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Biology of Hippo signaling pathway:Skeletal muscle development and beyond

Journal of Integrative Agriculture 2024年第6期23卷 1825-1838页

作者： shuqi qin Chaocheng Li Haiyan Lu Yulong Feng Tao Guo Yusong Han Yongsheng Zhang Zhonglin Tang Xinjiang Characteristic Livestock Breeding and Reproduction Team College of Animal Science and TechnologyShihezi UniversityShihezi 832003China Lanzhou Veterinary Research Institute Chinese Academy of Agricultural SciencesLanzhou 730046China Kunpeng Institute of Modern Agriculture at Foshan Foshan 528226China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China

Global demand for farm animals and their meat products i.e.,pork,chicken and other livestock meat,is steadily *** the ongoing life science research and the rapid development of biotechnology,it is a great opportunity to develop advanced molecular breeding markers to efficiently improve animal meat production *** is an important study subject because of its crucial role in the regulation of organ *** recent years,with the increase of research on Hippo signaling pathway,the integrative application of multi-omics technologies such as genomics,transcriptomics,proteomics,and metabolomics can help promote the in-depth involvement of Hippo signaling pathway in skeletal muscle development *** Hippo signaling pathway plays a key role in many biological events,including cell division,cell migration,cell proliferation,cell differentiation,cell apoptosis,as well as cell adhesion,cell polarity,homeostasis,maintenance of the face of mechanical overload,*** influence on the development of skeletal muscle has important research value for enhancing the efficiency of animal husbandry *** this study,we traced the origin of the Hippo pathway,comprehensively sorted out all the functional factors found in the pathway,deeply analyzed the molecular mechanism of its function,and classified it from a novel perspective based on its main functional domain and mode of *** aim is to systematically explore its regulatory role throughout skeletal muscle *** specifically focus on the Hippo signaling pathway in embryonic stem cell development,muscle satellite cell fate determination,myogenesis,skeletal muscle meat production and organ size regulation,muscle hypertrophy and atrophy,muscle fiber formation and its transformation between different types,and *** roles in proliferation and regeneration are methodically summarized and analyzed *** summary and prospect of the Hippo signaling pathway within this a

关键词： Hippo skeletal muscle organ size myogenesis C2C12 livestock animals

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Permafrost carbon cycle and its dynamics on the Tibetan Plateau

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Science China Life Sciences 2024年第09期 1833-1848页

作者： Leiyi Chen Guibiao Yang Yuxuan Bai Jinfeng Chang shuqi qin Futing Liu Mei He Yutong Song Fan Zhang Josep Pe?uelas Biao Zhu Guoying Zhou Yuanhe Yang Key Laboratory of Tibetan Medicine Research Chinese Academy of Sciences State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences China National Botanical Garden College of Environmental and Resource Sciences Zhejiang University Key Laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Ecology and Nature Conservation Institute Chinese Academy of Forestry University of Chinese Academy of Sciences Consejo Superior de Investigaciones Científicas (CSIC) Global Ecology Unit CREAF-CSIC-UAB (Universitat Autònoma de Barcelona) Centre for Ecological Research and Forestry (CREAF) Institute of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface Processes of the Ministry of Education Peking University Northwest Institute of Plateau Biology Chinese Academy of Sciences

Our knowledge on permafrost carbon(C) cycle is crucial for understanding its feedback to climate warming and developing nature-based solutions for mitigating climate change. To understand the characteristics of permafrost C cycle on the Tibetan Plateau, the largest alpine permafrost region around the world, we summarized recent advances including the stocks and fluxes of permafrost C and their responses to thawing, and depicted permafrost C dynamics within this century. We find that this alpine permafrost region stores approximately 14.1 Pg(1 Pg=1015g) of soil organic C(SOC) in the top 3 m. Both substantial gaseous emissions and lateral C transport occur across this permafrost region. Moreover, the mobilization of frozen C is expedited by permafrost thaw, especially by the formation of thermokarst landscapes,which could release significant amounts of C into the atmosphere and surrounding water bodies. This alpine permafrost region nevertheless remains an important C sink, and its capacity to sequester C will continue to increase by 2100. For future perspectives, we would suggest developing long-term in situ observation networks of C stocks and fluxes with improved temporal and spatial coverage, and exploring the mechanisms underlying the response of ecosystem C cycle to permafrost thaw. In addition, it is essential to improve the projection of permafrost C dynamics through in-depth model-data fusion on the Tibetan Plateau.

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青藏高原多年冻土微生物残体碳的分布特征及其驱动因素

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科学通报 2024年第7期69卷 925-938页

作者：贺美秦书琪冯雪徽张帆赵佳宁杨元合中国科学院植物研究所植被与环境变化国家重点实验室北京100093 国家植物园北京100093 中国科学院大学资源与环境学院北京100049

微生物残体碳是土壤稳定碳库的重要组成部分,对土壤有机碳(soil organic carbon,SOC)的贡献可达50%以上.然而,由于缺乏大尺度观测证据,目前学术界对多年冻土微生物残体碳分布特征及其驱动因素的认识十分有限.本研究基于野外样带调查和... 详细信息

微生物残体碳是土壤稳定碳库的重要组成部分,对土壤有机碳(soil organic carbon,SOC)的贡献可达50%以上.然而,由于缺乏大尺度观测证据,目前学术界对多年冻土微生物残体碳分布特征及其驱动因素的认识十分有限.本研究基于野外样带调查和室内分析相结合的方法,揭示了青藏高原多年冻土微生物残体碳的空间分布特征,对比了冻土层与活动层微生物残体碳对SOC的贡献差异.在此基础上,结合气候、土壤变量和微生物属性测定,探究了多年冻土微生物残体碳含量空间变异的驱动因素.结果显示,多年冻土总微生物残体碳、真菌和细菌残体碳含量均呈现自研究区西部向东部递增的趋势.平均而言,冻土层总微生物残体碳含量为2741.0±815.3 mg/kg(平均值±标准误差),占SOC的比例为13.2%±1.1%;真菌残体碳的含量及其对总微生物残体碳的贡献均显著高于细菌.冻土层总微生物残体碳和真菌残体碳的含量与贡献均显著低于活动层;冻土层细菌残体碳含量显著低于活动层,但其对SOC的贡献与活动层无显著差异.结构方程模型分析的结果显示,多年冻土含水率和微生物的生物量是影响多年冻土微生物残体碳含量空间变异的直接因素,气候因素则起着间接作用.总体来讲,上述结果意味着微生物残体碳是多年冻土碳的重要来源,其变化可能会影响多年冻土碳循环与气候变暖之间的正反馈关系.

关键词：碳循环多年冻土微生物残体碳真菌残体碳细菌残体碳

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Influence of sea-land breeze on the formation and dissipation of severe dense fog and its burst reinforcement in the Yellow Sea coastal area,China

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Science China Earth Sciences 2024年第2期67卷 432-449页

作者： Ya GAO Duanyang LIU shuqi YAN Wenjun ZHOU Hongbin WANG Fan ZU qin MEI Chuanxiang YI Ye SHENG Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing210041China Yancheng Meteorological Bureau Yancheng224000China Nanjing Joint Institute for Atmospheric Sciences Nanjing210041China Key Laboratory of Disaster Weather Chinese Academy of Meteorological SciencesBeijing100086China

Based on the global reanalysis data of the National Centers for Environmental Prediction(NCEP)/National Center for Atmospheric Research,the surface meteorological observation data,sounding data and satellite observation data,this paper comprehensively analyzes the evolution process and formation mechanism of a persistent severe dense fog process occurred on February 15–17,2015 in Yancheng,eastern *** the numerical simulation experiment of Weather Research and Forecast(WRF)model,we further analyze the impact of sea-land breeze on the formation and burst reinforcement of *** show that the precipitation caused by the southwesterly airflow in front of the upper-level trough and the low-pressure inverted trough are conducive to the formation of early rain fog,while the nighttime clear radiance under the control of surface cold high and the infiltration of weak cold advection are conducive to the formation and development of later radiation-advection *** WRF model simulates the fog evolution process,which is basically consistent with the actual fog area,and the simulation results are credible to a certain *** simulation results show that the establishment of sea breeze has an advection cooling effect on the near surface layer,which is conducive to the formation and development of the inversion layer on the near surface,providing stable stratification conditions for the formation and burst reinforcement of *** one hand,the strengthening of sea breeze circulation can continuously transport water vapor to the study *** the other,the occurrence of ultra-low level jet is favorable for the accumulation of low-level water *** the same time,the inversion intensity further strengthens,which is in favor of the burst reinforcement and long-term maintenance of fog.

关键词： Radiation-advection fog Sea-land breeze Atmospheric boundary layer Fog burst reinforcement WRF model

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Gut microbiota affects the estrus return of sows by regulating the metabolism of sex steroid hormones

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Journal of Animal Science and Biotechnology 2024年第2期15卷 578-599页

作者： Min Liu Jia Zhang Yunyan Zhou shuqi Xiong Mengqing Zhou Lin Wu qin Liu Zhe Chen Hui Jiang Jiawen Yang Yuxin Liu Yaxiang Wang Congying Chen Lusheng Huang National Key Laboratory of Swine Genetic Improvement and Germplasm Innovation Jiangxi Agricultural UniversityNanchang 330045China

Background Sex hormones play important roles in the estrus return of post-weaning *** studies have demonstrated a complex and bi-directional regulation between sex hormones and gut ***,the extent to which the gut microbiota affects estrus return of post-weaning sows is largely *** In this study,we first screened 207 fecal samples from well-phenotyped sows by 16S rRNA gene sequencing and identified significant associations between microbes and estrus return of post-weaning *** metagenomic sequencing data from 85 fecal samples,we identified 37 bacterial species that were significantly associated with estrus *** returning sows were characterized by increased abundances of *** and *** and decreased abundances of ***,***,and *** changes in gut microbial composition significantly altered the functional capacity of steroid hormone biosynthesis in the gut *** results were confirmed in a validation *** changes in sex steroid hormones and related compounds were found between normal and non-return sows via metabolome *** integrated analysis of differential bacterial species,metagenome,and fecal metabolome provided evidence that normal return-associated bacterial species *** and Prevotella *** in the degradation of pregnenolone,progesterone,and testosterone,thereby promoting estrogen ***,the microbial metabolites related to sow energy and nutrient supply or metabolic disorders also showed relationships with sow estrus *** An integrated analysis of differentially abundant bacterial species,metagenome,and fecal metabolome revealed the involvement of *** and Prevotella *** sow estrus *** findings provide deep insight into the role of gut microbiota in the estrus return of post-weaning sows and the complex cross-talk between gut microbiota and sex hormones,suggesting that the manipulatio

关键词： Estrus return Fecal metabolome Gut microbiota Metagenomics Sex steroid hormones Sow

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Robust Control Design of the Structural Vibration System via Eigenstructure Assignment

Robust Control Design of the Structural Vibration System via...

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第37届中国控制会议

作者： Wang Guosheng qin shuqi Liang Bing Weapon and Control Department Army Academy of Armored Forces School of Information Engineering Jiangxi University of Science and Technology

The robust control design in a class of structural vibration systems is considered in this paper. The aim is to design a state feedback controller such that the closed-loop system has the desired eigenvalues with minimum sensitivities with respect to system parameter perturbations. By utilizing a result of parametric eigenstructure assignment via state feedback, this robust control problem is changed into an optimal problem with some constraints and an algorithm for this optimization problem is established. This algorithm offers a parametric expression for the eigenvalue sensitivity index and utilizes directly the data of the original system, thus it is convenient to use in engineering applications. An example about three degrees of freedom shear structure system under vibration excitation is analyzed by using the proposed algorithm and the corresponding simulation results show the effectiveness of this algorithm.

关键词： structural vibration system robust control eigenstructure assignment vibration excitation

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基于光纤传感的电力变压器运行状态监测方法

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自动化应用 2022年第10期 1-3,7页

作者：秦数棋国电南瑞能源有限公司上海200000

为了提升电力变压器运行状态监测效果,提高监测绕组局部微小变形的灵敏度,进而实现快速定位,提出基于光纤传感的电力变压器运行状态监测方法。首先,根据光纤传感布里渊散射频谱的拟合方法定位电信号;其次,通过互相关拟合来辨识电力变压... 详细信息

为了提升电力变压器运行状态监测效果,提高监测绕组局部微小变形的灵敏度,进而实现快速定位,提出基于光纤传感的电力变压器运行状态监测方法。首先,根据光纤传感布里渊散射频谱的拟合方法定位电信号;其次,通过互相关拟合来辨识电力变压器绕组变形的特征;接着,结合在线测量的绕组参数数据,实现对电力变压器运行状态的监测;最后,以对比实验验证提出方法的可行性。实验验证了分布式光纤监测电力变压器变形的时间是传统方法的1/2,证明了新设计的电力变压器运行状态监测方法效果更好。

关键词：光纤传感电力变压器绕组变形运行状态监测

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《中欧全面投资协定》对中欧贸易的潜在影响

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中阿科技论坛（中英文） 2023年第7期 6-10页

作者：候杰覃舒其新疆财经大学新疆乌鲁木齐830012

近年来,中欧经贸往来日益密切,双边贸易额持续增加,呈现良好发展态势。《中欧全面投资协定》超越了传统的双方投资协定涵盖的范围,在市场准入和投资自由化、营造公平竞争环境、可持续发展等方面有重要突破,将为中欧贸易合作带来前所未... 详细信息

近年来,中欧经贸往来日益密切,双边贸易额持续增加,呈现良好发展态势。《中欧全面投资协定》超越了传统的双方投资协定涵盖的范围,在市场准入和投资自由化、营造公平竞争环境、可持续发展等方面有重要突破,将为中欧贸易合作带来前所未有的机遇和挑战。文章重点就《中欧全面投资协定》对我国对欧贸易发展现状、发展空间、存在的问题进行了分析,探讨了该协定将给我国对欧经贸产生的积极效应,并提出若干对欧贸易的建议。

关键词：中欧全面投资协定中欧贸易建议

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Formation control of multi robot based on UWB distance measurement

Formation control of multi robot based on UWB distance measu...

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第30届中国控制与决策会议

作者： Lv Qiang Wei Heng Lin Huican qin shuqi Duo Nanxun Liang Bing Department of weapon control Academy of Army Armored Forces School of Information Engineering Jiangxi University of Science and Technology

Robot formation control is the foundation of multi-mobile robot system. In view of the shortage of traditional formation control algorithm and the large network traffic of multi-robot, a formation control strategy based on state switching is proposed. The three kinds of traditional algorithms are compiled in a modular way, and then a state switching triggering mechanism based on composite information is designed. The reasonable selection of one or more formation control algorithms by the state of the robot and the surrounding environment and the timely triggering of the control law effectively reduce the complexity of the multi-robot formation control algorithm and reduce the communication burden on the robot. At the same time, a formation feedback mechanism based on UWB(Ultra Wide Band) ranging is proposed. UWB data structure is simple, which is convenient for processing on the micro-mobile robot and realizes the maintaining and feedback on the formation in real time. Finally, a multi-mobile robot platform is built, and the proposed strategy is applied to real robots. Multi-robot formation tracking and formation obstacle avoidance experiments are carried out, and the effectiveness and robustness of the proposed algorithm are verified.

关键词： UWB multi robot Chinese Formation control State switch

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UWB and IMU System Fusion for Indoor Navigation

UWB and IMU System Fusion for Indoor Navigation

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第37届中国控制会议

作者： Wang Guosheng qin shuqi Lv Qiang Wei Heng Lin Huican Liang Bing Weapon and Control Department Army Academy of Armored Forces School of Information Engineering Jiangxi University of Science and Technology

Ultra-wideband（UWB） localization is used for the indoor navigation, but the positioning accuracy will be affected by non-line-of-sight（NLOS） environment. And this error is difficult to accept for the indoor navigation. In this work, we mainly study the UWB\Inertial Measurement Unit（IMU） fusion algorithms based on the extend Kalman filter（EKF） and unscented Kalman filter（UKF）. And we put forward an errors complementary extend Kalman filter algorithm for indoor navigation on the NLOS environment. Then, we carry out the experiments with the omnidirectional robot. Through the experiment, we find that the new algorithm is also good for NLOS navigation. Compared with the other two algorithms, the new algorithm reduces the computational complexity.

关键词： UWB/IMU EKF UKF Errors Complementary

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