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翻转课堂在初中信息技术教学中的应用探讨

成才之路 2024年第14期 125-128页

作者：杨淑霞甘肃省民勤县教育评价中心甘肃民勤733399

基于信息技术的发展,翻转课堂作为一种新型教学模式广泛应用于初中信息技术教学中。与传统教学模式不同,翻转课堂注重凸显学生的课堂主体地位,并为学生提供更加灵活、个性化的学习方式,有助于培养学生的自主学习能力和创新思维,有助于... 详细信息

基于信息技术的发展,翻转课堂作为一种新型教学模式广泛应用于初中信息技术教学中。与传统教学模式不同,翻转课堂注重凸显学生的课堂主体地位,并为学生提供更加灵活、个性化的学习方式,有助于培养学生的自主学习能力和创新思维,有助于提高学生的信息技术素养和实践能力。在教学实践中,教师可基于信息技术教学存在的问题,积极应用翻转课堂教学模式,将课堂教学内容转移到课前预习环节,然后在课堂上引导学生以讨论、实践、应用的方式深入理解所学的信息技术知识。

关键词：翻转课堂信息技术游戏小组合作提问人工智能检查总结

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2016~2022年淄博市主要恶性肿瘤的早死概率和疾病负担分析

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肿瘤预防与治疗 2024年第7期37卷 585-591页

作者：刘靖靖杨淑霞宋代琴李东芝淄博市疾病预防控制中心地方病慢性病防制所山东淄博255026

目的:了解淄博市户籍居民主要恶性肿瘤早死概率和疾病负担情况,为恶性肿瘤防治提供理论依据。方法:收集2016~2022年淄博市户籍居民恶性肿瘤死亡资料,计算分析恶性肿瘤死亡率、早死概率和疾病负担。结果:2016~2022年淄博市恶性肿瘤标化... 详细信息

目的:了解淄博市户籍居民主要恶性肿瘤早死概率和疾病负担情况,为恶性肿瘤防治提供理论依据。方法:收集2016~2022年淄博市户籍居民恶性肿瘤死亡资料,计算分析恶性肿瘤死亡率、早死概率和疾病负担。结果:2016~2022年淄博市恶性肿瘤标化死亡率从95.76/10万下降至81.01/10万,年度变化百分比(annual percentage change,APC)为-2.60%(t=-9.588,P<0.05),男性恶性肿瘤死亡率是女性的1.75倍;恶性肿瘤死亡顺位前5位依次为:肺癌、胃癌、肝癌、结直肠癌和女性乳腺癌;恶性肿瘤早死概率为5.93%,APC为-2.84%(t=-6.766,P<0.05)。男性早死概率是女性的1.96倍。2016~2022年肺癌、肝癌和胃癌的早死概率呈下降趋势(P<0.05),APC分别为-3.28%、-5.07%、-3.44%,男性结直肠癌的早死概率呈上升趋势,APC为2.70%(P<0.05),女性恶性肿瘤早死概率排名中乳腺癌上升至第2位。2016~2022年淄博市恶性肿瘤导致的早死寿命损失年(year of life lost,YLL)率、伤残寿命损失年率和伤残调整寿命年(disability-adjusted life year,DALY)率分别为22.45/千人、0.20/千人和22.65/千人,全人群、男性和女性YLL率和DALY率均呈下降趋势(P<0.05),女性恶性肿瘤DALY率排名中乳腺癌上升至第3位;2016~2022年全人群和男性肝癌DALY率呈下降趋势(P<0.05),APC分别为-3.02%、-3.05%,全人群和男性结直肠癌DALY率呈上升趋势(P<0.05),APC分别为2.07%、3.00%,女性胃癌在1.69%~1.90%之间波动,女性乳腺癌DALY率在1.51%~1.97%之间波动。结论:2016~2022年淄博市恶性肿瘤标化死亡率和早死概率逐年下降,肺癌、肝癌、胃癌和女性乳腺癌疾病负担较为严峻,对淄博市户籍居民健康影响较大,应针对不同类型的恶性肿瘤,制定相应的防治对策。

关键词：恶性肿瘤死亡率早死概率疾病负担变化趋势

Rare earth inorganic-organic hybrid compounds based on Keggin-type polyoxometalate {SiW_(12)} with fast-responsive photochromism and switchable luminescence properties

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Journal of Rare Earths 2024年第2期42卷 286-292,I0003页

作者： Hong Cui Yanli yang Xue Bai Xu Han Wensha Zhang Ying Lu shuxia Liu Key Laboratory of Polyoxometalate and Reticular Material Chemistry of the Ministry of Education College of ChemistryNortheast Normal UniversityChangchun 130024China

Four rare earth inorganic-organic hybrid compounds based on Keggin-type polyoxometalate {SiW_(12)}with general formula [{RE(DMF)_(4)(H_(2)O)_4RE(DMF)_(6)}_(2){SiW_(12)O_(40)}_(3)](RE = La(1),Pr(2),Sm(3),Eu(4),DMF=N,N-dimethylformamide) were synthesized by the conventional solution *** analyses indicate that four compounds are isostructural and are all built from three [SiW_(12)O_(40)]^(4-) polyoxoanions and DMF ligands linked by RE^(3+).Compounds 1-4 are extremely sensitive to UV light and present excellent photochromic properties,in which the coloring and fading time of samples are both no more than 2 min,and the reversible coloring-fading process can be repeated for at least 10 cycles with little fatigue,suggesting that compounds 1-4 can be a series of fast-responsive and durable photochromic ***,the solid-state photoluminescence spectra of compounds 3(Sm) and 4(Eu)display strong characteristic emissions of rare earth ions based on f-f ***,compound4(Eu) has a longer fluorescence lifetime up to 566.74 μ***,co mpounds 3(Sm) and 4(Eu) exhibit the switchable luminescence behavior induced by photochromism,which allows them to be used as potential molecular switches.

关键词： Inorganic-organic hybrid Keggin-type polyoxometalates Rare earths Photochromism Photoluminescence

Numerical Investigation of Combined Production of Natural Gas Hydrate and Conventional Gas

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Fluid Dynamics & Materials Processing 2024年第3期20卷 505-523页

作者： Hongzhi Xu Jian Wang shuxia Li Fengrui Zhao Chengwen Wang yang Guo School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580China CPOE Research Institute of Engineering Technology Tianjin300451China CNPC Offshore Engineering Company Limited Beijing100028China

Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional ***,optimizing the production technology of these two gases should be seen as a relevant way to effectively reduce the exploitation cost of the gas *** this study,three types of models accounting for the coexistence of these gases are *** A considers the upper hydrate-bearing layer(HBL)adjacent to the lower conventional gas layer(CGL);with the Type B a permeable interlayer exists between the upper HBL and the lower CGL;with the type C there is an impermeable interlayer between the upper HBL and the lower *** production performances associated with the above three models are calculated under different conditions,including only a depressurized HBL(only HBL DP);only a depressurized CGL(only CGL DP);and both the HBL and the CGL being depressurized(HBL+CGL DP).The results show that for Type A and Type B coexistence accumulation models,when only HBL or CGL is depressurized,the gas from the other layer will flow into the production layer due to the pressure difference between the two *** the coexistence accumulation model of type C,the cumulative gas production is much lower than that of Type A and Type B,regardless of whether only HBL DP,only CGL DP,or HBL+CGL DP are *** indicates that the impermeable interlayer restricts the cross-flow of gas between HBL and *** three different coexistence accumulation models,CGL DP has the largest gas-to-water ratio.

关键词： Natural gas hydrate conventional gas coexistence accumulation depressurization combined production

Challenges and Strategies for Influenza Response After COVID-19 Pandemic

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Infectious Diseases & Immunity 2024年第2期4卷 51-55页

作者： Jiaying yang shuxia Lin Yuelong Shu School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Pathogen Infection Prevention and Control(MOE) State Key Laboratory of Respiratory Health and MultimorbidityNational Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 102629China.

After the World Health Organization(WHO)declared the coronavirus disease 2019(COVID-19)pandemic in March 2020,the implementation of the most effective interventions became a paramount public health priority in the global response to the COVID-19 pandemic,especially before vaccines were *** studies have demonstrated that nonpharmaceutical interventions(NPIs),such as social distancing,wearing facemasks,and school closures,can substantially control the transmission of respiratory infections,including severe acute respiratory syndrome,pandemic H1N1 in 2009,and the COVID-19 pandemic.[1–3]However,various respiratory infections have become more prevalent since the COVID-19 *** 2021,the incidence of respiratory syncytial virus(RSV)has rapidly increased in numerous countries,including the United States,[4]Australia,[5]England,[6]Italy,[7]Germany,[8]and Switzerland.[9]In December 2022,5 European countries,including France and the United Kingdom。

关键词： respiratory acute closure

A mutation in TBXT causes congenital vertebral malformations in humans and mice

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Journal of Genetics and Genomics 2024年第4期51卷 433-442页

作者： shuxia Chen Yunping Lei Yajun yang Chennan Liu Lele Kuang Li Jin Richard HFinnell Xueyan yang Hongyan Wang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic Engineering at School of Life SciencesKey Laboratory of Reproduction Regulation of NPFPCInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200438China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Center for Precision Environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTX 77030USA MOE Key Laboratory of Contemporary Anthropology School of Life SciencesFudan UniversityShanghai 200438China Department of Assisted Reproduction Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Children’s Hospital Fudan University399 Wanyuan RoadShanghai 201102China

T-box transcription factor T(TBXT;T)is required for mesodermal formation and axial skeletal *** it has been extensively studied in various model organisms,human congenital vertebral malformations(CVMs)involving T are not well ***,we report a family with 15 CVM patients distributed across 4 *** affected individuals carry a heterozygous mutation,T c.596A>G(p.Q199R),which is not found in unaffected family members,indicating co-segregation of the genotype and *** vitro assays show that T p.Q199R increases the nucleocytoplasmic ratio and enhances its DNA-binding affinity,but reduces its transcriptional activity compared to the *** determine the pathogenicity of this mutation in vivo,we generated a Q199R knock-in mouse model that recapitulates the human CVM *** heterozygous Q199R mice show subtle kinked or shortened tails,while homozygous mice exhibit tail filaments and severe vertebral ***,we show that the Q199R mutation in T causes CVM in humans and mice,providing previously unreported evidence supporting the function of T in the genetic etiology of human CVM.

关键词： Congenital vertebral malformation TBXT T gene Loss-of-function mutation

Interfacial assembly of 2D polydopamine/graphene heterostructures with well-defined mesopore and tunable thickness for high-energy planar micro-supercapacitors

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Chinese Chemical Letters 2024年第7期35卷 439-444页

作者： Jieqiong Qin Zhi yang Jiaxin Ma Liangzhu Zhang Feifei Xing Hongtao Zhang shuxia Tian Shuanghao Zheng Zhong-Shuai Wu College of Science Henan Agricultural UniversityZhengzhou 450002China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China Mechanical and Electrical Engineering Institute Zhengzhou University of Light IndustryZhengzhou 450002China

Two-dimensional(2D)mesoporous pseudocapacitive polymer/graphene heterostructures combine the advanced merits of 2D materials and mesoporous materials,possessing unique nanosheet structure,large specific surface area(SSA),abundant oxygen/nitrogen-containing groups,desirable electrical conductivity and admirable electrochemical redox activity,and hold great potential for constructing high-performance planar micro-supercapacitors(MSCs).Herein,we demonstrate the interfacial assembly of 2D mesoporous polydopamine/graphene(mPDG)heterostructures with well-defined mesopore structure(12 nm)and adjustable thickness(7.5–14.1 nm)for planar high-energy pseudocapacitive *** to medium thickness,exposed mesopore of 12 nm and large SSA of 108 m^(2)/g,the m PDG with 10.8 nm thickness reveals prominent mass capacitance of 419 F/g and impressive cycling stability with~96%capacitance retention after 5000 ***,the symmetric mPDG-based MSCs with“water-in-salt”gel electrolyte present wide voltage window of 1.6 V,superior volumetric energy density of 11.5 mWh/cm^(3),outstanding flexibility and self-integration ***,this work offers a new platform of controllably synthesizing 2D mesoporous heterostructures for high-performance MSCs.

关键词： 2D materials Mesopores Heterostructures Polydopamine High energy density Micro-supercapacitors

Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1βand BDNF

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Neuroscience Bulletin 2024年第4期40卷 466-482页

作者： shuxia Zhang Yeru Chen Yongjie Wang Hongwei Wang Dandan Yao Gang Chen Department of Anesthesiology School of MedicineSir Run Run Shaw HospitalZhejiang UniversityHangzhou310016China Key Laboratory of Elemene Anti-Cancer Medicine of Zhejiang Province and Holistic Integrative Pharmacy Institutes Hangzhou Normal UniversityHangzhou311121China Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province Holistic Integrative Pharmacy InstitutesHangzhou Normal UniversityHangzhou311121China

Microtubule-associated protein Tau is responsible for the stabilization of neuronal microtubules under normal physiological *** attention has been focused on Tau’s contribution to cognition,but little research has explored its role in emotions such as pain,anxiety,and *** the current study,we found a significant increase in the levels of p-Tau(Thr231),total Tau,IL-1β,and brain-derived neurotrophic factor(BDNF)on day 7 after complete Freund's adjuvant(CFA)injection;they were present in the vast majority of neurons in the spinal dorsal *** of Mapt-shRNA recombinant adeno-associated virus into the spinal dorsal cord alleviated CFA-induced inflammatory pain and inhibited CFA-induced IL-1βand BDNF ***,Tau overexpression was sufficient to induce hyperalgesia by increasing the expression of IL-1βand ***,the activation of glycogen synthase kinase 3 beta partly contributed to Tau *** findings suggest that Tau in the dorsal horn could be a promising target for chronic inflammatory pain therapy.

关键词： Tau Inflammatory pain IL-1β BDNF

Horizontal well spacing optimization and gas injection simulation for the ultra-low-permeability Yongjin reservoir

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Energy Geoscience 2024年第1期5卷 196-203页

作者： Yao Zhang Chengyuan Lv Zengmin Lun shuxia Zhao Yingfu He Ran Gao SINOPEC Exploration and Production Research Institute BeijingChina

Optimal spacing for vertical wells can be effectively predicted with several published methods,but methods suitable for assessing the proper horizontal well spacing are *** work proposes a method for calculating the optimal horizontal well spacing for an ultra-low permeability reservoir e the Yongjin reservoir in the Juggar Basin,northwestern *** result shows that a spacing of 640m is the most economical for the development of the *** better develop the reservoir,simulation approaches are used and a new model is built based on the calculated well *** the reservoir has an ultralow permeability,gas injection is regarded as the preferred enhanced oil recovery(EOR)*** of different gases including carbon dioxide,methane,nitrogen and mixed gas are *** results show that carbon dioxide injection is the most efficient and economical for the development of the ***,if the reservoir produces enough methane,reinjecting methane is even better than injecting carbon dioxide.

关键词： Ultra-low-permeability reservoir Well spacing optimization Numerical simulation Gas injection EOR