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A Post-Quantum Cross-Domain Authentication Sche.e Based on Multi-Chain Architecture

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Computers, Materials & Continua 2024年第2期78卷 2813-2827页

作者： Yi-Bo Cao Xiu-Bo che. Yun-Feng He Lu-Xi Liu Yin-Mei che.Xiao Wang Ke Xiao Gang Xu si-Yi che. Information Security Center State Key Laboratory ofNetworking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Information Center of China North Industries Group Corporation Beijing100089China School of Information Science and Technology North China University of TechnologyBeijing100144China

Due to the rapid advancements in network technology,blockchain is being employed for distributed data *** the Internet of Things(IoT)scenario,different participants manage multiple blockchains located in different trust domains,which has resulted in the extensive development of cross-domain authentication ***,the emergence of many attackers equipped with quantum computers has the potential to launch quantum computing attacks against cross-domain authentication sche.es based on traditional cryptography,posing a significant security *** response to the aforementioned challenges,our paper demonstrates a post-quantum cross-domain identity authentication sche.e to negotiate the session key used in the cross-chain asset exchange ***,our paper designs the hiding and recovery process of user identity index based on lattice cryptography and introduces the identity-based signature from lattice to construct a post-quantum cross-domain authentication ***,our paper utilizes the hashed time-locked contract to achieves the cross-chain asset exchange of blockchain nodes in different trust ***,the security analysis reduces the security of the identity index and signature to Learning With Errors(LWE)and Short Integer Solution(siS)assumption,respectively,indicating that our sche.e has post-quantum *** but not least,through comparison analysis,we display that our sche.e is efficient compared with the cross-domain authentication sche.e based on traditional cryptography.

关键词： Cross-domain identity authentication lattice-based cryptography blockchain hashed time-locked contract

Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF:not just ICsi failure

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Asian Journal of Andrology 2024年第2期26卷 175-182页

作者： Jian-Fang che.Hui-Xia Wu si-Cong Zeng Yue-Ren Wu Jing Dai De-Hua che.g Fei Gong Guang-Xiu Lu Ge Lin Can Dai School of Medicine Hunan Normal UniversityChangsha 410013China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410008China Clinical Research Center for Reproduction and Genetics in Hunan Province Changsha 410078China National Engineering and Research Center of Human Stem Cell Changsha 410205China

Phospholipase C zeta(PLC)is a key sperm-borne oocyte-activating factor that triggers Ca^(2+)oscillations and the subsequent block to polyspermy following gamete *** in PLCZ1,the gene encoding PLCζ,cause male infertility and intracytoplasmic sperm injection(ICsi)fertilization failure;and PLCζ expression and localization patterns are significantly correlated with ICsi fertilization rate(FR).However,in conventional in vitro fertilization(cIVF),whether and how sperm PLCζ affects fertilization remain ***,we identified one previously reported and two novel PLCZ1 mutations associated with polyspermy in vitro that are characterized by excessive sperm-zona binding and a delay in pronuclei(PN)*** staining and oocyte activation testing revealed that virtually all spermatozoa from patients lacked functional PLCζ and were thus unable to evoke Ca^(2+) *** with an artificial oocyte activation treatment successfully rescued the polyspermic phenotype and resulted in a live ***,we analyzed PLCζ in an additional 58 males after cIVF treatment in the Reproductive and Genetic Hospital of CiTiC-Xiangya(Changsha,China)between February 2019 and January *** found that the proportion of spermatozoa that expressed PLCζ was positively correlated with both 2PN rate and total *** optimal cutoff value below which males were likely to experience low FR(total FR≤30%)after clVF was 56.7%for the proportion of spermatozoa expressing *** study expands the mutation and the phenotypic spectrum of PLCZ1 and further suggests that PLCζ constitutes a promising biomarker for identifying low FRs cases in cIVF due to sperm-related oocyte activation deficiency and that sperm PLCζ analysis may benefit the widermale population and not onlymen with Icsi failure.

关键词： conventional IVF gene variants PLCζ polyspermy

Carrimycin inhibits coronavirus replication by decreasing the efficiency of programmed–1 ribosomal frameshifting through directly binding to the RNA pseudoknot of viral frameshift-stimulatory element

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Acta Pharmaceutica sinica B 2024年第6期14卷 2567-2580页

作者： Hongying Li Jianrui Li Jiayu Li Hu Li Xuekai Wang Jing Jiang Lei Lei Han Sun Mei Tang Biao Dong Weiqing He Shuyi si Bin Hong Yinghong Li Danqing Song Zonggen Peng Yongsheng che.Jian-Dong Jiang CAMS Key Laboratory of Antiviral Drug Research Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Key Laboratory of Biotechnology of Antibiotics the National Health and Family Planning Commission(NHFPC)Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

The pandemic of SARS-CoV-2 worldwide with successive emerging variants urgently calls for small-molecule oral drugs with broad-spectrum antiviral ***,we show that carrimycin,a new macrolide antibiotic in the clinic and an antiviral candidate for SARS-CoV-2 in phase III trials,decreases the efficiency of programmed–1 ribosomal frameshifting of coronaviruses and thus impedes viral replication in a broad-spectrum *** binds directly to the coronaviral frameshift-stimulatory element(FSE)RNA pseudoknot,interrupting the viral protein translation switch from ORF1a to ORF1b and thereby reducing the level of the core components of the viral replication and transcription *** carrimycin with known viral replicase inhibitors yielded a synergistic inhibitory effect on *** the FSE mechanism is essential in all coronaviruses,carrimycin could be a new broad-spectrum antiviral drug for human coronaviruses by directly targeting the conserved coronaviral FSE *** finding may open a new direction in antiviral drug discovery for coronavirus variants.

关键词： Carrimycin Coronavirus Broad-spectrum antiviral activity Programmed-1 ribosomal frameshifting RNA pseudoknot Antiviral agent RNA target Synergistic inhibitory effect

DNA methylation clocks for estimating biological age in Chinese cohorts

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Protein & Cell 2024年第8期15卷 575-593页

作者： Zikai Zheng Jiaming Li Tianzi Liu Yanling Fan Qiao-che.g Zhai Muzhao Xiong Qiao-Ran Wang Xiaoyan Sun Qi-Wen Zheng Shanshan che.Beier jiang Quan Zheng Cui Wang Lixiao Liu Jiale Ping si Wang Dan-Dan Gao Jinlin Ye Kuan Yang Yuesheng Zuo Shuai Ma Yun-GuiYang Jig Qu Feng Zhang Peilin Jia Guang-Hui Liu Weiqi Zhang CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Computational Biology Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China Division of Orthopaedics Quzhou Affliated Hospital of Wenzhou Medical UniversityQuzhou 324000China The Joint Innovation Center for Engineering in Medicine Quzhou Affliated Hospital of Wenzhou Medical UniversityQuzhou 324000China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center Intemational Center for Aging and CancerXuanwu HospitalCapital Medical UniversityBeijing 100053China Aging Biomarker Consortium Beijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China nstitute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China

Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation(DNAm)at specific CpG ***,a systematic comparison between DNA methylation data and other omics datasets has not yet been ***,available DNAm age predictors are based on datasets with limited ethnic *** address these knowledge gaps,we generated and analyzed DNA methylation datasets from two independent Chinese cohorts,revealing age-related DNAm ***,a DNA methylation aging clock(iCAS-DNAmAge)and a group of DNAm-based multi-modal clocks for Chinese individuals were developed,with most of them demonstrating strong predictive capabilities for chronological *** clocks were further employed to predict factors influencing aging *** DNAm aging clock,derived from multi-modal aging features(compositeAge-DNAmAge),exhibited a close association with multi-omics changes,lifestyles,and disease status,underscoring its robust potential for precise biological age *** findings offer novel insights into the regulatory mechanism of age-related DNAm changes and extend the application of the DNAm clock for measuring biological age and aging pace,providing the basis for evaluating aging intervention strategies.

关键词： DNA methylation aging clock aging age prediction

Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer

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World Journal of Clinical Oncology 2024年第3期15卷 391-410页

作者： Jin-Yu Shi Xin che.Rui Wen si-Jia Hou Yu-Jia Xi Yi-Qian Feng Ling-Xiao Wang Shi-Jia Liu Wen-Hao Lv Ya-Fen Zhang Department of Breast Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina The Fifth Clinical Medical College Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Colorectal Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina College of Pharmacy Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Urology The Second Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Breast Surgery The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Ferroptosis has recently been associated with multiple degenerative *** induction in cancer cells is a feasible method for treating neoplastic ***,the association of iron proliferation-related genes with prognosis in HER2+breast cancer(BC)patients is *** To identify and evaluate fresh ferroptosis-related biomarkers for HER2+*** First,we obtained the mRNA expression profiles and clinical information of HER2+BC patients from the TCGA and METABRIC public databases.A four gene prediction model comprising PROM2,SLC7A11,FANCD2,and FH was subsequently developed in the TCGA cohort and confirmed in the METABRIC *** were stratified into high-risk and low-risk groups based on their median risk score,an independent predictor of overall survival(OS).Based on these findings,immune infiltration,mutations,and medication sensitivity were analyzed in various risk ***,we assessed patient prognosis by combining the tumor mutation burden(TMB)with risk ***,we evaluated the expression of critical genes by analyzing single-cell RNA sequencing(scRNA-seq)data from malignant vs normal epithelial *** We found that the higher the risk score was,the worse the prognosis was(Psitivity were different between the different risk *** highrisk subgroup was associated with lower immune scores and high ***,we found that the combination of the TMB and risk score could stratify patients into three groups with distinct ***-HTMB patients had the worst prognosis,whereas LRisk-LTMB patients had the best prognosis(Psis of the scRNAseq data showed that PROM2,SLC7A11,and FANCD2 were significantly differentially expressed,whereas FH was not,suggesting that these genes are expressed mainly in cancer epithelial cells(PsiON Our model helps guide the prognosis of HER2+breast cancer pa

关键词： HER2+breast cancer Ferroptosis Tumor mutation burden single-cell RNA sequencing Prognosis

随掘地震地质构造精细监测在山西王坡煤矿的应用

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煤田地质与勘探 2024年第6期52卷 137-144页

作者：赵会波覃思陈超关奇赵星伟车建航山西天地王坡煤业有限公司山西晋城048021 中煤科工西安研究院(集团)有限公司陕西西安710077 煤炭智能开采与岩层控制全国重点实验室陕西西安710077

【目的】传统巷道地震超前探技术受限于炸药使用、停掘需求、预报速度、探测范围及能力等方面的不足,难以满足智能掘进工作面的高精度地质构造探测需求。【方法】随掘地震以掘进机截割煤壁的震动为震源,采用数据实时上传、自动处理及动... 详细信息

【目的】传统巷道地震超前探技术受限于炸药使用、停掘需求、预报速度、探测范围及能力等方面的不足,难以满足智能掘进工作面的高精度地质构造探测需求。【方法】随掘地震以掘进机截割煤壁的震动为震源,采用数据实时上传、自动处理及动态成像的工作模式,充分利用信息技术和软件支撑,借助于海量数据支撑下的实时连续超饱和叠加,大幅提升了对掘进工作面前方地质异常体的成像精细度。以山西王坡煤矿为研究对象,在2条掘进巷道中部署了随掘地震监测系统,开展地质构造精细探查。【结果和结论】实际工作中,利用监测作业开展后48 h内积累的数据,即可对掘进工作面前方200 m范围内地质异常体成像。在3217工作面回风巷中,成功揭示了掘进工作面前方97 m的矸石挤压带反射异常,预报误差1 m;在3303工作面运输巷中,揭示了掘进工作面前方39 m的陷落柱,预报误差2 m;在3303工作面运输巷中,揭示了2处煤层破碎带异常区,其中,一处位于掘进工作前方148 m,预报误差1 m,另一处位于掘进工作面前方211 m外,在前序陷落柱和煤层破碎带遮挡下,依然足以形成较强的成像结果,预报误差3 m。结果表明:该技术探测精度高、探测距离远且探测能力强,可为瓦斯灾害的防治提供技术支持,为煤矿巷道安全高效掘进提供可靠的地质保障。

关键词：矿井安全随掘地震地质构造煤层破碎带挤压带陷落柱

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多维相对贫困的精准测度与分解

重庆工商大学学报（社会科学版） 2024年第4期41卷 69-88页

作者：车四方重庆工商大学成渝地区双城经济圈建设研究院重庆400067 重庆市综合经济研究院重庆401120

缓解相对贫困是实现共同富裕的基本前提。构建包含心理健康、环境质量等要素的多维相对贫困指标体系,借鉴A-F贫困框架体系,利用中国家庭追踪调查(CFPS)数据,引入机器学习中的随机权神经网络(NNRW)法,精准测度并分解中国城乡间、区域间... 详细信息

缓解相对贫困是实现共同富裕的基本前提。构建包含心理健康、环境质量等要素的多维相对贫困指标体系,借鉴A-F贫困框架体系,利用中国家庭追踪调查(CFPS)数据,引入机器学习中的随机权神经网络(NNRW)法,精准测度并分解中国城乡间、区域间居民的多维相对贫困广度、深度和强度水平。研究发现:无论城乡间还是区域间,随着相对贫困维度的增加,多维相对贫困的广度、深度和强度指数均呈下降趋势,表明发生极端多维相对贫困的居民数量逐渐递减。同时,居民多维相对贫困指数呈“西高东低”态势,全国居民多维相对贫困水平大致与中部地区相当;农村居民的多维相对贫困水平显著高于城镇居民,且农村居民的多维相对贫困程度与西部地区相当;城镇居民的多维相对贫困水平大致与东部地区相当。此外,多维相对贫困指数分解结果显示,金融产品、生活环境、耐用品和人均纯收入等因素是城乡间、区域间居民发生相对贫困的主因,但是致贫主因对贫困广度、深度和强度的贡献率有所差别。研究结论为制定解决多维相对贫困长效机制提供了理论参考和政策依据。

关键词：多维相对贫困相对剥夺随机权神经网络环境质量

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基于多域故障传播的中央空调系统可维修性设计评价

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机械工程学报 2024年第11期60卷 191-204页

作者：李浩苗壮王昊琪张玉彦车福亮司红雷孙天兴王佳奇郑州轻工业大学河南省机械装备智能制造重点实验室郑州450002 亿联鑫工程科技有限公司郑州450002

中央空调系统集成化程度高,故障在相互关联的功能和结构中传播,但是设计阶段的功能和结构的关系模糊,故障传播对可维修性设计的影响难以评估。为了定量评价故障传播对中央空调系统可维修性设计的影响,在功能设计和结构设计的映射过程中... 详细信息

中央空调系统集成化程度高,故障在相互关联的功能和结构中传播,但是设计阶段的功能和结构的关系模糊,故障传播对可维修性设计的影响难以评估。为了定量评价故障传播对中央空调系统可维修性设计的影响,在功能设计和结构设计的映射过程中加入了原理域,建立“功能-原理-结构”(Function-principle-structure,FPS)多域矩阵,使用模糊综合评价量化矩阵中的影响关系,建立故障传播风险评估模型,通过变更传播管理(Change propagation management,CPM)算法评估故障传播的综合风险。通过比较相同的故障在不同设计方案中传播的综合风险,帮助设计师选择可维修性较高的设计。

关键词：维修性设计故障传播功能-原理-结构中央空调变更传播管理

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复合微生物菌剂对葡萄生长、品质及根际土壤环境的影响

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生物技术通报 2024年第8期40卷 264-274页

作者：车建美赖恭梯李思雨郭奥琳陈冰星陈杏刘波赖呈纯福建省农业科学院资源环境与土壤肥料研究所福州350002 福建省农业科学院农产品加工研究所福州350002

【目的】葡萄是我国栽培广泛的五大果树品种之一,长期过量施用化肥,破坏微生物生态,从而影响葡萄产量和品质。探究不同来源菌株的复合微生物菌剂对改善葡萄果实品质的作用。【方法】采用复合微生物菌剂[短短芽胞杆菌(Brevibacillus brev... 详细信息

【目的】葡萄是我国栽培广泛的五大果树品种之一,长期过量施用化肥,破坏微生物生态,从而影响葡萄产量和品质。探究不同来源菌株的复合微生物菌剂对改善葡萄果实品质的作用。【方法】采用复合微生物菌剂[短短芽胞杆菌(Brevibacillus brevis)FJAT-0809-GLX、贝莱斯芽胞杆菌(Bacillus velezensis)FJAT-55034及短短芽胞杆菌(***)FJAT-10623]灌根,分析复合微生物菌剂对葡萄生长和果实品质及根际土壤酶活性、可培养芽胞杆菌多样性等的影响。【结果】复合微生物菌剂能够促进葡萄叶片生长,提高叶片的叶绿素a和类胡萝卜素含量及POD和PPO活性。处理组葡萄幼果的叶绿素b含量、SOD和PPO活性分别比对照组提高了100%、11.77%和66.67%。施用复合微生物菌剂能够促进葡萄提早成熟及果实转色,提升果实品质,其中,单果重比对照高出29.06%,可溶性固形物和可溶性蛋白分别比对照组提高了7.31%和94.74%,且处理组成熟果实的PPO酶活性显著高于对照组。此外,复合微生物菌剂能够显著提高土壤淀粉酶、过氧化氢酶、纤维素酶、蔗糖酶活性及芽胞杆菌的种类和数量。相关性分析表明,辣椒芽胞杆菌(Bacillus zanthoxyli)和假蕈状芽胞杆菌(Bacillus pseudomycoides)可促进葡萄叶片生长及果实品质提升。【结论】复合微生物菌剂具有改良土壤、促进葡萄生长和提升果实品质的作用。

关键词：复合微生物短短芽孢杆菌贝莱斯芽孢杆菌葡萄品质土壤