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Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes tumor cell cytotoxicity

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Cellular & Molecular Immunology 2010年第5期7卷 396-408页

作者： Krishnendu Chakraborty Anamika Bose Tathagata Chakraborty Koustav Sarkar shyamal goswami Smarajit Pal Rathindranath Baral Department of Immunoregulation and Immunodiagnostics Chittaranjan National Cancer InstituteKolkataIndia Unit of Clinical Biochemistry Chittaranjan National Cancer InstituteKolkataIndia

Previous studies have shown that the CC chemokine receptor CCR5 is downregulated on monocyte/macrophage(MO/Mw)surfaces in head and neck squamous cell carcinoma(HNSCC)patients(stage IIIB).Ligands(RANTES,MIP-1a and MIP-1b)of this chemokine receptor were also secreted in lesser quantity from MO/Mw of HNSCC patients in comparison with healthy *** an aim to restore this dysregulated receptor–ligand signaling,we have used neem leaf glycoprotein(NLGP),a novel immunomodulator reported from our *** upregulated CCR5 expression,as evidenced from studies on MO/Mw of peripheral blood from HNSCC patients as well as healthy *** of RANTES,MIP-1a and MIP-1b was also upregulated following NLGP treatment of these cells in ***,NLGP has little effect on the expression of CCR5 and the ligand RANTES in oral cancer *** restored CCR5 receptor–ligand signaling seen in MO/Mw was reflected in improved CCR5-dependent,p38 mitogen-activated protein kinase(MAPK)-mediated migration of MO/Mw after NLGP treatment to a standard *** also induces better antigen presentation and simultaneous costimulation to effector T cells by MO/Mw by upregulating human leucocyte antigen(HLA)-ABC,CD80 and *** addition,NLGP-treated MO/Mw-primed T cells can effectively lyse tumor cells in *** effects of NLGP on monocyte migration and T cell-mediated oral tumor cell killing were further demonstrated in transwell assays with or without CCR5 *** results suggest a new approach in cancer immunotherapy by modulating dysregulated CCR5 signals from MO/Mw.

关键词： CCR5 chemokine head and neck squamous cell carcinoma monocytes neem leaf glycoprotein

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Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients

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Cellular & Molecular Immunology 2019年第4期16卷 367-379页

作者： Mei Liu Qiang Guo Chunmei Wu Delphine Sterlin shyamal goswami Ying Zhang Teng Li Chunde Bao Nan Shen Qiong Fu Xiaoming Zhang Key Laboratory of Molecular Virology&Immunology Institut Pasteur of ShanghaiChinese Academy of Sciences/University of Chinese Academy of SciencesShanghai 200031China Department of Rheumatology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200001China

A hallmark of systemic lupus erythematosus(SLE)is the breaking of B-cell tolerance with the generation of high-affinity autoantibodies;however,the antibody-independent features of the B-cell compartment in SLE are less *** this study,we performed an extensive examination of B-cell subsets and their proinflammatory properties in a Chinese cohort of new-onset SLE *** observed that SLE patients exhibited an increased frequency of transitional B cells compared with healthy donors and rheumatoid arthritis *** from SLE patients potently promoted the survival of transitional B cells in a type I IFN-dependent manner,which can be recapitulated by direct IFN-α***,the effect of IFN-αon enhanced survival of transitional B cells was associated with NF-κB pathway activation and reduced expression of the pro-apoptotic molecule *** B cells from SLE patients harbored a higher capacity to produce proinflammatory cytokine IL-6,which was also linked to the overactivated type I IFN *** addition,the frequency of IL-6-producing transitional B cells was positively correlated with disease activity in SLE patients,and these cells were significantly reduced after short-term standard ***,the current study provides a direct link between type I IFN pathway overactivation and the abnormally high frequency and proinflammatory properties of transitional B cells in active SLE patients,which contributes to the understanding of the roles of type I IFNs and B cells in the pathogenesis of SLE.

关键词： Systemic lupus erythematosus type I interferons transitional B cells apoptosis interleukin 6

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PD-1Hi CD8+ T cells Correlates of Exhausted Signature and Poor Clinical Outcome in Hepatocellular carcinoma

PD-1Hi CD8+ T cells Correlates of Exhausted Signature and Po...

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第十三届全国免疫学学术大会

作者： Jiaqiang Ma shyamal goswami Zhao Zhang Meng Duan Qiang Gao Xiaoming Zhang Institute Pasteur of Shanghai Chinese Academy of Sciences Liver Cancer Institute Zhongshan HospitalFudan University

Background & Aims:-Blockade of immune checkpoints to reinvigorate the tumor infiltrating CD8 T cells, especially exhausted CD8 T cells, through PD1-PDL1 pathway is one of the most promising immunotherapies. Here we investigated the characteristics of tumor infiltrating CD8 exhausted T cells of hepatocellular carcinoma(HCC) patients and its clinical significance for ***: We collected fresh HCC samples(T) with adjacent tumor-free tissues(P) and blood(B) specimens from 41 patients who underwent surgical resection at Zhongshan Hospital. CD8 T cells cytokine secretion and situ expression pattern was detected. The clinical prognosis was evaluated by Cox regression and Kaplan-Meier analysis. Results: Upon the expression level of PD1 and TIM3, tumor infiltration CD8 T cells were classified to three distinct subpopulations: PD1-negative(PD1-), PD1-intermediate(PD1 Int) and PD1-high(PD1 ). Compared with PD1-and PD1, PD1 CD8 T cells were significantly abundant in T than P and B, and correlated more aggressive clinical features. They expressed multi-inhibitory receptors including TIM3, CTLA4 and LAG3, and showed up-regulated expression of exhaustion related transcription factors, such as Eomes and Blimp-1. Moreover, pro-inflammatary cytokines were decreased while anti-inflammatary cytokine IL-10 was up-regulated. Intriguingly, PD1 and TIM3PD1 CD8 T cells were correlated with poor prognosis and more adjacent to CD68PDL1 macrophage than PD1CD8 T cells in spatial ***: PD1 was heterogeneously expressed in tumor infiltrating CD8 T cells in HCC. PD1 CD8 T cells were highly expressed in tumor and correlated with exhausted phenotypes. In spatial, CD68PDL1 macrophage might interact with PD1 and TIM3PD1 CD8 T cells and cause CD8 T cells exhausted besides tumor cells. PD1 and TIM3PD1 could be a potential biomarker to stratify patients for optimal therapy.

关键词： HCC CD8+ T cells PD1

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肝细胞癌组织ICOS^+T细胞的多重免疫组织化学检测及其预后价值研究

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中国癌症杂志 2019年第5期29卷 352-361页

作者：马家强曹春梅 shyamal goswami 陈沁高强张晓明上海大学生命科学学院上海200444 中国科学院上海巴斯德研究所上海200031 复旦大学附属肿瘤医院肿瘤研究所复旦大学上海医学院肿瘤学系上海200032 复旦大学附属中山医院肝脏外科上海200032

背景与目的:诱导共刺激分子(inducible costimulator,ICOS)属于B7-CD28免疫球蛋白超家族成员,表达于活化T细胞表面,在T细胞的激活和免疫应答中发挥重要作用;但目前对于ICOS及ICOS^+T细胞在肝细胞癌(hepatocellular carcinoma,HCC)肿瘤... 详细信息

背景与目的:诱导共刺激分子(inducible costimulator,ICOS)属于B7-CD28免疫球蛋白超家族成员,表达于活化T细胞表面,在T细胞的激活和免疫应答中发挥重要作用;但目前对于ICOS及ICOS^+T细胞在肝细胞癌(hepatocellular carcinoma,HCC)肿瘤组织中的表达及其意义尚不清楚。该研究旨在测定ICOS、ICOS^+T细胞在HCC患者肿瘤组织中的表达情况并探讨其预后价值。方法:应用组织芯片(tissue microarrays,TMAs)和多重免疫组织化学技术(multiplex immunohistochemistry,mIHC)检测2006-2007年在复旦大学附属中山医院接受手术治疗的358例原发性HCC患者肿瘤组织和癌旁组织中ICOS^+细胞、ICOS^+CD4^+及ICOS^+CD8^+T细胞的浸润密度和ICOS^+细胞占CD4^+、CD8^+T细胞的百分比。应用KaplanMeier法和多因素COX回归模型分析上述指标对患者预后的影响。结果:与癌旁组织相比,ICOS^+细胞和ICOS^+CD4^+T细胞在肿瘤组织中浸润数量显著增加(P<0.000 1和P=0.009 1),而ICOS^+CD8^+T细胞则呈相反的降低趋势(P=0.033);在肿瘤中,ICOS^+CD4^+T细胞的浸润程度显著高于ICOS^+CD8^+T细胞。此外,ICOS^+CD4^+和ICOS^+CD8^+T细胞占各自T细胞亚群的百分比在肿瘤组织中均显著增加(P均<0.000 1)。预后分析发现,肿瘤组织中ICOS^+细胞、ICOS^+CD4^+及ICOS^+CD8^+T细胞浸润高的患者总生存期(overall survival,OS)更长,多因素分析证实上述指标是HCC的独立预后良好因素。结论:ICOS在HCC患者的肿瘤组织中高表达,且ICOS^+细胞、ICOS^+CD4^+及ICOS^+CD8^+T细胞是OS的独立预后良好因素,提示上述指标可作为新的HCC预后免疫标志物。

关键词：肝细胞癌诱导共刺激分子多重免疫组织化学技术预后

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基于生物信息学对骨关节炎铁超载关键基因的筛选与验证

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中国组织工程研究 2025年第9期29卷 1972-1980页

作者：邓柯淇李光第 goswami ASHUTOSH 刘星余何孝勇贵州医科大学贵州省贵阳市550004 贵州医科大学附属医院骨外科贵州省贵阳市550004

背景:铁超载是指体内铁积累过多的情况,可引起各种组织的病理改变。目前,对于骨关节炎中铁超载相关的分子机制和潜在基因靶点,仍有待进一步的研究和探索。目的:通过生物信息学手段分析骨关节炎铁超载关键基因,并利用动物实验加以验证,... 详细信息

背景:铁超载是指体内铁积累过多的情况,可引起各种组织的病理改变。目前,对于骨关节炎中铁超载相关的分子机制和潜在基因靶点,仍有待进一步的研究和探索。目的:通过生物信息学手段分析骨关节炎铁超载关键基因,并利用动物实验加以验证,以期为铁超载角度防治骨关节炎提供新的思路。方法:使用GEO数据库和GeneCards数据库筛选出与骨关节炎相关的基因和铁超载相关的基因。然后,取两者的交集,得到骨关节炎和铁超载共同相关的基因集合。采用GO和KEGG富集分析筛选这些基因的功能和通路。为了进一步研究这些基因之间的相互作用,构建PPI网络,并利用Cytoscape软件的5种计算方法来识别骨关节炎铁超载的关键基因(Hub基因)。将12只雄性SD大鼠分为骨关节炎组与对照组(正常大鼠),每组6只,骨关节炎组大鼠采用改良Hulth方法建立膝骨关节炎模型,并使用PCR检测Hub基因在两组大鼠膝关节组织中的表达情况。结果与结论:①共获得51个骨关节炎铁超载基因,GO富集分析表明其主要参与细胞因子受体结合、趋化因子受体结合、细胞因子活性、生长因子受体结合及寡糖结合等过程;②KEGG富集分析表明骨关节炎铁超载基因主要参与肿瘤坏死因子信号通路、脂质和动脉粥样硬化等信号通路;③构建蛋白质-蛋白质相互作用网络,进一步分析获得细胞间黏附分子1(intercellular cell adhesion molecule-1,ICAM-1)、肿瘤坏死因子配体超家族成员11(tumor necrosis factor superfamily member 11,TNFSF11)、骨髓瘤细胞癌基因(myelocytomatosis oncogene,MYC)、Janus激酶2(janus kinase 2,JAK2)及白细胞介素6,5个骨关节炎铁超载Hub基因,动物实验证实其在对照组与骨关节炎组大鼠膝关节组织中的表达有显著差异(P<0.05);④结果显示,ICAM-1,TNFSF11,MYC,JAK2及白细胞介素6可作为骨关节炎铁超载的关键基因,有望成为防治骨关节炎的新靶点。

关键词：骨关节炎铁超载关键基因差异基因生物信息学动物实验实验验证生物标志物

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Analytics of an Imperfect Four-Layer Production Inventory Model Under Two-Level Credit Period Using Branch-and-Bound Technique

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Journal of the Operations Research Society of China 2022年第4期10卷 725-748页

作者： Subrata Panja shyamal Kumar Mondal Department of Applied Mathematics with Oceanology and Computer Programming Vidyasagar UniversityMidnaporeW.B.721102India

This paper explains an integrated production inventory supply chain model,which consists of a supplier,a manufacturer and a retailer under two-level credit *** is manufacturer’s credit period offered by the supplier,and other is retailer’s credit period offered by the ***,the manufacturer replenishes raw materials from the supplier and produces non-deteriorating products in some cycles of equal *** is noted that here four inventory structures have been considered to show the flow of the materials as either raw materials or finished products from supplier to retailer via *** in this model,manufacturer’s imperfect production has been *** imperfect items are not *** retailer receives good finished products from the manufacturer and sells these to his/her customers during some cycles of equal length in total time *** main objective is to find the optimal number of production and business cycles of the manufacturer such that the integrated system can get the maximum *** above discussed model is elaborated with the help of a numerical example,and a sensitivity analysis is done with respect to some parameters used in this model.

关键词： Supply chain Integrated production inventory Four-layer inventory system Imperfect production Two-level credit period

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Cosmological parameters for spatially flat dust filled Universe in Brans-Dicke theory

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Research in Astronomy and Astrophysics 2017年第3期17卷 55-66页

作者： Gopi Kant goswami Department of Mathematics Kalyan E G.CollegeBhilai-490 006C.G.India

We have investigated late time acceleration for a spatially fiat dust filled Universe in Brans- Dicke theory in the presence of a positive cosmological constant A. Expressions for Hubble＇s constant, luminosity distance and apparent magnitude have been obtained for our model. The theoretical results are compared with observed values of the latest 287 high redshift （0.3 ≤ z ≤1.4） Type Ia supernova data taken from the Union 2.1 compilation to estimate present values of matter and dark energy parame- ters, （Ωm）0 and （ΩA）0. We have also estimated the present value of Hubble＇s constant H0 in light of an updated sample of Hubble parameter measurements including 19 independent data points. The results are found to be in good agreement with recent astrophysical observations. We also calculated various physical parameters such as matter and dark energy densities, present age of the Universe and decelera- tion parameter. The value for Brans-Dicke-coupling constant ω is set to be 40 000 based on accuracy of solar system tests and recent experimental evidence.

关键词： cosmology osmological parameters - cosmology observations- dark energy-Brans-Dicke theory

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Plant growth-promoting rhizobacteria--alleviators of abiotic stresses in soil: A review

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Pedosphere 2020年第1期30卷 40-61页

作者： Madhurankhi goswami Suresh DEKA Environmental Biotechnology Laboratory Resource Management and Environment SectionLife Sciences DivisionInstitute of Advanced Study in Science and Technology(IASST)Guwahati Assam 781035(India)

With the continuous increase in human population,there is widespread usage of chemical fertilizers that are responsible for introducing abiotic stresses in agricultural crop *** stresses are major constraints for crop yield and global food security and therefore require an immediate *** implementation of plant growth-promoting rhizobacteria(PGPR)into the agricultural production system can be a profitable alternative because of its efficiency in plant growth regulation and abiotic stress *** bacteria have the potential to promote plant growth and to aid in the management of plant diseases and abiotic stresses in the soil through production of bacterial phytohormones and associated metabolites as well as through significant root morphological *** changes result in improved plant-water relations and nutritional status in plants and stimulate plants’defensive mechanisms to overcome unfavorable environmental ***,we describe the significance of plant-microbe interactions,highlighting the role of PGPR,bacterial phytohormones,and bacterial metabolites in relieving abiotic environmental stress in *** research is necessary to gather in-depth knowledge on PGPR-associated mechanisms and plant-microbe interactions in order to pave a way for field-scale application of beneficial rhizobacteria,with the aim of building a healthy and sustainable agricultural ***,this review aims to emphasize the role of PGPR in growth promotion and management of abiotic soil stress with the goal of developing an eco-friendly and cost-effective strategy for future agricultural sustainability.

关键词： phytohormones plant-microbe interaction root colonization root morphological change secondary metabolites stress alleviation stress tolerance

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Gut dysfunction in Parkinson's disease

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World Journal of Gastroenterology 2016年第25期22卷 5742-5752页

作者： Adreesh Mukherjee Atanu Biswas shyamal Kumar Das Department of Neurology Bangur Institute of Neurosciences and Institute of Post Graduate Medical Education and Research

Early involvement of gut is observed in Parkinson’s disease (PD) and symptoms such as constipation may precede motor symptoms. α-Synuclein pathology is extensively evident in the gut and appears to follow a rostrocaudal gradient. The gut may act as the starting point of PD pathology with spread toward the central nervous system. This spread of the synuclein pathology raises the possibility of prion-like propagation in PD pathogenesis. Recently, the role of gut microbiota in PD pathogenesis has received attention and some phenotypic correlation has also been shown. The extensive involvement of the gut in PD even in its early stages has led to the evaluation of enteric α-synuclein as a possible biomarker of early PD. The clinical manifestations of gastrointestinal dysfunction in PD include malnutrition, oral and dental disorders, sialorrhea, dysphagia, gastroparesis, constipation, and defecatory dysfunction. These conditions are quite distressing for the patients and require relevant investigations and adequate management. Treatment usually involves both pharmacological and non-pharmacological measures. One important aspect of gut dysfunction is its contribution to the clinical fluctuations in PD. Dysphagia and gastroparesis lead to inadequate absorption of oral anti-PD medications. These lead to response fluctuations, particularly delayed-on and no-on, and there is significant relationship between levodopa pharmacokinetics and gastric emptying in patients with PD. Therefore, in such cases, alternative routes of administration or drug delivery systems may be required.

关键词： Parkinson’ s disease Gut dysfunction Sialorrhea Dysphagia Gastroparesis Constipation Gut microbiota

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Phosphorene: Current status, challenges and opportunities

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 296-309页

作者： Anandarup goswami Manoj B.Gawande Division of Chemistry Department of Sciences and HumanitiesVignan's Foundation for ScienceTechnology and Research (VFSTR)VadlamudiGuntur-522213Andhra PradeshIndia Regional Centre of Advanced Technologies and Materials Department of Physical ChemistryFaculty of SciencePalacky University OlomoucSlechtitelu 27783 71 OlomoucCzech Republic

The field of 2-dimensional (2D) materials has witnessed a sharp growth since its inception and can majorly be attributed to the substantial technical and scientific developments, leading to significant improvements in their syntheses, characterization and applications. In the list of 2D materials, the relatively newer addition is phosphorene, which ideally consists of a single layer of black phosphorous. Keeping in mind the past, and ongoing research activities, this short account offers a brief overview of the present status and the associated challenges in the field of phosphorene-related research, with special emphasis on their syntheses, properties, applications and future opportunities.

关键词： phosphorene black phosphorous anisotropy single layer thermoelectric chemical vapor deposition catalysis battery supercapacitor

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