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Local recurrence is an important prognostic factor of hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第36期11卷 5601-5606页

作者： Eiichirou Arimura Kazuhiro Kotoh Makoto Nakamuta shusuke morizono Munechika Enjoji Hajime Nawata Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan

AIM: To clarify the importance of complete treatment by PEIT.METHODS: A total of 140 previously untreated cases of HCC were enrolled in this study from 1988 to 2002. The inclusion criteria were: a solitary tumor less than 4 cm in diameter or multiple tumors, fewer than four in number and less than 3 cm in diameter, without extrahepatic metastasis or vessel invasion. As general principles for the treatment of HCC, the patients underwent transcatheter arterial chemoembolization (TACE) prior to PEIT. After the initial treatment of the patients,ultrasonography and computed tomography were performed, and measurement of serum levels of α-fetoprotein (AFP) was determined. When tumor recurrences were detected, PEIT and/or TACE were repeated whenever the hepatic functional reserve of the patient permitted. We then analyzed the variables that could influence prognosis, including tumor size and number, the serum levels of AFP, the parameters of hepatic function (albumin, bilirubin, ALT, hepaplastin test,platelet number, and indocyanine green retention at 15min [ICG-R15]), combined therapy with TACE, distant recurrence, and local recurrence.RESULTS: Univariate analysis identified the ICG test,serum levels of AFP and albumin, tumor size and number,and local recurrence, but not distant recurrence, as significant prognostic variables. In multivariate analysis using those five parameters, the ICG test, tumor size, tumor number,and local recurrence were identified as significant prognostic factors. In both univariate and multivariate analyses, the relative risk for the ICG test was the highest, followed by local recurrence.CONCLUSION: We found that local recurrence is an independent prognostic factor of HCC, indicating that achieving complete treatment for HCC on first treatment is important for improving the prognosis of patients with HCC.

关键词：肝细胞癌血液循环临床表现超声检查

Scattered and rapid intrahepatic recurrences after radio frequency ablation for hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第43期11卷 6828-6832页

作者： Kazuhiro Kotoh Munechika Enjoji Eiichirou Arimura shusuke morizono Motoyuki Kohjima Hironori Sakai Makoto Nakamuta Department of Medicine and Bioregulatory Science Department of Gastroenterology

AIM: To evaluate a series of patients with hepatocellular carcinoma (HCC) treated with several different protocols and devices.METHODS: We treated 138 patients [chronic hepatitis/liver cirrhosis (Child-Pugh A/B/C), 3/135 (107/25/3)]with two different devices and protocols: cool-tip needle [initial ablation at 60 W (standard method) (n=37)or at 40 W (modified method) (n = 28)] or; ablation with a LeVeen needle using a standard single-step, full expansion (single-step) method (n = 39) or a multi-step,incremental expansion (multi-step) method.RESULTS: Eleven patients experienced rapid and scattered recurrences 1 to 7 mo after the ablation. Nine patients were treated by the cool-tip original protocol (60 W) (9/37=24%) and the other two by the LeVeen single-step method (2/39=5%). The location of the recurrence was surrounding and limited to the site of ablation segment in three cases, and spread over one lobule or both lobules in the other eight cases. There was no recurrence in the patients treated with the modified cool-tip modified method (40 W) or the LeVeen multi-step method.CONCLUSION: There is a risk of rapid and scattered recurrence after RFA, especially when the standard cooltip procedure is used. Because such recurrence would worsen the prognosis, we recommend that modified protocols for the cool-tip and LeVeen needle methods should be used in clinical practice.

关键词：肝内循环放射治疗肝细胞癌照射频率

Re-evaluation of antitumor effects of combination chemotherapy with interferon-α and 5-fluorouracil for advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第36期11卷 5685-5687页

作者： Munechika Enjoji shusuke morizono Kazuhiro Kotoh Motoyuki Kohjima Yuzuru Miyagi Tsuyoshi Yoshimoto Makoto Nakamuta Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan

AIM: To evaluate the efficacy of combination chemotherapy with interferon-α (IFNα) and 5-fluorouracil (5-FU) in patients with advanced hepatocellular carcinoma (HCC).METHODS: Twenty-eight HCC patients in advanced stage were enrolled in the study. They were treated with IFNα/5-FU combination chemotherapy. One cycle of therapy lasted for 4 wk. IFNα (3× 106 units) was subcutaneously injected thrice weekly on days 1, 3, and 5 for 3 wk, and 5-FU (500 mg/d) was administered via the proper hepatic artery for 5 consecutive days per week for 3 wk. No drugs were administered during the 4th wk. The effect of combination chemotherapy was evaluated in each patient after every cycle based on the reduction of tumor volume.RESULTS: After the 1st cycle of therapy, 16 patients showed a partial response (PR, 57.1%) but none showed a complete response (CR, 0%). At the end of therapy,the number of patients who showed a CR, PR, or no response (NR) was 1, 10, and 17, respectively. The response rate for therapy (CR+PR) was 21.5%. Biochemical tests before therapy were compared between responsive (CR+PR) and non-responsive (NR) patients, but no significant differences were found for any of the parameters examined, indicating that no reasonable predictors could be identified in our analysis.CONCLUSION: Attempts should be made to discriminate between responders and non-responders by evaluating tumor size after the first cycle of IFNα/5-FU combination chemotherapy. For non-responders, therapy should not proceed to the next cycle, and instead, different combination of anticancer drugs should be explored.

关键词：抗癌抗菌素化学疗法干扰素-α 5-氟尿嘧啶肝细胞癌

Arterial steroid injection therapy can inhibit the progression of severe acute hepatic failure toward fulminant liver failure

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World Journal of Gastroenterology 2006年第41期12卷 6678-6682页

作者： Kazuhiro Kotoh Munechika Enjoji Makoto Nakamuta Tsuyoshi Yoshimoto Motoyuki Kohjima shusuke morizono Shinsaku Yamashita Yuki Horikawa Kengo Yoshimitsu Tsuyoshi Tajima Yoshiki Asayama Kousei Ishigami Masakazu Hirakawa Department of Medicine and Bioregulatory Science Graduate School of Medical Science Kyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan Department of Clinical Radiology Graduate School of Medical ScienceKyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan

AIM: To utilize transcatheter arterial steroid injection therapy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic failure.METHODS: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. RESULTS: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. CONCLUSION: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure.

关键词：动脉疾病病理治疗临床肝疾病

Novel synthesis of single-crystalline TbCu_(7)-type Sm-Fe powder by low-temperature reduction-diffusion process using molten salt

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Journal of Rare Earths 2022年第7期40卷 1126-1133页

作者： shusuke Okada Kenta Takagi Magnetic Powder Metallurgy Research Center National Institute of Advanced Industrial Science and Technology(AIST)2266-98 AnagahoraShimoshidami MoriyamaNagoya463-8560Japan

In this study,molten salt was used as a solvent for calcium(Ca)to let a reduction-diffusion(R-D)reaction occur below the melting point of Ca(1115 K),which is the lower limit temperature of the co nventional RD process.When the R-D reaction is conducted below 923 K with LiCl molten salt,submicron-sized TbCu_(7)-type Sm-Fe powder is formed.The c/a ratio of the powder estimated by a synchrotron X-ray diffraction pattern is 0.8456,which is consistent with the Sm_(0.67)Fe_(5.667)(SmFe_(8.5))phase.An electron backscatter diffraction analysis reveals that single-crystalline TbCu_(7)-type SmFe_(8.5) powder was synthesized for the first time.

关键词： Reduction-diffusion TbCu_(7) Molten salt Permanent magnet Rare earths

Low-temperature synthesis of Sm-Fe binary compounds by reduction-diffusion process using an eutectic salt solvent

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Rare Metals 2023年第5期42卷 1724-1731页

作者： Jungryang Kim shusuke Okada Kenta Takagi Magnetic Powder Metallurgy Research Center National Institute of Advanced Industrial Science and Technology(AIST)NagoyaAichi463-8560Japan

In this study,the temperature of the low-temperature reduction-diffusion(LTRD)process was successfully decreased to below 600℃by introducing LiClKCl eutectic molten salt with a low eutectic point(352℃)as a solvent for Ca reductant.Therefore,the Sm-Fe binary compounds,which were synthesizable at previously-unexplored low temperatures by the LTRD process using LiCl-KCl eutectic molten salt,were investigated,including whether a new metastable or ThMn_(12)-type Sm-Fe binary phase was formed.The Sm-Fe phase transitions of the SmFe binary compounds at a low temperature were identified,and it was found that MgCu_(2)-type Sm-Fe,PuNi_(3)-type SmFe and TbCu_(7)-type Sm-Fe phases were synthesized and stable at 400,500 and 550℃respectively.Although no new metastable Sm-Fe and ThMn_(12)-type Sm-Fe compounds were discovered in this study,this work can demonstrate that it is possible to synthesize the Sm-Fe phase at very low temperatures by the LTRD process for the first time.

关键词： Low-temperature synthesis Reductiondiffusion process Molten salts Hard magnet Sm-Fe compounds

Relationship between body surface area and ALT normalization after long-term lamivudine treatment

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World Journal of Gastroenterology 2005年第44期11卷 6948-6953页

作者： Makoto Nakamuta shusuke morizono Yuichi Tanabe Eiji Kajiwara Junya Shimono Akihide Masumoto Toshihiro Maruyama Norihiro Furusyo Hideyuki Nomura Hironori Sakai Kazuhiro Takahashi Koichi Azuma Shinji Shimoda Kazuhiro Kotoh Munechika Enjoji Jun Hayashi Kyushu University liver Disease Study Group Department of Medicine and Bioregulatory Science Department of Medicine Department of Internal Medicine Department of Clinical Research Department of Environmental Medicine and Infectious Diseases Department of Gastroenterology Department of Medicine and Clinical Science Department of Medicine and Biosystemic Science

AIM: To further evaluate the relationship between BSA and the effects of lamivudine in a greater number of cases and over a longer period of observation than in our previous evaluation.METHODS: We evaluated 249 patients with chronic hepatitis B. The effects of treatment for one year (n = 249),two years (n = 147), and three years (n = 72) were evaluated from the levels of serum ALT and HBV-DNA,as biological and virological effects (undetectable levels by PCR), respectively. Moreover, several variables that could influence the response to treatment, including ALT,albumin, bilirubin, platelet counts, BSA, HBV-DNA, and HBeAg were analyzed.RESULTS: For 1-year treatment, multivariate analysis revealed that BSA (P=0.0002) was the only factor for the biological effect, and that ALT (P = 0.0017), HBVDNA (P = 0.0004), and HBeAg (P = 0.0021) were independent factors for the virological effect. For 2-year treatment, multivariate analysis again showed that BSA(P = 0.0147) was the only factor for the biological effect,and that ALT (P = 0.0192) and HBeAg (P = 0.0428) were independent factors for the virological effect. For 3-year treatment, multivariate analysis, however, could not reveal BSA (P = 0.0730) as a factor for the normalization of ALT levels.CONCLUSION: BSA is a significant predictor for the normalizing the effect of lamivudine therapy on ALT for an initial 2-year period, suggesting that lamivudine dosage should be based on the individual BSA.

关键词：乙型肝炎病毒治疗表面抗体 ALT

Time Series Forecasting with Multiple Deep Learners: Selection from a Bayesian Network

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Journal of Data Analysis and Information Processing 2017年第3期5卷 115-130页

作者： shusuke Kobayashi Susumu Shirayama Graduate School of Engineering the University of Tokyo Tokyo Japan

Considering the recent developments in deep learning, it has become increasingly important to verify what methods are valid for the prediction of multivariate time-series data. In this study, we propose a novel method of time-series prediction employing multiple deep learners combined with a Bayesian network where training data is divided into clusters using K-means clustering. We decided how many clusters are the best for K-means with the Bayesian information criteria. Depending on each cluster, the multiple deep learners are trained. We used three types of deep learners: deep neural network (DNN), recurrent neural network (RNN), and long short-term memory (LSTM). A naive Bayes classifier is used to determine which deep learner is in charge of predicting a particular time-series. Our proposed method will be applied to a set of financial time-series data, the Nikkei Average Stock price, to assess the accuracy of the predictions made. Compared with the conventional method of employing a single deep learner to acquire all the data, it is demonstrated by our proposed method that F-value and accuracy are improved.

关键词： Time-Series Data Deep Learning Bayesian Network Recurrent Neural Network Long Short-Term Memory Ensemble Learning K-Means

Improved Transfer Process for the Fully Additive Manufacturing of a Conductive Layer-Stacked Polymeric Cantilever

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Materials Sciences and Applications 2019年第1期10卷 45-52页

作者： shusuke Kanazawa Yasuyuki Kusaka Noritaka Yamamoto Hirobumi Ushijima Flexible Electronics Research Center National Institute of Advanced Industrial Science and Technology Tsukuba Japan

This paper reports on an efficient fabrication process for a polymeric cantilever covered with conductive nano silver. The entire structure can be constructed additively using a printing process, without the use of an etching process or a sacrificial layer. The fabricated cantilever exhibits good linearity and forms a submillimeter-ordered air gap between itself and the substrate surface. Fine operation of a capacitive force gauge was obtained using the capacitance between the conductive cantilever and an electrode on the substrate. This process is expected to make possible the efficient manufacturing of various types of sensors that measure mechanical strain in a cantilever structure.

关键词： Additive Manufacturing MEMS Screen Printing Polymer Sensor