检索结果-南通市图书馆

Complicated hollow turbine blades and surface grain refinement process

在线全文

学校读者我要写书评

暂无评论

China Foundry 2010年第2期7卷 121-126页

作者： Peng Zhijiang jia shuqin Zhang Zehai Liu Yan AVIC Shenyang Liming Aero-Engine （Group） Corporation Ltd Shenyang 110043 Shenyang Research Institute of Foundry Shenyang 110022 China

The control of grain size in superalloys is critical in the manufacture of gas turbine *** aim of the present research is to provide the technology for producing complicated hollow turbine blades with fine surface grains and better comprehensive mechanical *** melt superheating treatment and coating the internal surfaces of shell mould using a cobalt aluminate-bearing coating material,the in-uence of cobalt aluminate as inoculant on the surface grain sizes of turbine blade was studied with addition of cobalt aluminate:0,35%,45%-65% and 100% *** the same time,the effects of cooling circumstances of the blades on surface grain sizes were also experimented under the same addition of cobalt *** results showed that the melt superheating treatment plays a significant role in the grain size and carbide morphology;and fine surface grains were obtained when the internal surfaces of shell mould were coated using cobalt aluminate *** the addition of cobalt aluminate in coating is between 45%-65%,and the melt is poured into preheated shell moulds with fine silica sand as backing sand,the blades satisfied the surface grain size requirement is over 90%.In addition,comparisons of the surface grain size and the mechanical properties were also conducted between home-made and foreign-made blades.

关键词： complicated hollow turbine blades K465 alloy surface grain refinement melt superheating treatment

MAGI1 inhibits migration and invasion via blocking MAPK/ERK signaling pathway in gastric cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2017年第1期29卷 25-35页

作者： shuqin jia jiajia Lu Tingting Qu Yi Feng Xiaohong Wang Caixia Liu jiafu Ji Laboratory of Surgery the Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center for Molecular Diagnosis Peking University Cancer Hospital & InstituteBeijing 100142 China Department of Medical Oncology the Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Tissue Bank Peking University Cancer Hospital &Institute Beijing 100142 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Beijing 100142 China

Objective： To explore the association of membrane-associated guanylate kinase inverted 1（MAGI1） with gastric cancer（GC） and the related molecular ***： The reverse transcription-polymerase chain reaction（RT-PCR） and immunohistochemistry（IHC）were utilized to measure the MAGI1 expression level in GC tissues. Quantitative real-time PCR and Western blotting were used to ensure the MAGI1 expression in GC cell lines. Small hairpin RNA（sh RNA） was applied for knockdown of endogenous MAGI1 in GC cells. MTT assay and colony formation assay, scratch wounding migration assay and transwell chamber migration assay, as well as transwell chamber invasion assay were employed respectively to investigate the GC cell proliferation, migration and invasion in MAGI1-knockdown and control GC cells. The potential molecular mechanism mediated by MAGI1 was studied using Western blotting and RT- ***： RT-PCR and IHC verified MAGI1 was frequently expressed in matched adjacent noncancerous mucosa compared with GC tissues and the expression of MAGI1 was related to clinical pathological parameters. Functional assays indicated that MAGI1 knockdown significantly promoted GC cell migration and invasion. Further mechanism investigation demonstrated that one pathway of MAGI1 inhibiting migration and invasion was mainly by altering the expression of matrix metalloproteinases（MMPs） and epithelial-mesenchymal transition（EMT）-related molecules via inhibiting MAPK/ERK signaling ***： MAGI1 was associated with GC clinical pathological parameters and acted as a tumor suppressor via inhibiting of MAPK/ERK signaling pathway in GC.

关键词： MAGI1 migration invasion MAPK/ERK MMPs EMT gastric cancer

Germline mutations in hereditary diffuse gastric cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2018年第1期30卷 122-130页

作者： Hao Zhang Mengmeng Feng Yi Feng Zhaode Bu Ziyu Li shuqin jia jiafu Ji Surgery Laboratory the Affiliated Hospital of Inner Mongolia Medical University Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Molecular Diagnostics Peking University Cancer Hospital & Institute Department of Gynecology Weifang Maternal and Child Health Hospital Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal Surgery Peking University Cancer Hospital &Institute

Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Among which, about 1%–3% of gastric cancer patients were characterized by inherited gastric cancer predisposition syndromes, knowing as hereditary diffuse gastric cancer（HDGC）. Studies reported that CDH1 germline mutations are the main cause of HDGC. With the help of rapid development of genetic testing technologies and data analysis tools, more and more researchers focus on seeking candidate susceptibility genes for hereditary cancer syndromes. In addition, National Comprehensive Cancer Network（NCCN） guidelines recommend that the patients of HDGC carrying CDH1 mutations should undergo prophylactic gastrectomy or routine endoscopic surveillances. Therefore, genetic counseling plays a key role in helping individuals with pathogenic mutations make appropriate risk management plans. Moreover, experienced and professional genetic counselors as well as a systematic multidisciplinary team（MDT） are also required to facilitate the development of genetic counseling and benefit pathogenic mutation carriers who are in need of regular and standardized risk management solutions. In this review, we provided an overview about the germline mutations of several genes identified in HDGC, suggesting that these genes may potentially act as susceptibility genes for this malignant cancer syndrome. Furthermore, we introduced information for prevention, diagnosis and risk management of HDGC. Investigations on key factors that may have effect on risk management decision-making and genetic data collection of more cancer syndrome family pedigrees are required for the development of HDGC therapeutic strategies.

关键词： CDH1 CTNNA1 germline mutation hereditary diffuse gastric cancer genetic counseling

Depth of tumor invasion and tumor-occupied portions of stomach are predictive factors of intra-abdominal metastasis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2017年第2期29卷 109-117页

作者： Ziyu Li Zhemin Li shuqin jia Zhaode Bu Lianhai Zhang Xiaojiang Wu Shuangxi Li Fei Shan Xin Ji jiafu Ji Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center for Molecular Diagnostics Peking University Cancer Hospital & Institute Beijing 100142 China

Objective： Diagnostic laparoscopy is recommended for the pretherapeutic staging of gastric cancer to detect any unexpected or unconfirmed intra-abdominal metastasis. The aim of this study was to evaluate the role and indications of diagnostic laparoscopy in the detection of intra-abdominal metastasis. Methods： Standard diagnostic laparoscopy with peritoneal cytology examination was performed prospectively on patients who were clinically diagnosed with primary local advanced gastric cancer （CT≥2M0）. We calculated the rate of intra-abdominal metastases identified by diagnostic laparoscopy, and examined the relationship between peritoneal dissemination （P） and cytology results （CY）. Split-sample method was applied to find clinical risk factors for intra-abdominal metastasis. Multivariate logistic regression analysis and receiver-operator characteristic （ROC） analysis were performed in training set to find out risk factors ofintra-abdominal metastasis, and then validate it in testing set. Results： Out of 249 cM0 patients, 51 （20.5%） patients with intra-abdominal metastasis were identified by diagnostic laparoscopy, including 20 （8.0%） P1CY1, 17 （6.8%） POCY1 and 14 （5.6%） P1CY0 patients. In the training set, multivariate logistic regression analysis and ROC analysis showed that the depth of tumor invasion on computer tomography （CT） scan ≥21 mm and tumor-occupied 〉2 portions of stomach are predictive factors of metastasis. In the testing set, when diagnostic laparoscopy was performed on patients who had one or two of these risk factors, the sensitivity and positive predictive value for detecting intra-abdominal metastasis were 90.0% and 32.1%, respectively. Conclusions： According to our results, depth of tumor invasion and tumor-occupied portions of stomach are predictive factors ofintra-abdominal metastasis.

关键词： Gastric cancer diagnostic laparoscopy peritoneal dissemination intra-peritoneal free cancer cells pretherapeutic staging

TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第7期8卷 3512-3523页

作者： Xiaoxiao Ma shuqin jia Gangjian Wang Min Liang Ting Guo Hong Du Sisi Li Xiaomei Li Longtao Huangfu jianping Guo Xiaofang Xing jiafu Ji Department of Gastrointestinal Cancer Translational Research Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijingChina Department of Molecular Diagnostics Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijingChina Institute of Precision Medicine the First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510275China Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijingChina

Immune checkpoint blockade(ICB)offers a new opportunity for treatment for gastric cancer(G.C.).Understanding the upstream regulation of immune checkpoints is crucial to further improve the efficacy of ICB ***,using the CRISPR-Cas9-based genome-wide screening,we identified TRIM28 as one of the most significant regulators of PD-L1,a checkpoint protein,in ***.

关键词： cancer gastric immune

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

应用视觉显著性的小提花织物疵点检测

纺织学报 2016年第12期37卷 38-42,48页

作者：李敏崔树芹陈佳武汉纺织大学数学与计算机学院湖北武汉430072

为实现小提花织物的疵点检测,提出了一种基于视觉显著性的疵点定位与分割方法。针对小提花织物的花型具有周期性的特点,通过对织物图像进行快速傅里叶变换和形态滤波来抑制正常花纹的显著性,突出疵点区域的显著性,以获取图像的全局显著... 详细信息

为实现小提花织物的疵点检测,提出了一种基于视觉显著性的疵点定位与分割方法。针对小提花织物的花型具有周期性的特点,通过对织物图像进行快速傅里叶变换和形态滤波来抑制正常花纹的显著性,突出疵点区域的显著性,以获取图像的全局显著图;然后使用基于图论的视觉显著模型来计算图像的局部显著图,并对全局和局部显著图进行合并生成综合显著图;最后使用最大熵法对综合显著图进行分割,以得到疵点目标。实验结果表明,在对横裆、破洞、断头、打结和跳花等5种瑕疵进行测试时,该方法的正确率高达93.5%,非常适合于对小提花织物进行疵点检测。

关键词：小提花织物疵点检测视觉显著性最大熵法

在线全文

学校读者我要写书评

暂无评论

超音速化学氧碘激光器光腔扩张角

强激光与粒子束 2011年第2期23卷 329-333页

作者：怀英贾淑芹金玉奇中国科学院大连化学物理研究所化学激光重点实验室辽宁大连116023

在超音速化学氧碘激光器的设计中,为了削弱光腔部分的化学反应放热对激光器出光的负面效应,在光腔部分通常加入一扩张角。为了研究这一扩张角对激光器内流场的作用,根据kW级超音速化学氧碘激光器的实验平台,数值模拟了激光器内超音速混... 详细信息

在超音速化学氧碘激光器的设计中,为了削弱光腔部分的化学反应放热对激光器出光的负面效应,在光腔部分通常加入一扩张角。为了研究这一扩张角对激光器内流场的作用,根据kW级超音速化学氧碘激光器的实验平台,数值模拟了激光器内超音速混合喷管至光腔部分的流动过程,解析了光腔扩张角对内流场的流动参量和化学增益的影响,从维持压强和温度稳定性方面比对分析了不同扩张角度的性能,并探索了喷管高度和扩张角之间的规律。结果表明:此kW级超音速化学氧碘激光器的合理光扩张角度为4.5°。

关键词：化学氧碘激光器光腔扩张角热阻塞

化学氧碘激光器内流场亚跨超音速混合的大涡模拟研究

在线全文

学校读者我要写书评

暂无评论

强激光与粒子束 2009年第7期21卷 977-981页

作者：怀英贾淑芹金玉奇中国科学院大连化学物理研究所化学激光重点实验室辽宁大连116023

利用大涡模拟对化学氧碘激光器内的亚跨超音速混合过程进行模拟分析,其结果表明了大涡模拟对这种低压、低密度、亚跨超音速及夹杂多种介质的化学流场的可执行性。与传统的雷诺平均仿真结果相比较,大涡模拟能掌握更多的流场细节数据,能... 详细信息

利用大涡模拟对化学氧碘激光器内的亚跨超音速混合过程进行模拟分析,其结果表明了大涡模拟对这种低压、低密度、亚跨超音速及夹杂多种介质的化学流场的可执行性。与传统的雷诺平均仿真结果相比较,大涡模拟能掌握更多的流场细节数据,能够对混合过程进行精准地判断和分析。在此基础上,提出了碘流反向45°入流的设计方案以增强混合程度,计算表明采用此种方案在相应出光面上平均小信号增益系数提高了5%。

关键词：大涡模拟混合度超音速化学流场小信号增益化学氧碘激光

在线全文

学校读者我要写书评

暂无评论

高能化学激光多物理场耦合数值模拟

化工学报 2019年第11期70卷 4298-4305,F0003页

作者：怀英贾淑芹吴克难陈曦中国科学院大连化学物理研究所

高能化学激光是利用大量化学物质的原子受激辐射产生发光现象,为了合理解析这种过程,构建了多物理模型耦合计算体系,所构建的数值模拟体系包含了流场-化学场计算模块、光场计算模块和热-结构计算模块。三种物理过程强烈的时间尺度反差... 详细信息

高能化学激光是利用大量化学物质的原子受激辐射产生发光现象,为了合理解析这种过程,构建了多物理模型耦合计算体系,所构建的数值模拟体系包含了流场-化学场计算模块、光场计算模块和热-结构计算模块。三种物理过程强烈的时间尺度反差给多物理场耦合计算带来了困难,因而提出了非同步多时间尺度耦合策略,使全三维、高分辨率大尺度化学激光的模拟成为可能,以氧碘化学激光为例,数值解析了超音速化学氧碘激光器流动、光场演变及腔镜系统内各光学元件在激光辐照下的热力学过程,计算结果能直接反映激光器包括功率和光束质量等最为重要的性能指标,是实现高能激光关键问题辨析和优化设计的重要工具。

关键词：化学激光数值模拟流动热力学过程光学计算