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Relationship between crystallographic structure of complex inclusions MgAl_(2)O_(4)/Ti2O_(3)/MnS and improved toughness of heat-affected zone in shipbuilding steel

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Journal of Iron and Steel Research(International) 2022年第8期29卷 1277-1290页

作者： Yan wang Li-guang Zhu Jin-xia Huo Qing-jun Zhang Yao-guang Wu Wei Chen shuo-ming wang College of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210HebeiChina College of Materials Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050018HebeiChina China Analysis and Testing Center North China University of Science and TechnologyTangshan 063210HebeiChina MCC Capital Engineering&Research Incorporation Limited Metallurgical Engineering Consulting and Design DivisionBeijing 100176China

In accordance with the minimum degree of disregistry mechanism in oxide metallurgy, the intragranular acicular ferrite (IAF) generated by microalloying elements in austenite was studied. Herein, the effect of Mg treatment on the microstructure and toughness of the heat-affected zone (HAZ) in shipbuilding steel was investigated. Mg treatment produced inclusions that influenced the formation of acicular ferrite in the microstructure. This refined the HAZ microstructure and improved its toughness. Electron backscatter diffraction was used to determine the oxides of titanium and the MgO Al_(2)O_(3) or MgAl_(2)O_(4) complex inclusions that induced the formation of IAF. MnS precipitated on MgAl_(2)O_(4) on a specific habit plane and in a specific direction. MnS had a specific orientation relationship with MgAl_(2)O_(4), i.e., f100gMgAl_(2)O_(4) //{100}MnS. The 35-mm-thick plate obtained in the industrial test after welding at a welding heat input of 120 kJ/cm had an average impact absorbed energy of 282.7 J at - 40 ℃ and 2 mm from the weld joint in the HAZ. The twodimensional disregistry index between inclusions can be used as the basis for controlling their distribution and adsorption force. Microalloy addition in the order of Al-Mg-Ti is key to obtaining abundant dispersion and fine nucleation in austenite.

关键词： High heat input welding Mg treatment Disregistry mechanism Heat-affected zone

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A POSTERIORI ESTIMATOR OF NONCONFORming FINITE ELEMENT METHOD FOR FOURTH ORDER ELLIPTIC PERTURBATION PROBLEMS

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Journal of Computational Mathematics 2008年第4期26卷 554-577页

作者： shuo Zhang ming wang LMAM and School of Mathematical Sciences Peking University Beijing 100871 China

In this paper, we consider the nonconforming finite element approximations of fourth order elliptic perturbation problems in two dimensions. We present an a posteriori error estimator under certain conditions, and give an h-version adaptive algorithm based on the error estimation. The local behavior of the estimator is analyzed as well. This estimator works for several nonconforming methods, such as the modified Morley method and the modified Zienkiewicz method, and under some assumptions, it is an optimal one. Numerical examples are reported, with a linear stationary Cahn-HiUiard-type equation as a model problem.

关键词： Fourth order elliptic perturbation problems Nonconforming finite elementmethod A posteriori error estimator Adaptive algorithm Local behavior.

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Lin28 as a therapeutic target for central nervous system regeneration and repair

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Neural Regeneration Research 2024年第2期19卷 397-398页

作者： shuo wang Shuxin Li Shriners Hospitals Pediatric Research Center Department of Neural SciencesLewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

Axon disconnection in the central nervous system(CNS) usually causes signal transduction failure and severe functional deficits in patients with neurological disorders. Currently, there is no cure for patients with CNS axon injury and they usually suffer from life-long neurological defects(e.g., paralysis, loss of sensory function, and autonomic dysfunction) and life-threatening complications(e.g., autonomic dysreflexia).

关键词： paralysis therapeutic system

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Enrichment of anammox biomass during mainstream wastewater treatment driven by achievement of partial denitrification through the addition of bio-carriers

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Journal of Environmental Sciences 2024年第3期137卷 181-194页

作者： Yuqing Ma Bo wang Xiaodi Li shuo wang Wen wang Yongzhen Peng National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China

Anammox is widely considered as the most cost-effective and sustainable process for nitrogen removal.However,how to achieve the enrichment of anammox biomass remains a challenge for its large-scale application,especially in mainstream wastewater treatment.In this study,the feasibility of enrichment of anammox biomass was explored through the realization of partial denitrification and the addition of bio-carriers.By using ordinary activated sludge,a sequencing batch reactor(SBR)followed by an up-fow anaerobic sludge bed(UASB)was operated at 25±2℃ for 214 days.The long-term operation was divided into five phases,in which SBR and UASB were started-up in Phases I and II,respectively.By eliminating oxygen and adjusting the infow ratios in Phases III-V,advanced nitrogen removal was achieved with the effuent total nitrogen being 4.7 mg/L and the nitrogen removal efficiency being 90.5%in Phase V.Both in-situ and ex-situ activity tests demonstrated the occurrence of partial denitrification and anammox.Moreover,16S rRNA high-throughput sequencing analysis revealed that Candidatus Brocadia was enriched from below the detection limit to in biofilms(0.4%in SBR,2.2%in UASB)and the foc sludge(0.2%in SBR,1.3%in UASB),while Thauera was mainly detected in the foc sludge(8.1%in SBR,8.8%in UASB),which might play a key role in partial denitrification.Overall,this study provides a novel strategy to enrich anammox biomass driven by rapid achievement of partial denitrification through the addition of bio-carriers,which will improve large-scale application of anammox processes in mainstream wastewater treatment.

关键词： Enrichment Anammox biomass Bio-carriers Partial denitrification Mainstream wastewater

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Developing a diagnostic model for predicting prostate cancer: a retrospective study based on Chinese multicenter clinical data

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Asian Journal of Andrology 2024年第1期26卷 34-40页

作者： Chang-ming wang Lei Yuan Xue-Han Liu Shu-Qiu Chen Hai-Feng wang Qi-Fei Dong Bin Zhang ming-shuo Huang Zhi-Yong Zhang Jun Xiao Tao Tao Department of Urology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Core Facility Center for Medical Sciences The First Affiliated Hospital of USTcDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Urology Affiliated Zhongda Hospital of Southeast UniversityNanjing 210009China Department of Urology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Urology Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200000China Department of Urology Affiliated Anhui Provincial Hospital of Anhui Medical UniversityHefei 230001China

The overdiagnosis of prostate cancer(PCa)caused by nonspecific elevation serum prostate-specific antigen(PSA)and the overtreatment of indolent PCa have become a global problem that needs to be solved urgently.We aimed to construct a prediction model and provide a risk stratification system to reduce unnecessary biopsies.In this retrospective study,clinical data of 1807 patients from three Chinese hospitals were used.The final model was built using stepwise logistic regression analysis.The apparent performance of the model was assessed by receiver operating characteristic curves,calibration plots,and decision curve analysis.Finally,a risk stratification system of clinically significant prostate cancer(csPCa)was created,and diagnosis-free survival analyses were performed.Following multivariable screening and evaluation of the diagnostic performances,a final diagnostic model comprised of the PSA density and Prostate Imaging-Reporting and Data System(PI-RADS)score was established.Model validation in the development cohort and two external cohorts showed excellent discrimination and calibration.Finally,we created a risk stratification system using risk thresholds of 0.05 and 0.60 as the cut-off values.The follow-up results indicated that the diagnosis-free survival rate for csPCa at 12 months and 24 months postoperatively was 99.7%and 99.4%,respectively,for patients with a risk threshold below O.05 after the initial negative prostate biopsy,which was significantly better than patients with higher risk.Our diagnostic model and risk stratification system can achieve a personalized risk calculation of csPCa.It provides a standardized tool for Chinese patients and physicians when considering thenecessity of prostatebiopsy.

关键词： nomogram prostate biopsy prostate cancer Prostate Imaging-Reporting and Data System prostate-specific antigen density

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Repeated inoculation with rumen fluid accelerates the rumen bacterial transition with no benefit on production performance in postpartum Holstein dairy cows

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Journal of Animal Science and Biotechnology 2024年第2期15卷 795-811页

作者： Fanlin Kong Feiran wang Yijia Zhang shuo wang Wei wang Shengli Li Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control State Key Laboratory of Animal NutritionDepartment of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193PR China College of Veterinary Medicine Nanjing Agricultural UniversityNanjingJiangsu 210095PR China

Background The dairy cow’s postpartum period is characterized by dramatic physiological changes,therefore imposing severe challenges on the animal for maintaining health and milk output.The dynamics of the ruminal microbiota are also tremendous and may play a crucial role in lactation launch.We aim to investigate the potential benefits of early microbial intervention by fresh rumen microbiota transplantation(RMT)and sterile RMT in postpartum dairy cows.Twelve fistulated peak-lactation dairy cows were selected to be the donors for rumen fluid collection.Thirty postpartum cows were divided into 3 groups as the transplantation receptors respectively receiving 10 L fresh rumen fluid(FR),10 L sterile rumen fluid(SR),or 10 L saline(CON)during 3 d after calving.Results Production performance,plasma indices,plasma lipidome,ruminal microbiome,and liver transcriptome were recorded.After fresh and sterile RMT,we found that the molar proportion of propionic acid was increased on d 7 in the FR and SR groups and the bacterial composition was also significantly changed when compared with the CON group.A similarity analysis showed that the similarities between the CON group and FR or SR group on d 7 were 48.40%or 47.85%,whereas the similarities between microbiota on d 7 and 21 in the FR and SR groups were 68.34%or 66.85%.Dry matter intake and feed efficiency were not affected by treatments.Plasmaβ-hydroxybutyrate concentration in the FR group was decreased and significantly different lipids mainly included phosphatidylcholine and lysophosphatidylcholine containing polyunsaturated fatty acids.Hepatic transcriptomics analysis indicated acutephase response pathways were upregulated in the SR group.Conclusions Our study suggests that RMT can shorten the transition process of the ruminal microbiota of postpartum dairy cows with no benefit on dry matter intake or feed efficiency.Inoculation with rumen fluid may not be a useful approach to promote the recovery of postpartum dairy cows.

关键词： Dairy cow Lipidomics Liver Rumen microbiota transplantation Transition period

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Effect of icosahedral phase formation on the stress corrosion cracking(SCC)behaviors of the as-cast Mg-8%Li(in wt.%)based alloys

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Journal of Magnesium and Alloys 2024年第1期12卷 225-236页

作者： shuo wang Daokui Xu Dongliang wang Zhiqiang Zhang Baojie wang Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Engineering Research Center of Advanced Materials Preparing Technology Ministry of EducationNortheastern UniversityShenyang110819China School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang110159China Binzhou Institute of Technology BinzhouShandong Province256606China Shandong Key Laboratory of Advanced Aluminium Materials and Technology BinzhouShandong Province256606China

Through exploring the stress corrosion cracking(SCC)behaviors of the as-cast Mg-8%Li and Mg-8%Li-6%Zn-1.2%Y alloys in a 0.1 M NaCl solution,it revealed that the SCC susceptibility index(I_(SCC))of the Mg-8%Li alloy was 47%,whilst the I_(SCC)of the Mg-8%Li-6%Zn-1.2%Y alloy was 68%.Surface,cross-sectional and fractography observations indicated that for the Mg-8%Li alloy,theα-Mg/β-Li interfaces acted as the preferential crack initiation sites and propagation paths during the SCC process.With regard to the Mg-8%Li-6%Zn-1.2%Y alloy,the crack initiation sites included the I-phase and the interfaces of I-phase/β-Li andα-Mg/β-Li,and the preferential propagation paths were the I-phase/β-Li andα-Mg/β-Li interfaces.Moreover,the SCC of the two alloys was concerned with hydrogen embrittlement(HE)mechanism.

关键词： Magnesium-lithium alloy Stress corrosion cracking I-phase Fracture analysis

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Genetically modified pigs:Emerging animal models for hereditary hearing loss

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Zoological Research 2024年第2期45卷 284-291页

作者： Xiao wang Tian-Xia Liu Ying Zhang Liang-Wei Xu shuo-Long Yuan A-Long Cui Wei-Wei Guo Yan-Fang wang Shi-ming Yang Jian-Guo Zhao State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Department of Otolaryngology-Head and Neck Surgery Institute of OtolaryngologyChinese PLA General HospitalBeijing 100853China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230022China State Key Laboratory of Animal Biotech Breeding Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

Hereditary hearing loss(HHL),a genetic disorder that impairs auditory function,significantly affects quality of life and incurs substantial economic losses for society.To investigate the underlying causes of HHL and evaluate therapeutic outcomes,appropriate animal models are necessary.Pigs have been extensively used as valuable large animal models in biomedical research.In this review,we highlight the advantages of pig models in terms of ear anatomy,inner ear morphology,and electrophysiological characteristics,as well as recent advancements in the development of distinct genetically modified porcine models of hearing loss.Additionally,we discuss the prospects,challenges,and recommendations regarding the use pig models in HHL research.Overall,this review provides insights and perspectives for future studies on HHL using porcine models.

关键词： Pigs Animal models Hereditary hearing loss Genetic modification Inner ear

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Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey

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Asian Journal of Andrology 2024年第2期26卷 123-134页

作者： Lin Chen Yu-Xin Xu Yuan-shuo wang Jian-Liang Zhou School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou 311121China School of Pharmacy Guangxi Medical UniversityNanning530021China

Prostate cancer(PCa)is one of the most common malignancies in males worldwide,and its development and progression involve the regulation of multiple metabolic pathways.Alterations in lipid metabolism affect the proliferation and metastatic capabilities of PCa cells.Cancer cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy demands.Similarly,changes occur in amino acid metabolism in PCa.Cancer cells exhibit an increased demand for specific amino acids,and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival requirements.These changes are closely associated with disease progression and treatment response in PCa cells.Therefore,a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.

关键词： amino acid metabolism lipid metabolism metabolic pathways prostate cancer treatment strategies

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Comparison-embedded evidence-CNN model for fuzzy assessment of wear severity using multi-dimensional surface images

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Friction 2024年第6期12卷 1098-1118页

作者： Tao SHAO shuo wang Qinghua wang Tonghai WU Zhifu HUANG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China

Wear topography is a significant indicator of tribological behavior for the inspection of machine health conditions.An intelligent in-suit wear assessment method for random topography is here proposed.Three-dimension(3D)topography is employed to address the uncertainties in wear evaluation.Initially,3D topography reconstruction from a worn surface is accomplished with photometric stereo vision(PSV).Then,the wear features are identified by a contrastive learning-based extraction network(WSFE-Net)including the relative and temporal prior knowledge of wear mechanisms.Furthermore,the typical wear degrees including mild,moderate,and severe are evaluated by a wear severity assessment network(WSA-Net)for the probability and its associated uncertainty based on subjective logic.By integrating the evidence information from 2D and 3D-damage surfaces with Dempster–Shafer(D–S)evidence,the uncertainty of severity assessment results is further reduced.The proposed model could constrain the uncertainty below 0.066 in the wear degree evaluation of a continuous wear experiment,which reflects the high credibility of the evaluation result.

关键词： wear severity assessment contrastive learning subjective logic Dempster-Shafer(D-S)evidence theory

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