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Effects of fermented soy milk on the liver lipids under oxidative stress

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World Journal of Gastroenterology 2005年第46期11卷 7355-7358页

作者： Ching-Yi lin Zheng-Yu Tsai I-Chi Cheng shyh-hsiang lin Graduate Institute of Nutrition and Health SciencesTaipei Medical University TaipeiTaiwanChina

AIM： To investigate the effects of fermented soy milk powder on the antioxidative status and lipid metabolism in the livers of CCh-injected rats. METHODS： Forty-five healthy male Sprague-Dawley rats were randomly assigned to five groups according to five different diets： control （AIN-76）, AIN-76＋high- dose fermented soy milk powder, AIN-76＋low-dose fermented soy milk powder, AIN-76＋high-dose milk yogurt powder and AIN-76＋low-dose milk yogurt powder. The experiment lasted for 8 wk. After 4 wk, all the rats received intraperitoneal administration of CCh （0.2 mL/100 g body weight） every week. Total cholesterol （TC）, triglyceride （TG）, TBARS, ALP, and antioxidative enzymes in the liver were evaluated. RESULTS： There was also no significant difference in TBARS and antioxidative enzymes in the liver. TC and TG in the groups fed with fermented soy milk powder were generally lower than those fed with casein powder. CONCLUSION： Consumption of fermented soy milk was positive in lowering total cholesterol and TG accumulation in the liver under CCh-induced oxidative

关键词： Soy Fermented soy milk Antioxidative Liver protection

Effect of soy saponin on the growth of human colon cancer cells

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World Journal of Gastroenterology 2010年第27期16卷 3371-3376页

作者： Cheng-Yu Tsai Yue-Hwa Chen Yi-Wen Chien Wen-Hsuan Huang shyh-hsiang lin School of Nutrition and Health Sciences Taipei Medical University

AIM:To investigate the effect of extracted soybean saponins on the growth of human colon cancer ***:WiDr human colon cancer cells were treated with 150,300,600 or 1200 ppm of soy saponin to determine the effect on cell growth,cell morphology,alkaline phosphatase(AP) and protein kinase C(PKC) activities,and P53 protein,c-Fos and c-Jun gene ***:Soy saponin decreased the number of viable cells in a dose-dependent manner and suppressed 12-Otetradecanol-phorbol-13-acetate-stimulated PKC activity(P < 0.05).Cells treated with saponins developed cytoplasmic vesicles and the cell membrane became rougher and more irregular in a dose-dependent manner,and eventually *** 600 and 1200 ppm,the activity of AP was increased(P < 0.05).However,the apoptosis markers such as c-Jun and c-Fos were not significantly affected by ***:Soy saponin may be effective in preventing colon cancer by affecting cell morphology,cell proliferation enzymes,and cell growth.

关键词： Soy saponin Colon cancer Apoptosis Cell proliferation Cell differentiation

Serum lipid profiles are associated with semen quality

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Asian Journal of Andrology 2017年第6期19卷 633-638页

作者： Chin-Yu Liu Yu-Ching Chou shyh-hsiang lin Sheng-Tang Wu Tai-Lung Cha Hong-I Chen Chih-Wei Tsao Department of Nutritional Science Fu Jen Catholic University New Taipei City Taiwan China School of Public Health National Defense Medical Center Taipei Taiwan China School of Nutrition and Health Sciences College of Nutrition Taipei Medical University Taipei Taiwan China Division of Urology Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Graduate Institute of Medical Sciences Chang Jung Christian University Tainan Taiwan China

We aimed to explore the associations between different lipid profiles and semen quality in a large-scale general male population. Sperm concentration, total sperm motility, progressive motility, and normal sperm morphology of total 7601 participants were recorded. The association of these semen parameters with the triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein of serum lipid profiles was analyzed. Sperm concentration was statistically positively correlated with triglyceride and very low-density lipoprotein （adjusted P= 0.001 and P= 0.005, respectively）. Total sperm motility and progressive motility were statistically increased with increasing low-density lipoprotein and cholesterol levels （both adjusted P = 0.008 and P 〈 0.001, respectively）. The similar J-shaped associations （high-low-low-high） were noted between individual lipid profile and normal sperm morphology, especially low-density lipoprotein and cholesterol with statistical significance （adjusted P = 0.017 and P= 0.021, respectively）. The prevalence of abnormal total sperm motility and progressive motility was decreased in participants with high levels of cholesterol （P = 0.008 and P = 0.019, respectively）, and the reverse J-shaped associations （low-high-high-low） were noted between high-density lipoprotein, triglyceride, very low-density lipoprotein, and the prevalence of abnormal normal sperm morphology （P = 0.010, P = 0.037, and P = 0.025, respectively）. A high cholesterol level was associated with better sperm motility. Similar J-shaped associations were noted between all lipid profiles and normal sperm morphology; meanwhile, the reverse J-shaped trends were identified between them and abnormal normal sperm morphology prevalence.

关键词： cholesterol general population lipoprotein semen quality triglyceride

Consumption of Oriental Plums Improved the Cognitive Performance and Modulated the Cerebral Neurodegeneration-Related Protein Expressions in Rats with Nicotinamide/Streptozotocin-Induced Diabetes

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Food and Nutrition Sciences 2013年第11期4卷 1145-1154页

作者： Kao-Ting Lee Yue-Hwa Chen Ching-I lin Wan-Chun Chiu Hsang Liao shyh-hsiang lin School of Healthcare Management Kainan University Taoyuan Taiwan School of Nutrition and Health Sciences Taipei Medical University Taipei Taiwan

To examine the effect of consuming polyphenol-rich Oriental plum (Prunus salicina lindl) on the cognitive performance and the expressions of cerebral neurodegeneration-related proteins in diabetic rats, Wistar rats were assigned into 4 groups: control (C, n = 14), nicotinamide/streptozotocin-induced DM rats (DM, n = 13), DM rats fed metformin (0.05% w/w in the diet, MT, n = 18), and DM rats fed freeze-dried oriental plum powder (2% w/w in the diet, OP, n = 16) for 2 months. The cognitive performance was evaluated by testing in a Morris water maze. The insulin resistance, serum lipid peroxidation, expressions of pathological proteins of AD, beta-amyloid (Aβ) and phosphorylated tau protein were also measured. Consumption of plums significantly improved the spatial learning ability, reduced the insulin resistance, lipid peroxidation, Aβ and phosphorylated tau protein expressions in the cerebral cortex (all P β deposition in the hippocampus of diabetic rats. In conclusion, polyphenol-rich Oriental plums ameliorated the cognitive decline and reduced the expressions of pathological proteins of AD by possibly reducing hyperglycemia, insulin resistance, and oxidative stress in diabetic rats.

关键词： Neurodegeneration Diabetes Beta-Amyloid Alzheimer’s Polyphenols

TCEVis:Visual analytics of traffic congestion influencing factors based on explainable machine learning

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Visual Informatics 2024年第1期8卷 56-66页

作者： Jialu Dong Huijie Zhang Meiqi Cui Yiming lin hsiang-Yun Wu Chongke Bi School of Information Science and Technology Northeast Normal UniversityChangchunChina School of Computing Science Baicheng Normal UniversityBaichengChina St.Pölten University of Applied Sciences Austria College of Intelligence and Computing Tianjin UniversityTianjinChina

Traffic congestion is becoming increasingly severe as a result of urbanization,which not only impedes people’s ability to travel but also hinders the economic development of *** the correlation between congestion and its influencing factors using machine learning methods makes it possible to quickly identify congested road *** to the intrinsic black-box character of machine learning models,it is difficult for experts to trust the decision results of road congestion prediction models and understand the significance of congestion-causing *** this paper,we present a model interpretability method to investigate the potential causes of traffic congestion and quantify the importance of various influencing factors using the SHAP *** to the multidimensionality of these factors,it can be challenging to visually represent the impact of all *** response,we propose TCEVis,an interactive visual analytics system that enables multi-level exploration of road *** three case studies utilizing actual data,we demonstrate that the TCEVis system offers advantages for assisting traffic managers in analyzing the causes of traffic congestion and elucidating the significance of various influencing factors.

关键词： Visual analytics Speed prediction Explainable Traffic congestion

A fast forward computational method for nuclear measurement using volumetric detection constraints

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Nuclear Science and Techniques 2024年第2期35卷 47-63页

作者： Qiong Zhang lin-Lv lin University of Electronic Science and Technology of China Chengdu 610000China

Owing to the complex lithology of unconventional reservoirs,field interpreters usually need to provide a basis for interpretation using logging simulation *** the various detection tools that use nuclear sources,the detector response can reflect various types of information of the *** Monte Carlo method is one of the primary methods used to obtain nuclear detection responses in complex ***,this requires a computational process with extensive random sampling,consumes considerable resources,and does not provide real-time response ***,a novel fast forward computational method(FFCM)for nuclear measurement that uses volumetric detection constraints to rapidly calculate the detector response in various complex environments is ***,the data library required for the FFCM is built by collecting the detection volume,detector counts,and flux sensitivity functions through a Monte Carlo ***,based on perturbation theory and the Rytov approximation,a model for the detector response is derived using the flux sensitivity function method and a one-group diffusion *** environmental perturbation is constrained to optimize the model according to the tool structure and the impact of the formation and borehole within the effective detection ***,the method is applied to a neutron porosity tool for *** various complex simulation environments,the maximum relative error between the calculated porosity results of Monte Carlo and FFCM was 6.80%,with a rootmean-square error of 0.62 *** field well applications,the formation porosity model obtained using FFCM was in good agreement with the model obtained by interpreters,which demonstrates the validity and accuracy of the proposed method.

关键词： Nuclear measurement Fast forward computation Volumetric constraints

The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： Wei lin School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

Enhancing Safety in Autonomous Vehicle Navigation:An Optimized Path Planning Approach Leveraging Model Predictive Control

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Computers, Materials & Continua 2024年第9期80卷 3555-3572页

作者： Shih-lin lin Bo-Chen lin Graduate Institute of Vehicle Engineering National Changhua University of EducationChanghua50007TaiwanChina

This paper explores the application of Model Predictive Control(MPC)to enhance safety and efficiency in autonomous vehicle(AV)navigation through optimized path *** evolution of AV technology has progressed rapidly,moving from basic driver-assistance systems(Level 1)to fully autonomous capabilities(Level 5).Central to this advancement are two key functionalities:Lane-Change Maneuvers(LCM)and Adaptive Cruise Control(ACC).In this study,a detailed simulation environment is created to replicate the road network between Nantun andWuri on National Freeway No.1 in *** MPC controller is deployed to optimize vehicle trajectories,ensuring safe and efficient *** onboard sensors,including vehicle cameras and millimeterwave radar,are used to detect and respond to dynamic changes in the surrounding environment,enabling real-time decision-making for LCM and *** simulation resultshighlight the superiority of the MPC-based approach in maintaining safe distances,executing controlled lane changes,and optimizing fuel ***,the MPC controller effectively manages collision avoidance,reduces travel time,and contributes to smoother traffic flow compared to traditional path planning *** findings underscore the potential of MPC to enhance the reliability and safety of autonomous driving in complex traffic *** research will focus on validating these results through real-world testing,addressing computational challenges for real-time implementation,and exploring the adaptability of MPC under various environmental *** study provides a significant step towards achieving safer and more efficient autonomous vehicle navigation,paving the way for broader adoption of MPC in AV systems.

关键词： Autonomous driving model predictive control(MPC) lane change maneuver(LCM) adaptive cruise control(ACC)

Adaptive admittance tracking control for interactive robot with prescribed performance

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Journal of Systems Engineering and Electronics 2024年第2期35卷 444-450页

作者： MENG Qingrui lin Yan School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100190China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

An adaptive control approach is presented in this paper for tracking desired trajectories in interactive manipulators. The controller design incorporates prescribed performance functions (PPFs) to improve dynamic performance. Notably, the performance of the output error is confined in an envelope characterized by exponential convergence, leading to convergence to zero. This feature ensures a prompt response from admittance control and establishes a reliable safety framework for interactions. Simulation results provide practical insights,demonstrating the viability of the control scheme proposed in this paper.

关键词： prescribed performance admittance control adaptive control robots