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siRNA-mediated downregulation of TC21 sensitizes esophageal cancer cells to cisplatin

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World Journal of Gastroenterology 2012年第31期18卷 4127-4135页

作者： Md.Raghibul Hasan shyam singh Chauhan Rinu Sharma Ranju Ralhan Department of Biochemistry All India Institute of Medical SciencesNew Delhi 110029India Department of Biotechnology School of BiotechnologyGuru Gobind Singh Indraprastha UniversityNew Delhi 110075India Department of Otolaryngology-Head and Neck Surgery Joseph and Mildred Sonshine Family Centre for Head and Neck DiseasesMount Sinai HospitalTorontoON M5G 1X5Canada Department of Pathology and Laboratory Medicine Alex Simona Shnaider Laboratory for Molecular OncologyMount Sinai HospitalTorontoON M5G 1X5Canada

AIM： To determine the functional significance of TC21 in esophageal squamous cell carcinoma （ESCC）. METHODS： TC21 siRNA transfection was carried out using Hyperfectamine to knock down TC21, and tran- scripts were analyzed by reverse transcription-poly- merase chain reaction and protein by Western *** demonstrated the effect of TC21 downregulation of cell signaling in esophageal cancer cells by assess- ing the phosphorylation status of its downstream tar- gets, phosphoinositide 3-kinase （PI3K）, phosphatase and tensin homolog （PTEN）, protein kinase B （pAl〈t）, nuclear factor-KB （NF-~B） and cyclinD1 using specific antibodies. Cell survival analysis after cisplatin treat- ment was carried out by cell viability assay and cell cycle analysis using flow cytometry. RESULTS： TC21 knockdown in human ESCC cell line TEl3 cells, showed only a marginal increase （14.2%） in cell death compared with control cells. The expres- sions of the signaling proteins PI3K and pAkt, transcrip- tion factor NF-KB, and cell cycle protein cyclin D1 were markedly decreased in response to TC21 downregula- tion, whereas the level of pPTEN, an antagonist of PI3K, was increased. In addition, we evaluated the potential of TC21 as a putative target for sensitizing ESCC cells to the chemotherapeutic agent cisplatin. Increased cell death （38.4%） was observed in cells treated with cis- platin after TC21 knockdown compared with cells which were treated with cisplatin alone （20% cell death）. CONCLUSION： Results suggest that TC21 mediates its effects via the PI3K-Akt pathway, NF-KB and cyclin D1, and enhances chemoresistance in esophageal cancer cells.

关键词： TC21 Esophageal squamous cell carci-noma siRNA Cisplatin Chemosensitivity

Laser induced fluorescence study on the growth of maize plants

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Natural Science 2012年第6期4卷 395-401页

作者： Marius Hedimbi shyam singh A. kent Department of Biological Sciences University of Namibia Windhoek Namibia Department of Physics University of Namibia Windhoek Namibia

The laser induced fluorescence (LIF) spectra from plants give accurate information on the influences of ultraviolet A (UV-A) and ultraviolet B (UV-B) radiation on the growth of maize plants. In this paper, a thorough LIF study has been done on maize plants grown under controlled conditions. The maize (Zea mays) seeds were planted and exposed to UV-A and UV-B radiation from 0 to10 hours. The decrease in the ratios of peaks of LIF confirm a decrease in the height, diameter of stem, number of leaves in the plants exposed to UV-B and UV-A with the increase in the time of exposure.

关键词： UV-A Radiation UV-B Radiation Zea Mays LIF

Genetic gains with genomic versus phenotypic selection for drought and waterlogging tolerance in tropical maize(Zea mays L.)

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The Crop Journal 2021年第6期9卷 1438-1448页

作者： Reshmi Rani Das Madhumal Thayil Vinayan Kaliyamoorthy Seetharam Manish Patel Ramesh Kumar Phagna shyam Bir singh Jai Prakash Shahi Akashi Sarma Nagendra Sarma Barua Raman Babu Pervez Haider Zaidi International Maize and Wheat Improvement Center(CIMMYT) ICRISAT CampusPatancheru 502324HyderabadIndia Main Maize Research Station Anand Agriculture UniversityAnand 388001GujaratIndia ICAR-Indian Institute of Maize Research Ludhiana141001BiharIndia Institute of Agricultural Sciences Banaras Hindu UniversityVaranasi 221005Uttar PradeshIndia Assam Agricultural University Jorhat 785013AssamIndia

Erratic rainfall often results in intermittent drought and/or waterlogging and limits maize(Zea mays L.)productivity in many parts of the Asian *** climate-resilient maize germplasm possessing tolerance to these key abiotic stresses without a yield penalty under optimal growing conditions is a challenge for breeders working in stress-vulnerable agro-ecologies in the *** stress-resilient maize for rainfed stress-prone ecologies is identified as one of the priority areas for CIMMYT-Asia maize *** applied rapid cycle genomic selection(RCGS)on two multiparent yellow synthetic populations(MYS-1 and MYS-2)to improve grain yield simultaneously under drought and waterlogging conditions using genomic-estimated breeding values(GEBVs).Also,the populations were simultaneously advanced using recurrent phenotypic selection(PS)by exposing them to managed drought and waterlogging and intermating tolerant plants from the two selection *** cycles per se(C1,C2,and C3)of the two populations developed using RCGS and PS approach and their test-cross progenies were evaluated separately in multilocation trials under managed drought,waterlogging,and optimal moisture *** genetic gains were observed with both GS and PS,except with PS in MYS-2 under drought and with GS in MYS-1 under *** genetic gains from GS were relatively higher under drought conditions(110 and 135 kg ha^(-1) year^(-1))compared to waterlogging(38 and 113 kg ha^(-1) year^(-1))in both MYS-1 and MYS-2,***,under waterlogging stress PS showed at par or better than GS as gain per year with PS was 80 and 90 kg ha^(-1),whereas with GS it was 90 and 43 kg ha^(-1) for MYS-1 and MYS-2,*** findings suggested that careful constitution of a multiparent population by involving trait donors for targeted stresses,along with elite highyielding parents from diverse genetic background,and its improvement using RCGS is an effe

关键词： Drought Genomic selection Maize Phenotypic selection Waterlogging

Heat-tolerant maize for rainfed hot,dry environments in the lowland tropics:From breeding to improved seed delivery

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The Crop Journal 2023年第4期11卷 986-1000页

作者： Pervez H.Zaidi Madhumal Thayil Vinayan Sudha K.Nair Prakash H.Kuchanur Ramesh Kumar shyam Bir singh Mahendra Prasad Tripathi Ayyanagouda Patil Salahuddin Ahmed Aamir Hussain Atul Prabhakar Kulkarni Passang Wangmo Mitchell R.Tuinstra Boddupalli M.Prasanna International Maize and Wheat Improvement Center(CIMMYT) Hyderabad 502324India University of Agricultural Sciences Raichur 584104KarnatakaIndia ICAR-Indian Institute of Maize Research Ludhiana 141001BiharIndia National Maize Research Program RampurChitwan 44200Nepal Bangladesh Wheat and Maize Research Institute Dinajpur-5201Bangladesh Maize and Millet Research Institute YusafwalaSahiwal 57000Pakistan Agriculture Research and Development Centre Wengkhar 43001Bhutan Institute of Plant Sciences Purdue UniversityWest LafayetteIN 47906USA International Maize and Wheat Improvement Center(CIMMYT) NairobiKenya

Climate change-induced heat stress combines two challenges:high day-and nighttime temperatures,and physiological water deficit due to demand-side drought caused by increase in vapor-pressure *** is one of the major factors in low productivity of maize in rainfed stress-prone environments in South Asia,affecting a large population of smallholder farmers who depend on maize for their sustenance and *** International Maize and Wheat Improvement Center(CIMMYT)maize program in Asia,in partnership with public-sector maize research institutes and private-sector seed companies in South Asian countries,is implementing an intensive initiative for developing and deploying heat-tolerant maize that combines high yield potential with resilience to heat and drought *** the integration of novel breeding tools and methods,including genomics-assisted breeding,doubled haploidy,fieldbased precision phenotyping,and trait-based selection,new maize germplasm with increased tolerance to heat stress is being developed for the South Asian *** a decade of concerted effort has resulted in the successful development and release of 20 high-yielding heat-tolerant maize hybrids in CIMMYT genetic *** public–private partnerships,eight hybrids are presently being deployed on over 50,000 ha in South Asian countries,including Bangladesh,Bhutan,India,Nepal,and Pakistan.

关键词： Climate change Drought Heat stress Lowland tropics Maize Vapor pressure deficit

Anisotropic quintessence compact star in f(T)gravity with Tolman–Kuchowicz metric potentials

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Communications in Theoretical Physics 2024年第1期76卷 61-75页

作者： Piyali Bhar Farook Rahaman shyam Das Somi Aktar Abdelghani Errehymy Department of Mathematics Government General Degree College SingurHooghlyWest Bengal 712409India Department of Mathematics Jadavpur UniversityKolkata 700032West BengalIndia Department of Physics Malda College MaldaWest Bengal 732101India Astrophysics Research Centre School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa

To obtain analytically relativistic quintessence anisotropic spherical solutions in the f(T)paradigm is the primary objective of this *** do this,the pressure anisotropy condition is imposed,and we employ a metric potential of the Tolman–Kuchowicz(TK)*** also suppose that our current model incorporates a quintessence field characterized by a parameterωq,in addition to the anisotropic matter *** the presence of the parameterα,the field equations are modified by the choice of the f(T)*** f(T)gravity parameterαadds new components to the basic physical characteristics,such as density,pressure,subliminal sound velocity,surface redshift,etc,of the present *** selecting the compact star Her X-1 and varyingαfrom 0.5 to 2.5,we examined all the physical characteristics of the model parameter of the *** graphical process demonstrates that a more compact item is produced with greater values ofα.The hydrostatic equilibrium condition of the model is discussed,as well as the mass-radius relationship for our current model is obtained.

关键词： quintessence star f(T)gravity stability condition

Insights into the interface of NiCo_(2)O_(4) spinel/LaCoO_(3) perovskite nano-composite for CO and soot oxidation

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Journal of Environmental Sciences 2024年第4期138卷 339-349页

作者： Neha Harshita singh Satya Vir singh Department of Chemical Engineering Indian Institute of Technology(BHU)Varanasi221005India Department of Botany Institute of ScienceBanaras Hindu UniversityVaranasi221005India

In the quest for the development of thermally stable,highly active and low-cost catalysts for use in catalyzed diesel particulate filter,nano-composites are new areas of ***,we reported the easy synthesis of spinel NiCo_(2)O_(4)/perovskite LaCoO_(3) nano-composite,and its individual oxides NiCo_(2)O_(4)and LaCoO_(3) for *** detailed insights into the physio-chemical characteristics of formed NiCo_(2)O_(4)/LaCoO_(3) nano-composite were done based on various characterization analysis such as X-ray diffraction(XRD),Fourier transform infrared(FT-IR),N_(2) physiosorption,scanning electron microscopy-energy dispersive spectroscopy(SEM-EDX),transmission electron microscopy(TEM),and X-ray photoelectron spectroscopy(XPS).The characterization analysis of NiCo_(2)O_(4)/LaCoO_(3) revealed the successful formation of a chemical interface possessing strong interfacial interaction,resulting in desirable physicochemical characteristics such as small crystallite size,abundant mesoporosity,high specific surface area and activation of surface lattice *** to the desirable characteristics,the activity results over NiCo_(2)O_(4)/LaCoO_(3) nano-composite showed the excellent CO oxidation performance and high soot oxidation activity,recyclability and thermal *** work mainly attempts to emphasize the effectiveness of the facile,inexpensive and conventionally used precipitation method for the successful formation of highly efficient nano-composites.

关键词： LaCoO_(3) NiCo_(2)O_(4) Spinel/perovskite CO oxidation Soot oxidation Chemical interface

Snow and regolith albedo variations using CRISM data at McMurdo crater,Mars

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Earth and Planetary Physics 2024年第2期8卷 338-355页

作者： Sehajpal singh Deepak singh Centre of Studies in Resources Engineering Indian Institute of Technology BombayMumbaiIndia

The cryosphere component provides the most reliable and insightful indications of any planet’s climate *** data from the Compact Reconnaissance Imaging Spectrometer for Mars(CRISM),we develop a novel approach to determining the broadband Visible and Near Infrared(VNIR)albedo of the Martian *** study focuses on albedo changes in the McMurdo crater,part of Mars’s south polar layer *** compare seasonal and interannual variations of the McMurdo surface albedo before,during,and after the Global Dust Storm(GDS)of Martian Year(MY)*** the seasons progressed from spring to summer,the mean albedo in MY 32 and 34 plunged by over 40%,by about 35%in MY 33,and by slightly more than 30%in MY *** interannually,however,mean albedo values within both seasons(spring and summer)exhibited no significant differences in those same ***,interannual albedo difference maps reveal albedo variation of more than±0.3 in certain regions of the *** only snow-covered pixels,interannual albedo differences suggest that Mars dust had a pervasive impact on Mars’s *** in maximum and minimum albedo values as high as 0.5 were observed,depending upon differences in the dust levels in Martian snow/*** maximum and the minimum snow albedo values were lowest in MY 34,indicating the effect of the intense dust storm event that *** average snow albedo decreased from 0.45 in MY 32 to 0.40 in MY 33 and to 0.33 in MY 34,and then rose back to 0.40 in MY *** trajectory suggests a temporary deposition of dust,partially reversed after the GDS by self-cleaning mechanisms(local aeolian process and CO_(2)sublimation/deposition cycle).

关键词： Mars Martian ice albedo dust storm Mars surface Martian climate

Transfer Learning-Based Class Imbalance-Aware Shoulder Implant Classification from X-Ray Images

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Journal of Bionic Engineering 2024年第2期21卷 892-912页

作者： Marut Jindal Birmohan singh Department of Computer Science and Engineering Sant Longowal Institute of Engineering and TechnologySangrur148106PunjabIndia

Total shoulder arthroplasty is a standard restorative procedure practiced by orthopedists to diagnose shoulder arthritis in which a prosthesis replaces the whole joint or a part of the *** is often challenging for doctors to identify the exact model and manufacturer of the prosthesis when it is *** paper proposes a transfer learning-based class imbalance-aware prosthesis detection method to detect the implant’s manufacturer automatically from shoulder X-ray *** framework of the method proposes a novel training approach and a new set of batch-normalization,dropout,and fully convolutional layers in the head *** employs cyclical learning rates and weighting-based loss calculation *** modifications aid in faster convergence,avoid local-minima stagnation,and remove the training bias caused by imbalanced *** proposed method is evaluated using seven well-known pre-trained models of VGGNet,ResNet,and DenseNet *** is performed on a shoulder implant benchmark dataset consisting of 597 shoulder X-ray *** proposed method improves the classification performance of all pre-trained models by 10–12%.The DenseNet-201-based variant has achieved the highest classification accuracy of 89.5%,which is 10%higher than existing ***,to validate and generalize the proposed method,the existing baseline dataset is supplemented to six classes,including samples of two more implant *** results have shown average accuracy of 86.7%for the extended dataset and show the preeminence of the proposed method.

关键词： Biomedical engineering Artificial intelligence Total shoulder arthroplasty Prosthesis identification Biomedical image classification

Long-term fertilizer nitrogen management—Soil health conundrum

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Pedosphere 2024年第1期34卷 23-25页

作者： BIJAY-singh Department of Soil Science Punjab Agricultural UniversityLudhiana 141004India

The mental model that fertilizer nitrogen (N) acts as a replacement for N mineralized from soil organic matter (SOM) needs to be revisited. Soil organic matter, the storehouse of N in soil, is one of the most important indicators of soil health. It supplies more N to crop plants than the current-year fertilizer N even when applied at high rates. Limited research shows that the application of fertilizer N above the optimum levels on a long-term basis deteriorates soil health by mineralizing SOM and depleting the soil N pool. Because soil N includes portions of fertilizer N applied in several previous years, year after year application of fertilizer N below the optimum levels will also lead to a gradual decline in soil N pool or soil health. To sustain high crop yield levels, fertilizer N needs to be applied on a long-term basis neither above nor below the optimum levels to ensure that soil health in terms of sustaining supply of soil N is maintained, if not enhanced.

关键词： soil Soil optimum