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Extract of Yokukansan improves anxiety-like behavior and increases serum brain-derived neurotrophic factor in rats with cerebral ischemia combined with amyloid-β42 peptide

引用

Journal of Traditional Chinese Medicine 2019年第1期39卷 50-58页

作者： Ai Nogami-Hara Kaori Kubota Kotaro Takasaki Takuya Watanabe Nobuaki Egahira Hikari Iba Risako Fujikawa shutaro katsurabayashi Funda Bolukbasi Hatip Izzettin Hatip-Al-Khatib Katsunori Iwasaki Department of Neuropharmacology Faculty of Pharmaceutical ScienceFukuoka UniversityFukuoka 814-0180Japan Institute for Aging and Brain Sciences Fukuoka UniversityFukuoka 814-0180Japan Department of Pharmacy Kyushu University HospitalFukuoka 812-8582Japan Department of Medical Pharmacology Faculty of MedicinePamukkale UniversityDenizli 20070Turkey

OBJECTIVE: To examine the effects of Yokukansan(YKS) extract on two endogenous modulators of anxiety, brain-derived neurotrophic factor(BDNF)and serotonin (5-HT)_(2A) receptors pharmacologically, in the ischemic rat model of ***: The cerebral ischemia(CI) was induced by bilateral occlusion of the vertebral and common carotid arteries(4-vessel occlusion ischemia). The CI was combined with the amyloid-β42 peptide(A42) injected intracerebroventricularly, and referreβdto as CI+Aβ. Anxiety-like behaviors were assessed by elevated plus maze(enclosed arm), light/dark transition test(dark chamber), and open-field ***-dog shakes were induced by the 5-HT_(2A) receptor agonist 2, 5-dimethoxy-4-iodoamphetamine(DOI). The concentration of BDNF in serum was determined by enzyme-linked immuno sorbent ***: CI + Aβ increased anxiety, as demonstrated by the increase of time spent in the enclosed arms and dark chambers, and locomotion in the outer zone of the open field(thigmotaxis). CI + Adecreased the serum concentration of BDNF. YKS reβ-duced the anxiety-like behaviors, suppressed the DOI-induced wet-dog shakes and increased serum BDNF ***: Our findings suggest that YKS extract improves CI + Aβ-induced anxiety by antagonizing 5-HT_(2A) receptors and increasing BDNF.

关键词： Brain ischemia Amyloid beta-peptides Anxiety brain-derived neurotrophic factor Receptor serotonin 5-HT2A Yokukansan

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