检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

收入分配格局变迁之阶层变动分析

现代经济探讨 2010年第9期 74-78页

作者：宋树仁南开大学经济学院经济研究所博士生天津300071

2010年,中国居民收入分配问题再次成为全社会关注的焦点。该文选择了20个社会群体,测度出中国阶层收入分配格局,通过对比中国居民收入分配格局和中国阶层收入分配格局,从阶层视角,剖析了中国居民收入分配格局两次变迁过程中,阶层的分化... 详细信息

2010年,中国居民收入分配问题再次成为全社会关注的焦点。该文选择了20个社会群体,测度出中国阶层收入分配格局,通过对比中国居民收入分配格局和中国阶层收入分配格局,从阶层视角,剖析了中国居民收入分配格局两次变迁过程中,阶层的分化、重组与变动,并估测出现阶段和未来中国下产阶层、中产阶层和上产阶层构成和发展趋势。

关键词：收入分配格局变迁阶层

在线全文

学校读者我要写书评

暂无评论

国际气候合作中的公平性问题研究评述

江西社会科学 2010年第3期30卷 77-84页

作者：钟茂初史亚东宋树仁南开大学经济研究所

哥本哈根气候大会之所以没有达成实质性的协议,其根本原因在于各国对于应对全球气候变化责任分担的公平性难以达成共识。本文系统梳理了气候合作中关于公平性问题的学术讨论和政策主张,发现影响合作的主要矛盾可归纳为两点:一是公平原... 详细信息

哥本哈根气候大会之所以没有达成实质性的协议,其根本原因在于各国对于应对全球气候变化责任分担的公平性难以达成共识。本文系统梳理了气候合作中关于公平性问题的学术讨论和政策主张,发现影响合作的主要矛盾可归纳为两点:一是公平原则的南北分歧,二是公平与效率的分歧。本文认为,在促进全球合作尽快形成的目标下,解决公平争论、提出可被广泛接受的公平原则将是解决目前困境的研究方向。

关键词：国际气候合作京都议定书公平原则责任分担碳排放

城镇居民收入差距变动轨迹的总体特征及分解分析:1988～2008

在线全文

学校读者我要写书评

暂无评论

经济与管理研究 2010年第9期31卷 10-18页

作者：马草原李运达宋树仁南开大学经济研究所

本文使用全国数据分析了改革以来中国城镇居民收入差距的总体特征,并基于天津市典型调查数据,应用基尼系数分解方法研究了近20年来城镇居民收入差距的变动轨迹及其影响因素。针对基尼系数的收入构成分解研究显示,工资性收入的分布状况... 详细信息

本文使用全国数据分析了改革以来中国城镇居民收入差距的总体特征,并基于天津市典型调查数据,应用基尼系数分解方法研究了近20年来城镇居民收入差距的变动轨迹及其影响因素。针对基尼系数的收入构成分解研究显示,工资性收入的分布状况基本上决定了城镇居民收入差距的变动趋势,财产性收入和经营性收入的分配状况趋于相对均等化,转移性收入对总收入差距的平抑作用被大大削弱,社会保障体系在覆盖面扩大的同时可能存在识别和瞄准上的方向性偏误;而从人口特征角度进行的基尼系数分解研究则显示,居民行业差别、就业性质以及受教育程度成为影响城镇居民收入差距最重要的三大因素。

关键词：城镇居民收入差距基尼系数分解收入构成人口特征

The induction of PANoptosis in KRAS-mutant pancreatic ductal adenocarcinoma cells by a multispecific platinum complex

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2022年第10期65卷 1978-1984页

作者： Xin Yuan shuren Zhang Xuanmeng Zhong Hao Yuan Dongfan song Xiaoyu Wang Hanyang Yu Zijian Guo State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjing 210023China Department of Biomedical Engineering College of Engineering and Applied SciencesChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjing 210023China

Oncogenic KRAS reprograms pancreatic ductal adenocarcinoma(PDAC) cells to a state that is awfully resistant to *** alternative coping strategy is to trigger a nonapoptotic cell ***,a multi specific platinum complex SEP was constructed by conjugating a quinone derivative seratrodast to a prodrug of ***,SEP-treated KRAS-mutant PDAC cells showed the characteristics of pyroptosis,apoptosis and necroptosis,similar to PANoptosis(a newfound inflammatory cell death).Mechanistically,SEP could enter cancer cells effectively,then damage nuclear DNA,boost mitochondrial superoxide anion radicals and affect various signaling pathways related to redox homeostasis and tumor *** our best knowledge,SEP is the first metal complex,even small molecule,to elicit PANoptosis(pyroptosis,apoptosis and necroptosis) in cancer cells,providing a new strategy to overcome apoptotic resistance of KRAS-mutant PDAC.

关键词： metallodrug pancreatic ductal adenocarcinoma PANoptosis cell death platinum prodrug

Combining cisplatin and a STING agonist into one molecule for metalloimmunotherapy of cancer

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第1期11卷 107-119页

作者： shuren Zhang Dongfan song Wenhao Yu Ji Li Xiaoyu Wang Yachao Li Zihan Zhao Qi Xue Jing Zhao Jie P.Li Zijian Guo State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center (ChemBIC) Nanjing University Department of Urology Afflliated Drum Tower HospitalMedical SchoolNanjing University Nanchuang (Jiangsu)Institute of Chemistry and Health

Mounting evidence suggests that strategies combining DNA-damaging agents and stimulator of interferon genes(STING) agonists are promising cancer therapeutic regimens because they can amplify STING activation and remodel the immunosuppressive tumor microenvironment. However, a single molecular entity comprising both agents has not yet been developed. Herein, we designed two PtIV-MSA-2 conjugates(Ⅰand Ⅱ) containing the DNA-damaging chemotherapeutic drug cisplatin and the innate immuneactivating STING agonist MSA-2; these conjugates showed great potential as multispecific small-molecule drugs against pancreatic cancer. Mechanistic studies revealed that conjugate Ⅰ upregulated the expression of transcripts associated with innate immunity and metabolism in cancer cells, significantly differing from cisplatin and MSA-2. An analysis of the tumor microenvironment demonstrated that conjugate I could enhance the infiltration of natural killer(NK) cells into tumors and promote the activation of T cells, NK cells and dendritic cells in tumor tissues. These findings indicated that conjugate I, which was created by incorporating a Pt chemotherapeutic drug and STING agonist into one molecule, is a promising and potent anticancer drug candidate, opening new avenues for small-molecule-based cancer metalloimmunotherapy.

关键词： platinum drug STING agonist single-molecule multitarget metalloimmunology

Temperature and Tumor Microenvironment Dual Responsive Mesoporous Magnetic Nanospheres for Magnetothermal Effect-Induced Cancer Theranostics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2023年第2期5卷 469-485页

作者： Zhiyi Wang shuren Wang Xiaoguang Zhang Ziyuan Li Zeeshan Ali Donghai Yu Hongtao Zhang Fugeng Sheng song Gao Yanglong Hou Beijing Key Laboratory for Magnetoelectric Materials and Devices School of Materials Science and EngineeringPeking UniversityBeijing 100871 Institute of Spin-X Science and Technology South China University of TechnologyGuangzhou 510641 School of Chemical and Materials Engineering National University of Sciences&TechnologyIslamabad 44000 Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032 Fifth Medical Center of Chinese PLA General Hospital Beijing 100071

The development of smart drug delivery systems(SDDSs)based on engineered nanomaterials is important for clinical ***,controllable administration of chemotherapeutic drugs for deep tumors and the avoidance of side effects caused by off-targeting during delivery remain a great ***,a stimulus-responsive system of mesoporous nanospheres(composed of Cu@Fe_(2)C@mSiO_(2))with good magnetothermal effect is introduced into the tumor *** system plays an important role in image-guided controllable targeted drug delivery that is independent of tumor ***-induced emission luminogen-based fluorescence imaging and magnetic resonance imaging were utilized since these techniques visualize the delivery process in real *** addition,the degraded nanocarriers showed high catalytic activity for Fenton and Fenton-like reactions,upregulating the level of hydroxyl radicals(•OH)in cancer cells to realize chemodynamic *** induced•OH led to the overexpression of pho-STAT3,activating the STAT3 signaling pathway,eventually inducing cancer cell *** metabolic monitoring,this SDDS is removed from the body after its degradation in *** synergistically enhanced therapeutic effect was obtained in the chemo-chemodynamic therapy of 4T1 tumor-bearing mice,offering a platform for efficient cancer therapy with a personalized theranostic strategy.

关键词： smart drug delivery systems magnetothermal effect stimulus-responsive system tumor microenvironment chemo-chemodynamic therapy

A Study on the Beidou IGSO/MEO Satellite Orbit Determination and Prediction of the Different Yaw Control Mode

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Study on the Beidou IGSO/MEO Satellite Orbit Determination...

行业特色型大学“新学科”发展逻辑与行动策略

第四届中国卫星导航学术年会

作者： Wang Wei Chen Gucang Guo shuren song Xiaoyong Zhao Qile Beijing Institute of Tracking and Telecommunication Technology

During the conversion between yaw steering and orbit normal mode of the Beidou IGSO and MEO satellite, the dynamic model changes. As a result, the accuracy of the orbit determination and prediction decrease. As the yaw control mode changes, the variation of the dynamic model has been studied . Based on the empirical and analytical solar radiation pressure models, one piecewise model and one linear model have been proposed. The two models were tested with the actual Beidou satellites’ on-orbit data. The results showed that the two models which are raised in this paper can improve the accuracy of the Beidou IGSO/MEO orbit determination and prediction.

关键词： yaw steering · orbit normal · Precise orbit determination · parameter variation · Solar Radiation Pressure

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

学位与研究生教育 2020年第11期 32-37页

作者：高树仁宋丹大连理工大学高等教育研究院大连116024 大连理工大学党委大连116024

“新工科”“新医科”“新农科”等学科建设问题缘起于社会经济变迁的趋势对于高等教育学科建设模式和基本路径选择的思考。“新学科”建设不仅是学科内容扩张,更是理念变革、模式创新和结构调整过程。行业特色型大学遵循社会逻辑并将... 详细信息

“新工科”“新医科”“新农科”等学科建设问题缘起于社会经济变迁的趋势对于高等教育学科建设模式和基本路径选择的思考。“新学科”建设不仅是学科内容扩张,更是理念变革、模式创新和结构调整过程。行业特色型大学遵循社会逻辑并将服务行业发展作为既定目标,学科建设方面呈现学术引领和实践应用的双重特性。行业特色型大学是我国高等教育“新学科”建设的一个重要主体,应在学术逻辑、经济逻辑和管理逻辑基础上,寻求学科生成动力,维系学科发展方向,并最终实现“新学科”发展的价值目标。

关键词：行业特色型大学新工科新医科新农科学科逻辑

在线全文

学校读者我要写书评

暂无评论

高校创业教育的现状、问题及对策

教育发展研究 2011年第11期31卷 71-74页

作者：宋斌王磊浙江树人大学杭州310015

目前国内高校毕业生对创业的积极性正逐步提高,对高校的创业教育也有较为旺盛的需求。但国内高校开展创业教育存在诸多问题。社会和高校应该进一步认识到创业教育的重要性,将创业教育作为重要的教育内容和目标。同时,高校应优化课程结构... 详细信息

目前国内高校毕业生对创业的积极性正逐步提高,对高校的创业教育也有较为旺盛的需求。但国内高校开展创业教育存在诸多问题。社会和高校应该进一步认识到创业教育的重要性,将创业教育作为重要的教育内容和目标。同时,高校应优化课程结构,加强大学生创业实践环节,并加强与企业界的联系与合作,以此提高大学生创业的成功率。

关键词：大学生创业创业教育