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Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy

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Bioactive Materials 2022年第11期7卷 300-319页

作者： shuyan han Jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen518057China

Though increasing understanding and remarkable clinical successes have been made, enormous challenges remain to be solved in the field of cancer immunotherapy. In this context, biomaterial-based immunomodulatory strategies are being developed to boost antitumor immunity. For the local immunotherapy, macroscale bioma-terial scaffolds with 3D network structures show great superiority in the following aspects: facilitating the encapsulation, localized delivery, and controlled release of immunotherapeutic agents and even immunocytes for more efficient immunomodulation. The concentrating immunomodulation in situ could minimize systemic tox-icities, but still exert abscopal effects to harness the power of overall anticancer immune response for eradicating malignancy. To promote such promising immunotherapies, the design requirements of macroscale 3D scaffolds should comprehensively consider their physicochemical and biological properties, such as porosity, stiffness, surface modification, cargo release kinetics, biocompatibility, biodegradability, and delivery modes. To date, increasing studies have focused on the relationships between these parameters and the biosystems which will guide/assist the 3D biomaterial scaffolds to achieve the desired immunotherapeutic outcomes. In this review, by highlighting some recent achievements, we summarized the latest advances in the development of various 3D scaffolds as niches for cancer immunotherapy. We also discussed opportunities, challenges, current trends, and future perspectives in 3D macroscale biomaterial scaffold-assisted local treatment strategies. More importantly, this review put more efforts to illustrate how the 3D biomaterial systems affect to modulate antitumor immune activities, where we discussed how significant the roles and behaviours of 3D macroscale scaffolds towards in situ cancer immunotherapy in order to direct the design of 3D immunotherapeutic.

关键词： Three-dimensional(3D) Macroscale Hydrogels Scaffolds Cancer immunotherapy

Natural okra-based hydrogel for chronic diabetic wound healing

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中国化学快报:英文版 2023年第8期34卷 248-253页

作者： Peikun Xin shuyan han Jun Huang Conglai Zhou Jiayuan Zhang Xinru You Jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China Guizhou University of Chinese Traditional Medicine Guiyang 550025China School of Life Science Jilin UniversityChangchun 130012China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SARChina

As a representative of chronic wounds,the long-term high levels of oxidative stress and blood sugar in chronic diabetic wounds lead to serious complications,making them the biggest challenge in the research on wound healing.Many edible natural biomaterials rich in terpenes,phenols,and flavonoids can act as efficient antioxidants.In this study,okra extract was selected as the main component of a wound dressing.The okra extracts obtained via different methods comprehensively maintained the bioactivity of multiple molecules.The robust antioxidant properties of okra significantly reduced intracellular reactive oxygen species production,thereby accelerating the wound healing process.The results showed that okra extracts and their hydrogel dressings increased cell migration,angiogenesis,and re-epithelization of the chronic wound area,considerably promoting wound remodeling in diabetic rats.Therefore,okra-based hydrogels are promising candidates for skin regeneration and wider tissue engineering applications.

关键词： Okra Antioxidant Angiogenesis Wound healing Tissue engineering

STUDY ON THE OPTIMIZATION OF TRANSPORT CONTROL POLICY IN COMMUNICATION NETWORK

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Journal of Electronics(China) 2010年第2期27卷 261-266页

作者： Fan shuyan han Weizhan Lu Ran School of Telecommunication Engineering Xidian University Xi＇an 710071 China The 54th Research Institute of CETC Shijiazhuang 050081 China

In communication networks with policy-based Transport Control on-Demand (TCoD) function,the transport control policies play a great impact on the network effectiveness. To evaluate and optimize the transport policies in communication network,a policy-based TCoD network model is given and a comprehensive evaluation index system of the network effectiveness is put forward from both network application and handling mechanism perspectives. A TCoD network prototype system based on Asynchronous Transfer Mode/Multi-Protocol Label Switching (ATM/MPLS) is introduced and some experiments are performed on it. The prototype system is evaluated and analyzed with the comprehensive evaluation index system. The results show that the index system can be used to judge whether the communication network can meet the application requirements or not,and can provide references for the optimization of the transport policies so as to improve the communication network effectiveness.

关键词： Communication network Comprehensive evaluation index system Network Application Effectiveness (NAE) Transport Control on-Demand (TCoD) Policy optimization

Blocking neurodegenerative demages of Alzheimer’s disease by aromatic glycosides in multiple pathways

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Blocking neurodegenerative demages of Alzheimer’s disease b...

双功能MoNi_(4)电极实现水参与的氮杂环化合物转移氢化与脱氢

2013年中国药学大会暨第十三届中国药师周

作者： Yinghong Wang Shaoyang Zhao Ke Zhang Xu Ma Haixia Li shuyan han Yong Jiang Hounan Wu Zhuoping Huo Pengfei Tu Zhizhong Ma Department of Combined Traditional Chinese Medicine with Western Medicine School of Basic Medical Science Peking University Department of Natural Medicines School of Pharmaceutical Sciences Peking University Medical and Healthy Analytical Center Peking University Institute of Child and Adolescent Health School of public health Peking University

Blocking neurodegeneration of Alzheimer’s diseases is global puzzles in medicine. Single blocking either oxidative stress or inflammation is not ideal strategy for this complicated illness. Through our studies, we found some of phenolic glycosides （Xy-B-25、Xy-B-23、BL-B-14、 BL-E-8、SCI-Et-18、SC2-19 and IO-B-40） present significant inhibition on cortical neuronal death induced by Aβ1-42. Simultaneously, the endogenous ROS, biomarker of DNA, lipid and protein damages were all reduced dramatically. The ROS induced Aβ1-42 production, as well as p-38MAPK phosphorylation, were markedly deduced. Additionally, the activation of microglia and astrocyte, their releasing of inflammatory cytokines of COX-1、COX-2、IL-1β、TNFα, as well as p-38MAPK phosphorylation were inhibited. In SAM-P8 mice, which is expressed premature aging, senile demention and multiple neurodegenerations, were tested and the results showed that one of our compounds was effective in improving the learning and memory ability as well as reducing Aβ1-42 production and p-38MAPK phosphorylation.

关键词： Alzheimer’s disease phenolic glycosides Oxidative stress inflammation neurodegeneration

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Chinese Journal of Catalysis 2021年第11期42卷 1983-1991页

作者：李孟阳刘翠波黄义韩舒艳张兵天津大学理学院化学系分子+研究院天津300072 天津大学教育部合成生物前沿科学中心天津市分子光电科学重点实验室天津300072 郑州大学化学学院河南郑州450001

氮杂环的催化氢化在有机合成、药物研发、石油化工等领域有着重要应用.尽管发展了一系列均相和非均相催化加氢体系,但由于通常使用易燃易爆的氢气或价格昂贵且毒性较高的试剂(如:水合肼和硼氢化钠)为氢源,给安全生产及生态环境带来了严... 详细信息

氮杂环的催化氢化在有机合成、药物研发、石油化工等领域有着重要应用.尽管发展了一系列均相和非均相催化加氢体系,但由于通常使用易燃易爆的氢气或价格昂贵且毒性较高的试剂(如:水合肼和硼氢化钠)为氢源,给安全生产及生态环境带来了严重的问题.此外,由于动力学同位素效应,氘代药物具有重要应用.氮杂环结构作为生物医药的构筑单元与关键中间体,现有的策略由于没有合适的氘源难以用于氘代氮杂环化合物的合成.因此,急需开发一种基于非贵金属催化剂和安全易得氢(氘)源的氮杂环催化氢(氘)化策略.水相中的电化学氢化可利用水电解原位产生的活性氢替代传统的氢气裂解实现有机氢化产物的合成,已成为一种理想氢化策略,被广泛应用于二氧化碳还原、硝酸根还原和生物质氢解等.本课题组前期研究已经实现了以氘水为氘源的氘代分子的高效电化学合成(Angew.Chem.Int.Ed.,2020,59,18527-18531;Angew.Chem.Int.Ed.,2020,59,21170-21175;CCS Chem.,2021,3,507-515).然而,要开发一种电化学的杂环氢化方法,一方面要克服氮杂环化合物对催化剂的毒化,另一方面要在电极表面产生大量的活性氢.因此,开发具有较好的水离解性能的非贵金属电极材料是实现氮杂芳烃电化学氢化和氘代的关键.基于上述要求,MoNi_(4)(目前用于碱性电催化水分解制氢的活性较高的非贵金属材料)成为理想的电极材料.本文以喹喔啉(1,2,3,4-四氢喹喔啉骨架作为重要的结构单元存在于许多生物活性化合物中)作为模板底物,设计并制备了三维自支撑的MoNi_(4)多孔纳米片为双功能电极,以水和氘水为氢源和氘源,实现了喹喔啉及其他氮杂环分子的氢化与氢化,同时实现了四氢喹喔啉的电化学氧化脱氢.制备了MoNi4纳米片阵列,利用扫描电子显微镜、透射电子显微镜、X射线衍射和X光电子能谱等手段进行表征,评估了其在碱性电解液中用于喹喔啉电化学转移氢化的性能.结果表明,MoNi_(4)电极加速了动力学缓慢的Volmer步骤,在仅50 mV的过电势下以80%的法拉第效率实现了喹喔啉的电化学氢化.电子顺磁共振等证实水电解生成了H^(*),并与喹喔啉自由基阴离子偶联实现喹喔啉的氢化.同时,该电化学转移氢化方法可很好地应用于一系列喹喔啉衍生物和其他氮杂芳烃化合物.克级合成体现了该电化学转移氢化方法的潜在应用性.原位拉曼实验结果表明,在MoNi_(4)表面形成的NiOOH是实现1,2,3,4-四氢喹喔啉氧化脱氢的重要物种.此外,以D_(2)O代替H_(2)O,可以较好的收率和高达99%的氘化率实现氘代氮杂环的合成.与传统的氮杂环氢化方法相比,本文的电化学转移氢化策略具有绿色、温和、高效的特点,同时拓宽了电化学氢化在合成化学中的应用.

关键词：电催化转移氢化氘代水为氢源双功能电极

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选择性隐藏树型访问结构的CP-ABE方案

计算机工程 2020年第7期46卷 150-158页

作者：韩舒艳努尔买买提·黑力力新疆大学数学与系统科学学院乌鲁木齐830046

隐藏访问结构是密文策略属性基加密(CP-ABE)的安全操作,可有效防止敏感信息泄露,而现有树型访问结构的CP-ABE方案为完全公开或完全隐藏访问结构,造成策略保密性差及加解密计算量较大。为此,提出一种选择性隐藏树型访问结构的CP-ABE方案... 详细信息

隐藏访问结构是密文策略属性基加密(CP-ABE)的安全操作,可有效防止敏感信息泄露,而现有树型访问结构的CP-ABE方案为完全公开或完全隐藏访问结构,造成策略保密性差及加解密计算量较大。为此,提出一种选择性隐藏树型访问结构的CP-ABE方案。使用互信息方法提取敏感属性特征,筛选和隐藏访问结构中含有原始属性集信息的部分属性,使选择隐藏与完全隐藏具有相同的保密效果。同时,以最少匹配代价判断用户解密能力,使无解密能力的用户尽早放弃解密。分析结果表明,与公开访问或完全隐藏访问结构方案相比,该方案的安全性更高且计算量更小。

关键词：密文策略属性基加密属性提取选择性隐藏互信息属性匹配访问控制

数字普惠金融助力乡村振兴研究--以陕西省为例

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现代农业研究 2023年第7期29卷 24-26页

作者：韩淑妍孔令军熊湘辉冯若森陕西工商职业学院陕西西安710000

数字普惠性金融服务是近年来普惠金融服务蓬勃发展的高层次阶段,对乡村振兴进程有着巨大的推进意义。文章首先论述了数字普惠性金融服务对乡村振兴的巨大意义,然后研究了乡村振兴背景下数字普惠性金融服务建设面临的困难,并指出了对策... 详细信息

数字普惠性金融服务是近年来普惠金融服务蓬勃发展的高层次阶段,对乡村振兴进程有着巨大的推进意义。文章首先论述了数字普惠性金融服务对乡村振兴的巨大意义,然后研究了乡村振兴背景下数字普惠性金融服务建设面临的困难,并指出了对策。最后聚焦于陕西省,研究了陕西省数字普惠金融助力乡村振兴的现实情况。

关键词：数学普惠金融乡村振兴意义

平肝活血方治疗肝郁瘀阻型失眠症伴记忆力减退的临床分析

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中国中医药现代远程教育 2019年第1期17卷 72-73页

作者：韩淑艳吉林省长春市双阳区中医院内科吉林长春130600

目的研究平肝活血方治疗肝郁瘀阻型失眠症伴记忆力减退的临床效果。方法选取2016年7月—2017年7月收治的80例失眠症伴记忆衰退患者,抽取40例作为对照组,另外40例作为观察组。对照组采用中成药乌灵胶囊治疗,观察组采用平肝活血方治疗。... 详细信息

目的研究平肝活血方治疗肝郁瘀阻型失眠症伴记忆力减退的临床效果。方法选取2016年7月—2017年7月收治的80例失眠症伴记忆衰退患者,抽取40例作为对照组,另外40例作为观察组。对照组采用中成药乌灵胶囊治疗,观察组采用平肝活血方治疗。对比治疗前后睡眠质量评分、相关电位P300认知电位改善情况。结果治疗前及治疗后2周睡眠质量评分对比差异无统计学意义(P>0.05)。治疗后4周及6周观察组均低于对照组,对比差异有统计学意义(P0.05),即观察组在改善潜伏期方面明显优于对照组。结论平肝活血方治疗肝郁瘀阻型失眠症伴记忆力减退具有显著效果,能使治疗效果得到提升,改善睡眠质量,值得临床推广。

关键词：平肝活血方失眠记忆衰退肝郁瘀阻型

受教育程度对于家庭风险性金融资产投资的影响

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华北金融 2020年第11期 58-69页

作者：韩淑妍浦发银行宁波分行浙江宁波市315000 南开大学金融学院天津市300353

本文利用中国家庭金融调查(CHFS)2017年的横截面数据,研究受教育程度对于家庭风险性金融资产①投资的影响。研究结果表明,第一,家庭中户主受教育程度每增加1年,家庭参与股市的概率随之增加1.1%,参与股票和基金的概率增加1.2%,同时,家庭... 详细信息

本文利用中国家庭金融调查(CHFS)2017年的横截面数据,研究受教育程度对于家庭风险性金融资产①投资的影响。研究结果表明,第一,家庭中户主受教育程度每增加1年,家庭参与股市的概率随之增加1.1%,参与股票和基金的概率增加1.2%,同时,家庭股票投资市值占总金融资产比例增加0.4%,股票和基金的市值占比增加0.5%。第二,家庭中子女的受教育程度对家庭风险性金融资产投资的影响具有异质性,其中,女儿受教育程度会对家庭风险性金融资产市值占比有正向影响,而儿子受教育程度则对家庭风险性金融资产投资没有显著影响。

关键词：受教育程度风险性金融资产家庭金融代际影响