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Acta Pharmaceutica Sinica B 2020年第7期10卷 1294-1308页

作者： Yahui Huang shuqiang chen Shanchao Wu Guoqiang Dong Chunquan Sheng Department of Medicinal Chemistry School of PharmacySecond Military Medical UniversityShanghai 200433China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

A great challenge in multi-targetingdrug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug combinations.Inspired by our previous efforts in designing antitumor evodiamine derivatives,herein selective histone deacetylase 1(HDAC1)and topoisomerase 2(TOP2)dual inhibitors were successfully identified,which showed potent in vitro and in vivo antitumor potency.Particularly,compound 30 a was orally active and possessed excellent in vivo antitumor activity in the HCT116 xenograft model(TGI=75.2%,150 mg/kg,p.o.)without significant toxicity,which was more potent than HDAC inhibitor vorinostat,TOP inhibitor evodiamine and their combination.Taken together,this study highlights the therapeutic advantages of evodiamine-based HDAC1/TOP2 dual inhibitors and provides valuable leads for the development of novel multi-targeting antitumor agents.

关键词： Evodiamine Histone deacetylase Topoisomerase Dual inhibitors Antitumor activity

Novel fluorescent probes of 10-hydroxyevodiamine:autophagy and apoptosis-inducing anticancer mechanisms

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Acta Pharmaceutica Sinica B 2019年第1期9卷 144-156页

作者： shuqiang chen Guoqiang Dong Shanchao Wu Na Liu Wannian Zhang Chunquan Shengn School of Pharmacy Second Military Medical University

Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms.

关键词： Fluorescent probes 10-Hydroxyevodiamine Anticancer mechanisms Autophagy Apoptosis

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社会工作者参与政策实践的三大基础

社会政策研究 2024年第2期35卷 34-42,132页

作者：马凤芝陈树强北京大学社会学系中国青年政治学院社会工作系

社会工作既是基于价值的专业和理论驱动的专业,也是回应社会需要的专业。公平正义的价值观、生态系统理论和社会发展的现实需要,构成了社会工作者参与政策实践的三大基础,社会工作者可以且应当利用政策实践方法去实施、完善和创新社会... 详细信息

社会工作既是基于价值的专业和理论驱动的专业,也是回应社会需要的专业。公平正义的价值观、生态系统理论和社会发展的现实需要,构成了社会工作者参与政策实践的三大基础,社会工作者可以且应当利用政策实践方法去实施、完善和创新社会政策。

关键词：政策实践公平正义生态系统理论现实基础

同方期刊数据库博看期刊评论

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论社会工作学科体系本土化建设的三大关系

社会工作 2024年第1期 20-24,158,159页

作者：陈树强中国青年政治学院社会工作系北京100089

社会工作既是一门基于实践的专业,亦是一门学术学科。我们应立足中国、借鉴国外,处理好社会工作学科体系本土化建设过程中的三大关系:首先,在科学要求和实践要求之间,既要回应科学的挑战,更要适应实践的要求;其次,在社会工作学科与相关... 详细信息

社会工作既是一门基于实践的专业,亦是一门学术学科。我们应立足中国、借鉴国外,处理好社会工作学科体系本土化建设过程中的三大关系:首先,在科学要求和实践要求之间,既要回应科学的挑战,更要适应实践的要求;其次,在社会工作学科与相关学科之间,既要有社会工作学科自主意识,更要把握住社会工作的整合性学科性质;最后,在社会工作学科内部通用知识和专用知识之间的关系上,要面对中国式现代化的现实需要,注重通用知识加专用知识的建构。

关键词：学科体系学科化过程本土化

Genetic diversity and differentiation of masu salmon(Oncorhynchus masou masou)between and within cultured populations inferred from microsatellite DNA analysis

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Zoological Research 2012年第S2期33卷 33-39页

作者： Zhiying JIA Yuyong ZHANG shuqiang chen Lianyu SHI Heilongjiang River Fisheries Research Institute Chinese Academy of Fishery SciencesHarbin 150070China College of Fisheries and Life Science Shanghai Ocean UniversityShanghai 201306China

Masu salmon,Oncorhynchus masou masou,is one of the most valuable fishery species that has been introduced to China,though to date no studies on the genetic diversity and genetic relationship among hatchery populations has been performed with molecular markers.We undertook such a study and sampled 120 individuals from three hatchery stocks and analyzed 20 microsatellite loci.All loci were polymorphic and a total of 91 alleles were detected.A relatively low level of genetic diversity was revealed with effective number of allele of 3.1094,3.3299 and 3.1894 and expected heterozygosity of 0.6600,0.6648 and 0.6638 in the three stocks,respectively.Deviations from Hardy-Weinberg equilibrium were found due to heterozygote deficit.Accordingly,evidence of genetic bottlenecks were found in the three stocks.An individual assignment test demonstrated that 85%of individuals were correctly assigned into their original stocks.Pairwise Fst revealed that significant differentiation occurred between these three stocks.The results of the study indicated that disequilibrium of genetic structure and differentiation has occurred in all three stocks.This information collectively provides a basis for measures to avoid of loss of genetic diversity and introgression in Chinese aquaculture.

关键词： Oncorhynchus masou masou Microsatellite Genetic diversity Genetic differentiation

蜕膜组织NF-κB介导趋化因子与细胞因子调控子宫NK功能

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中国妇幼健康研究 2024年第4期35卷 10-17页

作者：余海鲲茅佳钦陈书强王晓红空军军医大学唐都医院妇产科生殖医学中心陕西西安710038

目的探讨人子宫内膜基质细胞(hESC)蜕膜化过程中核因子κB(NF-κB)介导调控趋化因子、细胞因子产生进而影响子宫自然杀伤细胞(uNK)功能。方法选取2022年10月1日至2023年3月1日在空军军医大学唐都医院妇产科行人工流产术终止妊娠的20... 详细信息

目的探讨人子宫内膜基质细胞(hESC)蜕膜化过程中核因子κB(NF-κB)介导调控趋化因子、细胞因子产生进而影响子宫自然杀伤细胞(uNK)功能。方法选取2022年10月1日至2023年3月1日在空军军医大学唐都医院妇产科行人工流产术终止妊娠的20名健康孕妇,收集其蜕膜组织并分离纯化出人uNK。将hESC转染siRel A以抑制NF-κB的活性,随后体外诱导蜕膜化,采用实时荧光定量聚合酶链式反应(RT-qPCR)检测相关趋化因子、细胞因子的mRNA水平。再转染siRel A的hESC诱导蜕膜化后与人原代uNK共培养,分别收获uNK和细胞上清液,采用流式细胞术检测uNK细胞因子分泌水平,通过体外成管实验、侵袭和划痕实验评估uNK上清体外促血管形成和促滋养层细胞侵袭迁移的能力。结果转染siRel A后诱导蜕膜化产生的蜕膜基质细胞(DSC)内干扰素γ(IFN-γ)、基质金属蛋白酶(MMP)9、趋化因子CCL2的mRNA表达水平均显著降低(t值分别为3.290、6.415、5.095,P<0.05)。抑制NF-κB活性并诱导蜕膜化产生的DSC与uNK共培养后,抑制了uNK相关因子血管内皮生长因子(VEGF)、胎盘生长因子(PLGF)和IFN-γ的分泌(t值分别为6.641、7.743、8.886,P<0.05)。此外,共培养后产生的uNK上清体外促血管形成能力受损(t值分别为4.629、5.522,P<0.05),并且促滋养层细胞侵袭和迁移能力均显著下降(t值分别为8.329、7.190,P<0.05)。结论 NF-κB调控蜕膜基质细胞趋化因子、细胞因子的表达,进而影响子宫自然杀伤细胞功能。

关键词： NF-κB 蜕膜基质细胞细胞因子趋化因子自然杀伤细胞

不同焊接方法对超高强装甲钢焊接接头力学性能与组织的影响

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焊接 2024年第3期 71-75,80页

作者：刘家奇薛正荣陈书强龙海滨赵雪双北汽越野车研究院北京101300

装甲钢MAG工艺常采用奥氏体、铁素体不锈钢焊丝,使得焊接接头抗拉强度和硬度会大幅度降低,同时造成热影响区的局部软化,降低了装甲车辆的防护性能。为了满足超高强装甲钢焊接接头强度和硬度防护要求,该文对超高强装甲钢激光焊接工艺进... 详细信息

装甲钢MAG工艺常采用奥氏体、铁素体不锈钢焊丝,使得焊接接头抗拉强度和硬度会大幅度降低,同时造成热影响区的局部软化,降低了装甲车辆的防护性能。为了满足超高强装甲钢焊接接头强度和硬度防护要求,该文对超高强装甲钢激光焊接工艺进行了研究,分别为MAG、激光自熔焊、激光填丝焊、激光‒电弧复合焊4种焊接方法,研究接头拉伸、弯曲、硬度等性能指标及接头组织。结果表明,激光焊接头的焊缝组织为粗大的板条马氏体,MAG焊缝组织为铁素体和粒状贝氏体;对于激光焊和MAG,淬火粗晶区均为粗针状马氏体,淬火细晶区为细小的针状马氏体,不完全淬火区为马氏体与铁素体的混合组织。激光焊接头的抗拉强度和硬度远高于MAG,激光焊接头的抗拉强度可达到母材的90%以上,硬度约为母材的82%,大大提高了防护型车辆的防护性能。然而,激光焊接头的抗弯强度要低于MAG,无论面弯还是背弯,激光焊弯曲试样通常在弯曲角度10°~30°之间即发生断裂,大大低于MAG弯曲角度90°(不断裂),从而限制了其使用场景。

关键词：激光焊超高强装甲钢力学性能组织

An Analytical Study on Bistability of Fabry-Perot Semiconductor Optical Amplifiers

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Photonic Sensors 2016年第3期6卷 268-273页

作者： Gang WANG shuqiang chen Huajun YANG School of Physical Electronics University of Electronic Science and Technology of China Chengdu 610054 China

光 bistabilities 被认为为传感器应用程序有用。作为一台典型非线性的设备， Fabry-Perot 半导体在某些条件下面的光放大器(FPSOA ) 展览 bistability。在这篇论文，在 FPSOA 的双稳态的特征理论上被调查。把光紧张基于在这个事件之间... 详细信息

光 bistabilities 被认为为传感器应用程序有用。作为一台典型非线性的设备， Fabry-Perot 半导体在某些条件下面的光放大器(FPSOA ) 展览 bistability。在这篇论文，在 FPSOA 的双稳态的特征理论上被调查。把光紧张基于在这个事件之间的亚当斯关系我在和 z 独立的平均 intracavity 紧张我 av , 在 SOA 的双稳态的循环宽度的一个分析表达式被导出。数字模拟证实分析结果的精确性。

关键词：半导体光放大器稳态分析入射光强度光学双稳性非线性器件解析表达式稳态特性数值模拟

卵巢过度刺激综合征危险因素和预测模型的研究进展

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解放军医学院学报 2024年第2期45卷 194-198页

作者：余良成巨瑛王璐陈书强王晓红空军军医大学唐都医院妇产科陕西西安710038

卵巢过度刺激综合征是控制性卵巢刺激过程中的常见并发症,不仅对胚胎移植策略产生影响,严重时甚至威胁患者的生命健康。目前已有越来越多的研究探讨卵巢过度刺激综合征的危险因素和生物标志物,并构建了一系列风险预测模型。本文对近年... 详细信息

卵巢过度刺激综合征是控制性卵巢刺激过程中的常见并发症,不仅对胚胎移植策略产生影响,严重时甚至威胁患者的生命健康。目前已有越来越多的研究探讨卵巢过度刺激综合征的危险因素和生物标志物,并构建了一系列风险预测模型。本文对近年来卵巢过度刺激综合征的危险因素和风险预测模型的研究进展进行综述,以期为临床早期识别高危人群、及时制定有效预防措施提供依据,并为模型的选择和改良提供参考。

关键词：控制性卵巢刺激卵巢过度刺激综合征危险因素预测模型研究进展

Experimental Study on Water Saving of Large-scale Mechanized Paddy Field Production Process in Heilongjiang Province

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Agricultural Biotechnology 2021年第1期10卷 120-125页

作者： Jingfang XUE shuqiang chen Yongsheng CAI Xiaodong DU Limin YANG Haixin ZHAO Tong ZHOU Mingxu ZHOU Linan WANG Rice Research Institute Heilongjiang Academy of Agricultural Sciences/Scientific Observation and Experimental Station of Cold Damage of Japonica Rice in Cold RegionMinistry of Agriculture and Rural AffairsKiamusze 154026China

In order to clarify the water-saving technologies and standards in large-scale mechanized production of paddy fields, the water-saving effects and cost-benefit situations of paddy field steeping, seedling transplanting and different land preparation methods were studied. The results showed that the suitable water layer height for the closing period of mechanized operation was 10 cm, which could save water, facilitate weed control, and lead to better effect and the highest yield. The treatment with a water layer height of 1 cm(Huadashui) for the seedling planting operation achieved better quality of seedling transplanting, lower vacancy rate and higher yield and was water-saving. From the perspective of saving water and taking into account the cost of land preparation, the method of steeping and beating the field was better than the method of plowing in autumn and rotary tillage and harrowing in spring, but it was very prone to lodging. From the perspective of high yield creation, the method of plowing in autumn and rotary tillage and harrowing in spring was significantly better than the method of steeping and beating the field. In order to reduce the cost of land preparation, it is recommended to change the way of plowing in autumn and rotary tillage and hallowing in spring to plowing in autumn and rotary tillage in spring or plowing and hallowing in spring to reduce the cost of one time of rotary tillage, and to simultaneously realize deeper plough layer, which is conducive to preventing lodging and obtaining high yield.

关键词： Rice Field steeping Transplanting seedlings Tillage and land preparation method Plowing in autumn and rotary tillage and harrowing in spring Steeping and beating the field in spring