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Journal of Genetics and Genomics 2021年第11期48卷 955-960页

作者： shuyi zhao Delai Huang Jinrong Peng College of Animal Sciences Zhejiang UniversityHangzhouZhejiang 310058China Department of Biology University of VirginiaCharlottesvilleVA 22904United States

The nucleolus,as the‘nucleus of the nucleus’,is a prominent subcellular organelle in a *** nucleolus serves as the centre for ribosome biogenesis,as well as an important site for cell-cycle regulation,cellular senescence,and stress *** protein composition of the nucleolus changes dynamically through protein turnover to meet the needs of cellular activities or stress *** studies have identified a nucleolus-localized protein degradation pathway in zebrafish and humans,namely the Def-CAPN3 pathway,which is essential to ribosome production and cell-cycle progression,by controlling the turnover of multiple substrates(e.g.,ribosomal small-subunit[SSU]processome component Mpp10,transcription factor p53,check-point proteins Chk1 and Wee1).This pathway relies on the Ca2þ-dependent cysteine proteinase CAPN3 and is independent of the ubiquitin-mediated proteasome ***3 is recruited by nucleolar protein Def from cytoplasm to nucleolus,where it proteolyzes its substrates which harbor a CAPN3 *** depletion leads to the exclusion of CAPN3 and accumulation of p53,Wee1,Chk1,and Mpp10 in the nucleolus that result in cell-cycle arrest and rRNA processing ***,we summarize the discovery of the Def-CAPN3 pathway and propose its biological role in cell-cycle control and ribosome biogenesis.

关键词： Nucleolus Protein degradation Def CAPN3 p53 Chk1 Wee1 Mpp10 Sas10

Modeling Trusted Computing

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Wuhan University Journal of Natural Sciences 2006年第6期11卷 1507-1510页

作者： CHEN shuyi WEN Yingyou zhao Hong School of Information Science and Engineering Northeastern University Shenyang 110004 Liaoning China

In this paper, a formal approach based on predicate logic is proposed for representing and reasoning of trusted computing models. Predicates are defined to represent the characteristics of the objects and the relationship among these objects in a trusted system according to trusted computing specifications. Inference rules of trusted relation are given too. With the semantics proposed, some trusted computing models are formalized and verified, which shows that Predicate calculus logic provides a general and effective method for modeling and reasoning trusted computing systems.

关键词： trusted computing group (TCG) trusted platform module (TPM) trusted computing root of trust predicate logic

Correlation analysis between vegetation coverage and climate drought conditions in North China during 2001–2013

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Journal of Geographical Sciences 2017年第2期27卷 143-160页

作者： GONG zhaoning zhao shuyi GU Jinzhi Beijing Laboratory of Water Resources Security Key Laboratory of 3D Information Acquisition and Application Ministry of Education Key Laboratory of Resources Environment and GIS of Beijing College of ResourceEnvironment&Tourism Capital Normal UniversityBeijing 100048China

Climate change is one of the most important factors that affect vegetation distribution in North China. Among all climatic factors, drought is considered to have the most significant effect on the environment. Based on previous studies, the climate drought index can be used to assess the evolutionary trend of the ecological environment under various arid climatic conditions. It is necessary for us to further explore the relationship between vegetation coverage（index） and climate drought conditions. Therefore, in this study, based on MODIS-NDVI products and meteorological observation data, the Palmer Drought Severity Index（PDSI） and vegetation coverage in North China were first calculated. Then, the interannual variations of PDSI and vegetation coverage during 2001–2013 were analyzed using a Theil-Sen slope estimator. Finally, an ecoregion perspective of the correlation between them was discussed. The experimental results demonstrated that the PDSI index and vegetation coverage value varied over different ecoregions. During the period 2001–2013, vegetation coverage increased in the southern and northern mountains of North China, while it showed a decreasing trend in the Beijing-Tianjin-Tangshan City Circle area and suburban agricultural zone located in Hebei Province and Henan Province）. Over 13 years, the climate of the northeastern part of North China became more humid, while in the southern part of North China, it tended to be dry. According to the correlation analysis results, 73.37% of North China showed a positive correlation between the vegetation coverage and climate drought index. A negative correlation was observed mainly in urban and suburban areas of Beijing, Tianjin, Hebei Province, and Henan Province. In most parts of North China, drought conditions in summer and autumn had a strong influence on vegetation coverage.

关键词： North China vegetation coverage PDSI ecoregion correlation analysis

Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1

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Journal of Genetics and Genomics 2024年第12期51卷 1375-1388页

作者： Yayue Chen Delai Huang Aixuan Xie Ying Shan shuyi zhao Ce Gao Jun Chen Hui Shi Weihuan Fang Jinrong Peng MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhouZhejiang 310058China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China

Mutations in calcium-dependent papain-like protease CALPAIN3(CAPN3)cause Limb-Girdle Muscular Dystrophy Recessive Type 1(LGMDR1),the most common limb-girdle muscular dystrophy in *** addition to progressive muscle weakness,persistent inflammatory infiltration is also a feature of *** the underlying mechanism remaining poorly understood,we consider that it may relate to the newly defined role of CAPN3/Capn3b in the ***,we report that the loss of function of zebrafish capn3b,the counterpart of human CAPN3,induces an autoimmune response akin to that in LGMDR1 ***3b mutant larvae are more susceptible to Listeria monocytogenes injection,characterized by recruiting more *** germ-free conditions,transcriptome analysis of the capn3b mutant muscle reveals a significant upregulation of the chemokine-production-related ***,more neutrophils are recruited to the injury site imposed by either muscle stabbing or tail fin *** proteomic analysis and enzymatic assays reveal NKAP,an activating factor of the NF-k B pathway,to be a target of *** conclude that the accumulation of Nkap and other factors in the capn3b mutant may be involved in the over-activation of innate *** studies indicate that the zebrafish capn3b mutant is a powerful model for studying the immunity-related progression of human LGMDR1.

关键词： capn3b Autoimmunity LGMDR1 Neutrophil Nkap Zebrafish

ESTABLISHMENT OF IMMUNOGLOBULIN M(IgM)-IMMUNOSORBENT AGGLUTINATION ASSAY(ISAGA) FOR DIAGNOSIS OF TOXOPLASMOSIS

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中国寄生虫学与寄生虫病杂志 1999年第4期 35-37页

作者： ZHANG shuyi, WEI Meixiong, zhao Huifen, SHI Gongfen Shanghai Detecting Center for Toxoplasmosis Shanghai Institute of Parasitic Disease Control and Rsesarch,Shanghai 200336

AIM∶To establish an immunosorbent agglutination assay (ISAGA)for detection of IgM antibodies against Toxoplasma gondii. METHODS∶In the ISAGA,wells of microtiter plates were coated with anti\|human IgM antibodies and sealed with 1% bovine serum *** the test sera were added and incubated,the plates were washed, *** tachyzoite antigen suspension was added, and incubated overnight at 37℃. The ISAGA results were evaluated by comparing with those detected by Danish ISAGA and ELISA and those detected by slide enzyme immunoassay (S\|EIA). RESULTS∶ Forty\|four sera from Danish pregnant women were tested by the IgM\|ISAGA,41(93\^2%)were consistent with the Danish results. Sixty\|seven sera from Danish and Shanghai pregnant women were detected by IgM\|IgM\|ISAGA and S\|EIA, the total consistency rate was 92\^5%.A significant correlation was found between the titers of the ISAGA and S\|EIA,with a Pearson correlation coefficient of 0\^589( P <0\^001).The titers of ISAGA were eighteen times higher than those of S\|*** method enables the detection of IgM antibodies as low as approximately 0\^08 IU/***∶The IgM\|ISAGA is therefore sensitive,specific, easy to perform, and is useful for mass screening and diagnosing recent Toxoplasma infection or reactivation.

关键词： Toxoplasma gondii immunodiagnosis IgM\|ISAGA

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韩国百济考古中的道教文化因素初探

世界宗教文化 2024年第2期 51-59页

作者：赵淑怡苏州工艺美术职业技术学院手工艺术学院

从考古发现来看,百济时期朝鲜半岛已经受到道教文化的影响,出现了本土化的三神山信仰。同时百济又将传播而来的道教文化活用于外交之中,推动和加强道教文化在东北亚范围内的传播与影响。本文结合文献与考古资料,从百济道教文化的初次发... 详细信息

从考古发现来看,百济时期朝鲜半岛已经受到道教文化的影响,出现了本土化的三神山信仰。同时百济又将传播而来的道教文化活用于外交之中,推动和加强道教文化在东北亚范围内的传播与影响。本文结合文献与考古资料,从百济道教文化的初次发现、渗透融合以及灵活应用三个方面,对百济考古中出现的道教文化因素加以考察,结合其时代背景,进一步理解当时百济的道教文化,进一步认识道教传播的重要影响。

关键词：百济考古道教神仙信仰

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我国中小型图书馆危机分析

图书情报工作 2009年第23期53卷 35-39,127页

作者：赵新赵树宜中国科学院理化技术研究所北京100190 中国科学院文献情报中心北京100190

概述中小型图书馆的定义、特点及存在意义以及中小型图书馆的危机特征,阐述研究意义。重点分析我国中小型图书馆面临的意识危机、管理危机、人才危机、资源危机、经费危机、服务危机、安全与突发事件危机、空间危机和地位危机,建议中小... 详细信息

概述中小型图书馆的定义、特点及存在意义以及中小型图书馆的危机特征,阐述研究意义。重点分析我国中小型图书馆面临的意识危机、管理危机、人才危机、资源危机、经费危机、服务危机、安全与突发事件危机、空间危机和地位危机,建议中小型图书馆应树立危机意识,明确自身定位,建立特色资源,加强人才队伍建设,转型服务模式,实行分馆制。

关键词：中小型图书馆公共图书馆高校图书馆专业图书馆危机管理

会“珰”洞鉴以昭然——古代东亚地区冠饰“珰”之探究

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艺术设计研究 2018年第1期 43-52页

作者：赵淑怡南京师范大学

"珰"作为一种冠饰,不仅可以作为"貂蝉冠"、"通天冠"、"步摇冠"之构件,亦可作为"骨苏"之构件。其形制特殊,包含了重要的政治意义和文化内涵。本文通过理"珰"、读"珰"以及对邻"珰"的对照比较,力求洞鉴,以达昭然。从考古实物资料出发,利用... 详细信息

"珰"作为一种冠饰,不仅可以作为"貂蝉冠"、"通天冠"、"步摇冠"之构件,亦可作为"骨苏"之构件。其形制特殊,包含了重要的政治意义和文化内涵。本文通过理"珰"、读"珰"以及对邻"珰"的对照比较,力求洞鉴,以达昭然。从考古实物资料出发,利用考古类型学的方法,对出土于两晋十六国时期墓葬中珰的形制分型分式,进行梳理研究,探究其时代特征、地域特征及演变规律。并联系珰所出墓葬墓主的身份,对照相关文献记载,结合壁画、雕塑、绘画资料中出现之珰的形制,对不同等级人群适用的不同形制的珰进行了划分。结合邻邦朝鲜半岛、日本出现的相似形制的珰,考察其传播与流变,从而探讨当时东亚地区的文化交流情况。

关键词：珰冠饰考古类型学东亚文化交流

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原发性失眠的磁共振氢质子波谱研究进展

磁共振成像 2022年第1期13卷 157-160页

作者：赵舒仪苏增锋安徽医科大学附属巢湖医院全科医学科巢湖238000

原发性失眠(primary insomnia,PI)是最常见的一种睡眠障碍。尽管我们对失眠的性质、病因和病理生理学的研究已在一定程度上取得进展,但目前仍然没有一种被普遍接受的病理生理学模型。现如今,最为广泛接受的假说认为PI是一种过度觉醒状... 详细信息

原发性失眠(primary insomnia,PI)是最常见的一种睡眠障碍。尽管我们对失眠的性质、病因和病理生理学的研究已在一定程度上取得进展,但目前仍然没有一种被普遍接受的病理生理学模型。现如今,最为广泛接受的假说认为PI是一种过度觉醒状态的表现。磁共振氢质子波谱(proton magnetic resonance spectroscopy,1H-MRS)提供了一种无创的方法来测量大脑中各神经递质与代谢产物的含量,新兴的多体素磁共振氢质子波谱甚至可以区别测量左右脑特定脑区域的神经递质与代谢产物浓度,这为PI的病理生理学、发病机制、诊断及治疗的研究打开一扇新的大门。本文系统总结了国内外以磁共振波谱为手段,研究原发性失眠各个脑区域不同神经递质与代谢产物的各项研究结果及其进展,为进一步探索PI的病理生理学机制及其诊断与治疗提供了新的视角。

关键词：原发性失眠磁共振波谱神经递质综述文献

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冲击波在膜基结构材料中传输的研究

中国激光 2016年第5期43卷 45-52页

作者：叶云霞赵抒怡左慧江苏大学机械工程学院江苏镇江212013 江苏大学激光技术研究所江苏镇江212013

将Abaqus模拟与实验相结合,研究了激光诱导冲击波在膜基结构材料中的传输及其对膜层-基体结合强度的影响。建立不同声阻抗匹配模式的膜基结构模型,改变膜层厚度,分别进行模拟和实验。分析不同时刻深度方向的应力分布,膜层脱落的凸起形貌... 详细信息

将Abaqus模拟与实验相结合,研究了激光诱导冲击波在膜基结构材料中的传输及其对膜层-基体结合强度的影响。建立不同声阻抗匹配模式的膜基结构模型,改变膜层厚度,分别进行模拟和实验。分析不同时刻深度方向的应力分布,膜层脱落的凸起形貌,不同膜层厚度对应的最大应力值、持续时间。结果发现:当膜层声阻抗小于基体时,膜层表面覆盖合适的约束层,可以避免膜层-基体界面处形成拉应力,两者结合强度不会减弱,材料表面性能得到强化;当膜层声阻抗大于基体时,应根据加工要求,决定是否可以进行激光冲击;当拉应力不可避免时,膜层厚度需慎重选择,既要考虑材料表面的强化效果,也要减小界面处拉应力强度。

关键词：激光技术激光冲击膜基结构冲击波传输结合强度数值模拟