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人工智能技术在煤矿巷道水雾除尘设备的应用探究

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陕西煤炭 2024年第6期43卷 157-160页

作者：王辉谷廷华刘述勋山东鼎安检测技术有限公司山东济南250031 济宁市金桥煤矿山东济宁272200

煤矿巷道是粉尘积聚和扩散的主要场所,对煤矿生产安全及矿工的健康造成严重影响,传统的巷道水幕除尘设备存在效果不佳、能耗较高等问题。人工智能技术在煤矿安全领域的应用日益受到关注,巷道水幕除尘设备变得更加智能化、高效化和可靠... 详细信息

煤矿巷道是粉尘积聚和扩散的主要场所,对煤矿生产安全及矿工的健康造成严重影响,传统的巷道水幕除尘设备存在效果不佳、能耗较高等问题。人工智能技术在煤矿安全领域的应用日益受到关注,巷道水幕除尘设备变得更加智能化、高效化和可靠化。首先介绍了人工智能技术的概念和发展,以及其在社会、经济、医疗、交通、教育等方面的应用前景。然后,分析了目前传统的巷道水雾除尘设备的应用现状和存在的局限性。最后,基于人工智能技术,提出了巷道水雾除尘设备的改进方向,包括智能监测与控制、数据分析与优化、自适应控制等。同时,探究了人工智能技术应用在智能水雾喷洒系统、智能风机控制系统和数据监测与分析系统中的效果。

关键词：人工智能技术煤矿巷道除尘设备水雾设备维护

Intracellular HSP70L1 inhibits human dendritic cell maturation by promoting suppressive H3K27me3 and H2AK119Ub1 histone modifications

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Cellular & Molecular Immunology 2020年第1期17卷 85-94页

作者： Lin Yi Zhiqing Li Tianju Hu Juan liu Nan Li Xuetao Cao shuxun liu National Key Laboratory of Medical Immunology&Institute of Immunology Second Military Medical University200433ShanghaiChina Department of Immunology&Center for Immunotherapy Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical Sciences100005 BeijingChina

Epigenetic regulation has been attracting increasing attention due to its role in cell differentiation and ***,the epigenetic mechanisms that regulate human dendritic cell(DC)differentiation and development remain poorly *** previous studies show that extracellular heat shock protein 70-like protein(HSP70L1)is a potent adjuvant of Th1 responses via stimulating DCs when released from cells;however,the role of intracellular HSP70L1 in DC differentiation and maturation remains ***,we demonstrate that intracellular HSP70L1 inhibits human DC maturation by suppressing MHC and costimulatory molecule expression,in contrast to the adjuvant activity of extracellular *** stability of intracellular HSP70L1 is dependent on DNAJC2,a known epigenetic ***,intracellular HSP70L1 inhibits the recruitment of Ash1l to and maintains the repressive H3K27me3 and H2AK119Ub1 modifications on the promoter regions of costimulatory,MHC and STAT3 ***,intracellular HSP70L1 is an inhibitor of human DC *** results provide new insights into the epigenetic regulation of cell development by intracellular HSP70L1.

关键词： HSP70L1 DNAJC2 Monocyte-derived dendritic cell Histone modification H3K27me3 H2AK119Ub1 H3K4me3

HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer

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Cellular & Molecular Immunology 2018年第2期15卷 135-145页

作者： shuxun liu Lin Yi Ma Ling Jinxia Jiang Lijun Song Juan liu Xuetao Cao National Key Laboratory of Medical Immunology Institute of ImmunologySecond Military Medical UniversityShanghai200433China Department of Immunology National Key Laboratory of Medical Molecular BiologyChinese Academy of Medical SciencesBeijing100730China

Heat-shock protein(HSP)-based immunotherapy is established on its adjuvant effects when applied via an extracellular approach to pulse and activate dendritic cells(DCs).Our previous studies indicate that DCs pulsed with recombinant fusion proteins of antigenic fragment and HSP70-like protein 1(HSP70L1)are potent in stimulating antigen-specific Th1 *** herein evaluated the cytotoxic T cell(CTL)response by an intracellular approach of priming DCs with transfection of recombinant adenovirus-expressing the fusion gene of the 576–699 fragment of carcinoembryonic antigen(CEA)and *** compared with DCs pulsed with extracellular fusion protein,the DCs transfected with recombinant adenovirus expressing the fusion gene displayed equivalent mature phenotypes but less inflammatory ***,the transfected DCs were superior to the pulsed DCs in inducing CEA-specific ***,immunization of HLA-A2.1/H-2Kb transgene mice with the transfected DCs could induce more quantities of HLA-A2.1-restricted CEA-specific CTLs,protecting nude mice more significantly from human CEA-expressing colon tumor challenge when adoptively *** investigation indicated that intracellular expression of the fusion protein empowered the transfected DCs by activation of STAT1 possibly via inducing IFN-βand ERK ***,the more potent ability to induce anti-CEA CTL responses enables the DCs,which transfected with recombinant adenovirus expressing the fusion gene of antigenic CEA fragment and Th1 adjuvant,as an alternative promising approach for the immunotherapy of CEA-positive tumors.

关键词： CTL dendritic cell HSP70L1 immunotherapy

Correction: HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer

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Cellular & Molecular Immunology 2020年第1期17卷 108-109页

作者： shuxun liu Lin Yi Ling Ma Jinxia Jiang Lijun Song Juan liu Xuetao Cao National Key Laboratory of Medical Immunology Institute of Immunology Second Military Medical University Shanghai 200433 China. liusx@***. National Key Laboratory of Medical Immunology Institute of Immunology Second Military Medical University Shanghai 200433 China. Department of Tumor Ningxia People's Hospital Yinchuan China. National Key Laboratory of Medical Immunology Institute of Immunology Second Military Medical University Shanghai 200433 China. caoxt@***. National Key Laboratory of Medical Molecular Biology Department of Immunology Chinese Academy of Medical Sciences Beijing 100730 China. caoxt@***.

In the published version of Fig.3D,the data of the CH and AdCtrl groups in the CFSE-Lovo/Medium panel were mistakenly presented with incorrected *** 3D has now been *** corrected version of Figure 3 is shown *** we regret our mistake during figure assembly and would like to apologize for any inconvenience it may have caused,we did not manipulate our data in any *** unintentional error also has no bearing on the workʼs scientific conclusions.

关键词： HSP70 Figure vaccination

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台阶型煤体孤岛开采自然发火防治技术应用

陕西煤炭 2024年第8期43卷 141-145页

作者：梁东辉曲柱谷廷华刘述勋济宁市金桥煤矿山东济宁272200 济宁矿业集团山东济宁272000

金桥煤矿1306工作面四面临空,孤岛布置,分层开采,上分层存在遗留煤柱,形成了特殊的“台阶型”构造。针对1306工作面漏风通道多,自然发火风险较大的实际,分正常回采、回撤2个阶段制定针对性防灭火措施。回采期间采取了沿空喷涂、采空区... 详细信息

金桥煤矿1306工作面四面临空,孤岛布置,分层开采,上分层存在遗留煤柱,形成了特殊的“台阶型”构造。针对1306工作面漏风通道多,自然发火风险较大的实际,分正常回采、回撤2个阶段制定针对性防灭火措施。回采期间采取了沿空喷涂、采空区注氮、停采线及采空区压注凝胶、遗煤喷洒阻化剂等措施,回撤期间重点采取了架后压注凝胶措施。通过对安全监控系统、采空区微漏风监测系统及人工检测数据进行耦合性分析,对1306工作面防灭火效果进行验证,得出1306工作面防灭火措施落实得当,肯定了台阶型煤体孤岛开采自然发火防治技术的成效。该技术能够为后续不规则工作面防灭火工作提供技术支撑,对类似开采条件的矿井有一定的借鉴作用。

关键词：台阶型煤体孤岛开采防灭火采空区注氮压注凝胶漏风通道

Cloning and Characterization of DULP,a Novel Ubiquitin-Like Molecule from Human Dendritic Cells

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Cellular & Molecular Immunology 2009年第1期6卷 27-33页

作者： Guoyan liu shuxun liu Ping Li Ling Tang Yanmei Han Huazhang An Jiangyan Li Xiankun Dai Nan Li Xuetao Cao Yizhi Yu Institute of Immunology and State Key Laboratory of Medical Immunology Second Military Medical University Shanghai 200433 China Guoyan liu and shuxun liu contributed equally to this study

We identified a novel ubiquitin-like molecule DULP from human dendritic cells. DULP contains a domain that shares 26% identity and 34% similarity with ubiquitin, and it possesses the corresponding Ile-44 hydrophobic patch used by mono- or poly-ubiquitin to interact with a ubiquitin-interaction motif （UIM） or ubiquitin-associated domain （UBA）. Lysine residue corresponding to 6 of ubiquitin, which is involved in the formation of a multi-ubiquitin chain that can bind proteasomal subunit Rpn10/S5a, is also conserved in its ubiquitin-homology domain. However, DULP does not possess the highly conserved C-terminus Gly-Gly required for ubiquitin conjugation or the Lys-48 required for the formation of polyubiquitin chain to target substrates for degradation, suggesting it might be a novel ubiquitin-domain protein （UDP）. DULP was found widely expressed in many cells and the ubiquitin-homology domain was not cleaved. We also confirmed that DULP expression was enriched in the nucleus and much weaker in the cytosol. Besides, we found that overexpression of DULP in 293T cells induced apoptosis, which might not be associated with the mitochondrial or proteasome pathway, with the specific mechanism remain unclear. Further investigations are needed to identify the precise biological functions of DULP. Cellular ＆ Molecular Immunology.

关键词： ubiquitin-like protein dendritic cell molecular cloning apoptosis

Electron theory study on mechanism of action of cobaltin Fe-Co-Cr based high-alloy steel

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Chinese Science Bulletin 2003年第2期48卷 208-210页

作者： LI Peijie, XIONG Yuhua, liu shuxun & ZENG DabenDepartment of Mechanical Engineering, Tsinghua University, Beijing100084, China Department of Mechanical Engineering Tsinghua University Beijing 100084 China

The valence electron structure of martensite in Fe-Co-Cr based high-alloy steel is calculated using the em-pirical electron theory of solids and molecules (EET). The results show that the incorporation of cobalt leads to a rise in nA from 0.3835 to 0.4684, which enhances the bonding forces between atoms in a-Fe matrix. Meanwhile, the incorporation of Co changes the valence electron structure of segregated structure units formed by C and other alloying elements, and increases nA for the segregated units containing C-Me sig-nificantly, resulting in changing the precipitation behavior of the secondary phases during tempering and strengtheningthe resistance to tempering.

关键词：钴价电子结构碳铁固溶体相互作用 Fe-Co-Cr基高合金钢电子理论

A modified HLA-A^(*)0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses

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Cellular & Molecular Immunology 2018年第8期15卷 768-781页

作者： Weihong Sun Junyi Shi Jian Wu Junchu Zhang Huabiao Chen Yuanyuan Li shuxun liu Yanfeng Wu Zhigang Tian Xuetao Cao Nan Li National Key Laboratory of Medical Immunology and Institute of Immunology Second Military Medical UniversityShanghai 200433China Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China Biotherapy Center The Affiliated Central Hospital of Qingdao UniversityQingdao 266042China Department of Surgery Changhai HospitalShanghai 200433China Department of Surgery Changzheng HospitalShanghai 200003China Shanghai Center for Bioinformation Technology Shanghai 201203China Institute of Immunology School of Life Sciences and Medical CenterUniversity of Science and Technology of ChinaHefei 230027China National Key Laboratory of Medical Molecular Biology and Department of Immunology Chinese Academy of Medical SciencesBeijing 100005China

We previously identified human phosphatidylethanolamine-binding protein 4(hPEBP4)as an antiapoptotic protein with increased expression levels in breast,ovarian and prostate cancer cells,but low expression levels in normal tissues,which makes hPEBP4 an attractive target for ***,we developed hPEBP4-derived immunogenic peptides for inducing antigen-specific cytotoxic T lymphocytes(CTLs)targeting breast cancer.A panel of hPEBP4-derived peptides predicted by peptide-MHC-binding algorithms was evaluated to characterize their HLAA2.1 affinity and *** identified a novel immunogenic peptide,P40–48(TLFCQGLEV),that was capable of eliciting specific CTL responses in HLA-A2.1/K^(b) transgenic mice,as well as in peripheral blood lymphocytes from breast cancer ***,amino-acid substitutions in the P40–48 sequence improved its immunogenicity against hPEBP4,a self-antigen,thus circumventing *** designed peptide analogs by preferred auxiliary HLA-A^(*)0201 anchor residue replacement,which induced CTLs that were crossreactive to the native *** analogs were able to stably bind to HLA-A^(*)0201 and elicit specific CTL responses better than the native ***,adoptive transfer of CTLs induced by vaccination with two analogs more effectively inhibited tumor growth than the native *** data indicate that peptide analogs with high immunogenicity represent promising candidates for peptide-mediated therapeutic cancer vaccines.

关键词： breast cancer cytotoxic T lymphocytes dendritic cells immunotherapy peptide epitope

Research on welding deformation control technology of battery electric vehicle framed aluminum body

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Progress in Natural Science:Materials International 2024年第1期34卷 108-121页

作者： Bo liu Jian Yang Jia Li Xiaolin Liao Qin Yang Jinsheng Zhang Tiegang Hu shuxun Jiang School of Mechanical Engineering University of Science and Technology Beijing Chongqing Industry Polytechnic College Global R&D Center Chongqing Changan Automobile Co. Ltd Farizon New Energy Commercial Vehicle Group

The welding process of aluminum(Al) alloy car body has problems such as poor weld quality, low welding co-efficient, and large welding deformation. This paper mainly focuses on material accuracy design, lap structure design, simulation, and process manufacturing to break through the precision control problems caused by welding deformation of battery electric vehicle Al alloy car body. First, the 209 key functional dimensional chains of Al body-in-white are analyzed and decomposed to component and profile tolerance dimensions step by ***, the differences of vertical butt, bevel butt, and plug structures are studied and joint matching is implemented in a targeted manner. Subsequently, through welding deformation simulation analysis and welding sequence optimization, the body-in-white welding process and tooling fixtures are guided and designed to ensure that the dimensional accuracy of the Al body is controlled to ±2 mm in all aspects. Finally, the design of the whole vehicle arrangement of mechanical, human-machine, and major components is carried out, and an all-Al framed battery electric vehicle lightweight platform with different sizes and ranges is innovatively created. The difficulties such as the contradiction between power battery size and arrangement space, unreasonable arrangement position, and load distribution are solved.

关键词： Aluminum alloy Frame structure Welding deformation simulation Dimensional accuracy control Battery electric vehicle lightweight platform