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Efficacy of autologous platelet-rich plasma in the treatment of chronic nonhealing leg ulcers

Plastic and Aesthetic Research 2014年第1期1卷 65-69页

作者： shwetha suryanarayan Leelavathy Budamakuntla Syed Iqbalulla Sha Khadri Sacchidanand Sarvajnamurthy Department of Dermatology STD and LeprosyBangalore Medical College and Research InstituteBengaluru 560001KarnatakaIndia Department of General Surgery Bowring and Lady Curzon HospitalBangalore Medical College and Research InstituteBengaluru 560001KarnatakaIndia.

Aim:The aim was to evaluate the efficacy of platelet-rich plasma(PRP)in the treatment of chronic nonhealing ***:A nonrandomized,uncontrolled study was performed on 24 patients with 33 nonhealing ulcers of various *** patients were treated with PRP at weekly intervals for a maximum of 6 *** the end of the 6-week period,reduction in size of the ulcers(area and volume)was ***:The mean age of the patients was 42.5 years(standard deviation[SD]12.48).Of 33 ulcers,there were 19 venous ulcers,7 traumatic ulcers,2 ulcers secondary to pyoderma gangrenosum,2 diabetic ulcers,2 trophic ulcers,and 1 vasculitic *** mean duration of healing of the ulcers was 5.6 weeks(SD 3.23).The mean percentage of reduction in area and volume of the ulcers was 91.7%(SD 18.4%)and 95%(SD 14%),*** 100%resolution in the area was seen in 25(76%)of the ulcers and 100%reduction in volume was seen in 24(73%)of the ulcers at the end of the 6th ***:Conventional therapies do not provide satisfactory healing for chronic nonhealing ulcers as they are not able to provide the necessary growth factors(GFs)(platelet-derived GF,epidermal GF,vascular endothelial GF,etc.)which are essential for the healing *** is a safe,affordable,biocompatible,and simple office-based procedure for the treatment of nonhealing ulcers.

关键词： Leg ulcers platelet-derived growth factor platelet rich plasma

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