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Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata

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Natural Products and Bioprospecting 2019年第4期9卷 297-302页

作者： si‑yue chen Chang‑An Geng Yun‑Bao Ma Ji‑Jun chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyYunnan Key Laboratory of Natural Medicinal ChemistryChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Gastrodia elata is a famous traditional Chinese herb with medicinal and edible *** this study,three new polybenzyls,gastropolybenzylols G-I(1-3)were isolated from the EtOAc extract of *** structures were identified by extensive spectroscopic analyses involving HREsiMS,UV,IR,1D and 2D *** 1 showed agonistic effects on MT1 and MT_(2) receptors with agonistic rates of 55.91±4.84%and 165.13±5.65%at the concentration of 0.5 mM,respectively,and an EC_(50) value of 76.24μM on MT_(2) receptor.

关键词： Gastrodia elata Gastropolybenzylols Melatonin receptors

Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期 152-156页

作者： Lihua Zhang Lingjing chen Huatian Shi yue Wei Gui chen Tai-Chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

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Nitrification-denitrifjcation Loss and N_2O Emission from Urea Applied to Crop-soil Systems in North China Plain

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Agricultural Sciences in China 2002年第2期1卷 184-188页

作者： DING Hong, CAI Gui-xin, WANG yue-si and chen De-li( Institute of Soil and Fertilizer , Fujian Academy of Agricultural Sciences , Fuzhou 350013 Institute of Soil Science, CAS, Nanjing 210008 LAPC , Institute of Atmospheric Physics, CAS, Beijing 100029 Institute of Food and Land Resources, Univ Melbourne , PV 3052 , Australia )

Nitrogen losses are not only important for agriculture but environment as well. Field experiments were set up in summer corn field at Fengqiu Agro-Ecological Experimental Station of CAS in North China Plain. The soil was in maize-chao soil. Nitrification-denitrification losses and N2O emission were determined by acetylene-inhibition soil-core incubation method in the soils applied urea. The results showed that urea was fast hydrolyzed and became to nitrate. The soil with non urea released 0.33kg N/ha N2O. However, the soil produced 2.91kg N/ha N2O, about 1.94% of the applied N, when the urea was spread on soil surface. N2O emission reduced to 2.50kg N/ha, about 1.67% of the applied N, when the urea was put in deep soil by digging a hole. The denitrification loss was 1.17kg N/ha in control soil. It increased to 3.00kg N/ ha and 2.09kg N/ha, which were 2.00% and 1.39% of the used N, in the soils received urea on surface and sub-surface respectively. It was suggested that nitrification-denitrification was probably not a main way of fertilizer nitrogen loss in this region.

关键词： Corn Urea N2O emission

High Fe‑Loading single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： si chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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手术室护士工作家庭冲突与睡眠质量相关研究

医院管理论坛 2017年第6期34卷 44-47页

作者：陈思思郑东月陈其余温州医科大学附属第二医院育英儿童医院

目的调查手术室护士感知的工作家庭冲突和睡眠质量的现状,分析工作家庭冲突对护士睡眠质量的影响。方法对367名手术室护士采用一般资料调查问卷、工作-家庭冲突量表和匹兹堡睡眠质量指数量表进行问卷调查,采用Pearson相关分析和多元逐... 详细信息

目的调查手术室护士感知的工作家庭冲突和睡眠质量的现状,分析工作家庭冲突对护士睡眠质量的影响。方法对367名手术室护士采用一般资料调查问卷、工作-家庭冲突量表和匹兹堡睡眠质量指数量表进行问卷调查,采用Pearson相关分析和多元逐步回归分析对变量间的相关关系进行检验。结果手术室护士工作-家庭冲突分量表得分为4.28±1.37分,家庭-工作冲突分量表得分为2.76±1.08分,睡眠质量量表总分7.83±3.41分。工作家庭冲突与睡眠质量及其各个维度均呈正相关,婚姻状况、受教育程度和工作-家庭冲突对手术室护士的睡眠质量有显著影响。结论手术室护士的工作家庭冲突较严重,睡眠质量亟待改善,工作家庭冲突与睡眠质量存在相关性,缓解工作家庭冲突是改善手术室护士睡眠质量的有效途径。

关键词：工作家庭冲突睡眠质量手术室护士

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia Xue Yi Liu Ran Zheng Ying chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan chen Yinkun Zhao Yujue Wang Qu yue Taotao Gao Wenlong Liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

Review of control and guidance technology on hypersonic vehicle

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Chinese Journal of Aeronautics 2022年第7期35卷 1-18页

作者： Yibo DING Xiaokui yue Guangshan chen Jiashun si School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Shanghai Aerospace Control Technology Institute Shanghai 201109China Beijing Reserarch Institute of Automation for Machinery Industry Co. LTD.Beijing 100124China

Air-breathing hypersonic vehicle has great military and potential economic value due to its characteristics:high velocity,long range,quick ***,the development of hypersonic vehicle and its guidance and control technology are reviewed in this ***,the development and classification of hypersonic vehicles around the world are summarized,and the geometric configuration and mission profile of typical air-breathing hypersonic vehicle are ***,the control difficulties of air-breathing hypersonic vehicle are introduced,including integrated design of engine and fuselage,static instability,strong nonlinearity,uncertain aerodynamic parameters,*** to its control requirements,the control methods considering external disturbance,fault-tolerant control methods,anti-saturation methods,and prescribed performance control methods considering transient performance constraints are summarized *** classification and comparison of various control methods are given,and the frontiers of theoretical development are ***,considering the effects of composite disturbances,the design of terminal guidance law under multiple constraints is overviewed,including guidance law with angle constraint,velocity constraint,acceleration constraint and time ***,the classification of guidance law design methods under different constraints,their advantages as well as the future development trend and requirements are introduced.

关键词： Classification of hypersonic vehicles Control equipmentaerospace applications Flight profiles Guidance strategy Hypersonic vehicles

Covalently Crosslinked Networks from Telechelic Polycyclooctene with Reinforced Properties

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Chinese Journal of Chemistry 2023年第16期41卷 2002-2009页

作者： Shengquan Zheng yue Liu Guifu si Min chen CAS Key laboratory of Soft Matter Chermistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physicol Science and Informotion Technology Anhui UniversityHefeiAnhui 230601China

Comprehensive Summary Introducing covalently crosslinked network to telechelic polymers can enable the formation of advanced polymeric materials with enhanced material *** this contribution,well-defined telechelic polymers bearing acetoacetate groups were synthesized via Ru-catalyzed ring-opening metathesis polymerization of cyclooctene in the presence of chain transfer *** the unique feature of muti-site reactive acetoacetate end groups,several crosslinked networks were constructed using different crosslinkers under mild *** the Michael addition reaction system,the introduction of di/trifunctional aliphatic acrylate as crosslinkers significantly enhanced the mechanical properties of the generated crosslinked network(tensile strength up to 27 MPa,elongation at break up to 500%).On the other hand,vitrimers with dynamic covalent crosslinked networks were accessed via transamination of vinylogous urethane reaction using telechelic polymers and tris(2-aminoethyl)amine.

关键词： Telechelic polycyclooctene Crosslinking Networks Vitrimers Reinforced properties Recyclable polymers