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Antibacterial and cytotoxic metabolites produced by Streptomyces tanashiensis BYF-112 isolated from Odontotermes formosanus

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Chinese Journal of Natural Medicines 2024年第9期22卷 822-830页

作者： WU Jun SONG Tao zhang Le HUANG Zhongdi HUANG Fang YIN Caiping zhang shuxiang LIU Xinhua zhang Yinglao School of Life Science Anhui Agricultural UniversityHefei 230036China School of Pharmacy Anhui Medical UniversityHefei 230036China

Chemical investigations of the termite-associated Streptomyces tanashiensis BYF-112 resulted in the discovery of four novel alkaloid derivatives: vegfrecines A and B(1 and 2), exfoliazone A(3), and venezueline H(7), in addition to nine known metabolites(4-6, 8-13). The structures of these compounds were elucidated through comprehensive spectroscopic analysis and comparison with existing literature data. Antibacterial assays revealed that viridomycin A(11) exhibited potent antibacterial activity against Staphylococcus aureus, with a zone of inhibition(ZOI) of 12.67 mm, in comparison to a ZOI of 17.67 mm for the positive control gentamicin sulfate. Viridomycin A(11) showed moderate activity against Micrococcus tetragenus and Pseudomonas syringae pv. actinidae, with ZOI values of 15.50 and 14.33 mm, respectively, which were inferior to those of gentamicin sulfate(34.67 and 24.00mm). Viridomycin F(12) also exhibited moderate antibacterial effects against S. aureus, M. tetragenus, and P. syringae pv. actinidae,with ZOI values of 8.33, 16.50, and 10.83 mm, respectively. Cytotoxicity assays demonstrated that viridobruunine A(5), exfoliazone(6), viridomycin A(11), and X-14881E(13) exhibited significant cytotoxicity against human malignant melanoma(A375), ovarian cancer(SKOV-3), and gastric cancer(MGC-803) cell lines, with IC_(50) values ranging from 4.61 to 19.28 μmol·L^(-1). Furthermore, bioinformatic analysis of the complete genome of S. tanashiensis suggested a putative biosynthetic gene cluster(BGC) responsible for the production of compounds 1-12. These findings indicate that the secondary metabolites of insect-associated S. tanashiensis BYF-112hold promise as potential sources of novel antibacterial and anticancer agents.

关键词： Odontotermes formosanus Streptomyces tanashiensis Alkaloid Cytotoxic activity Antibacterial activity Biosynthetic pathway

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当归在神经退行性疾病中的研究进展

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中国实验方剂学杂志 2024年第14期30卷 279-287页

作者：宋蔚宁刘树民王萌影田伟张淑香黑龙江中医药大学研究生院哈尔滨150040 黑龙江中医药大学中医药研究院哈尔滨150040 黑龙江中医药大学附属第一医院哈尔滨150040

神经退行性疾病是由于中枢神经系统细胞和组织发生变性和功能障碍所导致的一组疾病,主要包括阿尔兹海默病(AD)、帕金森病(PD)、癫痫等神经系统慢性疾病,这些疾病的临床表现均为认知功能下降。神经退行性疾病多发于老年人,随着人口老龄... 详细信息

神经退行性疾病是由于中枢神经系统细胞和组织发生变性和功能障碍所导致的一组疾病,主要包括阿尔兹海默病(AD)、帕金森病(PD)、癫痫等神经系统慢性疾病,这些疾病的临床表现均为认知功能下降。神经退行性疾病多发于老年人,随着人口老龄化的问题日益突出,神经退行性疾病逐渐成为大家关注的焦点,且严重影响着人类的健康和生活质量。神经退行性疾病的发病机制非常复杂,主要与线粒体功能障碍、细胞凋亡、神经毒素蛋白、神经递质异常、氧化应激和炎症反应等因素有关。市面上的西药虽能改善神经退行性疾病的症状,但不良反应大,不利于患者长期服用。中药当归最早被记载于《神农本草经》,具有活血补血、免疫调节、调经止痛等功效,研究发现其有效成分可以抑制神经退行性疾病的发病机制,对神经退行性疾病有一定的治疗作用。该文总结了近10年当归及其复方在神经退行性疾病中的作用,以期为当归在今后神经退行性疾病中的应用和研究提供参考。

关键词：当归活性成分复方神经退行性疾病研究进展

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Constructing nanocomposites with robust covalent connection between nanoparticles and polymer for high discharged energy density and excellent tensile properties

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Journal of Energy Chemistry 2022年第5期31卷 195-205页

作者： Jiachen Ma Yabin zhang Yan zhang Luqing zhang shuxiang zhang Xuchuan Jiang Hong Liu Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022ShandongChina Institute for Advanced Interdisciplinary Research University of JinanJinan 250022ShandongChina State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongChina Institute for Smart Materials&Engineering University of JinanJinan 250022ShandongChina

High discharged energy density and excellent flexible properties in dielectric materials are significantly sought to meet the rapid advancements in the electronics industry. In this study, covalent bonds are constructed between poly(vinylidene fluoride-chlorotrifluoroethylene), which contains olefinic bonds, and thiol-modified BaTiO_(3) at the interface before the nanocomposite films are fabricated. The presence of the covalent bonds is proved to promote the dispersibility of the modified BaTiO_(3) and enhance the interfacial adhesion between the modified BaTiO_(3) and the polymer, followed by a remarkably positive effect in suppressing the dielectric loss(tanδ) and increasing the breakdown strength(Eb) of the nanocomposite films. In addition, the cross-linking treatment in the preparation process is found to be favourable for improving the mechanical properties of the nanocomposite films, which benefits the enhancement of Eb. Furthermore, at 400% elongation, the stretched nanocomposite film doped with 5 vol% modified BaTiO_(3) exhibits an Eb15.6% greater than that of the unstretched film, and the discharged energy density reaches 11.4 J/cm^(3) with a high discharge energy efficiency of 84.5%. This study provides a novel strategy for preparing flexible nanocomposites with powerful interfacial adhesion at high filler content to achieve high discharged energy density.

关键词： Dielectric materials Energy density Mechanical properties Interfacial adhesion Breakdown strength

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针灸联合健脾滋肾汤治疗系统性红斑狼疮临床观察

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中国中医药现代远程教育 2024年第22期22卷 156-158页

作者：张淑香杨检生江西省于都县中医院中医内科江西于都342300 江西省于都县人民医院普外科江西于都342300

目的探讨针灸联合健脾滋肾汤治疗系统性红斑狼疮的效果。方法回顾性分析于都县中医院于2020年6月—2022年6月收治的66例系统性红斑狼疮患者,以治疗方案的不同作为分组依据,将32例采用常规西药(泼尼松+硫酸羟氯喹)治疗的患者纳入常规组... 详细信息

目的探讨针灸联合健脾滋肾汤治疗系统性红斑狼疮的效果。方法回顾性分析于都县中医院于2020年6月—2022年6月收治的66例系统性红斑狼疮患者,以治疗方案的不同作为分组依据,将32例采用常规西药(泼尼松+硫酸羟氯喹)治疗的患者纳入常规组,34例应用常规治疗+针灸联合健脾滋肾汤治疗的患者则归为研究组。治疗3个月后,比较两组C反应蛋白(CRP)、红细胞沉降率(ESR)以及补体C_(3)、C_(4)水平,同时对比中医证候积分,对临床疗效开展评估。结果治疗后,研究组CRP、ESR水平低于常规组,补体C_(3)、C_(4)水平高于常规组(P<0.05);研究组高热面赤、斑疹鲜红、肌肉关节酸痛评分均较常规组低(P<0.05)。研究组治疗总有效率为97.06%(33/34),高于常规组的81.25%(26/32)(P<0.05)。结论针灸联合健脾滋肾汤治疗系统性红斑狼疮,可实现生化指标的改善,有助于缓解机体炎症状态,改善免疫功能,对中医证候积分的降低有重要意义,效果确切。

关键词：温毒发斑系统性红斑狼疮针灸疗法健脾滋肾汤中西医结合疗法

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《金匮要略》痰饮病探微

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河南中医 2024年第8期44卷 1135-1139页

作者：张淑香党辉孙士玲河南中医药大学第一附属医院河南郑州450001

痰饮病为张仲景首创,症状多样,饮因于湿,在肺则咳,在胸则痞,在胃则呕,在胁则胀,在肠则泻,在肌肤则肿,在四肢经络则痹,弦脉为其主脉,临床中凡新病脉衰者为难治,久病脉盛者多不治。其总属本虚标实之证,病程日久,常有寒热虚实之间的相互转... 详细信息

痰饮病为张仲景首创,症状多样,饮因于湿,在肺则咳,在胸则痞,在胃则呕,在胁则胀,在肠则泻,在肌肤则肿,在四肢经络则痹,弦脉为其主脉,临床中凡新病脉衰者为难治,久病脉盛者多不治。其总属本虚标实之证,病程日久,常有寒热虚实之间的相互转化,且饮积可生痰,痰瘀互结,病情更加缠绵,若肾虚开阖不利,更可出现凌心、射肺等重证。治疗以“病痰饮者,当以温药和之”为总则,气和则化,气偏则结,借温热以伸其阳,痰饮阴邪则得祛也。可从痰饮病脉、痰饮病症、痰饮病方、痰饮病与水气病四个方面全面把握,根据标本虚实,表里寒热,脉证合参,分别采用温化、发汗、利小便、助水等法治疗。

关键词：痰饮病痰饮病脉痰饮病症痰饮病方水气病《金匮要略》张仲景

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In situ formation of nanometer-scale TiO_2/SiC functional compositional film on carbon fiber

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Science China(Technological Sciences) 2005年第1期48卷 53-60页

作者： ZHOU Chunhua YIN Yansheng zhang shuxiang LIU Wei College of Chemistry Chemical Engineering Jinan University Jinan 250022 China College of Material Science and Technologe Ocean University of China Qingdao 266003 China College of Chemistry Chemical Engineering Jinan University Jinan 250022 China College of Material Science and Technologe Ocean University of China Qingdao 266003 China College of Material Science and Technologe Ocean University of China Qingdao 266003 China

In the toluene solution of the precursor Polycarbosilane (PCS) containing low- molecular-mass additive Ti(OC4H9)4, TiO2/SiC nanometer-scale functional compositional film with the surface TiO2 layer on CF was formed in situ by means of polymer-derived precursors. The effects of Ti (OC4H9)4 concentrations and the maturating time were studied on the densification and TiO2 particle size of surface layer. The compositions of film were TiO2 and SiC crystal by XRD. According to the results of ESCA analysis, Ti(OC4H9)4 compound oozed gradiently from the pre-ceramic PCS to the surface layer after maturating time of 100 h. In the conditions of 45wt% Ti (OC4H9)4 and 100 h maturation, the nanometer-scale TiO2 particles on continuous surface layer were formed by SEM photographs. The nanometer-scale TiO2/SiC functional compositional film can modify the resistance to oxidation of carbon fiber.

关键词： polycarbosilane, TiO2/SiC nanometer-scale functional compositional film, CF, in situ formation.

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Preparation of slightly crosslinked monodisperse poly(maleic anhydride-cyclohexyl vinyl ether-divinylbenzene)functional microspheres with anhydride groups via precipitation polymerization

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Particuology 2015年第2期13卷 99-106页

作者： Cen Yin Anhou Xu Li Gong Luqing zhang Bing Geng shuxiang zhang Shandong Key Laboratory of Fluorine Chemistry and Chemical Materials School of Chemistry and Chemical Engineering University of Jinan Shandong Engineering Research Center for Fluorinated Material

Slightly crosslinked monodisperse poly（maleic anhydride-cyclohexyl vinyl ether-divinylbenzene）（MA-CHVE-DVB） microspheres were prepared via precipitation polymerization while using 2,2- azobisisobutyronitrile as an initiator in a mixture of methyl ethyl ketone and n-heptane without any stabilizer. The number-average diameter of the resultant poly（MA-CHVE-DVB） microspheres ranged from 0.478 to 1.386 μm with a polydispersity index of 1.00 to 1.02 that depended on the feed ratios of the MA/CHVE/DVB monomers. The introduction of one electron donor monomer cyclohexyl vinyl ether strongly affected the yield, size, and morphology of these slightly crosslinked microspheres. Quinoline- type chelating resins were obtained after combining the poly（MA-CHVE-DVB） with 8-hydroxyquinoline; the adsorption properties of these materials were measured through their ability to remove Cu^2＋ ions from water. The poly（MA-CHVE-DVB） microspheres with low degrees of crosslinking provided more effective functional groups and therefore better ion removal capabilities. These slightly crosslinked microspheres may have applications in water treatment as well as in sensing and drug delivery.

关键词： Precipitation polymerization Crosslinked functional microspheres Cyclohexyl vinyl ether Maleic anhydride Divinylbenzene

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恶性肿瘤患者经外周静脉穿刺的中心静脉导管相关性血栓的影响因素及预防措施研究进展

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中国肿瘤临床与康复 2024年第2期31卷 106-113页

作者：田江雪戴维莉张淑香国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院内科北京100021

恶性肿瘤患者留置经外周静脉穿刺的中心静脉导管(PICC)治疗时,常常面临着PICC相关性血栓的风险。文章旨在总结和分析现有文献,探讨恶性肿瘤患者PICC相关性血栓的高危因素及预防措施,为医务人员提供参考和指导,以期降低恶性肿瘤患者发生P... 详细信息

恶性肿瘤患者留置经外周静脉穿刺的中心静脉导管(PICC)治疗时,常常面临着PICC相关性血栓的风险。文章旨在总结和分析现有文献,探讨恶性肿瘤患者PICC相关性血栓的高危因素及预防措施,为医务人员提供参考和指导,以期降低恶性肿瘤患者发生PICC相关性血栓的风险,减少相关并发症并保障治疗顺利完成。

关键词：恶性肿瘤经外周静脉穿刺的中心静脉导管导管相关性血栓影响因素预防措施

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A cell retrievable strategy for harvesting extracellular matrix as active biointerface

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Journal of Materials Science & Technology 2022年第35期130卷 44-52页

作者： Xiangyu Dong shuxiang zhang Yi Xu Longquan Chen Qiang Wei Changsheng Zhao College of Polymer Science and Engineering State Key Laboratory of Polymer Materials and EngineeringSichuan UniversityChengdu 610065China School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China College of Biomedical Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200433China

Extracellular matrix(ECM) provides a variety of physical and chemical cues for cells. Here, a very simple and smart method is developed to glue living cells away for harvesting their ECMs. The obtained ECM coatings show less cell fragment residues comparing with those obtained by the traditional cell lysis. The glued cell sheets can even be re-cultured and reused after transferring to new environment. This moderate way well maintains the activity of the ECM proteins, which can promote cell adhesion and ***, the ECM coatings acquired from different functional cells can guide stem cell differentiation,which is attributed to the natural physical and biochemical cues on ECM coatings. Consequently, this method provides a substantial progress for preparing natural ECM coatings and shows promising potential in regenerative medicine and other related fields of biomedical engineering.

关键词： Extracellular matrix Regenerative medicine Biocoatings Cell sheets Differentiation

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三叉神经痛微球囊压迫术后无效或短期内复发机制及处理方法的研究进展

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医学综述 2024年第11期30卷 1314-1318页

作者：田晓静邢永国张淑祥天津中医药大学附属北辰中医医院脑外科天津300400

三叉神经痛(TN)是临床常见的疼痛性疾病,而经皮微球囊压迫术(PMC)是TN最有效的治疗方法。但PMC仍存在无效或复发的可能,且复发后病情也更加复杂。同时影响PMC治疗后无效或复发的因素也较多。因此,对于PMC治疗无效或复发的患者,治疗无效... 详细信息

三叉神经痛(TN)是临床常见的疼痛性疾病,而经皮微球囊压迫术(PMC)是TN最有效的治疗方法。但PMC仍存在无效或复发的可能,且复发后病情也更加复杂。同时影响PMC治疗后无效或复发的因素也较多。因此,对于PMC治疗无效或复发的患者,治疗无效或复发的病因、患者的身体状况、治疗的安全性等均是制订PMC治疗无效或复发后干预策略需要考虑的因素。目前关于PMC的治疗尚处于探索阶段,未来深入研究TN经PMC治疗后无效或复发的机制,可以为疾病的治疗提供新思路。

关键词：三叉神经痛经皮微球囊压迫术无效复发处理方法

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