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Author correction to‘Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy’[Acta Pharmaceutica Sinica B 11(2021)3508-3526]

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Acta Pharmaceutica Sinica B 2023年第2期13卷 897-898页

作者： shuyi Wang Jun Tao Huaguo chen Machender R.Kandadi Mingming Sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren Department of Emergency Shanghai Tenth People's HospitalSchool of Medicine Tongji UniversityShanghai 200072China Shanghai University School of Medicine Shanghai 200044China University of Wyoming College of Health Sciences LaramieWY 82071USA Department of Cardiovascular Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510000China Medprime Health Services LLC ParisTX 75460USA Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan Hospital Fudan UniversityShanghai 200032China Department of Cardiology Affiliated Hospital of Nantong UniversityNantong 226001China Cardiovascular Research Centre University of AlbertaEdmontonAlberta T6G 2S2Canada Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationDepartment of Endocrinology and MetabolismZhongshan Hospital Fudan UniversityShanghai 200032China Department of Laboratory Medicine and Pathology University of WashingtonSeattleWA 98195USA

The authors of the above-mentioned paper noticed an error in Fig.5a as reported.H&E staining was shown in wrong color during figure processing and DKO-LF group was accidently copied and pasted *** H&E images have been replaced with the correct color with the accurate grouping *** text content in figure legend or conclusion is affected by this *** authors sincerely apologize for any inconvenience caused to the journal and readers.

关键词： correction journal mentioned

Precisemodification of the surface charge of antigen enhances vaccine immunogenicity

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The Innovation 2023年第4期4卷 83-90页

作者： Xiaodong Zai Zhiling Zhang Chuge Zhou Fangxin Zhao Yue Zhang Xiaolin Wang Ruihua Li Yaohui Li Xiaofan Zhao shuyi Wang Yilong Yang Ying Yin Jun Zhang Junjie Xu Wei chen Institute of Biotechnology Academy of Military Medical SciencesBeijing 100071China College of pharmacy Nanjing University of Chinese MedicineNanjing 210023China School of Medicine Zhejiang UniversityHangzhou 310058China

Aluminum(alum)adjuvant is the most extensively used protein subunit vaccine adjuvant,and its effectiveness and safety have been widely *** surface charge of the antigen determines its electrostatic adsorption to alum adjuvant,which directly affects the immune efficacy of the protein *** our study,we precisely modified its surface charge by inserting charged amino acids into the flexible region of the SARS-CoV-2 receptorbinding domain(RBD),achieving electrostatic adsorption and a site-specific anchor between the immunogen and alum adjuvant.

关键词： charge electrostatic adsorption

基于嵌套型优势关系粗糙集与模糊理论的岩质边坡施工安全性评价

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铁道科学与工程学报 2023年第12期20卷 4571-4581页

作者：刘舒逸陈建宏中南大学数学与统计学院湖南长沙410083 中南大学资源与安全工程学院湖南长沙410083

为降低工程建设风险、解决岩质边坡施工安全性评价方法复杂等问题,对基于嵌套型优势关系粗糙集与模糊理论的岩质边坡施工安全性评价方法展开研究。首先,对岩质边坡施工安全性影响因素进行分析,通过文献研究及专家调查将岩质边坡施工安... 详细信息

为降低工程建设风险、解决岩质边坡施工安全性评价方法复杂等问题,对基于嵌套型优势关系粗糙集与模糊理论的岩质边坡施工安全性评价方法展开研究。首先,对岩质边坡施工安全性影响因素进行分析,通过文献研究及专家调查将岩质边坡施工安全性影响因素归为勘察设计风险、施工风险、工程地质风险及自然环境风险四大类,包含勘察资料准确性、边坡形式、支护结构及设计参数等19个2级影响因素指标,并针对定量指标构造了三相性隶属函数;其次,介绍了权重确定及指标分级模糊评价的具体方法;再次,阐述了建立评价决策表、数据离散、多级属性约简及偏好规则的生成等操作流程;最后,对15个比较有代表性的边坡进行实例研究,验证了该方法的可靠性。通过实践证明,基于嵌套型优势关系粗糙集与模糊理论的风险评价分析方法可行,可以为岩质边坡施工安全性风险评价与规律分析提供一种新思路。结果表明:嵌套型优势关系粗糙集理论对岩质边坡施工安全性风险的各级指标属性自上而下进行了约简,降低了原有系统的复杂性,同时考虑了指标中含有的偏好信息,考虑综合全面,规则分析可信度高;样本集数量和约简的选取对基于嵌套型优势关系粗糙集与模糊理论进行评价决策时影响较大,样本集越大生成的规则可信度越高,正确选取约简偏好规则生成就越合理。

关键词：模糊理论嵌套优势关系粗糙集岩质边坡施工安全评价

A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3584-3591页

作者： Xinghai Zhang Huajun Zhang Tingting Li Shaohong chen Feiyang Luo Junhui Zhou Peiyi Zheng shuyi Song Yan Wu Tengchuan Jin Ni Tang Aishun Jin chengyong Yang Guofeng cheng Rui Gong Sandra Chiu Ailong Huang CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430o71 HubeiChina Department of Immunology College of Basic MedicineChongqing Medical UniversityChongqing 400010China Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology Chongqing Medical UniversityChongqing 400010China University of Chinese Academy of Sciences 100049 BeijingChina Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026 AnhuiChina Key Laboratory of Molecular Biology on Infectious Diseases Ministry of EducationChongqing Medical UniversityChongqing 400010China Mindao Haoyue Co LtdSQ0042 Lanyuan HallNo.61 Daxuecheng Middle RoadChongqing 400042China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still rapidly spreading *** drugs and vaccines have been approved for clinical use show efficacy in the treatment and prevention of SARS-CoV-2 ***,the emergence of SARS-CoV-2 variants of concern(VOCs),such as Delta(B.1.617.2)and the recently emerged Omicron(B.1.1.529),has seriously challenged the application of current ***,there is still a pressing need for identification of new broad-spectrum ***,we further characterized a human antibody(58G6),which we previously isolated from a patient,with a broadly authentic virus-neutralizing activity that inhibits the Delta and Omicron variants with half-maximal inhibitory concentrations(ICso)of 1.69 ng/ml and 54.31 ng/ml,respectively.58G6 shows prophylactic and therapeutic effcacy in hamsters challenged with the Delta and Omicron variants through nasal ***,a very low dosage(2 mg/kg daily)of 58G6 efficiently prevented Omicron variant replication in the *** advantages may overcome the efficacy limitation of currently approved neutralizing antibodies that can be administered only by intravenous *** general,58G6 is a promising prophylactic and therapeutic candidate against current circulating VOCs and even future emerging *** the best of our knowledge,58G6 is one of the most potent neutralizing antibodies against Omicron,with a broader spectrum than those approved for clinical use.58G6 could be developed as a nebulized therapy,which would be more cost effective and user friendly and enhance the clinical outcome comparedto thatobtainedwithdirect nasaldelivery.

关键词： nasal dosage prevention

Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp.1647:Pseudo-Tetrapeptides Active Against Influenza A Viruses and Coronavirus HCoV-229E

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Engineering 2022年第9期16卷 176-186页

作者： Hongmin Sun Xingxing Li Minghua chen Ming Zhong Yihua Li Kun Wang Yu Du Xin Zhen Rongmei Gao Yexiang Wu Yuanyuan Shi Liyan Yu Yongsheng Che Yuhuan Li Jian-Dong Jiang Bin Hong shuyi Si NHC Key Laboratory of Biotechnology of Antibiotics Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China CAMS Key Laboratory of Synthetic Biology for Drug Innovation Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China CAMS Key Laboratory of Antiviral Drug Research Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Many microorganisms have mechanisms that protect cells against attack from *** fermentation components of Streptomyces sp.1647 exhibit potent anti-influenza A virus(IAV)*** strain was isolated from soil in southern China in the 1970s,but the chemical nature of its antiviral substance(s)has remained unknown until *** used an integrated multi-omics strategy to identify the antiviral agents from this *** antibiotics and Secondary Metabolite Analysis Shell(antiSMASH)analysis of its genome sequence revealed 38 biosynthetic gene clusters(BGCs)for secondary metabolites,and the target BGCs possibly responsible for the production of antiviral components were narrowed down to three BGCs by bioactivity-guided comparative transcriptomics *** bioinformatics analysis and genetic manipulation of the regulators and a biosynthetic gene,cluster 36 was identified as the BGC responsible for the biosynthesis of the antiviral ***-based molecular networking analysis of mass spectrometric data from different recombinant strains illustrated that the antiviral compounds were a class of structural ***,18 pseudo-tetrapeptides with an internal ureido linkage,omicsynins A1–A6,B1–B6,and C1–C6,were identified and/or isolated from fermentation *** them,11 compounds(omicsynins A1,A2,A6,B1–B3,B5,B6,C1,C2,and C6)are new *** B1–B4 exhibited potent antiviral activity against IAV with the 50%inhibitory concentration(IC_(50))of approximately 1μmol·L^(-1)and a selectivity index(SI)ranging from 100 to *** B1–B4 also showed significant antiviral activity against human coronavirus *** integrating multi-omics data,we discovered a number of novel antiviral pseudo-tetrapeptides produced by Streptomyces sp.1647,indicating that the secondary metabolites of microorganisms are a valuable source of novel antivirals.

关键词： Multi-omics Anti-influenza A virus Anti-coronavirus Streptomyces sp.1647 Pseudo-tetrapeptides

Pedagogical Construction and Practice of Interdisciplinary Courses——Taking Food Translation as an Example

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Pedagogical Construction and Practice of Interdisciplinary C...

关联交易蕴含着会计错报风险么?——基于关联交易的错报动机分析

2024社会发展与科技创新交流会

作者： Jiangling He Xu chen shuyi Li Zhenzhou Zhu School of Modern Industry for Selenium Science and Engineering Wuhan Polytechnic University National R&D Center for Se-rich Agricultural Products Processing Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural ProductsWuhan Polytechnic University

Relying on the practical course system of food and translation majors,this course combines the characteristics of the professional courses of the two majors,including the knowledge of food,which is stronger in professional nature,and the knowledge of translation,which is more prominent in practical ability,to cultivate cross-disciplinary talents in food and translation. This paper takes "Food and English Translation" course as an example,analyzes the potential connection between food and translation,creates teaching situations by using modern teaching methods,and promotes the cultivation mode of interdisciplinary composite talents and the innovation of in-depth integration of disciplines and specialties. In order to break down the barriers between disciplines and specialties and strengthen the construction of interdisciplinary innovative talents,we summarize the basic construction and practical experience of the general elective course of interdisciplinary cross-fertilization.

关键词： Food translation cross-disciplinary teaching practice

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管理评论 2022年第11期34卷 289-302页

作者：马晨敬舒贻西安欧亚学院金融学院西安710065 西北大学经济管理学院西安710127

基于关联交易可能构成会计错报的动机分析,本文检验了关联交易对会计错报的影响,发现:进行关联交易的公司更可能发生会计错报,而且主要集中在商品劳务的销售和购买这两类关联交易中;关联交易金额与会计错报呈正向关系,商品劳务销售关联... 详细信息

基于关联交易可能构成会计错报的动机分析,本文检验了关联交易对会计错报的影响,发现:进行关联交易的公司更可能发生会计错报,而且主要集中在商品劳务的销售和购买这两类关联交易中;关联交易金额与会计错报呈正向关系,商品劳务销售关联交易的金额正向影响会计错报,但本文未发现其他类型关联交易的金额对错报具有显著影响。进一步,本文还检验公司是否会在财务重述后调整关联交易以应对错报风险,本文发现财务重述后关联交易整体上下降,而且所有类别关联交易均会在财务重述后的头两年减少,但是商品劳务的销售和购买在第二年减少程度有限。进一步分析结果表明,关联交易对会计错报的正向影响主要存在于集团内关联交易中,然而财务重述后关联交易的降低主要存在于非集团内关联交易中,集团内关联交易不降反升,表明财务重述后公司试图通过降低关联交易以恢复声誉的行为只是“虚有其表”。

关键词：财务重述会计错报关联交易动机集团

完全各向同性解耦2T2R型并联机器人构型综合

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哈尔滨工业大学学报 2016年第7期48卷 94-100页

作者：曹毅秦友蕾陈海葛姝翌周辉江南大学机械工程学院江苏无锡214122 机械系统与振动国家重点实验室(上海交通大学) 上海2002404 机器人技术与系统国家重点实验室(哈尔滨工业大学) 哈尔滨150080 江苏省食品先进制造装备技术重点实验室(江南大学) 江苏无锡214122

为得到完全各向同性解耦并联机器人构型,基于GF集理论提出一种简单而有效的构型综合方法.阐述GF集的基本概念、运算法则以及转动特征存在条件;给出机构输入运动副选择原则和分支设计准则,确保了并联机构运动各向同性及解耦性;根据该构... 详细信息

为得到完全各向同性解耦并联机器人构型,基于GF集理论提出一种简单而有效的构型综合方法.阐述GF集的基本概念、运算法则以及转动特征存在条件;给出机构输入运动副选择原则和分支设计准则,确保了并联机构运动各向同性及解耦性;根据该构型综合原理,完成2T2R四自由度完全各向同性解耦并联机构型综合,得到大量新构型;针对所综合的一种新型并联解耦机构,基于螺旋理论求得该机构运动输出,通过求解到的雅克比矩阵,验证该机构的完全各向同性,证明了该构型方法的有效性.

关键词：并联机构型综合 GF 集完全各向同性解耦

基于G_F集理论的五自由度混联机器人构型综合

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农业机械学报 2015年第11期46卷 392-398页

作者：曹毅秦友蕾陈海葛姝翌周辉江南大学机械工程学院无锡214122 江苏省食品先进制造装备技术重点实验室无锡214122

基于GF集理论提出了一种简单而有效的混联机器人构型综合方法。首先阐述了GF集的基本概念、运算法则及转动特征存在条件。其次通过分析混联机构结构组成特点,提出了基于GF集元素组合和转动轴线迁移定理安排混联机构拓扑结构的方法,建立... 详细信息

基于GF集理论提出了一种简单而有效的混联机器人构型综合方法。首先阐述了GF集的基本概念、运算法则及转动特征存在条件。其次通过分析混联机构结构组成特点,提出了基于GF集元素组合和转动轴线迁移定理安排混联机构拓扑结构的方法,建立了混联机构数综合方程并给出了混联机构构型综合的具体步骤。基于该构型综合理论,综合出了具有确定运动特征的3T2R混联机构。针对综合出的混联机构,提出了一种混联机构末端运动特征的分析方法,运用该方法分析了一种综合得到的3PRPaR&RR混联机构,证明了该构型理论的正确性。设计出的3PRPaR&RR混联机构具有结构紧凑、定位精确、高速等优点,同时给出了实例应用。

关键词：混联机构构型综合 GF集