MoKα） = 0.353 mm^-1. The preliminary biological tests showed that the title compound has definite insecticidal and fungicidal activities.

关键词： crystal structure biological activity (R)-3-methyl-2-(4-chlorophenyl)butyric acid 2-amino-6-chloro-4-methoxy-pyrimidine