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Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy

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Bioactive Materials 2022年第11期7卷 300-319页

作者： shuyan han Jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen518057China

Though increasing understanding and remarkable clinical successes have been made, enormous challenges remain to be solved in the field of cancer immunotherapy. In this context, biomaterial-based immunomodulatory strategies are being developed to boost antitumor immunity. For the local immunotherapy, macroscale bioma-terial scaffolds with 3D network structures show great superiority in the following aspects: facilitating the encapsulation, localized delivery, and controlled release of immunotherapeutic agents and even immunocytes for more efficient immunomodulation. The concentrating immunomodulation in situ could minimize systemic tox-icities, but still exert abscopal effects to harness the power of overall anticancer immune response for eradicating malignancy. To promote such promising immunotherapies, the design requirements of macroscale 3D scaffolds should comprehensively consider their physicochemical and biological properties, such as porosity, stiffness, surface modification, cargo release kinetics, biocompatibility, biodegradability, and delivery modes. To date, increasing studies have focused on the relationships between these parameters and the biosystems which will guide/assist the 3D biomaterial scaffolds to achieve the desired immunotherapeutic outcomes. In this review, by highlighting some recent achievements, we summarized the latest advances in the development of various 3D scaffolds as niches for cancer immunotherapy. We also discussed opportunities, challenges, current trends, and future perspectives in 3D macroscale biomaterial scaffold-assisted local treatment strategies. More importantly, this review put more efforts to illustrate how the 3D biomaterial systems affect to modulate antitumor immune activities, where we discussed how significant the roles and behaviours of 3D macroscale scaffolds towards in situ cancer immunotherapy in order to direct the design of 3D immunotherapeutic.

关键词： Three-dimensional(3D) Macroscale Hydrogels Scaffolds Cancer immunotherapy

Natural okra-based hydrogel for chronic diabetic wound healing

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中国化学快报:英文版 2023年第8期34卷 248-253页

作者： Peikun Xin shuyan han Jun Huang Conglai Zhou Jiayuan Zhang Xinru You Jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China Guizhou University of Chinese Traditional Medicine Guiyang 550025China School of Life Science Jilin UniversityChangchun 130012China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SARChina

As a representative of chronic wounds,the long-term high levels of oxidative stress and blood sugar in chronic diabetic wounds lead to serious complications,making them the biggest challenge in the research on wound *** edible natural biomaterials rich in terpenes,phenols,and flavonoids can act as efficient *** this study,okra extract was selected as the main component of a wound *** okra extracts obtained via different methods comprehensively maintained the bioactivity of multiple *** robust antioxidant properties of okra significantly reduced intracellular reactive oxygen species production,thereby accelerating the wound healing *** results showed that okra extracts and their hydrogel dressings increased cell migration,angiogenesis,and re-epithelization of the chronic wound area,considerably promoting wound remodeling in diabetic ***,okra-based hydrogels are promising candidates for skin regeneration and wider tissue engineering applications.

关键词： Okra Antioxidant Angiogenesis Wound healing Tissue engineering

Catalytic effects of V-and O-species derived from PrF_(3)/V_(2)C for efficient hydrogen storage in MgH_(2)

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Nano Research 2024年第8期17卷 7117-7125页

作者： Zhenluo Yuan Yuhang Wang Xiuxiu Zhang shuyan Guan Xiaojiao Wang Liqiang Ji Qiuming Peng Shumin han Yanping Fan Baozhong Liu College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo 454000China Henan Famous Diamond Co. Ltd.Mengzhou 454763China School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

Magnesium hydride(MgH_(2))is considered as an ideal hydrogen storage material with excellent hydrogen capacity,but the slow kinetics impedes its ***,an efficient additive of V2C MXene-anchored PrF_(3) nanoparticles(PrF_(3)/V_(2)C)was synthesized,which presents excellent catalytic effect in improving the reversibility and stability of hydrogen storage in MgH_(2).The initial dehydrogenation temperature of the 5 wt.% PrF_(3)/V_(2)C-containing MgH_(2)(182℃) is 105℃ lower than that of pure MgH_(2),and 6.5 wt.%hydrogen is rapidly released from 5 wt.%PrF_(3)/V_(2)C-added MgH_(2)sample in 6 min at 240℃.In addition,5 wt.%PrF_(3)/V_(2)C-containing MgH_(2) sample possesses outstanding reversible hydrogen storage capability of 6.5 wt.% after 10 cycles of dehydrogenation and *** analysis shows that the introduction of Pr improves the stability of V-species(V^(0)and V^(2+))and O-species(lattice oxygen(OL)and vacancy oxygen(OV))formed during ball milling,promotes the interaction between V-species and O-species,and enhances their reversibility,which contributes to the significant improvement in re/dehydrogenation reversibility and cycling stability of MgH_(2).This study provides effective ideas and strategies for the purpose of designing and fabricating high-efficient catalysts for solid-state hydrogen storage materials.

关键词： hydrogen storage materials MgH_(2) dehydrogenation reversibility cyclic stability

Water-involving transfer hydrogenation and dehydrogenation of N-heterocycles over a bifunctional MoNi_(4)electrode

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Chinese Journal of Catalysis 2021年第11期42卷 1983-1991页

作者： Mengyang Li Cuibo Liu Yi Huang shuyan han Bin Zhang Department of Chemistry School of ScienceInstitute of Molecular PlusTianjin UniversityTianjin 300072China Frontiers Science Center for Synthetic Biology(Ministry of Education) Tianjin Key Laboratory of Molecular Optoelectronic SciencesTianjian UniversityTianjin 300072China College of Chemistry Zhengzhou UniversityZhengzhou 450001HenanChina

A room-temperature electrochemical strategy for hydrogenation(deuteration)and reverse dehydrogenation of N-heterocycles over a bifunctional MoNi_(4)electrode is developed,which includes the hydrogenation of quinoxaline using H2O as the hydrogen source with 80%Faradaic efficiency and the reverse dehydrogenation of hydrogen-rich 1,2,3,4-tetrahydroquinoxaline with up to 99%yield and *** in situ generated active hydrogen atom(H^(*))is plausibly involved in the hydrogenation of quinoxaline,where a consecutive hydrogen radical coupled electron transfer pathway is ***,the MoNi_(4)alloy exhibits efficient quinoxaline hydrogenation at an overpotential of only 50 mV,owing to its superior water dissociation ability to provide H^(*)in alkaline *** situ Raman tests indicate that the Ni^(Ⅱ)/Ni^(Ⅲ)redox couple can promote the dehydrogenation process,representing a promising anodic alternative to low-value oxygen ***,electrocatalytic deuteration is easily achieved with up to 99%deuteration ratios using *** method is capable of producing a series of functionalized hydrogenated and deuterated quinoxalines.

关键词： Electrocatalysis Transfer hydrogenation Deuteration Water as the hydrogen source Bifunctional electrode

STUDY ON THE OPTIMIZATION OF TRANSPORT CONTROL POLICY IN COMMUNICATION NETWORK

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Journal of Electronics(China) 2010年第2期27卷 261-266页

作者： Fan shuyan han Weizhan Lu Ran School of Telecommunication Engineering Xidian University Xi＇an 710071 China The 54th Research Institute of CETC Shijiazhuang 050081 China

In communication networks with policy-based Transport Control on-Demand (TCoD) function,the transport control policies play a great impact on the network effectiveness. To evaluate and optimize the transport policies in communication network,a policy-based TCoD network model is given and a comprehensive evaluation index system of the network effectiveness is put forward from both network application and handling mechanism perspectives. A TCoD network prototype system based on Asynchronous Transfer Mode/Multi-Protocol Label Switching (ATM/MPLS) is introduced and some experiments are performed on it. The prototype system is evaluated and analyzed with the comprehensive evaluation index system. The results show that the index system can be used to judge whether the communication network can meet the application requirements or not,and can provide references for the optimization of the transport policies so as to improve the communication network effectiveness.

关键词： Communication network Comprehensive evaluation index system Network Application Effectiveness (NAE) Transport Control on-Demand (TCoD) Policy optimization

平肝活血方治疗肝郁瘀阻型失眠症伴记忆力减退的临床分析

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中国中医药现代远程教育 2019年第1期17卷 72-73页

作者：韩淑艳吉林省长春市双阳区中医院内科吉林长春130600

目的研究平肝活血方治疗肝郁瘀阻型失眠症伴记忆力减退的临床效果。方法选取2016年7月—2017年7月收治的80例失眠症伴记忆衰退患者,抽取40例作为对照组,另外40例作为观察组。对照组采用中成药乌灵胶囊治疗,观察组采用平肝活血方治疗。... 详细信息

目的研究平肝活血方治疗肝郁瘀阻型失眠症伴记忆力减退的临床效果。方法选取2016年7月—2017年7月收治的80例失眠症伴记忆衰退患者,抽取40例作为对照组,另外40例作为观察组。对照组采用中成药乌灵胶囊治疗,观察组采用平肝活血方治疗。对比治疗前后睡眠质量评分、相关电位P300认知电位改善情况。结果治疗前及治疗后2周睡眠质量评分对比差异无统计学意义(P>0.05)。治疗后4周及6周观察组均低于对照组,对比差异有统计学意义(P0.05),即观察组在改善潜伏期方面明显优于对照组。结论平肝活血方治疗肝郁瘀阻型失眠症伴记忆力减退具有显著效果,能使治疗效果得到提升,改善睡眠质量,值得临床推广。

关键词：平肝活血方失眠记忆衰退肝郁瘀阻型

数字普惠金融助力乡村振兴研究--以陕西省为例

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现代农业研究 2023年第7期29卷 24-26页

作者：韩淑妍孔令军熊湘辉冯若森陕西工商职业学院陕西西安710000

数字普惠性金融服务是近年来普惠金融服务蓬勃发展的高层次阶段,对乡村振兴进程有着巨大的推进意义。文章首先论述了数字普惠性金融服务对乡村振兴的巨大意义,然后研究了乡村振兴背景下数字普惠性金融服务建设面临的困难,并指出了对策... 详细信息

数字普惠性金融服务是近年来普惠金融服务蓬勃发展的高层次阶段,对乡村振兴进程有着巨大的推进意义。文章首先论述了数字普惠性金融服务对乡村振兴的巨大意义,然后研究了乡村振兴背景下数字普惠性金融服务建设面临的困难,并指出了对策。最后聚焦于陕西省,研究了陕西省数字普惠金融助力乡村振兴的现实情况。

关键词：数学普惠金融乡村振兴意义

受教育程度对于家庭风险性金融资产投资的影响

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华北金融 2020年第11期 58-69页

作者：韩淑妍浦发银行宁波分行浙江宁波市315000 南开大学金融学院天津市300353

本文利用中国家庭金融调查(CHFS)2017年的横截面数据,研究受教育程度对于家庭风险性金融资产①投资的影响。研究结果表明,第一,家庭中户主受教育程度每增加1年,家庭参与股市的概率随之增加1.1%,参与股票和基金的概率增加1.2%,同时,家庭... 详细信息

本文利用中国家庭金融调查(CHFS)2017年的横截面数据,研究受教育程度对于家庭风险性金融资产①投资的影响。研究结果表明,第一,家庭中户主受教育程度每增加1年,家庭参与股市的概率随之增加1.1%,参与股票和基金的概率增加1.2%,同时,家庭股票投资市值占总金融资产比例增加0.4%,股票和基金的市值占比增加0.5%。第二,家庭中子女的受教育程度对家庭风险性金融资产投资的影响具有异质性,其中,女儿受教育程度会对家庭风险性金融资产市值占比有正向影响,而儿子受教育程度则对家庭风险性金融资产投资没有显著影响。

关键词：受教育程度风险性金融资产家庭金融代际影响

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选择性隐藏树型访问结构的CP-ABE方案

计算机工程 2020年第7期46卷 150-158页

作者：韩舒艳努尔买买提·黑力力新疆大学数学与系统科学学院乌鲁木齐830046

隐藏访问结构是密文策略属性基加密(CP-ABE)的安全操作,可有效防止敏感信息泄露,而现有树型访问结构的CP-ABE方案为完全公开或完全隐藏访问结构,造成策略保密性差及加解密计算量较大。为此,提出一种选择性隐藏树型访问结构的CP-ABE方案... 详细信息

隐藏访问结构是密文策略属性基加密(CP-ABE)的安全操作,可有效防止敏感信息泄露,而现有树型访问结构的CP-ABE方案为完全公开或完全隐藏访问结构,造成策略保密性差及加解密计算量较大。为此,提出一种选择性隐藏树型访问结构的CP-ABE方案。使用互信息方法提取敏感属性特征,筛选和隐藏访问结构中含有原始属性集信息的部分属性,使选择隐藏与完全隐藏具有相同的保密效果。同时,以最少匹配代价判断用户解密能力,使无解密能力的用户尽早放弃解密。分析结果表明,与公开访问或完全隐藏访问结构方案相比,该方案的安全性更高且计算量更小。

关键词：密文策略属性基加密属性提取选择性隐藏互信息属性匹配访问控制