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Expert Consensus on Diagnosis and Treatment of End-Stage Liver Disease Complicated with Infections

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Infectious Diseases & Immunity 2022年第3期2卷 168-178页

作者： Qin Ning Tao Chen Guiqiang wang Dong Xu yanyan Yu Qing Mao Taisheng Li Lanjuan Li Jun Li Xiaoju Lu Jiabin Li Zhiwei Li Wenhong Zhang Yonghong Xiao Qinghua Meng Yuqiang Mi Jia Shang Yunsong Yu Yingren zhao Caiyan zhao Hong zhao Jianrong Huang Jie Peng Hong Tang Xiaoping Tang Jinhua Hu Bijie Hu wei Guo Bo Zheng Baiyi Chen Yuexin Zhang Jia wei Jifang Sheng Zhi Chen Minggui wang Qing Xie Yuming wang Fu-Sheng wang Jinlin Hou Zhongping Duan Lai wei Jidong Jia Chinese Society of Infectious Disease of Chinese Medical Association Department of Infectious Disease Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Infectious Disease Center for Liver DiseasePeking University First HospitalBeijing 100034China Department of Infectious Diseases Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Infectious Diseases Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of Infectious Disease The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029China Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041China Department of Infectious Diseases First Affiliated Hospital of Anhui Medical UniversityHefei 230031China Department of Infectious Diseases Shengjing HospitalAffiliated Hospital of China Medical UniversityShenyang 110801China Department of Infectious Diseases Institute of Infectious DiseasesHuashan HospitalFudan UniversityShanghai 200040China Department of Severe Liver Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Nankai University Second People’s Hospital Tianjin 300071China Department of Infectious Disease People’s Hospital of Henan ProvinceZhengzhou 450003China Department of Infectious Diseases Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020China Department of Infectious Diseases First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Department of Infectious Diseases Third Affiliated Hospital of Hebei Medical UniversityShijiazhuang 050051China State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis ResearchDepartment o

End-stage liver disease(ESLD)is a life-threatening clinical syndrome that markedly increases mortality in patients with *** patients with ESLD,infections can induce or aggravate the occurrence of liver ***,infections are among the most common complications of disease *** is a lack of working procedure for early diagnosis and appropriate management for patients with ESLD complicated by infections as well as local and international guidelines or *** consensus assembled up-to-date knowledge and experience across Chinese colleagues,providing data on principles as well as working procedures for the diagnosis and treatment of patients with ESLD complicated by infections.

关键词： Consensus Diagnosis End stage of liver disease Infection Therapy

大白菜蜡质缺失突变体YW71的遗传及序列变异分析

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中国瓜菜 2024年第1期37卷 32-38页

作者：杨双娟唐昊赵艳艳魏小春王志勇苏贺楠张文静李林王坐京原玉香张晓伟河南省农业科学院蔬菜研究所郑州450002 河南科技学院园艺园林学院河南新乡453003

以大白菜蜡质突变体YW71为对象,研究其亮绿无蜡粉性状的遗传规律和调控基因。通过遗传分析,表明YW71中的亮绿无蜡粉性状由隐性单基因控制。通过等位基因互补实验证明YW71的亮绿性状是BrWAX2等位突变引起的。序列分析表明,在YW71中BrWAX... 详细信息

以大白菜蜡质突变体YW71为对象,研究其亮绿无蜡粉性状的遗传规律和调控基因。通过遗传分析,表明YW71中的亮绿无蜡粉性状由隐性单基因控制。通过等位基因互补实验证明YW71的亮绿性状是BrWAX2等位突变引起的。序列分析表明,在YW71中BrWAX2基因在第3个外显子末端发生了39 bp的缺失,进而引起转录水平的可变剪切和翻译水平的提前终止。表达模式分析表明,BrWAX2基因在YW71茎和叶中表达量显著下降。此外,研究针对39 bp的变异开发并验证了共显性标记BrWAX2-In Del1。研究结果丰富了白菜类蔬菜蜡质突变遗传资源,将为亮绿无蜡粉品种的分子育种提供理论指导和技术支持。

关键词：大白菜亮绿突变体等位基因互补实验序列变异分析

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超大电流量值传递用光纤电流传感技术

红外与激光工程 2017年第7期46卷 114-120页

作者：李传生邵海明赵伟王家福张煌辉中国计量科学研究院北京100029

面向工业、国防及重大科学研究领域超大电流在线计量的迫切需求,提出基于光纤电流传感器量程自扩展特性实现超大电流计量标准的量值传递。基于微分琼斯矩阵方法,建立了光纤敏感环路的数学模型,揭示了线性双折射对传感器量程自扩展特性... 详细信息

面向工业、国防及重大科学研究领域超大电流在线计量的迫切需求,提出基于光纤电流传感器量程自扩展特性实现超大电流计量标准的量值传递。基于微分琼斯矩阵方法,建立了光纤敏感环路的数学模型,揭示了线性双折射对传感器量程自扩展特性的影响机理,并证明了采用椭圆双折射光纤的电流传感器具有良好的量程自扩展能力,可通过光纤圈数对Faraday效应的比例放大作用,利用小电流实现传感器在超大电流下的等效校准。研制了干涉式数字闭环柔性光纤电流传感器,可在不断开载流母线的情况下直接形成敏感环路,实现在线计量。样机性能测试结果表明:在直流等效10~210 k A范围内,样机的测量准确度优于±0.1%;在工频额定等效25 k A条件下,样机的比差准确度满足IEC60044-8 0.2 S级要求;样机的带宽大于10 k Hz。

关键词：光纤电流传感器 Faraday效应椭圆双折射光纤超大电流计量

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1845-1855页

作者： Huijie Bian zhao-Hui Zheng Ding wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li yanyan Jia Lin-Na Liu Zhe Zhang zhao-wei Gao Hong Du Na Yao Qing wang Ke wang Jie-Jie Geng Bin wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao wang Xue Liang Fei Huo Zhe wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi wang Zhi-Nan Chen Ping Zhu National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'anChina Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi'anChina Center for Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Nuclear Medicine Xijing HospitalFourth Military Medical UniversityXi'anChina department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXKanChina College of Military Preventive Medicine Fourth Military Medical UniversityXi'anChina Department of Pharmaceutics Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Pathology Fourth Military Medical UniversityXi'anChina Jiangsu Pacific Meinuoke Biopharmaceutical Co.Ltd ChangzhouChina Department of Foreign Languages Fourth Military Medical UniversityXi'anChina

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 *** is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)***,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 *** phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was *** serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic *** obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each *** biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to *** the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent *** meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control *** results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.

关键词： patients dosage phase

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气喷式免耕播种机的气喷作业机理研究

农机化研究 2014年第1期36卷 69-72页

作者：赵伟段燕燕王宁宁河南科技大学车辆与动力工程学院河南洛阳471003

为了提高玉米和大豆的播种生产率和播种质量，进一步减小播种作业时对土壤环境的破坏，提出了播种速度最高可达10—12kin／h的气喷式高速免耕播种机的设计思路，重点研究了气喷播种的喷种作业机理、排种器快速排种技术和土壤高速耕作方... 详细信息

为了提高玉米和大豆的播种生产率和播种质量，进一步减小播种作业时对土壤环境的破坏，提出了播种速度最高可达10—12kin／h的气喷式高速免耕播种机的设计思路，重点研究了气喷播种的喷种作业机理、排种器快速排种技术和土壤高速耕作方式。与目前国内外其它类型的免耕播种机相比，所研究的气喷式高速免耕播种机采用高压气体喷射投种的方式进行播种，并利用新型排种器进行快速精密排种，可加快播种速度和种子落地速度，减少播种过程中漏种和缺种的几率，提高播种效率和播种质量，研究结果对提高玉米和大豆等农作物的播种生产率、增加粮食产量和保护环境具有重要意义。

关键词：免耕播种气喷精密播种作业机理

A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism

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Journal of Molecular Cell Biology 2022年第2期14卷 56-71页

作者： Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian wang Zhonglan Su Yan Lu Di Wu Jingping Shi wei Liu Li Dong Yinbing Pan Baiqiao zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui wang yanyan Pan Ling wang Xianrong Xu Jing zhao Xiuqin wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning wang State Key Laboratory of Reproductive Medicine Center of Clinical Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Rheumatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Obstetrics The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Dermatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Burn and Plastic Surgery The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nuclear Medicine The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Infection The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Anesthesiology and Pain Management The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First People’s Hospital of LianyungangLianyungang 222061China Department of Nephrology Northern Jiangsu People’s HospitalYangzhou 225001China Department of General Medicine Geriatric Hospital of Nanjing Medical UniversityNanjing 210024China Department of Nephrology BenQ Medical CenterThe Affiliated BenQ Hospital of Nanjing Medical Uni

Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven ***,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified *** of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was *** release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were *** further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude *** the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the *** followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear *** biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged *** infusion or local treatment-related adverse events ***,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity.

关键词： calciphylaxis chronic kidney disease vascular calcification multidisciplinary rescue human amnion-derived mesenchymal stem cells preclinical research regenerative medicine

热处理联合不同包装对鲜切马铃薯贮藏品质的影响

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食品科学 2023年第13期44卷 166-174页

作者：代羽可欣郑鄢燕韦雪王宇滨赵晓燕谢宏沈阳农业大学食品学院辽宁沈阳110866 北京市农林科学院农产品加工与食品营养研究所果蔬农产品保鲜与加工北京市重点实验室农业农村部蔬菜采后处理重点实验室北京100097

为解决鲜切马铃薯贮藏品质劣变快、货架期短的问题,本研究探讨45℃热处理3 min联合真空包装和30%CO_(2)+70%N_(2)气调包装对鲜切马铃薯贮藏品质的影响。结果表明:热处理联合气调包装可延缓鲜切马铃薯呼吸速率的上升,显著抑制丙二醛(malo... 详细信息

为解决鲜切马铃薯贮藏品质劣变快、货架期短的问题,本研究探讨45℃热处理3 min联合真空包装和30%CO_(2)+70%N_(2)气调包装对鲜切马铃薯贮藏品质的影响。结果表明:热处理联合气调包装可延缓鲜切马铃薯呼吸速率的上升,显著抑制丙二醛(malondialdehyde,MDA)含量上升及苯丙氨酸解氨酶(phenylalanine ammonia-lyase,PAL)、过氧化物酶(peroxidase,POD)、多酚氧化酶(polyphenol oxidase,PPO)活力(P<0.05),有效维持总酚、抗坏血酸(ascorbic acid,AsA)、可溶性固形物含量(soluble solids content,SSC)和淀粉含量,抑制细菌菌落总数的增长,保持马铃薯原有挥发性风味和感官品质。综上,热处理联合气调包装可以使鲜切马铃薯保持较好的感官和营养品质,抑制微生物生长以及褐变酶活性,从而延长鲜切马铃薯货架期。

关键词：真空包装气调包装热处理挥发性物质贮藏品质

嵌合抗原受体-T细胞免疫治疗桥接异基因造血干细胞移植患者的免疫重建

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中华检验医学杂志 2022年第8期45卷 833-839页

作者：赵玮陈曼胡培娟陈美花安彦彦王卉赵艳丽北京陆道培医院移植科北京100176 河北燕达陆道培医院检验科廊坊065201 河北燕达陆道培医院移植科廊坊065201

目的观察嵌合抗原受体(CAR)-T细胞免疫治疗桥接异基因造血干细胞移植(allo-HSCT)患者的免疫重建表现。方法回顾性分析2018年8月至2021年12月期间在北京陆道培医院接受CAR-T细胞桥接allo-HSCT治疗的所有急性B淋巴细胞白血病(B-ALL)患者... 详细信息

目的观察嵌合抗原受体(CAR)-T细胞免疫治疗桥接异基因造血干细胞移植(allo-HSCT)患者的免疫重建表现。方法回顾性分析2018年8月至2021年12月期间在北京陆道培医院接受CAR-T细胞桥接allo-HSCT治疗的所有急性B淋巴细胞白血病(B-ALL)患者临床病历资料,年龄14(7,30)岁,其中男39例,女22例。CAR-T细胞免疫治疗32例,非CAR-T细胞免疫治疗29例。随访时间561(235,784)d。用多色流式检测患者移植前及移植后1、2、3、6、8、10、12个月外周血各淋巴细胞亚群即总淋巴细胞、T淋巴细胞、辅助性T细胞、细胞毒性T细胞、B淋巴细胞、自然杀伤细胞、Treg细胞计数,以评估患者在移植后免疫重建表现。结果移植前血清球蛋白:CAR-T组IgA水平0.18(0.06,0.49)g/L低于非CAR-T组1.03(0.63,1.56)g/L患者(U=103.5,P0.05)。对比2组患者临床特征,CAR-T组患者移植前病史981.00(368.50,1514.75)d比非CAR-T组323.00(167.50,450.50)d长(U=263.0,P=0.004),CAR-T组患者预处理方案中兔抗人胸腺细胞免疫球蛋白(ATG)用量5.00(5.00,7.50)mg/kg比非CAR-T组患者7.00(5.00,7.50)mg/kg低(U=288.5,P=0.018),CAR-T组移植物CD34+回输剂量5.91(4.23,6.02)×10^(6)/kg比非CAR-T组患者高4.51(4.00,5.93)×10^(6)/kg(U=291.0,P=0.012),CAR-T组移植后环孢素应用时间167.00(119.25,299.50)d,比非CAR-T组患者197.00(102.50,450.50)d短(U=421.0,P=0.001)。结论对于移植前免疫功能偏低的CAR-T患者,可通过降低预处理ATG剂量、增加移植物CD34+输注剂量、移植后尽早停用环孢素等方式,使其与非CAR-T患者达到相似的免疫重建状态。

关键词：造血干细胞移植 CAR-T治疗免疫细胞亚群免疫重建

鄂尔多斯盆地东缘煤系富氦资源的发现及其资源潜力与勘探开发对策

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油气与新能源 2024年第4期36卷 38-48,66页

作者：刘祥柏陶士振杨秀春赵群刘自扬裴向兵王龙飞伊伟冯建秋张谭陈燕燕高建荣陶小晚宋泽章柳庄小雪李超正杨怡青陈悦中国石油勘探开发研究院北京100083 中石油煤层气有限责任公司北京100028 中国石油大学(北京)地球科学学院北京102249

中国氦气利用对外依存度高,资源安全问题突出,寻找氦气资源、明确氦气富集机理、寻找勘探开发对策是目前面临的紧迫任务。鄂尔多斯盆地煤系气资源十分丰富,目前的勘探开发成效显著。为查明鄂尔多斯盆地煤系氦气资源潜力及分布,在对鄂尔... 详细信息

中国氦气利用对外依存度高,资源安全问题突出,寻找氦气资源、明确氦气富集机理、寻找勘探开发对策是目前面临的紧迫任务。鄂尔多斯盆地煤系气资源十分丰富,目前的勘探开发成效显著。为查明鄂尔多斯盆地煤系氦气资源潜力及分布,在对鄂尔多斯盆地东缘(简称鄂东缘)煤系气系统取样检测的基础上,对鄂尔多斯盆地煤系氦气资源分布展开了研究。结果表明:鄂东缘三交北地区煤系气整体可以达到富氦天然气的标准,按2020年底的探明储量折算氦气探明储量约4000×10^(4) m^(3),因此,鄂尔多斯盆地煤系地层中或存在氦气富集区。大宁—吉县地区按2021年提交的深层煤层气探明地质储量1121.62×10^(8) m^(3)测算,折算深层煤层氦气探明储量约3400×10^(4) m^(3),因此,鄂尔多斯盆地具备建设煤系氦气战略储备基地的基础,建议加快三交北区块煤系氦气的分离开发,避免氦气资源的浪费。氦同位素比值揭示鄂东缘煤系氦气以壳源成因为主,三交北地区煤系地层具备良好的氦气富集条件,是煤系氦气资源勘查的重点地区,在开展煤系氦气资源普查的同时,应加强对煤系氦气资源勘查技术与富集规律研究,为有效利用煤系氦气提供技术支撑,以保障国家的氦气资源安全。

关键词：煤系气氦气资源潜力鄂尔多斯盆地