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Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis:a comprehensive and systematic

Signal Transduction and Targeted Therapy 2023年第4期8卷 1743-1783页

作者： Rexiati Ruze Jianlu Song Xinpeng yin Yuan Chen Ruiyuan Xu Chengcheng Wang Yupei Zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College100730 BeijingChina Key Laboratory of Research in Pancreatic Tumors Chinese Academy of Medical Sciences100023 BeijingChina Chinese Academy of Medical Sciences and Peking Union Medical College No.9 Dongdan SantiaoBeijingChina

Research on obesity-and diabetes mellitus(DM)-related carcinogenesis has expanded exponentially since these two diseases were recognized as important risk factors for *** growing interest in this area is prominently actuated by the increasing obesity and DM prevalence,which is partially responsible for the slight but constant increase in pancreatic cancer(PC)*** is a highly lethal malignancy characterized by its insidious symptoms,delayed diagnosis,and devastating *** intricate process of obesity and DM promoting pancreatic carcinogenesis involves their local impact on the pancreas and concurrent wholebody systemic changes that are suitable for cancer *** main mechanisms involved in this process include the excessive accumulation of various nutrients and metabolites promoting carcinogenesis directly while also aggravating mutagenic and carcinogenic metabolic disorders by affecting multiple *** alterations in gastrointestinal and sex hormone levels and microbiome dysfunction further compromise immunometabolic regulation and contribute to the establishment of an immunosuppressive tumor microenvironment(TME)for carcinogenesis,which can be exacerbated by several crucial pathophysiological processes and TME components,such as autophagy,endoplasmic reticulum stress,oxidative stress,epithelialmesenchymal transition,and exosome *** review provides a comprehensive and critical analysis of the immunometabolic mechanisms of obesity-and DM-related pancreatic carcinogenesis and dissects how metabolic disorders impair anticancer immunity and influence pathophysiological processes to favor cancer initiation.

关键词： carcinogenesis obesity immunity

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Analysis of the Sedimentary Characteristics of a Modern Distributive Fluvial System:A Case Study of the Great Halten River in the Sugan Lake Basin,Qinghai,China

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Journal of Earth Science 2023年第4期34卷 1249-1262页

作者： Xianghui Zhang Changmin Zhang Adrian Hartley Qinghai Xu Wenjie Feng Taiju yin Rui Zhu School of Geosciences Yangtze UniversityWuhan 430100China Department of Geology and Petroleum Geology School of GeosciencesUniversity of AberdeenAberdeen AB243UEUK

Understanding controls on river planform changes can help to build predictive models for distributive fluvial systems,and then guide the oil and gas *** do this we have undertaken a detailed investigation of the modern Great Halten River distributive fluvial system from the Sugan Lake Basin,Qinghai,*** aerial vehicle(UAV) photography,satellite remote sensing data and elemental analysis were used to determine differences in the sedimentary characteristics of the distributive fluvial *** the apex to the toe,the changes in the slope,river morphology,sedimentary characteristics and element content in different regions were determined and three facies belts:“proximal”,“medial” and “distal” were *** found that the sedimentary structure and elemental content characteristics of each facies differ *** compare the large-scale evolution of rivers from braided to meandering rivers,and the fine description of sedimentary characteristics in combination with each observation,we strengthen our overall understanding of the modern DFS from macro to micro *** the same time,we summarize the sedimentation model of the Great Halten River DFS,and our study provides a reference for establishing the sedimentary model in continental petroliferous basins.

关键词： Sugan Lake Basin distributive fluvial system river morphology sedimentary model sedimentary structure sedimentology.

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Novel Cs-Mg-Al mixed oxide with improved mobility of oxygen species for passive NO_(x)adsorption

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Green Energy & Environment 2024年第10期9卷 1581-1591页

作者： Yimeng yin Chizhong Wang Lei Qiu Xing Li Feilin Zhao Jie Yu Jinchi Han Huazhen Chang School of Environment and Natural Resources Renmin University of ChinaBeijing100872China Department of Earth System Science Tsinghua UniversityBeijing100084China

The development of passive NO_(x)adsorbers with cost-benefit and high NO_(x)storage capacity remains an on-going challenge to after-treatment technologies at lower temperatures associated with cold-start NO_(x)***,Cs_(1)Mg_(3)Al catalyst prepared by sol-gel method was cyclic tested in NO_(x)storage under 5 vol%*** 100°C,the NO_(x)storage capacity(1219 μmol g^(-1))was much higher than that of Pt/BaO/Al_(2)O_(3)(610 μmol g^(-1)).This provided new insights for non-noble metal catalysts in low-temperature passive NO_(x)*** addition of Cs improved the mobility of oxygen species and thus improved the NO_(x)storage *** XRD,XPS,IR spectra and in situ DRIFTs with NH3 probe showed an interaction between CsO_(x)and AlO_(x)sites via oxygen species formed on Cs_(1)Mg_(3)Al *** improved mobility of oxygen species inferred from O2-TPD was consistent with high NO_(x)storage capacity related to enhanced formation of nitrate and additional nitrite species by NO_(x)***,the addition of Mg might improve the stability of Cs_(1)Mg_(3)Al by stabilizing surface active oxygen species in cyclic experiments.

关键词： Passive NO_(x)adsorber Low-temperature NO_(x)storage Cesium O_(x)ygen mobility

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Nitrogen cold plasma treatment stabilizes Cu^(0)/Cu^(+) electrocatalysts to enhance CO_(2) to C2 conversion

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Journal of Energy Chemistry 2023年第9期84卷 321-328页

作者： Qiang Zhang Jianlin Wang Fang Guo Ge He Xiaohui Yang Wei Li Junqiang Xu Zongyou yin School of Chemistry&Chemical Engineering Chongqing University of TechnologyChongqing 400054China College of Biomass Science and Engineering Sichuan UniversityChengdu 610065SichuanChina Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China Research School of Chemistry Australian National UniversityCanberraACT 2601Australia

Cu-based materials are ideal catalysts for CO_(2) electrocatalytic reduction reaction(CO_(2)RR) into multicarbon ***,such reactions require stringent conditions on local environments of catalyst surfaces,which currently are the global pressing ***,a stabilized activation of Cu^(0)/Cu^(+)-onAg interface by N_(2) cold plasma treatment was developed for improving Faradaic efficiency(FE) of CO_(2)RR into C2 *** resultant Ag@Cu-CuN_x exhibits a C2 FE of 72% with a partial current density of-14.9 mA cm^(-2) at-1.0 V ***(reversible hydrogen electrode).Combining density functional theory(DFT) and experimental investigations,we unveiled that Cu^(0)/Cu^(+) species can be co ntrollably tu ned by the incorporation of nitrogen to form CuN_x on Ag surface,i.e.,Ag@Cu-CuN_*** strategy enhances ^(*)CO intermediates generation and accelerates C-C coupling both thermodynamically and *** intermediates O^(*)C^(*)CO,^(*)COOH,and ^(*)CO were detected by in-situ attenuated total internal reflection surface enhanced infrared absorption spectroscopy(ATR-SEIRAS).The uncovered CO_(2)RR-into-C2 products were carried out along CO_(2)→^(*)COOH→^(*)CO→O^(*)C^(*)CO→^(*)C_(2)H_(3)O→^(*)C_(2)H_(4)O→ C_(2)H_(5)OH(or ^(*)C_(2)H_(3)O→^(*)O+C_(2)H_(4)) paths over Ag@Cu-CuN_x *** work provides a new approach to design Cu-based electrocatalysts with high-efficiency,mild condition,and stable CO_(2)RR to C2 products.

关键词： Nitrogen cold plasma Cu-based metal nitride Carbon dioxide electroreduction C2 products Stabilizes

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A low noise interface circuit design of micro-machined gyroscope

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Journal of Semiconductors 2017年第7期38卷 117-120页

作者： Qiang Fu Xipeng Di Liang yin Xiaowei Liu MEMS Center Harbin Institute of Technology Harbin 150001 China

The analyses of MEMS gyroscope interface circuit on thermal noise, 1/f noise and phase noise are made in this paper. A closed-loop differential driving circuit and a low-noise differential detecting circuit based on the high frequency modulation are designed to limit the noise. The interface chip is implemented in a standard0.5 μm CMOS process. The test results show that the resolution of sensitive capacity can reach to 6.47×10^（-20） F at the bandwidth of 60 Hz. The measuring range is ± 200°/s and the nonlinearity is 310 ppm. The output noise density is 5.8°/（h·（Hz）^（1/2））. The angular random walk（allen-variance） is 0.092°/h^（1/2） and the bias instability is 2.63°/h.

关键词： gyroscope low noise interface circuit

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Stable,intense supercontinuum light generation at 1 kHz by electric field assisted femtosecond laser filamentation in air

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Light(Science & Applications) 2024年第2期13卷 354-365页

作者： Yaoxiang Liu Fukang yin Tie-Jun Wang Yuxin Leng Ruxin Li Zhizhan Xu See Leang Chin State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics and CAS Center for Excellence in Ultra-intense Laser ScienceChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina Centre d’Optique Photonique et Laser(COPL)and Département de physiquede génie physique et d’optiqueUniversitéLavalQuébecQuébecCanada

Supercontinuum(SC)light source has advanced ultrafast laser spectroscopy in condensed matter science,biology,physics,and *** to the frequently used photonic crystal fibers and bulk materials,femtosecond laser filamentation in gases is damage-immune for supercontinuum generation.A bottleneck problem is the strong jitters from filament induced self-heating at kHz repetition rate *** demonstrated stable kHz supercontinuum generation directly in air with multiple mJ level pulse *** was achieved by applying an external DC electric field to the air plasma *** pointing jitters of the 1 kHz air filament induced SC light were reduced by more than 2 *** stabilized high repetition rate laser filament offers the opportunity for stable intense SC generation and its applications in air.

关键词： intense repetition light

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Tissue adhesive,ROS scavenging and injectable PRP-based‘plasticine’for promoting cartilage repair

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Regenerative Biomaterials 2024年第1期3卷 94-107页

作者： Shiao Li Dawei Niu Haowei Fang Yancheng Chen Jinyan Li Kunxi Zhang Jingbo yin Peiliang Fu Department of Orthopedics Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003P.R.China Department of Polymer Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200444P.R.China

Platelet-rich plasma(PRP)that has various growth factors has been used clinically in cartilage ***,the short residence time and release time at the injury site limit its therapeutic *** present study fabricated a granular hydrogel that was assembled from gelatin microspheres and tannic acid through their abundant hydrogen *** microspheres with the gelatin concentration of 10wt%and the diameter distribution of 1-10 lm were used to assemble by tannic acid to form the granular hydrogel,which exhibited elasticity under low shear strain,but flowability under higher shear *** viscosity decreased with the increase in shear ***,the granular hydrogel exhibited self-healing feature during rheology ***,granular hydrogel carrying PRP not only exhibited well-performed injectability but also performed like a‘plasticine’that possessed good *** granular hydrogel showed tissue adhesion ability and reactive oxygen species scavenging *** hydrogel carrying PRP transplanted to full-thickness articular cartilage defects could integrate well with native cartilage,resulting in newly formed cartilage articular fully filled in defects and well-integrated with the native cartilage and subchondral *** unique features of the present granular hydrogel,including injectability,plasticity,porous structure,tissue adhesion and reactive oxygen species scavenging provided an ideal PRP carrier toward cartilage tissue engineering.

关键词： cartilage regeneration granular hydrogel gelatin tannic acid PRP

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Photocatalytic H2 Evolution on TiO2 Assembled with Ti3C2 MXene and Metallic 1T-WS2 as Co-catalysts

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Nano-Micro Letters 2020年第1期12卷 63-74页

作者： Yujie Li Lei Ding Shujun yin Zhangqian Liang Yanjun Xue Xinzhen Wang Hongzhi Cui Jian Tian School of Materials Science and Engineering Shandong University of Science and Technology

The biggest challenging issue in photocatalysis is efficient separation of the photoinduced carriers and the aggregation of photoexcited electrons on photocatalyst’s *** this paper,we report that double metallic co-catalysts Ti3C2 MXene and metallic octahedral(1T)phase tungsten disulfide(WS2)act pathways transferring photoexcited electrons in assisting the photocatalytic H2 ***2 nanosheets were in situ grown on highly conductive Ti3C2 MXenes and 1T-WS2 nanoparticles were then uniformly distributed on TiO2@Ti3C2 ***,a distinctive 1T-WS2@TiO2@Ti3C2 composite with double metallic co-catalysts was achieved,and the content of 1T phase reaches 73%.The photocatalytic H2 evolution performance of 1T-WS2@TiO2@Ti3C2 composite with an optimized 15 wt%WS2 ratio is nearly 50 times higher than that of TiO2 nanosheets because of conductive Ti3C2 MXene and 1T-WS2 resulting in the increase of electron transfer ***,the 1T-WS2 on the surface of TiO2@Ti3C2 composite enhances the Brunauer–Emmett–Teller surface area and boosts the density of active site.

关键词： Photocatalytic H2 production Ti3C2 MXene Octahedral phase WS2 TiO2 nanosheets Co-catalysts

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Crustal deformation and dynamics of Early Cretaceous in the North China Craton

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Science China Earth Sciences 2021年第9期64卷 1428-1450页

作者： Guang ZHU Yuanchao LU Nan SU Xiaodong WU Hao yin Shuai ZHANG Chenglong XIE Manlan NIU School of Resource and Environmental Engineering Hefei University of TechnologyHefei230009China

The Early Cretaceous represents a peak period of the North China Craton(NCC)destruction.A comprehensive analysis of crustal deformation during this period can reveal processes and dynamics of the *** peak destruction of the NCC was associated with intense extension whose representative deformation products are metamorphic core complexes(MCCs),extensional domes and rifted *** MCCs occurred along both northern and southern margins of the NCC,and resulted from synchronous extension and magmatism,showing difference from the typical orogen-type MCCs in many *** MCCs of the Early Cretaceous were replaced by extensional domes under relatively weak extension and *** contrast to a major depression-type basin of the Early Cretaceous in the western NCC,rifted basins of the same age in the eastern NCC appeared as medium-to small-scale ones *** the eastern NCC,the rifted basins north of the Bohai Bay are characterized by a feature similar to an active rift whereas those south of the Bohai present similarity to a passive *** sorts of extensional structures developed during the peak destruction indicate a stable stress state of NE-SE extension over the entire central to eastern NCC,consistent with the plate margin-driven stress *** distribution of the extensional structures presents an 1800 km wide back-arc extension region in the central to eastern NCC,consistent with the Paleo-Pacific slab rollback model following flat ***-spatial variation of initial extension and volcanic activity during the peak period also supports the rollback model right after the flat oceanic *** crustal deformation evolution demonstrates that the peak destruction of the NCC took place after the B-episode compression of the Yanshan Movement of the earliest Early Cretaceous and terminated with onset of the C-episode compression of the earliest Late Cretaceous.

关键词： Peak period of craton destruction Metamorphic core complex Extensional domes Rifted basins Dynamic setting

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Structures and Physical Properties of V-Based Kagome Metals CsV_(6)Sb_(6)and Cs V_(8)Sb_(12)

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Chinese Physics Letters 2021年第12期38卷 62-68页

作者： Qiangwei yin Zhijun Tu Chunsheng Gong Shangjie Tian Hechang Lei Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials&Micro-nano Devices Renmin University of ChinaBeijing 100872China

We report two new members of V-based kagome metals CSV_(6)Sb_(6)and CsV_(8)Sb_(12).The most striking structural feature of CSV_(6)Sb_(6)is the V kagome *** CsV_(8)Sb_(12),there is an intergrowth of two-dimensional V kagome layers and one-dimensional V chains,and the latter ones lead to the orthorhombic symmetry of this *** measurements indicate that these two materials exhibit metallic and Pauli paramagnetic *** importantly,different from CSV_(3) Sb_(5),the charge density wave state and superconductivity do not emerge in CSV_(6)Sb_(6)and CsV_(8)Sb_(12)when temperature is above 2 *** magnetoresistance with saturation behavior and linear field dependence of Hall resistivity at high field and low temperature suggest that the carriers in both materials should be uncompensated with much different *** discovery of these two new V-based kagome metals sheds light on the exploration of correlated topological materials based on kagome lattice.

关键词： resistivity striking

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