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Applying Machine Learning Approach to Explore Childhood Circumstances and Self-Rated Health in Old Age-China and the US,2020-2021

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China CDC weekly 2024年第11期6卷 213-218,I0008-I0013页

作者： shutong huo Derek Feng Thomas M.Gill Xi Chen Department of Health Society&BehaviorPublic HealthUniversity of CaliforniaIrvineCAUSA Department of Statistics and Data Science Yale UniversityNew HavenCTUS Department of Internal Medicine Yale School of MedicineNew HavenCTUS Department of Health Policy and Management Yale School of Public HealthNew HavenCTUS Department of Economics Yale UniversityNew HavenCTUS.

Introduction:Childhood circumstances impact senior health,prompting the introduction of machine learning methods to assess their individual and collective contributions to senior ***:Using health and retirement study(HRS)and China Health and Retirement Longitudinal Study(CHARLS),we analyzed 2,434 American and 5,612 Chinese participants aged 60 and *** inference trees and forests were employed to estimate the influence of childhood circumstances on self-rated health(SRH).Results:The conventional method estimated higher inequality of opportunity(IOP)values in both China(0.039,accounting for 22.67%of the total Gini coefficient 0.172)and the US(0.067,accounting for 35.08%of the total Gini coefficient 0.191).In contrast,the conditional inference tree yielded lower estimates(China:0.022,accounting for 12.79%of 0.172;US:0.044,accounting for 23.04%of 0.191),as did the forest(China:0.035,accounting for 20.35%of 0.172;US:0.054,accounting for 28.27%of 0.191).Childhood health,financial status,and regional differences were key determinants of senior *** conditional inference forest consistently outperformed others in predictive accuracy,as demonstrated by lower out-of-sample mean squared error(MSE).Discussion:The findings emphasize the need for early-life interventions to promote health equity in aging *** learning showcases the potential in identifying contributing factors.

关键词： collective inequality estimates

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High-entropy ferrite with tunable magnetic properties for excellent microwave absorption

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 668-677页

作者： Yuying huo Zhengyan Wang Yanlan Zhang Yongzhen Wang College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Joint Laboratory of Coal based Solid Waste Resource Utilization and Green Ecological Development Taiyuan 030024China

High-entropy design is attracting growing interest as it offers unique structures and unprecedented application potential for *** this article,a novel high-entropy ferrite(CoNi)_(x/2)(CuZnAl)_((1-x)/3)Fe_(2)O_(4)(x=0.25,0.34,0.40,0.50)with a single spinel phase of space group Fd3m was successfully developed by the solid-state reaction *** tuning the Co-Ni content,the magnetic properties of the material,especially the coercivity,changed regularly,and the microwave absorption properties were *** particular,the ef-fective absorption bandwidth of the material increased from 4.8 to 7.2 GHz,and the matched thickness decreased from 3.9 to 2.3 mm,while the minimum reflection loss remained below-20 *** study provides a practical method for modifying the properties of fer-rites used to absorb electromagnetic waves.

关键词： high-entropy oxide spinel ferrite oxygen vacancy radar cross section

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Fe3+ ion quantification with reusable bioinspired nanopores

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Chinese Chemical Letters 2025年第2期36卷 207-212页

作者： Yanqiong Wang Yaqi Hou Fengwei huo Xu Hou Institute of Flexible Electronics (IFE Future Technologies) Xiang’an Campus Xiamen University State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Institute of Artificial Intelligence Xiamen University Department of Physics Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Laboratory for Soft Materials Research Jiujiang Research Institute College of Physical Science and Technology Xiamen University Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM) Engineering Research Center of Electrochemical Technologies of Ministry of Education Xiamen University

Excessive Fe3+ion concentrations in wastewater pose a long-standing threat to human *** low-cost,high-efficiency quantification of Fe3+ion concentration in unknown solutions can guide environmental management decisions and optimize water treatment *** this study,by leveraging the rapid,real-time detection capabilities of nanopores and the specific chemical binding affinity of tannic acid to Fe3+,a linear relationship between the ion current and Fe3+ion concentration was *** this linear relationship,quantification of Fe3+ion concentration in unknown solutions was ***,ethylenediaminetetraacetic acid disodium salt was employed to displace Fe3+from the nanopores,allowing them to be restored to their initial conditions and reused for Fe3+ion *** reusable bioinspired nanopores remain functional over 330 days of *** recycling capability and the long-term stability of the nanopores contribute to a significant reduction in *** study provides a strategy for the quantification of unknown Fe3+concentration using nanopores,with potential applications in environmental assessment,health monitoring,and so forth.

关键词： Bioinspired nanopores Chemical binding affinity Fe3+ ion quantification Reusability Tannic acid

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Deformation mechanism and NPR anchor cable truss coupling support in tunnel through fault fracture zone

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Journal of Mountain Science 2025年第1期22卷 354-374页

作者： huo Shusen TAO Zhigang HE Manchao WANG Fengnian XU Chuang State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China

To address the issue of extensive deformation in the Tabaiyi Tunnel caused by the fault zone,nuclear magnetic resonance(NMR)technology was employed to analyze the physical and mechanical properties of waterabsorbing *** analysis aimed to understand the mechanism behind the significant *** from the principle of excavation stress compensation,a support scheme featuring NPR anchorcables and an asymmetric truss support system was *** validate the scheme,numerical analysis using a combination of the Discrete Element Method(DEM)-Finite Element Method(FEM)was ***,similar material model tests and engineering measurements were carried *** experiments were also performed to evaluate the NPR anchor-cable and truss support system,focusing on anchor cable forces,pressures between the truss and surrounding rock,pressures between the initial support and secondary lining,as well as the magnitude of settlement and convergence deformation in the surrounding *** results indicate that the waterinduced expansion of clay minerals,resulting from damage caused by fissure water,accelerated the softening of the mudstone's internal structure,leading to significant deformations in the Tabaiyi Tunnel under high tectonic *** original support design fell short as the length of the anchor rods was smaller than the expansion depth of the plastic *** a result,the initial support structure bore the entire load from the surrounding rock,and a non-coupled deformation contact was observed between the double-arch truss and the surrounding *** adoption of NPR asymmetric anchor-cable support effectively restrained the expansion and asymmetric distribution characteristics of the plastic *** the mechanical degradation caused by water absorption in mudstone,the rigid constraint provided by the truss proved crucial for controlling the stability of the surrounding *** research findings hold significant implicatio

关键词： Fault fracture zone Large deformation Nuclear magnetic resonance NPR anchor cable truss support Coupled simulation

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Armoring hydrophilic wood-structured ultrathick electrode with bimetallic nitride enables high energy-density supercapacitor

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Green Energy & Environment 2025年第2期10卷 345-357页

作者： Nannan Ming Jikun Xu Jingfang Lei Cankun Hu Kaifu huo Institute of Advanced Materials and Nanotechnology School of Chemistry and Chemical EngineeringWuhan University of Science and TechnologyWuhan430081China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China

Thick electrodes can reduce the ratio of inactive constituents in a holistic energy storage system while improving energy and power ***,traditional slurry-casting electrodes induce high-tortuous ionic diffusion routes that directly depress the capacitance with a thickening *** overcome this,a novel 3D low-tortuosity,self-supporting,wood-structured ultrathick electrode(NiMoN@WC,a thickness of~1400 mm)with hierarchical porosity and artificial array-distributed small holes was constructed via anchoring bimetallic nitrides into the monolithic wood *** the embedded NiMoN nanoclusters with well-designed geometric and electronic structure,the vertically low-tortuous channels,enlarged specific surface area and pore volume,superhydrophilic interface,and excellent charge conductivities,a superior capacitance of NiMoN@WC thick electrodes(~5350 mF cm^(-2)and 184.5 F g^(-1))is achieved without the structural *** especial,monolithic wood carbons with gradient porous network not only function as the high-flux matrices to ameliorate the NiMoN loading via cell wall engineering but also allow fully-exposed electroactive substance and efficient current collection,thereby deliver an acceptable rate capability over 75%retention even at a high sweep rate of 20 mA cm^(-2).Additionally,an asymmetric NiMoN@WC//WC supercapacitor with an available working voltage of 1.0-1.8 V is assembled to demonstrate a maximum energy density of~2.04 mWh cm^(-2)(17.4 Wh kg^(-1))at a power density of 1620 mW cm^(-2),along with a decent long-term lifespan over 10,000 charging-discharging *** a guideline,the rational design of wood ultrathick electrode with nanostructured transition metal nitrides sketch a promising blueprint for alleviating global energy scarcity while expanding carbon-neutral technologies.

关键词： Wood-structured thick electrode Supercapacitors Transition metal nitrides Low tortuosity

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Maternal stress and the early embryonic microenvironment:investigating long‑term cortisol effects on bovine oviductal epithelial cells using air–liquid interface culture

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Journal of Animal Science and Biotechnology 2025年第1期16卷 153-166页

作者： Fiona Wahl Jianchao huo Shuaizhi Du Jennifer Schoen Shuai Chen Department of Reproduction Biology Leibniz Institute for Zoo and Wildlife Research(IZW)Alfred‑Kowalke‑Straße 1710315 BerlinGermany Institute of Biotechnology Technische Universität BerlinStraße Des 17.Juni 13510623 BerlinGermany Institute of Reproductive Biology Research Institute for Farm Animal Biology(FBN)Wilhelm‑Stahl‑Allee 218196 DummerstorfGermany

The oviduct epithelium is the initial maternal contact site for embryos after fertilization,offering the microenviron-ment before *** early gestation period is particularly sensitive to stress,which can cause reduced fertil-ity and reproductive disorders in ***,the local impact of elevated stress hormones on the ovi-duct epithelium has received limited attention to date,except for a few reports on polyovulatory species like mice and *** this study,we focused on the effects of chronic maternal stress on cattle,given its association with infertil-ity issues in this monoovulatory *** oviduct epithelial cells(BOEC)differentiated at the air–liquid interface(ALI)were stimulated with 250 nmol/L cortisol for 1 or 3 ***,they were assessed for morphology,bioelectrical properties,and gene expression related to oviduct function,glucocorticoid pathway,cortisol metabo-lism,inflammation,and *** revealed adverse effects of cortisol on epithelium structure,featured by deciliation,vacuole formation,and ***,cortisol exposure led to an increase in transepithelial potential difference,downregulated mRNA expression of the major glucocorticoid receptor(NR3C1),upregulated the expression of cortisol-responsive genes(FKBP5,TSC22D3),and significant downregulation of oviductal glycopro-tein 1(OVGP1)and steroid receptors PGR and *** systematic comparison to a similar experiment previously performed by us in porcine oviduct epithelial cells,indicated that bovine cultures were more susceptible to elevated cortisol levels than *** distinct responses between both species are likely linked to their divergence in the cortisol-induced expression changes of HSD11B2,an enzyme controlling the cellular capacity to metabolise *** findings provide insights into the species-specific reactions and reproductive consequences triggered by maternal stress.

关键词： Air–liquid interface Bovine Cortisol Early embryonic microenvironment Epithelial cells Maternal stress Oviduct

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Rapid and specific fluorescent probe visualizes dynamic correlation of Cys and HClO in OGD/R

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Chinese Chemical Letters 2025年第1期36卷 437-441页

作者： Pei Huang Weijie Zhang Junping Wang Fangjun huo Caixia Yin Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan 030006China Research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China

Intracellular redox homeostasis is of indispensable importance in *** order to maintain the balance of the redox state within the cell,reactive oxygen species(ROS)and reactive sulfur species(RSS)react and transform with each other,and their levels also directly reflect the degree of oxidative stress and *** acid(HClO)and cysteine(Cys)usually co-exist in organisms,interacting with each other in many important physiological processes and synergistically maintaining the dynamic redox balance in the *** understand the relevance and pathophysiological effects of these two signaling molecules in oxidative stress,unique fluorescence imaging tools are ***,we designed and developed a dual-channel fluorescent probe HP,for the individual and continuous detection of HClO and *** probe could simultaneously monitor the changes in the concentrations of HClO and Cys in cells,and was characterized by a fast response,high sensitivity and high selectivity,especially compared with glutathione(GSH)and homocysteine(Hcy),the probe had a good specificity for ***,probe HP successfully observed dynamic changes in HCl O-and Cys-mediated redox status in the oxygenglucose deprivation/reperfusion(OGD/R)model of HeLa cells and dynamically monitored fluctuations in endogenous HClO levels in lipopolysaccharides(LPS)-induced peritonitis mice.

关键词： Redox homeostasis Dual-channel OGD/R Fluctuations Peritonitis

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Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao LIURui ZHENG Liang DENG Jiahui ZHANG Wenzheng huo Jinlu HUANG Li Shanghai Marine Diesel Engine Research Institute Shanghai 201108China National Key Laboratory of Marine Engine Science and Technology Shanghai 201108China Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm)and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC)with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT)imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： dual-orifice nozzle nozzle structure atomization spray flame asymmetry

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Development of ESIPT-based specific fluorescent probes for bioactive species based on the protection-deprotection of the hydroxyl

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Chinese Chemical Letters 2025年第2期36卷 49-56页

作者： Haixian Ren Yuting Du Xiaojing Yang Fangjun huo Le Zhang Caixia Yin Department of Chemistry Xinzhou Normal University Research Institute of Applied Chemistry Shanxi University Department of Chemistry The University of Texas at Austin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province Institute of Molecular ScienceShanxi University

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence probes are particularly attractive due to their unique properties including environmental sensitivity, a large Stokes shift, and potential for ratiometric sensing. In general, ESIPT-based fluorophore incorporates an intramolecular hydrogen bonding interaction between a hydrogen bond donor (–OH and NH2are common) and a hydrogen bond acceptor(C=N and C=O). More, protection–deprotection of hydroxyl group as hydrogen bond donor could induce an off-on switch of ESIPT-based emission. Therefore, protection–deprotection of hydroxyl group has been the widely used strategy to design fluorescent probes, where the potential key issue is selecting a protective group that can specifically leave in the presence of the target analyte. In this review, we mainly summarize the specific protecting groups (sites) and deprotection mechanisms for biologically important species (including reactive sulfur species (RSS), reactive oxygen species (ROS), enzymes, etc.), and analyze the advantages and disadvantages of different protection mechanisms from some aspects including probe stability, selectivity, response rate and assay system, etc. Based on the aforementioned, we further point out the current challenges and the potential future direction for developing ESIPT-based probes.

关键词： Bioimaging ESIPT Fluorescence probe Protection-deprotection Specificity

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