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Avian Research 2023年第4期14卷 663-670页

作者： Na Zhu Jing Shang shuping zhang Key Laboratory of Ecology and Environment in Minority Areas(National Ethnic Affairs Commission) Minzu University of ChinaBeijing 100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China

Night lighting has been shown to affect wild *** date,the effects of night lighting on the metabolic homeostasis of birds that spend short time in urban environments remain *** model bird species Zebra Finch(Taeniopygia guttata),we investigated the effects of short-term night lighting on liver transcriptome,blood glucose,triglyceride,and thyroxine(T4 and T3)levels in birds exposed to two different night lighting duration periods(three days and six days).After three days of night lighting exposure,the expression of genes involved in fat synthesis in the liver was upregulated while the expression of genes involved in fatty acid oxidation and triglyceride decomposition was *** was also a reduction in blood triglyceride,glucose,and T3 ***,after six days of night lighting,the expression of genes associated with fatty acid decomposition and hyperglycemia in the liver was upregulated,while the expression of genes involved in fat synthesis was ***,blood glucose levels and T3 concentration *** findings indicate that short-term exposure to night lighting can disrupt the lipid and glucose metabolism of small passerine birds,and longer stopovers in urban area with intense night lighting may cause birds to consume more lipid energy.

关键词： Birds Glucose Lipid Metabolism Night lighting Short-term

Variaiton in the composition of small molecule compounds in the egg yolks of Asian Short-toed Larks between early and late broods

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Avian Research 2023年第4期14卷 671-678页

作者： Shiyun Ding Na Zhu shuping zhang Key Laboratory of Ecology and Environment in Minority Areas(National Ethnic Affairs Commission) Minzu University of ChinaBeijing100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing100081China

The egg yolks of birds contain most of the maternally derived materials required for embryo development and are an important factor influencing embryo development and offspring *** variation in egg-laying date frequently occurs in passerines inhabiting highly seasonal *** laying in early and late stages of the breeding season encounter different environment temperatures and food conditions,which can affect the levels of metabolities in their bodies,thereby altering the transmission of these materials to the *** test a hypothesis that yolk small molecule compounds of Asian Short-toed Lark(Alaudala cheleensis)could vary between early(mid-May)and late(mid-June)*** the UHPLC-MS/MS method,683 compounds belonging to 21 compound groups are detected in the *** contents of 18 compounds are significantly different between early and late *** differential compounds are significantly higher in the early laid eggs,among whichγ-aminobutyric acid,creatine,prostaglandins,palmitoleic acid,linoleic acid,and trans linoleic acid are related to low environment temperature *** eggs laid in late stage exhibit significantly higher levels of 5-L-glutamyl-L-alanine andγ-glutamate-leucine,1,3-dimethyluric acid and mannose,which may be attributed to females in the late group consuming more *** suggest conducting a comprehensive investigation to reveal the yolk small molecule compounds mediated maternal effects on offspring phenotypes under varying ecological conditions.

关键词： Asian Short-toed Lark Egg laying date Small molecule compounds Variation Yolk

Endocrine response of early-hatching Asian Short-toed Lark nestlings exposed to cold temperature in a high-latitude grassland habitat

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Avian Research 2021年第4期12卷 750-758页

作者： Jing Shang Liang zhang Xinyu Li shuping zhang Key Laboratory of Ecology and Environment in Minority Areas(National Ethnic Affairs Commission) Minzu University of ChinaBeijing 100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China

Background:In high latitude grassland habitats,altricial nestlings hatching in open-cup nests early in the breeding season must cope with cold temperature *** hormones(triiodothyronine,T_(3)and thyroxine,T_(4))and corticosterone play a crucial role in avian thermoregulation response to *** the endocrine response of altricial nestlings to temperature variation is important for understanding the adaptive mechanisms of individual variation in the timing of breeding in ***:We compared nest temperature,ambient temperature,body temperature,plasma T_(3),T_(4)and corticosterone levels in Asian Short-toed Lark(Alaudala cheleensis)nestlings hatching in the early-,middle-,and late-stages of the breeding season in Hulunbuir grassland,northeast ***:Mean nest temperature in the early-,middle-and late-stage groups was-1.85,3.81 and 10.23℃,respectively,for the 3-day-old nestlings,and 6.83,10.41 and 11.81℃,respectively,for the 6-day-old *** nest temperature significantly correlated with body temperature,plasma T_(3),T_(4)and corticosterone concentrations of *** temperature of 3-day-old nestlings in the early and middle groups was significantly lower than that of the late group,but there was no significant difference between the nestlings in the early and middle *** T_(4)and T_(3)concentrations and the ratio of T_(3)/T_(4)of both 3-and 6-day-old nestlings in the early-stage group were significantly higher compared to the middle and late *** corticosterone levels of 3-day-old nestlings were significantly higher in the early-stage group compared to the middle-and late-stage ***:Nestlings hatching early responded to cold temperature by increasing thyroid hormones and corticosterone levels even in the early days of post hatching development when the endothermy has not been *** hormones may play a physiological role in neonatal nestlings coping with cold temperature challenges.

关键词： Endocrine response of early-hatching Asian Short-toed Lark nestlings exposed to cold temperature in a high-latitude grassland habitat

Temperature effect on luteinizing hormone secretion of Eurasian Skylark(Alauda arvensis) and Great Tit(Parus major) in China

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Avian Research 2018年第1期9卷 81-87页

作者： Lijun Gao Jing Gao shuping zhang College of Life and Environment Sciences Minzu University of China

Background: Global warming caused trophic mismatch has affected the breeding success, and even the survival, of some bird *** ability of birds to accelerate their reproduction onset in the warmer spring could be critical to the survival of some *** activation of the reproductive endocrine axis in birds is a key physiological process that determines the onset of *** birds change the HPG axis endocrine rhythm under the temperature rising condition?Methods: Using plasma LH level as an indicator of initiation of the reproductive endocrine and artificially controlling temperature, we compared variations in the timing of activation of the reproductive endocrine axis in response to temperature in two Chinese bird species, the Eurasian Skylark(Alauda arvensis) and the Great Tit(Parus major) at both the population and individual ***: At the population level, temperature only significantly influenced LH level in the Eurasian Skylark, and had no significant effect on the LH levels in the Great *** LH level of Eurasian Skylarks in the 20 ℃ group was higher than that of those in the 15 ℃ group throughout the *** individual variations in the timing of peak LH levels were observed in the high and the low temperature groups of both Eurasian Skylarks and Great ***: These results indicate that the effects of temperature differ among ***, there appears to be a degree of within population polymorphism in the timing of reproductive endocrine axis activation in some *** polymorphism could provide the variation required for bird populations to cope with the possible change of their food peak under the climate warming condition.

关键词： Reproductive endocrine rhythm Temperature Climate warming Eurasian Skylark Great Tit

Differential cell stress responses to food availability by the nestlings of Asian Short-toed Lark(Calandrella cheleensis)

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Avian Research 2019年第4期10卷 478-484页

作者： Liang zhang Lidan Zhao Xinjie zhang Wei Liang shuping zhang College of Life and Environment Sciences Minzu University of ChinaBeijing 100081China Ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life SciencesHainan Normal UniversityHaikou 571158China.Received

Background:Timing of breeding season of temperate passerines has been considered to be adjusted to their food *** is little work to reveal the cell stress responses of the nestlings hatched asynchronized with the food abundance peak,which is important for understanding the physiological link between the timing of breeding and the fitness of ***:Using gene expression level of blood HSP70 and HSP90 as indicators,we compared the cell stress response of Asian Short-toed Lark(Calandrella cheleensis)nestlings hatched under conditions of low,mid or high food(grasshopper nymph)availability in ***:Nymph biomass,sample time and interaction of these two factors significantly influenced the blood gene expression level of HSP70 and HSP90 of Asian Short-toed Lark ***70 and HSP90 gene expression levels of the nestlings at 14:00 were significantly higher than those at 5:*** either 5:00 or 14:00,the gene expression levels of HSP70 and HSP90 increase with the decrease of nymph ***:These results indicate that food availability is an important environment factor inducing cellular stress of Asian Short-toed Lark *** interactive effect of the nymph abundance and sample time on the HSPs response may be related with the daily temperature variation of the *** cell stress response may be one of physiological factor mediating the effect of food availability and the nestling’s fitness.

关键词： Asian Short-toed Lark nestling Cell stress Food availability HSP70 HSP90

Immune regulation by CD8^(+) Treg cells:novel possibilities for anticancer immunotherapy

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Cellular & Molecular Immunology 2018年第9期15卷 805-807页

作者： shuping zhang Meng Wu Fang Wang Department of Laboratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Laboratory Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China National Key Clinical Department of Laboratory Medicine Nanjing 210029China

Regulatory T(Treg)cells comprise diverse subsets of immunosuppressive cells that play a pivotal role in regulating immune homeostasis and preventing *** cancers,Treg cells can suppress antitumor immune responses and support the establishment of an immunosuppressive tumor micro-environment,thus promoting immune evasion and cancer progression.1 Treg cells are increased or activated in the tumor microenvironment,which is associated with a poor clinical outcome.2 Although CD4^(+) Treg cells have been extensively studied,the lack of universal markers to distinguish CD8^(+) Treg cells from conventional CD8^(+)T cells means that the function of CD8^(+) Treg cells in cancer has not been fully ***,an increasing body of research has revealed that CD8^(+)Treg cells(CD8^(+)CD25^(+)Foxp3^(+),CD25^(+)CD122^(+)Foxp3^(+) and CD8^(+)CD28−)3–5 accumulate in the tumor microenvironment and suppress antitumor immunity(Fig.1).However,the influence of CD8^(+) Treg cells on tumor progression in ovarian cancer(OC)is less ***,there are a limited number of studies describing the molecular signatures involved in the induction of CD8^(+) Treg cells.

关键词： Foxp3 Treg immunity

Significant concurrent decrease in PM_(2.5) and NO_(2) concentrations in China during COVID-19 epidemic

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Journal of Environmental Sciences 2021年第1期33卷 346-353页

作者： Biiuu Chu shuping zhang Jun Liu Qingxin Ma Hong He State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Enuironmental SciencesChinese Academy of SciencesBeijing 100085China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

The strict control measures and social lockdowns initiated to combat COVID-19 epidemic have had a notable impact on air pollutant *** to observation data obtained from the China National Environmental Monitoring Center,compared to levels in 2019,the average concentration of NO_(2) in early 2020 during COVID-19 epidemic has decreased by 53%,50%,and 30%in Wuhan city,Hubei Province(Wuhan excluded),and China(Hubei excluded),***,PM_(2.5) concentration has decreased by 35%,29%,and 19%in Wuhan,Hubei(Wuhan excluded),and China(Hubei excluded),*** significant declines have also been found for SO_(2) and CO *** also analyzed the temporal variation and spatial distribution of air pollutant concentrations in China during COVID-19 *** decreases in PM_(2.5) and NO_(2) concentrations showed relatively consistent temporal variation and spatial *** results support control of NO x to further reduce PM_(2.5) pollution in *** concurrent decrease in NOx and PM_(2.5) concentrations resulted in an increase of O3 concentrations across China during COVID-19 epidemic,indicating that coordinated control of other pollutants is needed.

关键词： Covid-19 epidemic Air quality Temporal variation and spatial distribution Coordinated control PM_(2.5) O3

Analysis of CD8＋ Treg cells in patients with ovarian cancer： a possible mechanism for immune impairment

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Cellular & Molecular Immunology 2015年第5期12卷 580-591页

作者： shuping zhang Department of Laboratory Medicine the First Affiliated Hospital of Nanjing Medical University Nanjing China National Key Clinical Department of Laboratory Medicine Nanjing China Department of Obstetrics and Gynecology Southwest Hospital Third Military Medical University Chongqing China Department of Obstetrics and Gynecology Jinling Hospital Nanjing University School of Medicine Nanjing China

Regulatory T （Treg） cells may participate in mediating a suppressive microenvironment that blunts successful anti-tumor immunotherapy. Recent studies show that CD8＋ Treg cells might impede effective immune responses to established tumors. However, there is limited research regarding CD8＋ Treg cells in ovarian cancer （OC） patients. Here, we investigated CD8＋ Treg cells in OC patients and their in vitro induction. The immunohistochemistry of tumor-infiltrating lymphocytes revealed a significant correlation between the intratumoral CD8＋ T cells and the forkhead box p3 （Foxp3）＋ cells in the intraepithelial and stromal areas of advanced OC tissues. We examined the expression of Treg markers in CD8＋ T cells from the peripheral blood and fresh tumor tissues of OC patients using flow cytometry. Our results indicated an increase in the CD8＋ Treg cell subsets of OC patients compared with those in patients with benign ovarian tumors and healthy controls, including a n increased expression of CD25, cytotoxic T-lymphocyte-associated protein 4 （CTLA-4）, and Foxp3 and decreased CD28 expression. To demonstrate whether the tumor microenvironment could convert CD8＋ effector T cells into suppressor cells, we used an in vitro transwell culturing system. Compared with the CD8＋ T cells cultured alone, the CD8＋ Treg cells induced in vitro by coculture with SK-OV-3/A2780 showed increased CTLA-4 and Foxp3 expression and decreased CD28 expression. In addition, the in vitro-induced CD8＋ Treg cells inhibited naive CD4＋ T-cell proliferation, which was partially mediated through TGF-β1 and IFN-γ. Our study suggests that CD8＋ Treg cells were increased in OC patients and could be induced in vitro, which may be the way that tumors limit antitumor immunity and evade immune surveillance.

关键词： CD8+ T cell ovarian cancer regulatory T cell tumor-infiltrating lymphocyte

Incubation temperature induced developmental plasticity of cold responsive physiological phenotypes in Japanese Quails

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Avian Research 2024年第3期15卷 385-394页

作者： Yingxin Kou Rongmiao zhang Xiaoqian Li Na Zhu Yihang Huang shuping zhang College of Life and Environmental Sciences Minzu University of ChinaBeijing100081China

Embryonic development is a critical period for phenotype *** variation during embryonic development can induce changes in postnatal phenotypes of *** thyroxine secretion and aerobic metabolic activity of small birds are important phenotypes closely related to their winter *** the context of climate change,it is necessary to determine whether temperature variation during incubation in birds leads to developmental plasticity of these cold responsive *** incubated Japanese Quail(Coturnix japonica)eggs at 36.8℃,37.8℃,and 38.8℃,and raised the chicks to 35-day old at 22℃with same raising conditions,then all the quails were exposed to gradually temperature dropping environment(from 15℃to 0℃).After cold treatment,serum T3 level,resting metabolic rate,skeletal muscle and liver metabolomes of the birds were *** serum T3 levels were significantly lower in the 38.8℃group and significantly higher in the 36.8℃group compared to the 37.8℃*** metabolic rate in the 38.8℃group was significantly lower compared to the 37.8℃*** with the 37.8℃group,metabolites involved in the tricarboxylic acid cycle in the liver were significantly lower in the 38.8℃group,and metabolites related to lipid oxidation metabolism and fatty acid biosynthesis were significantly lower in the skeletal muscles in the 38.8℃group but significantly higher in the 36.8℃*** results indicate that incubation temperature variation can lead to developmental plasticity in cold responsive physiological *** incubation temperature may impair the capacity of birds coping with cold challenge.

关键词： Cold response Developmental plasticity Incubation temperature Metabolic rate Metabolomes Precocial bird Thyroxin

Mild spring temperature rising affects the anti-oxidation and immune functions of Asian Short-toed Larks

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Avian Research 2020年第2期11卷 115-121页

作者： Na Zhu Tingting Liu Fei Wang Wei Liang shuping zhang College of Life and Environment Sciences Minzu University of ChinaBeijing 100081China Ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life SciencesHainan Normal UniversityHaikou 571158China.

Background:Predicting the possibility of severe effects of global warming on animals is important for understanding the ecological consequences of climate change on *** is the season during which birds have to physiologically prepare for the subsequent breeding period,and unusual spring temperature rising probably becomes a heat stress to the birds which have adapted to the low spring ***,it is necessary to understand the physiological effect of spring warming on the temperate ***:Using the activities of blood anti-oxidative enzymes(SOD,CAT,GPx)and the concentrations of serum immunogloblins(IgA,IgY,IgM)as indicators,we compared the anti-oxidative and immune functions of Asian Shorttoed Larks(Calandrella cheleensis)captured between 10 and 15 March,2015 and housed under conditions of 21°C and 16°***:The SOD activities of birds in 21°C group were significantly lower than those in 16°C group on all the treatment *** CAT activities of the birds in 21°C group were significantly lower than those in 16°C group on the 1 st,5 th,13 th,17 treatment *** GPx activities of the birds in 21°C group were signifthicantly lower than those in 16°C group on the 1 st,13 th and 17 th,but significantly higher on the 21 st treatment *** IgA,IgY and IgM concentrations of birds in 21°C group were significantly lower than those in 16°C group on all the treatment ***:This study shows that spring temperature rising negatively influences antioxibative and humoral immune functions,which indicates that spring climate warming might reduce the fitness of the temperate passerine birds which have adapted to the low spring temperature.

关键词： Mild temperature rising Anti-oxidant capacity Immunity Asian Short-toed Larks Spring