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Regulatable interfacial adhesion between stamp and ink for transfer printing

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Interdisciplinary Materials 2024年第1期3卷 29-53页

作者： Yiheng Li Feilong zhang shutao Wang CAS Key Laboratory of Bio‐inspired Materials and Interfacial Science Technical Institute of Physicsand ChemistryChinese Academy of SciencesBeijingChina School of Future Technology University of Chinese Academy of ciencesBeijingChina

As an emerging processing technology,transfer printing enables the assembly of functional material arrays(called inks)on various substrates with micro/nanoscale resolution and has been widely used in the fabrication of flexible electronics and display *** critical steps in transfer printing are the ink pick-up and printing processes governed by the switching of adhesion states at the stamp/ink *** this review,we first introduce the history of transfer printing in terms of the transfer methods,transferred materials,and ***,the fundamental characteristics of the transfer printing system and typical strategies for regulating the stamp/ink interfacial adhesion strength are summarized and ***,future challenges and opportunities for developing the novel stamps,inks,and substrates with intelligent adhesion capability are discussed,aiming to inspire the innovation in the design of transfer printing systems.

关键词： interfacial adhesion switchable adhesion transfer printing

Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus,persisters and biofilms

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Bioactive Materials 2022年第8期7卷 272-289页

作者： shutao zhang Xinhua Qu Juyang Jiao Haozheng Tang Minqi Wang You Wang Hongtao Yang Weien Yuan Bing Yue Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalShanghai Jiaotong University School of MedicineChina School of Medical Science and Engineering Beihang UniversityBeijing100191China Engineering Research Center of Cell&Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai200240China

Methicillin-resistant Staphylococcus aureus(MRSA),biofilms,and persisters are three major factors leading to recurrent and recalcitrant implant *** antibiotics are still the primary treatment for chronic implant infections in clinical,only few drugs are effective in clearing persisters and formed ***,felodipine,a dihydropyridine calcium channel blocker,was reported for the first time to have antibacterial effects against MRSA,biofilm,and *** after continuous exposure to sub-lethal concentrations of felodipine,bacteria are less likely to develop ***,low doses of felodipine enhances the antibacterial activity of gentamicin by inhibiting the expression of protein associated with aminoglycoside resistance(aacA-aphD).Next,biofilm eradication test and persisters killing assay suggested felodipine has an excellent bactericidal effect against formed biofilms and ***,the result of protein profiling,and quantitative metabonomics analysis indicated felodipine reduce MRSA virulence(agrABC),biofilm formation and TCA ***,molecular docking showed felodipine inhibit the growth of persisters by binding to the H pocket of ClpP protease,which could lead to substantial protein ***,murine infection models suggested felodipine in combination with gentamicin alleviate bacterial burden and inflammatory *** conclusion,low dose of felodipine might be a promising agent for biomaterial delivery to enhance aminoglycosides efficacy against implant infections caused by MRSA,biofilm,and persisters.

关键词： Aminoglycosides Felodipine Persisters Methicillin-resistant Staphylococcus aureus Implant infection

Immunomodulatory biomaterials against bacterial infections:Progress,challenges,and future perspectives

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The Innovation 2023年第6期4卷 101-114页

作者： shutao zhang Hongtao Yang Minqi Wang Diego Mantovani Ke Yang Frank Witte Lili Tan Bing Yue Xinhua Qu Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200001China School of Engineering Medicine Beihang UniversityBejjing 100191China Laboratory for Biomaterials and Bioengineering Canada Research Chair 1 in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-MaterialsEngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineL aval UniversityQuebec CityQC G1V 0A6Canada Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Department of Prosthodontics Geriatic Dentistry and Craniomandibular DisordersCharite Medical UniversityAssmannshauser Strasse 4-614197 BerlinGermany

Bacterial infectious diseases are one of the leading causes of death *** with the use of multiple antibiotic treatment strategies,4.95 million people died from drug-resistant bacterial infections in *** 2050,the number of deaths will reach 10 milion *** increasing mortality may be partly due to bacterial heterogeneity in the infection microenvironment,such as drug-resistant bacteria,biofilms,persister cells,intracellular bacteria,and small colony *** addition,the complexity of the immune microenvironment at different stages of infection makes biomaterials with direct antimicrobial activity unsatisfactory for the longterm treatment of chronic bacterial *** increasing mortality may be partly attributed to the biomaterials failing to modulate the active antimicrobial action of immune ***,there is an urgent need for effective alternatives to treat bacterial ***,the development of immunomodulatory antimicrobial biomaterials has recently received considerable interest;however,a comprehensive review of their research progress is *** this review,we focus mainly on the research progress and future perspectives of immunomodulatory antimicrobial biomaterials used at different stages of ***,we describe the characteristics of the immune microenvironment in the acute and chronic phases of bacterial ***,we highlight the immunomodulatory strategies for antimicrobial biomaterials at different stages of infection and their corresponding advantages and ***,we discuss biomaterial-mediated bacterial vaccines'potential applications and challenges for activating innate and adaptive immune *** review will serve as a reference for future studies to develop next-generation immunomodulatory biomaterials and accelerate their translation into clinical practice.

关键词： infections biomaterials modulator

Real-World Wireless Network Modeling and Optimization:From Model/Data-Driven Perspective

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Chinese Journal of Electronics 2022年第6期31卷 991-1012页

作者： LI Yang zhang shutao REN Xiaohui ZHU Jianhang HUANG Jiajie HE Pengcheng SHEN Kaiming YAO Zhiqiang GONG Jie CHANG Tsunghui SHI Qingjiang LUO Zhiquan Shenzhen Research Institute of Big Data Pengcheng Lab School of Science and Engineering The Chinese University of Hong Kong (Shenzhen) College of Mathematics and Computational Sciences Xiangtan University School of Computer Science and Engineering Sun Yat-Sen University School of Software Engineering Tongji University

With the rapid development of the fifth-generation wireless communication systems, a profound revolution in terms of transmission capacity, energy efficiency, reliability, latency, and connectivity is highly expected to support a new batch of industries and applications. To achieve this goal, wireless networks are becoming extremely dynamic, heterogeneous, and complex. The modeling and optimization for the performance of realworld wireless networks are extremely challenging due to the difficulty to predict the network performance as a function of network parameters, and the prohibitively huge number of parameters to optimize. The conventional network modeling and optimization approaches rely on drive test, trial-and-error, and engineering experience,which are labor intensive, error-prone, and far from optimal. On the other hand, while the research community has spent significant efforts in understanding the fundamental limits of radio channels and developing physical layer techniques to operate close to it, very little is known about the performance limits of wireless networks, where millions of radio channels interact with one another in complex manners. This paper reviews the very recent mathematical and learning based techniques for modeling and optimizing the performance of real-world wireless networks in five aspects, including channel modeling, user demand and traffic modeling, throughput modeling and prediction, network parameter optimization, and IRS empowered performance optimization, and also presents the corresponding notable performance gains.

关键词： Mathematical methods Learning based methods Network performance modeling Network performance optimization

加权Hardy-Sobolev不等式及其应用

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数学物理学报（A辑） 2013年第4期33卷 621-626页

作者：张书陶中国计量学院数学系杭州310018

受Chern等讨论Caffarelli-Kohn-Nirenberg不等式极小值问题中函数变换的启发,该文获得一类加权的Hardy-Sobolev不等式;作为应用,当1

关键词：加权Hardy-Sobolev不等式 Caffarelli-Kohn-Nirenberg不等式

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控权论视角下政府绩效问责的有效治理路径

浙江工商大学学报 2022年第5期 156-164页

作者：张书涛河南师范大学公共政策与社会管理创新研究中心河南新乡453000

政府绩效问责作为一种执行工具和制度安排,具有绩效激励与问责控制的双重功能。在控权论视角下,绩效与责任并重、控制与激励兼容以及科层体制的制度保障构成绩效问责的控权治理基础,事前目标设定、事中检查验收与事后激励奖惩则形成绩... 详细信息

政府绩效问责作为一种执行工具和制度安排,具有绩效激励与问责控制的双重功能。在控权论视角下,绩效与责任并重、控制与激励兼容以及科层体制的制度保障构成绩效问责的控权治理基础,事前目标设定、事中检查验收与事后激励奖惩则形成绩效问责的控权行动规程。政府绩效问责的有效治理取决于整体制度与行动系统的逻辑匹配、功能互补与流程衔接。政府绩效问责所面临的目标偏离、信息障碍、标准模糊等制度困境和责任厘定、行为监测与绩效反馈等执行难题,主要归因于科层体制下绩效激励与问责控制的非一致性与非协同性。对此,需要总体上审视绩效问责制度均衡条件与行动支持机制,通过分层设置绩效目标任务、实施清单式检查验收和分级对位奖惩,达成全域定责、全程督责与底线追责的有效控权和高效问责。

关键词：政府绩效问责科层体制委托—代理关系控制权理论

基于Tau理论的机器人抓取运动仿生轨迹规划

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机械工程学报 2014年第13期50卷 42-51页

作者：张书涛张震钱晋武上海大学机电工程与自动化学院上海200072

针对机器人在抓取目标前的接近运动,提出一种基于Tau理论的仿生轨迹规划方法。Tau理论是认知科学研究者通过试验研究总结出的人和动物在接近和抓取物体时的运动策略。在Tau理论的基础上,对Tau理论的两种基本运动策略(Tau耦合策略和内部T... 详细信息

针对机器人在抓取目标前的接近运动,提出一种基于Tau理论的仿生轨迹规划方法。Tau理论是认知科学研究者通过试验研究总结出的人和动物在接近和抓取物体时的运动策略。在Tau理论的基础上,对Tau理论的两种基本运动策略(Tau耦合策略和内部Tau-g引导策略)进行运动学分析。针对内部Tau-g引导策略初始加速度不为零的问题,提出内部jerk引导的策略(内部Tau-j引导策略),并推导出基于Tau理论的机器人接近运动的轨迹规划公式。以三自由度平面机器人为例,进行轨迹规划、运动学分析、动力学分析、仿真和试验。结果表明,运用Tau理论进行轨迹规划,机器人手部的位置和姿态可在确定的时间同时到达目标,关节速度曲线、加速度曲线和驱动力矩曲线光滑连续,笛卡儿空间的轨迹是具有'钟形'光滑连续速度曲线的直线,验证了方法的有效性。

关键词： Tau理论仿生机器人轨迹规划

政府绩效评估的嵌入治理与偏差控制:一个结构-关系的分析框架

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河南师范大学学报（哲学社会科学版） 2021年第3期48卷 48-54页

作者：张书涛河南师范大学公共政策与社会管理创新研究中心河南新乡453007

压力型体制下上级政府主要凭借科层制正式权力结构运用“命令-控制”机制,自上而下地推进评估政策的执行,而下级政府则采取自下而上的“自主-应对”方式进行非正式策略回应。“结构-关系”框架为政府绩效评估嵌入治理的有效运作提供了... 详细信息

压力型体制下上级政府主要凭借科层制正式权力结构运用“命令-控制”机制,自上而下地推进评估政策的执行,而下级政府则采取自下而上的“自主-应对”方式进行非正式策略回应。“结构-关系”框架为政府绩效评估嵌入治理的有效运作提供了治理基础和效能保障。面对上下级政府之间的关系扭曲、行为失范、参与排斥和合法性缺失等治理偏差问题,需要在厘清诸治理要素及其逻辑关系的基础上构建具有一致性和协同性的政府绩效评估制度系统。通过政府规制对政府绩效评估的政策执行进行整体化控制,通过政策规范对政府绩效评估自主性行为进行限制,同时,确立政府绩效评估的价值目标与合作导向,实现政府、社会与公众的多层次治理协同。

关键词：政府绩效评估嵌入治理偏差控制制度协同

政府绩效评估的政策悖论与执行控制——一个多层治理的分析框架

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行政论坛 2022年第5期29卷 61-67页

作者：张书涛河南师范大学公共政策与社会管理创新研究中心河南新乡453000

运用多层治理理论分析政府绩效评估的组织结构与政策体系,发现绩效评估被裹挟在府际科层关系与多层次政策网络之中,并以纵向与横向两种运行方式相互作用。一方面,评估政策制定与执行体现为纵向政府层级的科层控制和横向部门的政策分割;... 详细信息

运用多层治理理论分析政府绩效评估的组织结构与政策体系,发现绩效评估被裹挟在府际科层关系与多层次政策网络之中,并以纵向与横向两种运行方式相互作用。一方面,评估政策制定与执行体现为纵向政府层级的科层控制和横向部门的政策分割;另一方面,多层次政策网络彰显了多属性的政策系统和跨层次的政策需求。政府绩效评估多层治理的嵌入过程存在多层评估系统与科层运作的结构失配、制度供给与绩效需求的系统张力、政策系统与技术标准的匹配困境等三重悖论。因此,要对多属性的政策系统进行分类,设计跨层次的评估政策体系,满足政府、社会与公众的多元绩效需求。

关键词：政府绩效评估多层治理政策悖论