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Nociceptors and Macrophages in Bacterial Meningitis:Partners in Crime?

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Neuroscience Bulletin 2024年第3期40卷 418-420页

作者： Fang gao Hongzhen Hu The Kimberly and Eric J.Waldman Department of Dermatology Icahn School of Medicine at Mount SinaiNew York NY10029USA The Nash Family Department of Neuroscience Icahn School of Medicine at Mount SinaiNew York NY10029USA The Mark Lebwohl Center for Neuroinfammation and Sensation Icahn School of Medicine at Mount SinaiNew York NY10029USA Friedman Brain Institute Icahn School of Medicine at Mount SinaiNew York NY10029USA

Bacterial meningitis is a serious and potentially life-threatening infection that affects the protective layers surrounding the brain and spinal cord,known as the *** types of bacteria,including Streptococcus pneumoniae,Neisseria meningitidis,and Haemophilus influenzae,can cause this *** populations,such as infants,children,immunocompromised adults,and the elderly,are particularly vulnerable to these *** of bacterial meningitis can manifest suddenly and may include high fever,severe and persistent headache,stiff neck,vomiting,sensitivity to light,and confusion or changes in mental state[1,2].Identifying these symptoms in infants can be more challenging and may lead to long-term disability or death[3].Despite the effectiveness of vaccines,it is crucial to understand how bacteria invade the brain and how our innate immune system responds to infection(Fig.1).

关键词： protective infection suddenly

Three-dimensional porous In_(2)O_(3) arrays for self-powered transparent solar-blind photodetectors with high responsivity and excellent spectral selectivity

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Nano Research 2024年第5期17卷 4471-4477页

作者： Nana Zhang Xinyu gao Haoran Guan Simin Sun Jiaming Liu Zhitao Shao Qiyue gao Yuan Zhang Ruyu Sun Guang Yang Feng gao Wei Feng College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040China Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China

Transparent solar-blind ultraviolet photodetectors(SBUV PDs)have extensive applications in versatile scenarios,such as optical ***,it is still challenging to simultaneously achieve high responsivity,high transparency,and satisfying self-powered ***,we demonstrated high-performance,transparent,and self-powered photoelectrochemical-type(PEC)SBUV PDs based on vertically grown ultrathin In_(2)O_(3) nanosheet arrays(NAs)with a three-dimensional(3D)porous *** 3D porous structure simultaneously improves the transmittance in the visible light region,accelerates interfacial reaction kinetics,and promotes photogenerated carrier *** performance of In_(2)O_(3) NAs photoanodes exceeds most reported self-powered PEC SBUV PDs,exhibiting a high transmittance of approximately 80%in the visible light region,a high responsivity of 86.15 mA/W for 254 nm light irradiation,a fast response speed of 15/18 ms,and good multicycle *** In_(2)O_(3) NAs also show excellent spectral selectivity with an ultrahigh solar-blind rejection ratio of 1319.30,attributed to the quantum confinement effect induced by the ultrathin feature(2-3 nm).Furthermore,In_(2)O_(3) NAs photoanodes show good capability in underwater optical *** work demonstrated that a 3D porous structure is a powerful strategy to synchronously achieve high responsivity and transparency and provides a new perspective for designing high-performance,transparent,and self-powered PEC SBUV PDs.

关键词： In_(2)O_(3) three-dimensional porous transparent photoelectrochemical solar-blind photodetectors

OnFractional(g,f,n′,m)-Critical Covered Graphs

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Journal of the Operations Research Society of China 2024年第2期12卷 446-460页

作者： Wei gao Wei-Fan Wang School of Information Science and Technology Yunnan Normal UniversityKunming 650500YunnanChina Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina

The main contribution in this article is threefold:(1)we show the necessary and sufficient condition for graphs to be fractional(g,f)-covered which can be expressed in different forms,and extended to fractional(g,f,m)-covered graphs;(2)the concept of fractional-critical covered graph is put forward and its necessary and sufficient condition is given;(3)we present the degree condition for a graph to be fractional(g,f,n′,m)-critical covered,and show that degree bound is sharp when m is ***,the related result in fractional(a,b,n′,m)-critical covered setting is also verified.

关键词： Network Fractional factor Data transmission Fractional covered graph Fractional critical covered graph

Spatiotemporal pattern of climate change in the China-Myanmar Economic Corridor from 1901 to 2018

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Journal of Mountain Science 2024年第1期21卷 131-145页

作者： YANG Xiaoliu LI Yungang gao Lu Institute of Geography Fujian Normal UniversityFuzhou 350117China School of Geographical Sciences Fujian Normal UniversityFuzhou 350117China Institute of International Rivers and Eco-Security Yunnan UniversityKunming 650500China Fujian Provincial Engineering Research Center for Monitoring and Accessing Terrestrial Disasters Fujian Normal UniversityFuzhou 350117China Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350117China

The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal patterns of temperature and precipitation in the CMEC over the past century were investigated using linear tendency estimation, the Mann-Kendall mutation test, the T-test, and wavelet analysis based on the monthly mean climatic data from 1901 to 2018 released by the Climatic Research Unit(CRU) of the University of East Anglia, UK. The results show that the CMEC demonstrated a trend of warming and drying over the past 100 years, and the rate of change in Myanmar was stronger than that in Yunnan Province of China. The warming rate was 0.039 ℃/10a. Precipitation decreased at a rate of -6.1 mm/10a. From the perspective of spatial distribution, temperature was high in the central and southern, low in the north of the CMEC, and the high-temperature centers were mainly distributed in the southern plain and river valley. Precipitation decreased from west to east and from south to north of the CMEC. From the perspective of the rate of change, warming was stronger in central and northern CMEC than in southern and northeastern CMEC. The rate of precipitation decline was stronger in the central and western regions than in the eastern region. This study provides a scientific reference for the CMEC to address climate change and ensure sustainable social and economic development and ecological security.

关键词： China-Myanmar Economic Corridor CRU Air temperature Precipitation Spatiotemporal pattern

Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression

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Neural Regeneration Research 2024年第10期19卷 2144-2156页

作者： Ying Ma Yue Qiao Xiang gao Spinal Cord and Brain Injury Research Group Stark Neuroscience Research InstituteIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cognitive decline, depression, and Alzheimer's disease. The largescale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients. Yet, few basic studies have been conducted to address the potential molecular mechanisms. One of possible factors underlying the depression is the reduction of adult hippocampal neurogenesis which may come from less physical activity, social isolation, chronic pain, and elevated neuroinflammation after spinal cord injury. However, there is no clear consensus yet. In this review, we will first summarize the alteration of hippocampal neurogenesis post-spinal cord injury. Then, we will discuss possible mechanisms underlie this important spinal cord injury consequence. Finally, we will outline the potential therapeutic options aimed at enhancing hippocampal neurogenesis to ameliorate depression.

关键词： antidepressants chronic pain depression exercise hippocampal neurogenesis inflammation inhibition neuroinflammation physical activity deficits social isolation spinal cord injury

Incentive Feedback Stackelberg Strategy in Mean-Field Type Stochastic Difference Games

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Journal of Systems Science & Complexity 2024年第4期37卷 1425-1445页

作者： gao Wenhui LIN Yaning ZHANG Weihai School of Mathematics and Statistics Shandong University of TechnologyZibo 255000China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

This paper designs an incentive Stackelberg strategy for the discrete-time stochastic systems with mean-field *** conditions for the existence of such a design are ***,the incentive strategy is obtained as a feedback form including the deviation of the state and its mathematical ***,the stability analysis is *** is found that the stability can be guaranteed by the *** addition,the specific algorithm is proposed and its effectiveness is checked by two examples.

关键词： Discrete-time mean-field stochastic systems incentive strategy Stackelberg game teamoptimal solution

Study on thermal cycling ageing resistance of performances of polypropylene/elastomer/boron nitride nanocomposites for high voltage direct current cable insulation

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High Voltage 2024年第3期9卷 556-565页

作者： Jing Li Yu gao Zheng Song Baixin Liu Chenyi Guo Yu Chen Junguo gao Boxue Du School of Electrical and Information Engineering Tianjin UniversityTianjinChina State Grid Tianjin Chengxi Electric Power Supply Branch TianjinChina State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anChina Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbinChina

The influences of thermal cycling ageing on structures and insulation performances of polypropylene(PP)/elastomer/boron nitride(BN)nanocomposites are *** Melt blending method was used to prepare the nanocomposites,in which propylene-based elastomer(PBE)or ethylene-octene copolymer elastomer(EOC)was contained for ***,the samples were treated using a thermal cycling process with a temperature range from-30 to 150℃,and the number of thermal cycles was set from 0 to *** electron microscope(SEM),Fourier transform infrared spectroscopy(FTIR),differential scanning calorimetry and X-ray diffraction measurements were taken to facilitate the comprehension of structural ***,measurements were taken to assess the trap distribution and direct current(DC)breakdown strength of the *** obtained results revealed that following thermal cycling ageing,the morphology and crystallinity of PP/PBE/BN remained almost *** contrast,PP/EOC/BN exhibited substantial microstructural damage accompanied by a significant reduction in *** the number of thermal cycles increased,the trap level and DC breakdown strength of PP/PBE/BN were maintained at high levels,while those of PP/EOC/BN initially remained stable but then experienced a sharp *** is sug-gested that the addition of BN nanoparticles enhances the thermal cycling ageing resis-tance of the PP/PBE blend,whereas it weakens this resistance of the PP/EOC blend.

关键词： cycling resistance thermal

From concept to commercialization:A review of tubular solid oxide fuel cell technology

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Journal of Energy Chemistry 2024年第10期97卷 79-109,I0003页

作者： Ruyan Chen Yuan gao Jiutao gao Huiyu Zhang Martin Motola Muhammad Bilal Hanif Cheng-Xin Li State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'anShaanxChina Department of Inorganic Chemistry Faculty of Natural SciencesComenius University Bratislava84215 BratislavaSlovakia

The reduced sealing difficulty of tubular solid oxide fuel cells(SOFCs)makes the stacking of tubular cell groups relatively easy,and the thermal stress constraints during stack operation are smaller,which helps the stack to operate stably for a long *** special design of tubular SOFC structures can completely solve the problem of high-temperature sealing,especially in the design of multiple single-cell series integrated into one tube,where each cell tube is equivalent to a small electric stack,with unique characteristics of high voltage and low current output,which can significantly reduce the ohmic polarization loss of tubular *** paper provides an overview of typical tubular SOFC structural designs both domestically and *** on the geometric structure of tubular SOFCs,they can be divided into bamboo tubes,bamboo flat tubes,single-section tubes,and single-section flat tube ***,this article provides an overview of commonly used materials and preparation methods for tubular SOFCs,including commonly used materials and preparation methods for support and functional layers,as well as a comparison of commonly used preparation methods for microtubule SOFCs,It introduced the three most important parts of building a fuel cell stack:manifold,current collector,and ceramic adhesive,and also provided a detailed introduction to the power generation systems of different tubular SOFCs,Finally,the development prospects of tubular SOFCs were discussed.

关键词： Tubular solid oxide fuel cell Support material Geometric structure Preparation methods Stack

A weak but inert hindered urethane bond for high-performance dynamic polyurethane polymers

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Chinese Chemical Letters 2024年第5期35卷 238-243页

作者： Fangzhou Wang Wentong gao Chenghui Li State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China

Covalent adaptable networks(CANs),which share the properties of both thermosets and thermoplastics at the same time,are desirable for many *** bulky substituents is a feasible way to design dynamic covalent bonds for constructing CANs,as evidenced by the successful implementation in CANs based on hindered urea bonds(HUBs).However,the dynamicity induced by introducing bulky substituents always come with low bond energy,resulting in low mechanical strength and poor stability of the ***,we designed a novel hindered urethane bond,which is weak in thermodynamic(K_(eq)=1701.23 L/mol at 25℃)and inert in kinetic at low temperature,but stable in thermodynamic(K_(eq)=1.54×10^(4) L/mol at 100℃)and active in kinetic at high temperature(k_(-1)=0.105 h^(-1) at 80℃ and 0.315 h^(-1) at 120℃).As a result,the polyurethane based on it exhibits high mechanical properties(with Youngs’modulus of 1011±29MPa and flexible modulus reached 1833±50MPa)and excellent reversibility(can be reprocessed at 60℃ under 100 kPa in 30 min and completely healed at 40℃ in 10 min).Moreover,unlike to many CANs based on hindered urea bonds,our dynamic polyurethanes are highly stable in humid environment or even water solutions due to the slow hydrolysis *** highperformance dynamic polyurethane polymers are attractive for many applications.

关键词： Covalent adaptable networks Urethane bond Kinetics Thermodynamics