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Crosstalk-free multichannel sensor based on a dual-Sagnac interferometer interrogated by microwave photonic filter

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Optoelectronics Letters 2025年

作者： ZHANG Ailing WANG Bo ZHANG Yongfu CHANG Pengxiang WANG Minghe lin Rui Engineering Research Center of Optoelectronic Devices & Communication Technology， Ministry of Education， Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Electrical and Electronic Engineering， Tianjin University of Technology

A crosstalk-free multichannel sensor based on a dual-Sagnac interferometer interrogated by microwave photonic filter (MPF) is demonstrated theoretically and experimentally in this paper. The dual-Sagnac interferometer is taken as the sensing element as well as an optical spectrum slicer to implement a dual-passband MPF. Experimental results show that the proposed multichannel sensor is crosstalk-free， and the temperature sensitivity of each channel is -0.9884 MHz/℃ and -1.9302 MHz/℃， respectively. The sensing interrogation system has good linearity and stability and it is suitable for application scenarios where multiple points of temperature are required to monitor simultaneously.

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Weak feedback self-mixing interference fringe slope discrimination method based on deep learning

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Optoelectronics Letters 2025年

作者： ZHAO Yan lin Maohua DU Shengzhi TONG Jigang LIU Bin HAN Fangfang School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Applications in Complicated Systems Department of Electrical Engineering， Tshwane University of Technology

In order to identify the tilt direction of the self-mixing interference (SMI) signals under weak feedback regime interfered by noise， a deep learning method is proposed. The one-dimensional U-Net (1D U-Net) neural network can discriminate the direction of self-mixing fringes accurately and quickly. For experimental SMI signals， the 1D U-Net can be used for discriminant direction after a one-step normalization. Simulation and experimental results show that the proposed method is suitable for SMI signals with noise within the whole weak feedback regime， and can maintain a high discrimination accuracy for signals interfered by 5dB noise. Combined with fringe counting method， accurate and rapid SMI signal displacement reconstruction can be realized.

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Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-Chi Hsu lin Chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN lin ZHONG LUJI HUANG FU CHENG XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CAlin ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

CEPT污泥发酵液强化前置反硝化生物滤池脱氮研究

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水处理技术 2025年第1期51卷 120-127页

作者：潘雷王琳中国海洋大学环境科学与工程学院山东青岛266000

考察不同运行参数对前置反硝化生物滤池工艺处理性能的影响,综合考虑最佳HRT为4 h,硝化液回流比为100%,投加乙酸钠调节COD/TN为5。在上述最佳条件下,采用CEPT污泥发酵液作碳源各污染物的去除效率相较于乙酸钠虽然都有所降低,但是基本能... 详细信息

考察不同运行参数对前置反硝化生物滤池工艺处理性能的影响,综合考虑最佳HRT为4 h,硝化液回流比为100%,投加乙酸钠调节COD/TN为5。在上述最佳条件下,采用CEPT污泥发酵液作碳源各污染物的去除效率相较于乙酸钠虽然都有所降低,但是基本能够满足出水要求;发酵液的平均比反硝化速率仅仅略低于乙酸钠,这进一步证明了发酵液作为反硝化碳源的可行性。微生物群落组成分析表明Y-A组中的绿弯菌和放线菌比F-A组高,这可能能解释乙酸钠的脱氮效果优于污泥发酵液;功能分析表明F-A组与Y-A组各代谢通路丰度相当,Y-A组的napAB+narGHI、nirKS相对丰度比F-A组略高,这可能是添加乙酸钠相较于CEPT污泥发酵液具有更强的反硝化性能的原因之一。

关键词： CEPT污泥发酵液前置反硝化生物滤池碳源微生物群落组成和功能

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多目标协同建筑结构消能减震技术研究进展

The correlation between plasma cytokine levels in jaundice-free children with biliary atresia

工程力学 2025年第1期42卷 1-9页

作者：李爱群解琳琳杨参天北京建筑大学土木与交通工程学院北京100044

消能减震技术是提升建筑结构抗震性能的有效手段。随着城乡建设的发展，以“最大层间位移角”作为主要控制目标的传统消能减震技术，逐渐难以满足更综合性、系统性的结构地震安全需求，催生了多目标协同减震技术。该文重点介绍和总结课... 详细信息

消能减震技术是提升建筑结构抗震性能的有效手段。随着城乡建设的发展，以“最大层间位移角”作为主要控制目标的传统消能减震技术，逐渐难以满足更综合性、系统性的结构地震安全需求，催生了多目标协同减震技术。该文重点介绍和总结课题组在多目标协同减震技术领域的研究工作，以“结构最大响应与损伤集中协同控制”、“多地震水准响应协同控制”和“结构刚度与耗能能力的协同控制”三种协同减震策略为例，逐一阐述分析协同控制的需求，概括介绍团队提出的协同控制思路和研究进展，并展望多目标协同减震技术未来的发展方向。

关键词：减震结构多目标协同减震消能减震装置双阶阻尼器组合减震

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World Journal of Pediatrics 2015年第4期11卷 352-357页

作者： Zhi-Hong Jian Li-Ching Wang Chieh-Chung lin Jiaan-der Wang Division of Pediatric Gastroenterology Department of PediatricsTaichung Veterans General HospitalTaichung City 40705TaiwanChina Department of Public Health and Institute of Public Health Chung Shan Medical UniversityTaichung City 40201TaiwanChina School of Medicine China Medical UniversityTaichungTaiwanChina

Background:T helper(Th)cell cytokines modulate inflammation and play a role in biliary atresia(BA).The aim of the study is a cross-sectional assessment of the levels of Th cytokines in the jaundice-free post Kasai procedure ***:There were 40 jaundice-free patients with BA and 28 normal controls *** were divided into 3 groups,including normal liver function,impaired liver function,and portal *** concentration of Th1[interferon-γ(INF-γ),interleukin(IL)-2],Th2(IL-4,IL-10),Th3[transforming growth factor-β1(TGF-β1)],Th17(IL-17)cytokines,and stromal cell-derived factor-1α(SDF-1α)were ***:The IFN-γ level was significantly higher in the BA patients with impaired liver function and portal hypertension than controls(P<0.0001 andP<0.0001,respectively).There was a signifi cantly increase of TGF-β1 in all BA groups compared with controls(P=0.003).The reduction of SDF-1αexpression was found in BA groups(P<0.0001).IL-10 levels significantly correlated with aspartate aminotransferase to platelet ratio index(r=0.496,P=0.001).For the cytokine correlations,there were no correlations of Th1,Th2 and Th17 cytokine with the other measured cytokines,but TGF-β1 was negatively correlated with SDF-1αlevels(r=-0.327,P=0.039).Conclusions:IFN-γand IL-10 are likely to be involved in the disease progression in ***,TGF-β1 is found to be a suppression marker associated with SDF-1αlevels and reduced production of TGF-β1 may be associated with the disease progression.

关键词： biliary atresia gastroenterology immunology pediatric disease

形成性评价在口腔医学理论教学中的实践与反思

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黑龙江高教研究 2025年第1期43卷 60-65页

作者：郭若兰林思宇林江首都医科大学附属北京同仁医院北京100730

目的:利用形成性评价对学生的教学评价进行改进,对口腔医学理论的教学方法进行修正,以期望提升临床教学的效果。方法:实验对象为某医科大学临床医学专业学生(包括五年制和5+3一体化两种学制),通过是否参与形成性评价教学分为对照组和实... 详细信息

目的:利用形成性评价对学生的教学评价进行改进,对口腔医学理论的教学方法进行修正,以期望提升临床教学的效果。方法:实验对象为某医科大学临床医学专业学生(包括五年制和5+3一体化两种学制),通过是否参与形成性评价教学分为对照组和实验组。对照组采用传统教学模式,主要利用教师课堂授课;实验组利用形成性评价改进教学模式,不断对学生的学习情况进行反馈和改进,最终通过期末考试定量评价对比学生的学习效果。结果:在两种学制中,实验组学生均比同学制对照组学生期末成绩有所提高,且差异具有统计学意义(P<0.05)。结论:通过形成性评价改进教学模式,能促进学生自主学习,提高学生综合学习的能力,提升学习效果。

关键词：形成性评价口腔医学教学方法