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Nano Research 2020年第6期13卷 1668-1676页

作者： Zhi-Jun li shuya li Andrew Hunter Davis Elan Hofman Gyu Leem Weiwei Zheng Department of Chemistry Syracuse UniversitySyracuseNY13244USA Department of Chemistry State University of New York College of Environmental Science and ForestrySyracuseNY13210USA The Michael M.Szwarc Polymer Research Institute SyracuseNY13210USA

Transition-metal ions doped nanocrystals(NCs),specifically Mn-doped NCs,hold great potential in the field of photocatalysis,especially,to improve photocatalytic performance for singlet oxygen(1O2)***,we report the design of a novel Mn-doped NC-based nanocomposites,specifically,silica-coated Mn-doped CdS/ZnS NCs decorated with Pt NCs(denoted as Mn-NCs@SiO2-Pt),which enhance photocatalytic 1O2 *** to the long-lived Mn excited state(on the order of ms),the energy-transfer between Mn-NCs and molecular oxygen is facilitated with the assistance of the Pt NCs adhered to the Mn-NC@SiO2 ***,the Mn-NCs@SiO2-Pt composites,integrate the advantages of Mn-doped NCs,a protective silica layer,and Pt NCs to exhibit excellent catalytic activity and selectivity for the selective oxidation of primary benzylic alcohols to aldehydes through an 1O2 engaged oxidation process under visible-light *** work paves the way for enhancing catalytic performance via facilitated energy transfer relaxation by utilizing the long-lived excited-state of Mn2+dopant ions in nanocomposites.

关键词： doped nanocrystals energy transfer photocatalysis singlet oxygen selective oxidation

Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours(RAISE):rationale and design of a multicentre,prospective,randomised,open-label,blinded-endpoint,controlled phase 3 non-inferiority trial

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Stroke & Vascular Neurology 2024年第5期9卷 568-573页

作者： shuya li Hong-Qiu Gu Hongguo Dai Guozhi Lu Yongjun Wang Department of Neurology and Department of Clinical Trial CenterBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Emergency Linfen Central HospitalShanxi ProvinceChina Department of Neurology Keshiketeng Banner Traditional Chinese Medicine Mongolian Medical HospitalThe Inner Mongolia autonomous regionChina

Background and purpose Reteplase is the third generation of alternative thrombolytic *** hypothesis that reteplase will be non-inferior to alteplase in achieving excellent functional outcome at 90 days among eligible patients with acute ischaemic *** and design Reteplase versus alteplase for acute ischaemic stroke within 4.5hours(RAISE)trial is a multicentre,prospective,randomised,open-label,blinded endpoint(PROBE),controlled phase 3 non-inferiority trial.A total of 1412 eligible patients will be randomly assigned to receive either reteplase at a dose of 18 mg+18mg or alteplase 0.9mg/kg at a ratio of 1:*** independent data monitoring committee will review the trail’s progress and safety *** outcomes The primary efficacy outcome of this study is proportion of individuals attaining an excellent functional outcome,defined as modified Rankin Scale(mRS)0–1 at 90 *** secondary efficacy outcomes encompass favourable functional outcome defined as mRS 0–2,major neurological improvement on the National Institutes of Health Stroke Scale,ordinal distribution of mRS and Barthel Index score of at least 95 points at 90 *** primary safety outcomes are symptomatic intracranial haemorrhage at 36 hours within 90 *** The RAISE trial will provide crucial insights into the selection of thrombolytic agents for stroke *** registration number NCT05295173.

关键词： centre endpoint random

Surface seasonal mass changes and vertical crustal deformation in North China from GPS and GRACE measurements

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Geodesy and Geodynamics 2020年第1期11卷 46-55页

作者： shuya li Wenbin Shen Yuanjin Pan Tengxu Zhang School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China

The Earth is an elastic body,and the surface mass loading changes will lead to elastic loading deformation on the surface of the *** this study,we investigated the surface seasonal mass changes and vertical crustal deformation in North China using the data obtained by the techniques of the Global Positioning System(GPS),Gravity Recovery and Climate Experiment(GRACE)and Surface Loading Models(SLMs).The seasonal annual signal and semi-annual signal obtained by the three techniques show strong *** average value of the weighted root-mean-square(WRMS)of the all 30 sites is 58%after deducting the GRACE-obtained vertical deformation from the GPS-derived vertical ***,the consistency of results between GPS and SLMs is not so good,with a 31%mean WRMS reduction,due to the fact that the global SLMs perform not well in North *** GRACEmeasured long-term trend is deducted from the GPS-obtained vertical rates to reveal the crustal displacement caused by the underground factors such as tectonic movement and groundwater in North *** results show that the rates of stations HECX and TJBH are very large,more than 10 mm/yr,which suggests that the surface subsidence is caused by excessive exploitation of groundwater.

关键词： Continuous GPS measurement GRACE measurement Surface Loading Models Seasonal mass changes Vertical crustal displacement

Tenecteplase versus alteplase for acute ischaemic stroke:a meta-analysis of phaseⅢrandomised trials

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Stroke & Vascular Neurology 2024年第4期9卷 360-366,I0001-I0021页

作者： Yunyun Xiong liyuan Wang Guangshuo li Kai-Xuan Yang Manjun Hao shuya li Yuesong Pan Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Chinese Institute for Brain Research BeijingChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina

Background Tenecteplase(TNK)was found non-inferior to alteplase in recent clinical *** aimed to elucidate the efficacy and safety of TNK versus alteplase for acute ischaemic stroke(AIS).Methods Systematic literature search and a meta-analysis of phaseⅢclinical trials in ischaemic stroke patients with TNK use were *** primary outcome was excellent functional outcome which was defined as modified Rankin Scale score of 0–1 at 90 days and safety outcomes included symptomatic intracerebral haemorrhage and death at 90 *** used random-effects model to estimate the pooled risk difference and 95%CI in R package‘Meta’.The included trials were adapted to the non-inferiority analysis with a margin of-4%.Results Three trials enrolling 4094 patients were identified by systematic *** trials included AIS patients within 4.5hours time ***-analysis indicated that 1089(53.0%)of 2056 patients in the TNK arm and 1016(50.5%)of 2012 in the alteplase arm had excellent functional outcome at 90 days(0.03(95%CI-0.00 to 0.06);I^(2)=0%),meeting the prespecified non-inferiority *** TNK thrombolysis was not correlated with increased risk of symptomatic intracerebral haemorrhage(0.00(95%CI-0.01 to 0.01);I^(2)=0%)or death(0.01(95%CI-0.01 to 0.02);I^(2)=0%)at 90 *** sensitivity analysis with the 0.25mg/kg trials exclusively showed similar results to the main *** TNK was non-inferior to alteplase for achieving excellent functional outcome at 90 days without increasing the safety concern in treating patients with *** findings suggest that TNK can be an alternative to alteplase.

关键词： analysis random phase

Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design

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Stroke & Vascular Neurology 2022年第1期7卷 71-76页

作者： shuya li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao li Yuesong Pan Yongjun Wang China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Medicine and Neurology University of MelbourneMelbourneVictoriaAustralia Department of Neurology and Comprehensive Stroke Center Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology Liverpool HospitalSouth Western Sydney Clinical SchoolSydneyNew South WalesAustralia

Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke *** and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority *** eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 *** considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day *** outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 *** efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke *** outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any *** There is no completed registration study of TNK in AIS *** Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China.

关键词： infusion acute rational

Safety and efficacy of tenecteplase versus alteplase in patients with acute ischaemic stroke (TRACE): a multicentre, randomised, open label, blinded-endpoint (PROBE) controlled phase II study

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Stroke & Vascular Neurology 2022年第1期7卷 47-53页

作者： shuya li Yuesong Pan Ziran Wang Zhigang liang Huisheng Chen Dong Wang Yi Sui Xingquan Zhao Yilong Wang Wanliang Du Huaguang Zheng Yongjun Wang China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalBeijingChina Department of Neurology Beijing Tiantan HospitalBeijingChina Department of Neurology Linyi People's HospitalLinyiChina Department of Neurology Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical CollegeYanTaiChina Department of Neurology General Hospital of Northern Theatre CommandShenyangLiaoningChina Department of Neurology Baogang Hospital of Inner MongliaInner MongliaChina Department of Neurology The First People’s Hospital of ShenyangShenyangChina Neurology Beijing Tiantan HospitalBeijingChina

Background Tenecteplase(TNK)possesses several pharmacological characteristics superior to conventional alteplase(rt-PA),with well-established safety and efficacy profile in *** exists controversy over the optimal dose of intravenous rt-PA for East Asians with acute ischaemic stroke(AIS).Current study aimed to determine the safety dose range of recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)for patients with AIS in *** This multicentre,prospective,randomised,open-label,blinded end-point,phase II study compared three tiers of 0.1,0.25,0.32 mg/kg rhTNK-tPA(to a maximum of 40 mg)with standard 0.9 mg/kg rt-PA(to a maximum of 90 mg)in patients who were eligible for intravenous *** safety outcome were symptomatic intracranial haemorrhage(sICH)within 36 *** Between May 2018 and February 2020,240 patients were randomly assigned to four group,4 of whom did not receive study *** intention-to-treat analysis included 236 *** was no difference in the improvement on National Institutes of Health Stroke Scale at day 14 in the 3 tiers and control group(63.3%,77.2%,66.7%vs 62.7%).The number of sICH was 3 of 60(5.0%)in the 0.1 mg/kg group,none in the 0.25 mg/kg group,2 of 60(3.3%)in the 0.32 mg/kg group and 1(1.7%)of 59 in the rt-PA *** were no significant between-group differences in severe adverse *** Similar to the Caucasians,rhTNK-tPA was well tolerated in Chinese patients with AIS at all doses administered within 3 hours of symptom *** dose-efficacy profile of rhTNK-tPA needs to be established with future investigations.

关键词： patients doses centre

High Magnetic Property and Toxicity of Particulate Matter Generated during Welding and Cutting Processes

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Environment & Health 2024年第6期2卷 381-389页

作者： Wei Cui Zizhen Ma Yuanzheng Chen shuya li Di Wu Xiu Chen Yuankai Shao Yuzhe liu Qing li Jianmin Chen Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266520China Shanghai Institute of Eco-Chongming(SIEC) Shanghai 200062China National Engineering Laboratory for Mobile Source Emission Control Technology China Automotive Technology&Research Center Co.LtdTianjin 300300China

Magnetic particulate matter(PM)has raised increasing concern due to its abundant presence in ambient air and negative health ***,there is still a lack of comprehensive understanding of their emission sources and *** here report the observation of high magnetic property and toxicity of PM generated during typical welding and cutting ***,formed during high-temperature operation with less oxygen pressure,was revealed to be the major magnetic *** averaged saturation magnetization and magnetic susceptibility values of fine PM(PM_(2.5))from welding processes are 1.4−4.2 times greater than those of PM emitted from other unintended emission sources,including iron and steel plants and brake wear,while they are 2.0−5.7 times greater for the cutting ***,PM_(2.5)from welding and cutting processes are nearly 3.5−4.5 times more neurovirulent and 2.1−7.0 times more likely to induce oxidative stress than those from other magnetic sources in the nerve cells ***,all of these magnetic PM_(2.5)exhibit greater negative health effects than typical atmospheric PM_(2.5)collected in Shanghai urban *** new findings suggest that appropriate occupational protection measures should be implemented for the welding and cutting process to reduce adverse health impacts.

关键词： pollutant emission magnetic property particulate matters magnetite welding and cutting

Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2

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Protein & Cell 2021年第9期12卷 734-740页

作者： Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu shuya li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin li Fengcai Zhu Xiaokun Shen Haitao li Pilong li Jianyang Zeng Institute for Interdisciplinary Information Sciences Tsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Structural Biology Frontier Research Center for Biological Structure School of Life SciencesTsinghua UniversityBeijing 100084China Winghua-Peking Center for life Sciences Tsinghua UniversityBeijing 100084China Silexon Al Technology Co. LtdNanjing 210033China NHC Key Laboratory of Enteric Pathogenic Microbiology Jiangsu Provincial Center for Diseases Control and PreventionNanjing 210009China Bioinformatics Division BNRIST/Department of Computer Science and TechnologyTsinghua UniversityBeijing 100084China Protein Preparation and Identification Facility Technology Center for Protein ScienceTsinghua UniversityBeijing 100084China Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Center for Global Health Nanjing Medical UniversityNanjing 210009China Convalife(Shanghai)Co. LtdShanghai 201203China Ministry of Education Key Laboratory of Protein Sciences Beijing Advaneed Innovation Center for Structural BiologyBeijing Frontier Research Center for Biological StructureDepartment of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijing 100084China

Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA *** nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020).

关键词： respiratory acute therapeutic

三种淡漠量表在初筛为轻度认知功能障碍老年人知情者中的应用分析

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中华神经科杂志 2018年第5期51卷 342-348页

作者：李树亚李峥北京协和医学院护理学院 100144

目的对里尔淡漠评定量表-知情者版（LARS-i）、淡漠评定量表-知情者版（AES-I）、神经精神问卷-淡漠亚量表（NPI-Apathy）在初筛为轻度认知功能障碍（MCI）老年人知情者中的应用结果进行比较分析,为淡漠表现的测评提供参考依据.方法使... 详细信息

目的对里尔淡漠评定量表-知情者版（LARS-i）、淡漠评定量表-知情者版（AES-I）、神经精神问卷-淡漠亚量表（NPI-Apathy）在初筛为轻度认知功能障碍（MCI）老年人知情者中的应用结果进行比较分析,为淡漠表现的测评提供参考依据.方法使用LARS-i、AES-I、NPI-Apathy对181名社区初筛为MCI老年人的家属进行调查,并采用相关性分析法、受试者工作特征曲线对比分析法对3种淡漠量表进行对比分析.结果对于初筛为MCI的老年人,中文版量表LARS-i、AES-I分别选取-16分、33分为界值时,对应量表的敏感度、特异度较高,分别为72.00％、65.38％和75.31％、75.76％.中文版量表LARS-i得分与AES-I得分、AES-I得分与NPI-Apathy得分间存在正相关关系（r =0.566、0.388,均P＜0.01）;AES-I、NPI-Apathy得分与老年抑郁量表（GDS）得分间存在正相关关系（r =0.250、0.169,均P＜0.05）,LARS-i得分与GDS得分无相关关系;LARS-i、AES-I得分与MoCA得分呈负相关关系（r=-0.232、-0.239,均P＜0.01）,NPI-Apathy得分与MoCA得分无相关关系;量表AES-I与LARS-i测评的淡漠发生情况类似（分别为94例、81例）,多于NPI-Apathy测评所得的淡漠例数（25例）.结论中文版量表LARS-i与AES-I在初筛为MCI老年人知情者中的应用结果类似,优于NPI-Apathy,且LARS-i对淡漠、抑郁表现有一定的区分度.

关键词：认知障碍情感淡漠评价研究

ABO sequence analysis in an AB type with anti-B patient

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Chinese Medical Journal 2014年第5期127卷 971-972页

作者： Chen Qing Xiao Jianyu Wang shuya li Jiahuang Du Leilei Lu Le Huang Chengyin li Min li Ping Jiangsu Province Blood Center Nanjing Jiangsu 210042 China Soochow University Suzhou Jiangsu 215007 China

ABO blood group system is the first to be discovered and the most clinically important in transfusion medicine.1The ABO gene encodes a glycosyltransferase which synthesize the oligosaccharide *** difference between the consensus A gene （A101 allele） usually used as the reference and the consensus B gene （B101 allele） are 7 in-frame single nucleotide polymorphisms （SNPs）,among which only 4 alleles cause amino acid mutations in the *** A allele was inherited from one parent and B allele was inherited from the other which produced the AB blood group,this is known as ***-AB is characterized as mutant ABO alleles encoding a glycosyltransferase capable of synthesizing both A and B antigens which is very rare.

关键词： ABO blood group system cis-AB ABO discrepancy genotype