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Alcohol-dispersed polymer complex as an effective and durable interface modifier for n-i-p perovskite solar cells

Journal of Energy Chemistry 2024年第6期93卷 243-252,I0007页

作者： Chang Shi Jiangling Li shuping xiao Ziyi Wang Wuchen Xiang Rui Wu Yang Liu Yinhua Zhou Weijun Ke Guojia Fang Pingli Qin Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205HubeiChina Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074HubeiChina School of Physics and Technology Key Laboratory of Artificial Micro-and Nano-structures of the Ministry of Education and School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina

Abundant interfacial defects remain a significant challenge that hampers both the efficiency and stability of perovskite solar cells(PSCs).Herein,an alcohol-dispersed conducting polymer complex,denoted as PEDOT:F(Poly(3,4-ethylene dioxythiophene):Perfluorinated sulfonic acid ionomers),is introduced into the interface between perovskite and hole transporting layer in regular-structured ***:F serves as a multi-functional interface layer(filling grain boundaries and covering perovskite's grain-surface)to achieve a robust interaction with organic groups within perovskites,which could induce a structural transformation of PEDOT to increase its conductivity for the efficient ***,the strong interaction between PEDOT and perovskites could promote an effective coupling of undercoordinated Pb~(2+)ions with the lone electron pairs near O&S atoms in PEDOT molecules,thereby enhancing defect ***,PEDOT:F with inherent hydrophobic properties prevents effectively moisture invasion into perovskites for the improved long-term stability of the ***,the PEDOT:F-based PSCs achieved a champion efficiency of 24.81%,and maintained ca.92%of their initial efficiency after 7680 h of storage in a dry air environment,accompanied by the enhanced photothermal stability.

关键词： Alcohol-dispersed conducting polymer complex Interface passivation Grain boundaries Device stability Perovskite solar cells

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盐酸氨溴索支气管镜下肺泡灌洗治疗重症肺炎支原体肺炎患儿的效果

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中国民康医学 2024年第12期36卷 72-75页

作者：肖淑萍赣州市人民医院儿科江西赣州341000

目的:观察盐酸氨溴索支气管镜下肺泡灌洗治疗重症肺炎支原体肺炎(SMPP)患儿的效果。方法:选取2022年12月至2023年12月该院收治的120例SMPP患儿进行前瞻性研究,按随机数字表法将其分为对照组和观察组各60例。对照组采用支气管镜下肺泡灌... 详细信息

目的:观察盐酸氨溴索支气管镜下肺泡灌洗治疗重症肺炎支原体肺炎(SMPP)患儿的效果。方法:选取2022年12月至2023年12月该院收治的120例SMPP患儿进行前瞻性研究,按随机数字表法将其分为对照组和观察组各60例。对照组采用支气管镜下肺泡灌洗治疗,观察组采用盐酸氨溴索支气管镜下肺泡灌洗治疗,比较两组临床疗效、治疗前后炎性指标[降钙素原(PCT)、白细胞计数(WBC)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]水平、临床症状持续时间、住院时间、血清学指标[乳酸脱氢酶(LDH)]水平和不良反应发生率。结果:观察组治疗总有效率为96.67%(58/60),高于对照组的86.67%(52/60),差异有统计学意义(P0.05)。结论:盐酸氨溴索支气管镜下肺泡灌洗治疗SMPP患儿可提高治疗总有效率,缩短症状持续时间和住院时间,降低炎性指标水平和LDH水平,效果优于单纯支气管镜下肺泡灌洗治疗。

关键词：重症肺炎支原体肺炎儿童支气管镜下肺泡灌洗盐酸氨溴索炎性指标不良反应

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双螺杆挤出机强化三角形转子作用下的腔内分布混合模拟

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化工学报 2024年第3期75卷 858-866页

作者：徐百平梁瑞凤喻慧文吴桂群肖书平五邑大学江门市高分子材料智能制造重点实验室广东江门529020 广东轻工职业技术学院广东省高分子材料先进加工工程技术研究中心广东广州510300

三角形转子作用下的腔内混合行为代表了典型的混合问题,具有广泛的工程应用潜力。为进一步改善分布混合,提出了增加转子边长、转子形状摄动变形以及改变转子拓扑结构等三种强化混合的方法。考虑转子运动的周期性,采用有限元叠加网格技术... 详细信息

三角形转子作用下的腔内混合行为代表了典型的混合问题,具有广泛的工程应用潜力。为进一步改善分布混合,提出了增加转子边长、转子形状摄动变形以及改变转子拓扑结构等三种强化混合的方法。考虑转子运动的周期性,采用有限元叠加网格技术,建立了不同转子作用下的高黏度流体流动的数值模拟模型,求解得到瞬态速度场。采用自行开发的具有4阶精度的Runge-Kutta代码开展流体混合动力学研究。借助拉格朗日相干结构、示踪剂界面拉伸以及Poincaré截面等对搅拌腔内的分布混合行为进行表征。当转子边长为40 mm时,腔内出现围绕左右转子的两个独立的Komogorov-Arnold-Moser(KAM)岛;当边长增加到45 mm时,腔内的混合机理发生了改变,KAM岛演变为1个,并且沿着联通双环准周期轨道扫掠左右腔,提升分布混合的效果最好。相比改变转子形状,改变拓扑结构更有利于提升分布混合,而且功率消耗更低,但混合机理与转子边长40 mm时相同。

关键词：混合三角形转子数值模拟流体动力学拉格朗日相干结构

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Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： shuping Li Xin Li Jiaqi Meng Weier Bao Shuang Wang Peng Ye xiao-Dong Gao Wei Wei Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

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Effects of traditional Chinese medicine on treatment outcomes in severe COVID-19 patients:a single-centre study

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Chinese Journal of Natural Medicines 2024年第1期22卷 89-96页

作者： xiao Yongjiu LI Binbin LIU Chang HUANG Xiuyu MA Ling QIAN Zhirong ZHANG xiaopeng ZHANG Qian LI Dunqing CAI xiaoqing YAN Xiangyong LUO shuping XIANG Dawei xiao Kun Emergency Department the 940th Hospital of Jiont Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Scientific Research Center the Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China School of Medicine Nankai universityTianjin 300000China Department of Cardiology the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Department of Radiation Oncology Fujian Medical University Union HospitalFuzhou 350000China Department of Traditional Chinese Medicine the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Department of Geriatric Diseases the Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China Health and Sport Administration Muskingum UniversityOhioanUSA Laboratory of Vaccine and Antibody Engineering Beijing Institute of BiotechnologyBeijing 100071China Department of Pulmonary and Critical Care Medicine the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050China Center of Pulmonary&Critical Care Medicine Chinese People’s Liberation Army(PLA)General HospitalBeijing 100853China

As the search for effective treatments for COVID-19 continues,the high mortality rate among critically ill patients in Intensive Care Units(ICU)presents a profound *** study explores the potential benefits of traditional Chinese medicine(TCM)as a supplementary treatment for severe COVID-19.A total of 110 critically ill COVID-19 patients at the Intensive Care Unit(ICU)of Vulcan Hill Hospital between Feb.,2020,and April,2020(Wuhan,China)participated in this observational *** patients received standard supportive care protocols,with a subset of 81 also receiving TCM as an adjunct *** characteristics during the treatment period and the clinical outcome of each patient were closely monitored and *** findings indicated that the TCM group exhibited a significantly lower mortality rate compared with the non-TCM group(16 of 81 vs 24 of 29;0.3 vs 2.3 person/month).In the adjusted Cox proportional hazards models,TCM treatment was associated with improved survival odds(P<0.001).Furthermore,the analysis also revealed that TCM treatment could partially mitigate inflammatory responses,as evidenced by the reduced levels of proinflammatory cytokines,and contribute to the recovery of multiple organic functions,thereby potentially increasing the survival rate of critically ill COVID-19 patients.

关键词： COVID-19 Pneumonia Novel coronavirus Critically ill Traditional Chinese medicine Clinical outcome

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A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer

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Acta Pharmaceutica Sinica B 2024年第1期14卷 207-222页

作者： Hongrui Zhu Yamin Gao Liyun Liu Mengyu Tao xiao Lin Yijia Cheng Yaoyao Shen Haitao Xue Li Guan Huimin Zhao Li Liu shuping Wang Fan Yang Yongjun Zhou Hongze Liao Fan Sun Houwen Lin Research Center for Marine Drugs Department of PharmacyRen Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Oncology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Institute of Marine Drugs Guangxi University of Chinese MedicineNanning 530200China State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Professional and Technical Ser-vice Center for Biological Material Drug-ability EvaluationShanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 200437China Institute of Marine Biomedicine Shenzhen PolytechnicShenzhen 518055China

Modulating Tankyrases(TNKS),interactions with USP25 to promote TNKS degradation,rather than inhibiting their enzymatic activities,is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin ***,we identified UAT-B,a novel neoantimycin analog isolated from Streptomyces conglobatus,as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction(PPI)to overcome multi-drug resistance in colorectal cancer(CRC).The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels,triggering cell apoptosis through modulation of the Wnt/β-catenin ***,UAT-B successfully inhibited the CRC cells growth that harbored high TNKS levels,as demonstrated in various in vitro and in vivo studies utilizing cell line-based and patient-derived xenografts,as well as APC^(min/+)spontaneous CRC ***,these findings suggest that targeting the TNKS-USP25 PPI using a small-molecule inhibitor represents a compelling therapeutic strategy for CRC treatment,and UAT-B emerges as a promising candidate for further preclinical and clinical investigations.

关键词： Colorectal cancer TNKSeUSP25 interaction Multi-drug resistance TNKS overexpression Wnt pathway Apoptosis Neoantimycin analog

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一种改进的EMD图像信号去噪算法

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现代电子技术 2016年第16期39卷 91-93页

作者：肖淑苹贺毅岳西安翻译学院工程技术学院陕西西安710105 西北大学经济管理学院陕西西安710127

针对当前阈值类算法在图像去噪的同时均会将原图像有用成分滤掉,破坏图像的完整性,处理后的图像模糊等问题,提出EMD-SG算法为图像去噪。依据EMD算法对图像的拆分,利用SG滤波器对每个采集点的邻域进行滤波。同时利用最小二乘法方法拟合... 详细信息

针对当前阈值类算法在图像去噪的同时均会将原图像有用成分滤掉,破坏图像的完整性,处理后的图像模糊等问题,提出EMD-SG算法为图像去噪。依据EMD算法对图像的拆分,利用SG滤波器对每个采集点的邻域进行滤波。同时利用最小二乘法方法拟合出采集点邻域内最佳值,并结合IMF进行图像重构。该算法使图像处理过程良好地兼顾了图像除噪效果与图像信号完整性。实验结果表明此算法相比于其他算法具有优良的去噪能力。

关键词： EMD SG滤波器图像去噪图像重构

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边底水油藏开采机理与含水上升规律

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断块油气田 2009年第6期16卷 68-70页

作者：肖春艳李伟肖淑萍长江大学油气钻采工程湖北省重点实验室湖北荆州434023 塔里木油田分公司勘探开发研究院新疆库尔勒841000 江汉油田分公司清河采油厂山东寿光262716

针对靖安侏罗系边底水油藏的开发特征,以边底水生产开采机理和控制底水锥进的理论方法为指导,根据油藏动态分析研究,结合数值模拟结果,分析了新52井区边含水上升规律,研究了井区含水上升影响因素,提出人工注水是油藏实现"控水稳油"和高... 详细信息

针对靖安侏罗系边底水油藏的开发特征,以边底水生产开采机理和控制底水锥进的理论方法为指导,根据油藏动态分析研究,结合数值模拟结果,分析了新52井区边含水上升规律,研究了井区含水上升影响因素,提出人工注水是油藏实现"控水稳油"和高效开发的有效途径。新52井区注水开发延缓边底水锥进的效果,有效减缓了油田含水上升,确保了油藏的稳产开发,为油藏中后期开发调整积累了经验。

关键词：侏罗系油藏底水锥进含水上升率注水开发

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