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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Mechanisms of neratinib resistance in HER2-mutant metastatic breast cancer

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Cancer drug Resistance 2022年第4期5卷 873-881页

作者： Lisa d.Eli shyam M.Kavuri Translational Medicine and diagnostics Puma BiotechnologyInc.Los AngelesCA 90024USA Lester and Sue Smith Breast Center Baylor College of MedicineHoustonTX 77030USA department of Medicine Baylor College of MedicineHoustonTX 77030USA

Human epidermal growth factor receptor 2 (HER2) is a major drug target and clinical biomarker in breast cancertreatment. Targeting HER2 gene amplification is one of the greatest successes in oncology, resulting in the use of awide array of HER2-directed agents in the clinic. The discovery of HER2-activating mutations as novel therapeutictargets in breast and other cancers marked a significant advance in the field, which led to the metastatic breast andother solid tumor trials MutHER (NCT01670877), SUMMIT (NCT01953926), and one arm of plasmaMATCH(NCT03182634). These trials reported initial clinical benefit followed by eventual relapse ascribed to eitherprimary or acquired resistance. These resistance mechanisms are mediated by additional secondary genomicalterations within HER2 itself and via hyperactivation of oncogenic signaling within the downstream signaling axis.

关键词： Neratinib HER2 ERBB2 estrogen receptor mutation

White matter hyperintensity progression is associated with incident probable dementia or mild cognitive impairment

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Stroke & Vascular Neurology 2022年第4期7卷 364-366页

作者： Adam de Havenon Kevin N Sheth Sharon d Yeatts Tanya N Turan shyam Prabhakaran Neurology Yale UniversityNew HavenConnecticutUSA Public Health Sciences MUSCCharlestonSouth CarolinaUSA Neurology MUSCCharlestonSouth CarolinaUSA Neurology University of Chicago Pritzker School of MedicineChicagoIllinoisUSA

Background White matter hyperintensity(WMH)on brain MRI is associated with developing dementia or mild cognitive impairment(MCI),but WMH progression over time has not been fully investigated as an independent risk *** We performed a post hoc analysis of the Systolic Blood Pressure Intervention Trial-Memory and Cognition in decreased Hypertension(SPRINT MINd)*** primary outcome was incident probable dementia or MCI(dementia/MCI)before the follow-up MRI at 48 months from *** primary predictor was WMH progression,defined as the Z score difference between the follow-up and baseline WMH *** secondary predictor was a binary WMH progression threshold(≥1.4 mL vsded patients,33(7.6%)developed dementia/*** were 156(36.0%)patients who met the WMH progression threshold of≥1.4 mL,in whom the rate of dementia/MCI was 12.8%(20/156)vs 4.7%(13/277)of patients withd with dementia/MCI(OR 1.51,95%CI 1.12 to 2.04,p=0.007)as was the WMH progression threshold of≥1.4 mL(OR 2.89,95%CI 1.23 to 6.81,p=0.015).Conclusions In this post hoc analysis of SPRINT MINd,WMH progression over 48 months was associated with the development of probable dementia or MCI.

关键词： impairment Blood incident

A phylogenetic census of global diversity of gut anaerobic fungiand a new taxonomic framework

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Fungal diversity 2018年第2期89卷 253-266页

作者： shyam Sundar Paul dengpan Bu Jianchu Xu Kevin d.Hyde Zhongtang Yu department of Animal Sciences The Ohio State University2029 Fyffe CourtColumbusOH 43210USA ICAR-Central Institute for Research on Buffaloes Sirsa RoadHisarHaryana 125001India State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China CAAS-ICRAF Joint Lab on Agroforestry and Sustainable Animal Husbandry World Agroforestry CentreEast and Central AsiaBeijing 100193China Hunan Co-Innovation Center of Animal Production Safety CICAPSChangsha 410128China Kunming Institute of Botany Chinese Academy of SciencesKunming 650201China Center of Excellence in Fungal diversity Mae Fah Luang UniversityChiang Rai 57100Thailand

Obligate anaerobic fungi of the phylum Neocallimastigomycota play a key role in digesting fibrous feeds in the gut ofherbivores, but little is known about their global diversity. In this study, the collective diversity of gut anaerobic fungi wasexamined using all curated internal transcribed spacer 1 (ITS1) sequences of anaerobic gut fungi available in *** 262,770 quality-checked fungal ITS1 sequences downloaded from GenBank were assigned to 274 operational taxonomic units (OTUs) at the approximate species level. Of these approximate species-equivalent (Sp-eq) OTUs, 119 wererepresented by at least five ITS1 sequences, with 38 containing known species and 81 containing no known species. Basedon a rarefaction analysis, the currently available ITS1 sequences represent nearly all the major species of gut anaerobicfungi, but much more sequencing effort is needed to assess the actual richness of minor OTUs. One dataset of ITS1reference sequences (referred to as AF-RefSeq) and one comprehensive taxonomic framework are also presented, and theyare shown to be suitable for taxonomic classification of most of the ITS1 sequences in GenBank. The results of the presentstudy may help guide future studies involving taxonomic and phylogenetic analysis of ITS1 sequences of anaerobic fungiand targeted isolation and characterization of new anaerobic fungi.

关键词： Anaerobic fungi Global diversity ITS1 sequences Rumen Taxonomic framework

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.dongale Atul C.Khot Chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Excitatory and inhibitory actions of a memristor bridge synapse

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Science China(Information Sciences) 2018年第6期61卷 168-169页

作者： Changju YANG shyam Prasad AdHIKARI Hyongsuk KIM division of Electronics Chonbuk National University

dear editor,One of the bottlenecks of the analog circuit implementation of neural networks comes from the fact that the number of synapses to be implemented is *** important functions needed to be specified in a synap... 详细信息

关键词： In Excitatory and inhibitory actions of a memristor bridge synapse

Old vs new: Risk factors predicting early onset colorectal cancer

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1011-1020页

作者： Aslam R Syed Payal Thakkar Zachary d Horne Heitham Abdul-Baki Gursimran Kochhar Katie Farah shyam Thakkar division of Gastroenterology Allegheny Health NetworkPittsburghPA 15212United States Allegheny Singer Research Institute Allegheny Health NetworkPittsburghPA 15212United States division of Radiation Oncology Allegheny Health Network Cancer InstitutePittsburghPA 15212United States

BACKGROUNd Colorectal cancer(CRC)is the second leading cause of all cancer related deaths in the United States and *** the incidence has been decreasing for individuals’≥50,it has been on the rise for individualsdentify potential risk factors for early-onset *** A population-based cohort analysis using a national database,Explorys,screened all patients with an active electronic medical record from January 2012 to december 2016 with a diagnosis of *** were stratified based on age(25–49 years vs≥50 years).demographics,comorbidities,and symptom profiles were recorded and compared between both age ***,the younger group was also compared with a control group consisting of individuals aged 25-49 years within the same timeframe without a diagnosis of *** points for CRC related factors were analyzed to identify potential risk factors specific to early-onset *** A total of 68860 patients were identified with CRC,of which 5710(8.3%)were younger than 50 years old,with 4140(73%)between 40-49 years of *** analysis was reported using odds ratio(OR)with 95%CI and demonstrated that several factors were associated with an increased risk of CRC in the early-onset group versus the later-onset *** factors included:African-American race(OR 1.18,95%CI:1.09-1.27,Pdominal pain(OR 1.82,95%CI:1.72-1.92,Pd bowel function(OR 1.12,95%CI:1.05-1.19,P=0.0005),having a family history of any cancer(OR 1.78,95%CI:1.67-1.90,Pd obesity(OR 1.14,95%CI:1.08-1.20,Pd with an increased risk of CRC were:male gender(OR 1.34,95%CI:1.27-1.41),Pd African-American race(OR 1

关键词： Colorectal cancer Early-onset colorectal cancer Colorectal cancer screening Epidemiology analysis Colorectal neoplasm Average-risk screening