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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu Xu lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

支持IPv4/IPv6双栈的5G通信网络可靠性组网部署研究

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现代电子技术 2025年第1期48卷 102-106页

作者：黄琳黄劼蒋平湖北师范大学计算机与信息工程学院湖北黄石435002 腾讯科技(深圳)有限公司广州深圳518000 湖北理工学院计算机学院湖北黄石435003

5G网络要求更多的基站部署以支持更高的数据传输速率和连接密度。为实现网络数据的并行高速传输,确保网络应用业务的实时性和稳定性,文中提出一种支持IPv4/IPv6双栈的5G通信网络可靠性组网部署方法。结合IPv4和IPv6双栈,构建双栈转换机... 详细信息

5G网络要求更多的基站部署以支持更高的数据传输速率和连接密度。为实现网络数据的并行高速传输,确保网络应用业务的实时性和稳定性,文中提出一种支持IPv4/IPv6双栈的5G通信网络可靠性组网部署方法。结合IPv4和IPv6双栈,构建双栈转换机制结合有限双协议栈模型,在模型下构建5G通信网络结构,并通过高架立体交叉网优化IPv4/IPv6双栈的5G通信网络组网结构,提升IPv4/IPv6双栈5G通信网络的通信速度。采用冗余路径算法,实现5G网络IPv4/IPv6双栈通信中的服务功能链编排,解决IPv4/IPv6双栈通信中的冗余问题。实验结果表明,该方法能够构建一种更稳定、更高效的5G通信网络组网结构,提高了网络频谱效率,优化了网络环境。

关键词： 5G通信网络 IPv4/IPv6双栈可靠性组网部署服务功能链冗余路径算法有限双协议栈模型

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Light tuning CO/H_(2)composition on Ag:Unraveling CO_(2)mass transfer and electron-phonon coupling in plasmon-enhanced electrocatalysis

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Nano Research 2025年第1期18卷 173-185页

作者： Rui lin Dong Fan Luca MBerger Thomas Possmayer Yu Zhou Jiexin Zhu Xingbao Chen Wen Luo Lars Allmendinger Andreas Tittl Leonardo de Souza Menezes Guillaume Maurin Shihe Yang and Stefan AMaier Nanoinstitute Munich Faculty of PhysicsLudwig-Maximilians-Universität München80539 MunichGermany Institut Charles Gerhardt Montpellier UMR 5253 CNRS ENSCM UniversitéMontpellierPlace E.Bataillon34090 MontpellierFrance Guangdong Provincial Key Lab of Nano-Micro Material Research School of Advanced MaterialsPeking University Shenzhen Graduate SchoolShenzhen 518055China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München81377 MunichGermany Departamento de Física Universidade Federal de Pernambuco50670-901 Recife-PEBrazil School of Physics and Astronomy Monash University Clayton CampusMelbourneVictoria 3800Australia Department of Physics Imperial College LondonSW72AZ LondonUK

Plasmon-enhanced electrocatalysis(PEEC)is an emerging approach to mitigate CO_(2)*** mechanisms behind CO_(2)adsorption and reduction at the catalyst-electrolyte interface in PEEC still need to be further ***,we employ a well-defined Ag nanostructure to elucidate these pivotal *** shining light with wavelengths of 625,525,405 nm on Ag,an adjustable CO/H_(2)ratio from 35 to 1 can be *** reaction pathway changing under plasmonic excitation does not originate from the lowered CO_(2)mass transfer in the vicinity of Ag,as the electrochemical quartz crystal microbalance results unravel that a slightly elevated temperature in bulk electrolyte caused by light irradiation cannot weaken the CO_(2)adsorption at the Ag catalyst-electrolyte *** calculations reveal that optical excitation towards shorter wavelengths leads to a progressive lowered energy barrier for H_(2)formation together with an enhanced energy barrier for^(*)COOH *** thermodynamically suppressed,CO_(2)reduction can still be improved kinetically by optimizing the excitation wavelength and intensity,being accompanied with the enhanced *** absorption spectroscopy results further correlate the higher photocurrent with a prolonged electron-phonon coupling time,verifying that the improvement of CO_(2)reduction kinetics in PEEC can be realized by hot electron harnessing.

关键词： plasmonic catalysis photoelectrochemical CO_(2)reduction CO/H_(2)ratio hot electron generation electronphonon coupling thermal effect

粉质黏土和风化粉砂岩中变径抗浮锚杆高效绿色成孔关键技术

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山西建筑 2025年第1期51卷 80-83,133页

作者：林飞江苏省新能源地质调查大队江苏南京210041 江苏华东建设基础工程有限公司江苏南京210007

为了提高粉质黏土和全风化、强风化粉砂岩地层中变径抗浮锚杆的成孔工效,对长螺旋钻机进行了改进,使其具有送风功能,开发了长螺旋钻机引孔接力高压旋喷钻机扩孔下变径抗浮锚杆成孔关键技术,并提出了相应的施工参数。采用关键技术和施工... 详细信息

为了提高粉质黏土和全风化、强风化粉砂岩地层中变径抗浮锚杆的成孔工效,对长螺旋钻机进行了改进,使其具有送风功能,开发了长螺旋钻机引孔接力高压旋喷钻机扩孔下变径抗浮锚杆成孔关键技术,并提出了相应的施工参数。采用关键技术和施工参数,保证变径抗浮锚杆抗拔力达到设计要求外,与单一高压旋喷钻机进行变径抗浮锚杆成孔的常规工艺相比,减少了13%的工期。鉴于粉质黏土和全风化、强风化粉砂岩地层中,高压送风长螺旋钻机引孔时会产生扬尘,开发了配套的降尘结构,消除了扬尘引起的环境问题及对作业人员的危害,实现了绿色施工。

关键词：变径抗浮锚杆粉质黏土长螺旋钻机引孔扩孔

Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

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World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li Liu Fang-Zhen lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong Liu Xiang Chen Jie Peng Yun-Fa Wang Zhi-lin Wang Bin Chen De-Le Liu Yun Liu Zheng-Zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-Jie lin You Li Yan-Yan Qiu Xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

Simulation and Experimental Research on Liquid Spreading in a Wire-Sawn Kerf

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Chinese Journal of Mechanical Engineering 2023年第6期36卷 247-260页

作者： lin lin Hui Huang State Key Institute of Manufacturing Engineering Huaqiao UniversityXiamen 361021China

The significance of liquids in abrasive wire sawing has been demonstrated in several ***,the perfor-mance of its spreading behavior is limited by the current development trend,where the wafer has a larger area and the kerf is ***,there are very few studies on the liquid spreading behavior in wire-sawn ***,a 3D CFD(computational fluid dynamics)model is presented in this paper and used to simulate the liquid spreading behavior in a kerf based on a VOF(volume of fluid)method with a CSF(continuum surface force)model,which is used to simulate multiphase flow,and an empirical correlation for characterizing the liquid dynamic contact angle using UDF(user defined functions).Subsequently,parametric simulations are performed on the kerf area,kerf width,liquid viscosity,liquid surface tension,and liquid velocity at the inlet area of the kerf,and verification experi-ments are conducted to determine the validity of the simulation *** the simulation and experimental results,three typical liquid spreading regimes that exhibit different effects on wire sawing in the kerfs are found,and their limiting conditions are identified using non-dimensional ***,a prediction model is pro-posed for the liquid spreading regime based on a set of Weber and Capillary *** wire sawing,an increase in the wafer area does not change the liquid spreading regime in the kerf;however,a reduction in the kerf width sig-nificantly hinders the liquid spreading ***,the spreading regime can be effectively converted to facili-tate wire sawing by adjusting the physical properties and supply conditions of the liquid.

关键词： Spreading regime Kerf CFD Non-dimensional analysis Prediction model

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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中国县域医共体研究热点与前沿分析

中国全科医学 2025年第1期28卷 83-88页

作者：王舒云梁夏李霞林琳冯启明黄照权广西医科大学卫生与健康政策研究中心广西壮族自治区南宁市530021 广西医科大学广西壮族自治区南宁市530021

背景推进县域医共体建设是推动构建分级诊疗秩序的重要举措,国内学术界在县域医共体领域开展了丰富的理论和实证研究,但对现有研究成果的归纳与总结不足。运用文献计量学方法系统梳理该领域相关文献的研究进展,可以为全面推进县域医共... 详细信息

背景推进县域医共体建设是推动构建分级诊疗秩序的重要举措,国内学术界在县域医共体领域开展了丰富的理论和实证研究,但对现有研究成果的归纳与总结不足。运用文献计量学方法系统梳理该领域相关文献的研究进展,可以为全面推进县域医共体高质量发展提供借鉴与参考。目的基于中国县域医共体领域的文献数据进行可视化分析,探讨该领域的研究热点和前沿趋势。方法于2024-02-25,系统检索中国知网收录的县域医共体相关文献,检索时限为2016-2023年。采用CiteSpace软件对文献的发表年份、作者和机构,以及关键词共现、聚类、时间线分布、突现等情况开展文献计量学可视化分析。结果共纳入文献481篇,该领域的发文量受政策因素驱动呈递增趋势,2016-2019年发文65篇(13.51%),2020-2021年发文167篇(34.72%),2022-2023年发文249篇(51.77%)。发文量排在前3位的作者分别为陈迎春、王芳、郑英,发文量均为8篇。关键词的中心度和聚类规模排在前2位的是“医共体”和“分级诊疗”。时间线分布提示,“分级诊疗”是该领域出现最早且延续性最好的研究热点,此外,“医防融合”“绩效考核”“对策”“患者”等聚类也为研究热点。关键词突现分析显示,“医保基金”“慢性病”“管理模式”“发展策略”“乡村医生”是该领域近年来的研究热点和未来方向。结论关注分级诊疗制度建设,聚焦慢性病和公共卫生医防融合服务,探索绩效考核路径是县域医共体的研究热点。未来该领域在深化政策内涵研究,以县域医共体建设推动构建分级诊疗秩序、推进医防融合创新、强化绩效考核与优化内部管理领域表现出较强的研究趋势。

关键词：县域医共体分级诊疗文献计量学可视化