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A novel multiscale simulation framework for low-dimensional memristors

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Science China(Physics,Mechanics & Astronomy) 2023年第7期66卷 79-87页

作者： shurong pan Li Liu Qijun Huang Jin He Hao Wang Sheng Chang Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan 430072China School of Microelectronics Wuhan UniversityWuhan 430072China

In recent years,the memristor has been widely considered an emerging device,but it has rarely been *** obstacle is the change in the intrinsic atomic level when it *** the density functional theory(DFT),this atomic level change in structure cannot be *** molecular dynamics(MD),memristor electronic transport properties cannot be *** this study,we propose a novel multiscale simulation framework merging MD,DFT,and the nonequilibrium Green’s function method,which can reveal not only a memristor’s basic working mechanism but also its transport *** verify our framework’s availability in guiding innovative memristor design,a new type of memristor,a planar monolayer MoS_(2)-based memristor,is simulated for the first *** popped S atoms’effect on its carrier transport is revealed,which clarifies the working mechanism of the planar monolayer MoS_(2)-based memory *** hope that this framework can shed light on the analysis and design of low-dimensional memristors.

关键词： multiscale framework memristor planar monolayer transport properties MoS_(2)

Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 795-807页

作者： Yongchun pan Xiaowei Luan Fei Zeng Xuyuan Wang shurong Qin Qianglan Lu Guanzhong He Yanfeng Gao Xiaolian Sun Xin Han Bangshun He Yujun Song Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 211198China School of Medicine&Holistic Integrative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene ***,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor ***,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer *** this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are *** intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as *** the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target *** tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation ***,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

关键词： CRISPRdelivery Enzymeencapsulation Logic gate Hybridmaterial Hypoxia Gene editing Precise nanomedicine Multimodal therapy

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广东和海南土壤中微量元素丰度与相关性研究

热带地理 1989年第1期9卷 55-66页

作者：李小彬潘树荣广州地理研究所中山大学地理系

本文对广东和海南9种土壤类型中14种微量元素进行了丰度和相关性研究。提出用Mn/Zr和Mn+Zr2个指标来估计土壤中微量元素的丰度状况及判断土壤风化成土程度。分析表明，本区土壤与母质间微量元素含量均超过0.01水平显著值，土壤中微量元... 详细信息

本文对广东和海南9种土壤类型中14种微量元素进行了丰度和相关性研究。提出用Mn/Zr和Mn+Zr2个指标来估计土壤中微量元素的丰度状况及判断土壤风化成土程度。分析表明，本区土壤与母质间微量元素含量均超过0.01水平显著值，土壤中微量元素间含量有一定相关性。

关键词：土壤微量元素相关性地球化学广东海南丰度锰锌

Modeling of Mesoscale Creep Behaviors and Macroscale Creep Responses of Composite Fuels Under Irradiation Conditions

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Acta Mechanica Solida Sinica 2022年第6期35卷 1040-1054页

作者： Jing Zhang Jingyu Zhang Haoyu Wang Changbing Tang pan Yuan Chunyu Yin shurong Ding Yuanming Li Institute of Mechanics and Computational Engineering Department of Aeronautics and AstronauticsFudan UniversityShanghai200433China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu610213China

A finite-strain homogenization creep model for composite fuels under irradiation conditions is developed and verified,with the irradiation creep strains of the fuel particles and matrix correlated to the macroscale creep responses,excluding the contributions of volumetric strain induced by the irradiation swelling deformations of fuel particles.A finite element(FE)modeling method for uniaxial tensile creep tests is established with the irradiation effects of nuclear materials taken into *** proposed models and simulation strategy are numerically implemented to a kind of composite nuclear fuel,and the predicted mesoscale creep behaviors and the macroscale creep responses are *** research results indicate that:(1)the macroscale creep responses and the mesoscale stress and strain fields are all greatly affected by the irradiation swelling of fuel particles,owing to the strengthened mechanical interactions between the fuel particles and the matrix.(2)The effective creep rates for a certain case are approximately two constants before and after the critical fission density,which results from the accelerated fission gas swelling after fuel grain recrystallization,and the effects of macroscale tensile stress will be more enhanced at higher temperatures.(3)The macroscale creep contributions from the fuel particles and matrix depend mainly on the current volume fractions varying with fission density.(4)As a function of the macroscale stress,temperature,initial particle volume fraction and particle fission rate,a multi-variable mathematical model for effective creep rates is fitted out for the considered composite fuels,which matches well with the FE *** study supplies important theoretical models and research methods for the multi-scale creep behaviors of various composite fuels and provides a basis for simulation of the thermal–mechanical behavior in related composite fuel elements and assemblies.

关键词： Composite fuels Effective irradiation creep rate model Homogenization creep theory Irradiation swelling Large deformation

多层螺旋CT并多平面重建技术在非裂孔性膈疝与膈膨升术前诊断中的应用

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中华疝和腹壁外科杂志（电子版） 2024年第2期18卷 228-233页

作者：赵智勇闫玉昌关磊金淑溶潘振宇首都医科大学附属北京朝阳医院京西院区放射科 100043 首都医科大学附属北京朝阳医院疝和腹壁外科 100043

目的分析和探究多层螺旋CT并多平面重建技术在非裂孔性膈疝与膈膨升术前评价中的应用及临床意义。方法选取2017年8月至2023年8月于首都医科大学附属北京朝阳医院西院区行手术证实的非裂孔性膈疝27例、膈膨升11例患者,对其影像学资料、... 详细信息

目的分析和探究多层螺旋CT并多平面重建技术在非裂孔性膈疝与膈膨升术前评价中的应用及临床意义。方法选取2017年8月至2023年8月于首都医科大学附属北京朝阳医院西院区行手术证实的非裂孔性膈疝27例、膈膨升11例患者,对其影像学资料、临床手术资料进行回顾性分析,总结易误诊点及鉴别点。应用多平面重建技术测量膈疝疝口左右径数值及前后径数值,并与术中测量的径线值进行比较,检验之间相关性。结果手术证实为膈疝27例患者中,经CT薄层扫描并多平面重建技术观察影像诊断为膈疝24例,影像诊断准确率为88.88%(24/27);手术证实为膈膨升11例患者中,经影像观察诊断为膈膨升8例,准确率为72.72%(8/11)。关于膈疝左右径值、前后径值,多层螺旋CT多平面重建上与术中测量的值比较,差异均无统计学意义(P>0.05);左右径值、前后径值各自间均具有较强相关性(r=0.97,0.99;均P<0.01)。结论多层螺旋CT在非裂孔性膈疝与膈膨升术前准确诊断中发挥重要作用,辅以多平面重建技术观察可明显提高术前诊断准确率。多平面重建可多角度显示膈肌形态,准确判断膈肌的完整性及分辨胸腹腔邻近结构,并在相应手术方式的选择及膈疝修补术前合适大小疝补片选择上有较大临床指导意义。

关键词：非裂孔性膈疝膈膨升多层螺旋CT 多平面重建技术疝修补术

有限转角力矩电机电磁转矩与霍尔感应磁场研究

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微电机 2024年第2期57卷 6-12页

作者：张恩静潘鹤张书荣卢书君王顺周力周龙赵静中国航发贵州红林航空动力控制科技有限公司贵阳550000 空军装备部驻成都地区军事代表局驻贵阳地区第二军代表室贵阳550000 北京理工大学自动化学院北京100081

永磁式齿槽式集中绕组形式有限转角力矩电机一般具有较小的气隙,进而可以增加电机的气隙磁密幅值,提高力矩输出能力。根据这一优势,通过理论设计和有限元仿真软件设计出一种符合基本性能要求的旋转式直驱阀有限转角力矩电机,并研究了充... 详细信息

永磁式齿槽式集中绕组形式有限转角力矩电机一般具有较小的气隙,进而可以增加电机的气隙磁密幅值,提高力矩输出能力。根据这一优势,通过理论设计和有限元仿真软件设计出一种符合基本性能要求的旋转式直驱阀有限转角力矩电机,并研究了充磁方向、斜槽对齿槽转矩和输出转矩的影响,从而达到抑制转矩波动、改善转矩波形的目的。根据线性霍尔具有体积小、反馈信号线性度好等优点,选用线性霍尔接收信号,并研究霍尔位置和偏心距对霍尔波形畸变率的影响。研究表明,对霍尔波形进行优化后成功将谐波畸变率从最初的4.9%降低到0.1%以下,这在工程研究领域具有重要参考意义。

关键词：有限转角力矩电机转矩波动线性霍尔偏心距霍尔波形畸变率

置信专业活动在神经内科住培模式构建中的研究与实践

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中国继续医学教育 2024年第11期16卷 178-182页

作者：吕蔓华薛腾腾曾圆圆段淑荣沈月娥郭庆峰潘永惠哈尔滨医科大学附属第一医院神经内科黑龙江哈尔滨150001 哈尔滨医科大学附属第一医院教务科黑龙江哈尔滨150001

第三代医学教育改革的特点是强调以胜任力为导向的医学教育,但仍存在着无法忽视的不足,因此文章引入了置信专业活动这一概念。置信专业活动是指在临床环境中监督者通过观察和衡量后可以信任并委托给学员的专业活动,这一活动可以高效并... 详细信息

第三代医学教育改革的特点是强调以胜任力为导向的医学教育,但仍存在着无法忽视的不足,因此文章引入了置信专业活动这一概念。置信专业活动是指在临床环境中监督者通过观察和衡量后可以信任并委托给学员的专业活动,这一活动可以高效并且可靠地帮助监督者判断住培学员的能力,并促进住培学员能力的提升。目前为止,我国神经内科现有形成性评价体系仍不全面,无法有效地评价住院医师规范化培训(以下简称“住培”)学员在临床工作中的能力,国内也没有神经内科住培相关的置信专业活动。文章立足2020—2023年国内外临床医学教育相关研究,借鉴国际经验并结合我国实践经验分析置信专业活动的发展起源、现状、阻碍和前景,为我国神经内科住培模式构建的研究与实践提供思路及方向。

关键词：置信专业活动胜任力医学教育神经内科住院医师规范化培训形成性评价

Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia

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Acta Pharmaceutica Sinica B 2020年第2期10卷 249-261页

作者： Libin pan Pei Han shurong Ma Ran Peng Can Wang Weijia Kong Lin Cong Jie Fu Zhengwei Zhang Hang Yu Yan Wang Jiandong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Insitute of Medicinal Biotechnology Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China

The progression of hyperuricemia disease is often accompanied by damage to renal ***,there are few studies on hyperuricemia nephropathy,especially its association with intestinal *** study combines metabolomics and gut microbiota diversity analysis to explore metabolic changes using a rat model as well as the changes in intestinal flora *** results showed that amino acid metabolism was disturbed with serine,glutamate and glutamine being downregulated whilst glycine,hydroxyproline and alanine being *** combined glycine,serine and glutamate could predict hyperuricemia nephropathy with an area under the curve of *** intestinal flora was also ***,Myroides,Corynebacterium,Alcaligenaceae,Oligella and other conditional pathogens increased significantly in the model group,while Blautia and Roseburia,the shortchain fatty acid producing bacteria,declined *** phylum,family and genus levels,disordered nitrogen circulation in gut microbiota was *** the model group,the uric acid decomposition pathway was enhanced with reinforced urea liver-intestine *** results implied that the intestinal flora play a vital role in the pathogenesis of hyperuricemia ***,modulation of gut microbiota or targeting at metabolic enzymes,i.e.,urease,could assist the treatment and prevention of this disease.

关键词： Hyperuricemia Renal function Gut microbiota Metabolomics Urease

特色办刊提升地质学科技期刊的影响力——以《岩矿测试》为例

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中国科技期刊研究 2022年第2期33卷 209-214页

作者：潘静徐书荣储彬彬中国地质科学院期刊处北京市100037 国家地质实验测试中心《岩矿测试》编辑部北京市100037

【目的】在数字化出版背景下,探索如何提升地质学专业性科技期刊的学术质量和影响力。【方法】以地质学科技期刊《岩矿测试》为例,结合近年来改革办刊举措,探讨专业学术期刊发展的可行性方案。【结果】通过提高论文学术质量、推进数字... 详细信息

【目的】在数字化出版背景下,探索如何提升地质学专业性科技期刊的学术质量和影响力。【方法】以地质学科技期刊《岩矿测试》为例,结合近年来改革办刊举措,探讨专业学术期刊发展的可行性方案。【结果】通过提高论文学术质量、推进数字化出版、利用大数据服务办刊、举办作者培训班等一系列期刊品牌建设举措,《岩矿测试》的行业认可度和学术影响力得到提升。【结论】寻求特色的办刊之路是提高专业性科技期刊核心竞争力和整体影响力的关键。

关键词：《岩矿测试》特色办刊学术影响力新媒体传播数字化出版