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Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： Vishal singh Arnab Choudhury hyung jin Ahn Department of Pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

Gastric subepithelial lesion complicated with abscess: Case report and literature review

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World Journal of Gastroenterology 2015年第20期21卷 6398-6403页

作者： Sung Bum Kim Myung jin Oh si hyung Lee Department of Internal Medicine Yeungnam University College of Medicine

Gastric abscess is a localized pyogenic inflammation of the gastric wall, which is a rare form of suppurative gastritis. The rarity of gastric abscess may be associated with the difficulty of early diagnosis and high mortality as a result. In general, subepithelial lesions (SELs) of the stomach are incidentally detected during the course of upper endoscopy without specific clinical symptoms and signs. However, some gastric SELs present rarely as a form of hemorrhage, obstruction, perforation, and abscess. Here we report a 45-year-old man with gastric SEL presenting as a gastric abscess, which was diagnosed as an ectopic pancreas of the stomach, along with a review of the literature. Although gastric SEL presenting as an abscess is known as a serious and life-threatening lesion, the patient made a complete recovery through surgical resection as well as medical treatment.

关键词： Suppurative gastritis Gastric abscess Subepithelial lesion Ectopic pancreas Endoscopicultrasound

Influences of etiology and endoscopic appearance on the long-term outcomes of gastric antral vascular ectasia

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World Journal of Clinical Cases 2022年第18期10卷 6050-6059页

作者： Hyo jin Kwon si hyung Lee Joon Hyun Cho Division of Gastroenterology and Hepatology Department of Internal MedicineYeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Gastric antral vascular ectasia(GAVE)has diverse associations and presumed causes,which include liver cirrhosis,chronic kidney disease,and autoimmune *** heterogeneity of underlying disorders suggests that the pathogenesis of GAVE may be *** To compare the clinical features and long-term outcomes of GAVE according to endoscopic patterns and *** The medical records and endoscopic images of 23 consecutive patients diagnosed with GAVE by endoscopy at Yeungnam University Hospital from January 2006 to December 2020 were retrospectively *** were allocated to cirrhosis(16 patients)and non-cirrhosis groups(7 patients).GAVE subtypes,as determined by endoscopy,were categorized as punctate(a diffuse,honeycomb-like appearance,17 patients)or striped(a linear,watermelon-like appearance,6 patients).RESULTS All GAVE patients with cirrhosis(16/16,100%)had a punctate pattern by endoscopy,whereas the majority of patients(6/7,85.7%)without cirrhosis had a striped pattern(Psignificantly more common in the non-cirrhosis group than in the cirrhosis group(6/7,85.7%vs 4/16,25.0%;P=0.019),and more common in the striped group than in the punctate group(5/6,83.3%vs 5/17,29.4%;P=0.052).However,mean numbers of admissions due to GAVE bleeding and argon plasma coagulation(APC)sessions to address overt bleeding were similar in the cirrhosis and non-cirrhosis groups and in the punctate and striped *** patients with GAVE bleeding were successfully treated by APC,and no patient died from GAVE-related blood loss during a median follow-up of 24 *** Punctate-type GAVE is strongly associated with liver cirrhosis,and GAVE patients without cirrhosis tend to be more prone to overt ***,the presence of cirrhosis and endoscopic patterns did not influence long-term clinical courses or outcomes in cases of overt bleeding.

关键词： Gastric antral vascular ectasia Cirrhosis Endoscopy Gastrointestinal bleeding Argon plasma coagulation

Esophageal subepithelial lesion diagnosed as malignant gastrointestinal neuroectodermal tumor

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World Journal of Gastroenterology 2015年第18期21卷 5739-5743页

作者： Sung Bum Kim si hyung Lee Mi jin Gu Department of Internal Medicine Yeungnam University Hospital Department of Pathology Yeungnam University Hospital

A 21-year-old male visited our hospital with a complaint of aggravating dysphagia and odynophagia for a few *** showed huge bulging mucosa with an intact surface causing luminal narrowing at 35 cm from the incisor *** ultrasonography showed an about 35 mm sized irregular margined in-homogenous hypoechoic lesion with an obscure layer of *** ultrasonography fine needle aspiration revealed spindle cell proliferation without immunoreactivity for CD117,SMA,and *** patient underwent excision of the subepithelial lesion at the distal *** pathologic examination of the specimen,the tumor was composed of short fascicles of oval to spindle cells with eosinophilic and clear cytoplasm and vesicular *** tumor cells were positive for S-100 and SOX10and negative for CD117,SMA,HMB-45,melan-A,cytokeratin,and *** split-apart signal was detected in EWSR1 on FISH,suggesting a malignant gastrointestinal neuroectodermal *** the time of writing,the patient is on radiation therapy at the operated site of esophagus and doing well,with no recurrence for three *** gastrointestinal neuroectodermal tumor is a rare gastrointestinal tumor with features of clear cell sarcoma,without melanocytic differentiation,and shows a poor *** is the first reported case of malignant gastrointestinal neuroectodermal tumor arising as subepithelial lesion in the esophagus.

关键词： Subepithelial lesion Esophagus Malignant gastrointestinal neuroectodermal tumor Ewing sarcoma break point region 1 gene Fluorescence in situ hybridization

Early gastric cancer presenting as a typical submucosal tumor cured by endoscopic submucosal dissection:A case report

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World Journal of Gastroenterology 2022年第25期28卷 2994-3000页

作者： Joon Hyun Cho si hyung Lee Division of Gastroenterology and Hepatology Department of Internal MedicineYeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Submucosal tumor(SMT)-like gastric cancer is rare,and almost all cases undergo curative surgical treatment because the submucosal layer is usually deeply invaded by tumor cells or because histopathologic types of SMT-like gastric cancer are undifferentiated or poorly *** report has been issued on an SMT-like gastric cancer cured by endoscopic resection alone or on changes in the endoscopic features of this type of tumor over several *** SUMMARY We describe an exceptional case of a 53-year-old male with a 1.5 cm-sized SMTlike lesion covered by normal-appearing mucosa discovered by esophagogastroduodenoscopy(EGD)at the gastric *** ultrasound(EUS)visualized a homogeneous,well-circumscribed hypoechogenic lesion arising from the second sonographic layer with associated subtle obliteration of the third sonographic *** endoscopic biopsy was negative for *** patient refused to undergo an invasive procedure and was subsequently lost to *** years after initial detection,EGD revealed the lesion had become markedly erythematous,and at 4 years after initial EGD it had increased in size to 1.8 cm and developed a central ulcer and a heterogeneous EUS ***,endoscopic submucosal dissection(ESD)was performed,and histopathologic examination revealed a moderately differentiated adenocarcinoma had minutely invaded the submucosal layer(invasion depth 169μm)but without lymphovascular invasion and with negative resection ***,no additional surgical treatment was *** has been followed for 4 years after ESD without any evidence of local or distant *** This report describes an extremely rare case of early gastric cancer presenting as SMT that was cured by ESD after a treatment delay of 4 years and the endoscopic changes that occurred during this *** report highlights the importance of considering the possibility of gastric cancer when SMT is encountered in clini

关键词： Subepithelial lesion Submucosal tumor Early gastric cancer Adenocarcinoma Endoscopic mucosal dissection Case report

先天性心脏病儿童156例营养不良发生现状及影响因素分析

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安徽医药 2025年第1期29卷 83-86页

作者：肖瑾朱琳陈思陕西省森林工业职工医院儿童保健科陕西西安710300

目的探讨先天性心脏病儿童营养不良发生现状及影响因素。方法选取陕西省森林工业职工医院2019年6月至2022年7月收治的156例先天性心脏病病人,采用Z评分法评估病人的营养状况。根据病人营养状况将其分为营养不良组和正常组,比较两组病人... 详细信息

目的探讨先天性心脏病儿童营养不良发生现状及影响因素。方法选取陕西省森林工业职工医院2019年6月至2022年7月收治的156例先天性心脏病病人,采用Z评分法评估病人的营养状况。根据病人营养状况将其分为营养不良组和正常组,比较两组病人一般资料,采用多因素回归分析先天性心脏病病人营养不良的影响因素。结果156例先天性心脏病病人中营养不良发生率为58.97%,其中急性营养不良发生率为26.92%,慢性营养不良发生率为32.05%;营养不良组病情复杂占比(57.61%比34.37%)、家庭经济收入低占比(45.65%比21.88%)、母亲对疾病感知度不准确占比(57.61%比35.94%)、低出生体质量儿占比(38.04%比23.44%)、心脏增大占比(21.74%比9.37%)、治疗前有症状占比(73.91%比34.38%)、确诊时间≥1年占比(68.48%比29.69%)、住院次数>4次占比(33.70%比12.50%)、感染占比(70.65%比29.69%)及来自农村占比(63.04%比40.62%)均高于营养正常组(均P<0.05);logistic回归分析发现,病情复杂程度、家庭经济收入、出生体质量、确诊时间、住院次数及感染均是先天性心脏病病人发生营养不良的独立危险因素(P<0.05)。结论病情复杂程度、出生体质量、住院次数以及家庭来源均是先天性心脏病病人营养不良的独立危险因素。

关键词：先天性心脏病儿童营养不良营养状况影响因素

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Is combined lipid-regulating therapy safe and feasible for the very old patients with mixed dyslipidemia?

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Journal of Geriatric Cardiology 2013年第4期10卷 349-354页

作者： Xiao Zou Quan-jin si The First Department of the Geriatric Cardiology Chinese PLA General Hospital NO.28 Fuxing Road Beijing 100853 China

OBJECTIVES: To detect the efficacy and safety of combined lipid-regulating therapies in the very old patients with mixed dyslipidemia and determine an appropriate therapy for them。 METHODS: Four hundred and fifty patients aged over 75 with mixed dyslipidemia were divided into five groups according to different combination therapies。 Lipid levels and drug related adverse events were tested during the study。 RESULTS: Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were reduced in every group compared to baseline: statin + ezetimibe: -30.0% and -55.5%; statin + policosanol: -31.1% and -51.2%; statin + fibrates: -23.7% and -44.6%; statin + niacin: -25.2% and -43.0%; and niacin + fibrates: -11。3% and -23.5%。 The target achievement rates of LDL-C all exceeded 50%, except in niacin + fibrates (42.0%); statin + ezetimibe: 57.0%; statin + policosanol: 56.0%; statin + niacin: 52.0%; and statin + fibrates: 50.0%。 However, overall, the niacin + fibrates group was the most effective in decreasing triglyceride (TG) and increasing high-density lipoprotein cholesterol (HDL-C) as follows: niacin + fibrates: -39.3% and 28.6%; statin + fibrates: -29.3% and 18.4%; statin + niacin: -18.5% and 16.7%; statin + ezetimibe: -17.1% and 7.1%; and statin + policosanol: -15.6% and 9.5%。 The achievement rates of TG and HDL-C levels in niacin + fibrates (58.0% and 39.0%) were better than the other four groups: statin + niacin (34.0% and 34.0%), statin + fibrates (43.0% and 28.0%), statin + policosanol (30.0% and 24.0%) and statin + ezetimibe (28.0% and 25.0%)。 Patients in all five groups experiencing drug adverse events were only 2% and no severe adverse events occurred。 CONCLUsiONS: Statin + ezetimibe was the most effective group in lowering TC and LDL-C levels, while niacin + fibrates was the most effective in decreasing TG and increasing HDL-C levels。 The commonly used combined lipid-regulating therapies with common dosages in this study were all quite safe and fea

关键词： Combination therapies Elderly patients Mixed dyslipidemia Safety

Development of a two-stage virtual impactor for the generation of micrometer-scale monodisperse aerosols

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Particuology 2024年第12期95卷 189-197页

作者： Jun-hyung Lim Igor Kim Se-jin Yook School of Mechanical Engineering Hanyang UniversitySeoul04763Republic of Korea

Monodisperse particles are useful across a wide range of industrial applications,such as LCD displays,solar cells and rechargeable batteries,due to their uniformly small ***,generating high volumes of monodisperse particles remains *** this study,it was aimed to generate mono-disperse aerosols by classifying micrometer-scale solid aerosol particles within a narrow size ***,a new particle-size classification device with two virtual impactors connected in series and clean air cores was *** first-stage virtual impactor had a slightly larger cutoff size than the second-stage,and the major flow discharged from the first-stage was directed to the *** target particle size range was altered by changing the nozzle sizes in the first and second stages or by adjusting the flow ***,the classification performance of the two-stage virtual impactor was simulated and validated through an experiment using Arizona test *** implemented combi-nations of cutoff sizes for the first and second stages were 3.0 and 2.0μm,3.9 and 2.7μm,or 6.7 and 4.8μ*** a result,monodisperse aerosol particles were classified at a geometric standard deviation of 1.04-1.14 and a particle size range of 2-6.7μ*** two-stage virtual impactor developed herein may be useful for various research and performance evaluations,as it can classify micrometer-scale solid particle aerosols that exhibit high monodispersity.

关键词： Virtual impactor Clean air core Dust collection efficiency Monodispersity

Time-domain channel estimator based on cyclic correlationfor OFDM systems with guard interval

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The Journal of China Universities of Posts and Telecommunications 2008年第2期15卷 26-31页

作者： IM Se-bin CHOI hyung-jin Communication Research Center Harbin Institute of Technology

Channel impulse response （CIR） can be estimated on the basis of cyclic correlation in time-domain for orthogonal frequency division multiplexing （OFDM） systems, This article proposes a generalized channel estimation method to reduce the estimation error by taking the average of different CIRs. Channel impulse responses are derived according to the different starting points of cyclic correlation. In addition, an effective CIR length estimation algorithm is also presented. The whole proposed methods are more effective to OFDM systems, especialiy to those with longer cyclic prefix. The analysis and the simulation results verify that the mean square error performance is 4-5 dB better than the conventional schemes under the same conditions.

关键词： CIR OFDM channel estimation mean squareerror (MSE)