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Research 2023年第4期2023卷 793-820页

作者： shuo wang Mengmeng Zhao Yibo Yan Peng Li Wei Huang Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi'anChina

Microneedles(MNs)have drawn rising attention owing to their merits of convenience,noninvasiveness,flexible applicability,painless microchannels with boosted metabolism,and precisely tailored multifunction control.MNs can be modified to serve as novel transdermal drug delivery,which conventionally confront with the penetration barrier caused by skin stratum corneum.The micrometer-sized needles create channels through stratum corneum,enabling efficient drug delivery to the dermis for gratifying efficacy.Then,incorporating photosensitizer or photothermal agents into MNs can conduct photodynamic or photothermal therapy,respectively.Besides,health monitoring and medical detection by MN sensors can extract information from skin interstitial fluid and other biochemical/electronic signals.Here,this review discloses a novel monitoring,diagnostic,and therapeutic pattern by MNs,with elaborate discussion about the classified formation of MNs together with various applications and inherent mechanism.Hereby,multifunction development and outlook from biomedical/nanotechnology/photoelectric/devices/informatics to multidisciplinary applications are provided.Programmable intelligent MNs enable logic encoding of diverse monitoring and treatment pathways to extract signals,optimize the therapy efficacy,real-time monitoring,remote control,and drug screening,and take instant treatment.

关键词： stratum sized enable

Hepatic arterial anastomosis in adult liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 650-652页

作者： Kai-Wun Chang Zhe Yang shuo wang Shu-Sen Zheng Zhejiang University School of Medicine Hangzhou 310000China Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China National Clinical Research Center of Infectious Diseases Hangzhou 310003China

Hepatic arterial reconstruction remains a critically challenging technique in liver transplantation,as efficient graft and patient survival are dependent on strong and continuous arterial blood supply to the donor liver[1,2].Complex arterial reconstruction has been identified as a crucial risk factor for arterial thrombosis[1–5].Consequently,selecting the appropriate arterial reconstruction method to decrease hepatic artery thrombosis has garnered the attention of the surgical community.

关键词： arterial Hepatic liver

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Compression Behavior and Failure Mechanisms of Bionic Porous NiTi Structures Built via Selective Laser Melting

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Acta Metallurgica Sinica(English Letters) 2023年第6期36卷 926-936页

作者： Xiaolong Zhang Yue Jiang Shupeng wang shuo wang Ziqiang wang Zhenglei Yu Zhihui Zhang Luquan Ren Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China Luoyang Ship Material Research Institute Luoyang 471023China

Inspired by the crystal microstructure of metals and the bamboo,the bionic porous NiTi structures with the porosities in the range of 75.8%–84.9%were built via selective laser melting(SLM).The compression behavior and the failure mechanisms of the porous NiTi structures were evaluated.It demonstrated an increase in the elastic modulus and ultimate strength when the porosity was decreased,from 3.06 to 7.66 GPa and from 34.1 to 147.6 MPa,respectively.The relationship between the elastic modulus and the porosity obtained by the finite element analysis exhibited similar tendency with the experiment,and agreed well with the Gibson-Ashby model’s prediction.Based on the theoretical model above and the observation of the deformation processing,the plastic deformation behavior and failure mechanisms of the SLMed porous NiTi structures were analyzed.

关键词： Selective laser melting NiTi shape memory alloys Additive manufacturing Porous structure Bionic design

Modified Multifidelity Surrogate Model Based on Radial Basis Function with Adaptive Scale Factor

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Chinese Journal of Mechanical Engineering 2022年第4期35卷 109-123页

作者： Yin Liu shuo wang Qi Zhou Liye Lv Wei Sun Xueguan Song School of Mechanical Engineering Dalian University of Technology School of Aerospace Engineering Huazhong University of Science and Technology School of Mechanical Engineering and Automation Zhejiang Sci-Tech University

Multifidelity surrogates(MFSs) replace computationally intensive models by synergistically combining information from different fidelity data with a significant improvement in modeling efficiency. In this paper, a modified MFS(MMFS) model based on a radial basis function(RBF) is proposed, in which two fidelities of information can be analyzed by adaptively obtaining the scale factor. In the MMFS, an RBF was employed to establish the low-fidelity model.The correlation matrix of the high-fidelity samples and corresponding low-fidelity responses were integrated into an expansion matrix to determine the scaling function parameters. The shape parameters of the basis function were optimized by minimizing the leave-one-out cross-validation error of the high-fidelity sample points. The performance of the MMFS was compared with those of other MFS models(MFS-RBF and cooperative RBF) and single-fidelity RBF using four benchmark test functions, by which the impacts of different high-fidelity sample sizes on the prediction accuracy were also analyzed. The sensitivity of the MMFS model to the randomness of the design of experiments(DoE) was investigated by repeating sampling plans with 20 different DoEs. Stress analysis of the steel plate is presented to highlight the prediction ability of the proposed MMFS model. This research proposes a new multifidelity modeling method that can fully use two fidelity sample sets, rapidly calculate model parameters, and exhibit good prediction accuracy and robustness.

关键词： Multi-fidelity surrogate RBF Adaptive scaling factor LOOCV Expansion matrix

Coronavirus Mask Protection Algorithm:A New Bio-inspired Optimization Algorithm and Its Applications

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Journal of Bionic Engineering 2023年第4期20卷 1747-1765页

作者： Yongliang Yuan Qianlong Shen shuo wang Jianji Ren Donghao Yang Qingkang Yang Junkai Fan Xiaokai Mu School of Mechanical and Power Engineering Henan Polytechnic UniversityJiaozuo454003China School of Mechanical Engineering Dalian University of TechnologyDalian116024China School of Software Henan Polytechnic UniversityJiaozuo454003China

Nowadays,meta-heuristic algorithms are attracting widespread interest in solving high-dimensional nonlinear optimization problems.In this paper,a COVID-19 prevention-inspired bionic optimization algorithm,named Coronavirus Mask Protection Algorithm(CMPA),is proposed based on the virus transmission of COVID-19.The main inspiration for the CMPA originated from human self-protection behavior against COVID-19.In CMPA,the process of infection and immunity consists of three phases,including the infection stage,diffusion stage,and immune stage.Notably,wearing masks correctly and safe social distancing are two essential factors for humans to protect themselves,which are similar to the exploration and exploitation in optimization algorithms.This study simulates the self-protection behavior mathematically and offers an optimization algorithm.The performance of the proposed CMPA is evaluated and compared to other state-of-the-art metaheuristic optimizers using benchmark functions,CEC2020 suite problems,and three truss design problems.The statistical results demonstrate that the CMPA is more competitive among these state-of-the-art algorithms.Further,the CMPA is performed to identify the parameters of the main girder of a gantry crane.Results show that the mass and deflection of the main girder can be improved by 16.44%and 7.49%,respectively.

关键词： Coronavirus Mask Protection Algorithm Bionic algorithm Metaheuristic algorithm Optimization algorithm Truss optimization Parameter identification

Supraclinoid internal carotid artery blister-like aneurysms:hypothesized pathogenesis and microsurgical clipping outcomes

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Chinese Neurosurgical Journal 2022年第1期8卷 16-25页

作者： Shanwen Chen Xin Chen Bo Ning Yong Cao shuo wang Department of Neurosurgery the Hospital of Shunyi DistrictNo.3 Guangming Nan StreetShunyi DistrictBeijing 101300China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityChina National Clinical Research Center for Neurological DiseasesNo.119 South 4th Ring West RoadFengtai DistrictBeijing 100050China Department of Neurosurgery Guangzhou Red Cross HospitalJinan UniversityNo.396 Tongfu Zhong RoadHaizhu DistrictGuangzhou 510220GuangdongChina

Background:Blister-like aneurysms(BLAs)on the supraclinoid segment of the internal carotid artery(ICA)are an enigma of cerebrovascular disease.Neither has a definite pathogenesis been so far identified,nor have uniform treatment guidelines been established for them.Our aim was to develop a hypothesis regarding the evolution of BLAs according to their macroscopic morphologies and to evaluate the efficacy of microsurgical clipping.Methods:The clinical data and morphological features of 15 consecutive patients with 16 BLAs on the supraclinoid ICA were retrospectively reviewed.The treatment strategies were analyzed,and functional outcomes were evaluated using the modified Rankin scale(mRS).Favorable outcomes were defined as a mRS score of 0-2.Results:Morphologically,aneurysm growth with expansion of the aneurysm neck before the surgical procedure occurred in two ruptured and one unruptured aneurysm.Daughter bleb formation was observed in two ruptured and five unruptured aneurysms.A varied degree of parent artery sclerosis was observed in nine patients.Thirteen patients were treated with direct surgical clipping,one patient was treated with clipping and wrapping,and the remaining patient was treated with an encircling clipping graft.Favorable and unfavorable outcomes were observed in 13 and two cases,respectively.Follow-up angiograms revealed 4 cases of stenosis with respective degree of mild,30%,50%,and 80%without any neurological dysfunction.Conclusions:We suggest a hypothesis that BLAs on the supraclinoid ICA may share different evolving mechanisms between ruptured and unruptured lesions.A majority of them can be reliably and safely obliterated by direct clipping technique,except for the aneurysms accompanied with severely atherosclerotic parent walls.

关键词： Blister-like aneurysm Internal carotid artery Microsurgical clipping Morphology Prognosis

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A real-world study of the differences in Traditional Chinese Medicine diagnosis and treatment rules for coronavirus disease 2019 between Northern and Southern China

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Journal of Traditional Chinese Medicine 2024年第4期 822-829页

作者： SU Rui SU Youzhu wang shuo FAN Jie LIU Qingquan LIU Mifeng Department of infectious diseases Capital Medical University Beijing Hospital of Traditional Chinese Medicine

OBJECTIVE: To explore the differences in Traditional Chinese Medicine(TCM) diagnosis and treatment rules for coronavirus disease 2019(COVID-19) between Northern and Southern China based on the real-world data from 982 COVID-19 patients. METHODS: All consecutive cases of COVID-19 admitted to the TCM department of designated COVID-19 hospitals in eight provinces and cities were retrospectively analyzed. Patients were divided into a Northern and a Southern group according to the location of the admitting hospital. The symptoms, syndrome elements, syndrome distribution and herbal treatments were analyzed. The core prescriptions were extracted using the multiscale backbone-based network comparison algorithm(msbNC). RESULTS: The distribution of syndrome elements showed that dampness was common in Northern and Southern China, wind and heat were more often present in the South, while fire toxin and spleen deficiency were more often encountered in the North. The distribution of syndromes showed that the South was dominated by heat dampness accumulating in the lung(55.69%), while the North was dominated by dampness-toxin stagnating in the lung(44.90%).The results of core prescription mining showed that dispelling dampness, dispersing wind, clearing heat and strengthening spleen were the common treatment methods in Northern and Southern China. For mild cases, Jinyinhua(Flos Lonicerae) and Lianqiao(Fructus Forsythiae Suspensae) were often used in the South to clear heat and relieve exterior symptoms, while Chaihu(Radix Bupleuri Chinensis) and Huangqin(Radix Scutellariae Baicalensis) were often used in the North to relieve muscles by expelling heat. For moderate cases, Chaihu(Radix Bupleuri Chinensis), Qinghao(Herba Artemisiae Annuae), and Shigao(Gypsum Fibrosum) were often used to clear heat of Tri-jiao Channel and stomach in the South, while Fuling(Poria), Chenpi(Pericarpium Citri Reticulatae), and Dangshen(Radix Codonopsis) were often used to invigorate spleen and remove dampness in the North. For severe cases, spleen invi

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Achieving highest Young’s modulus in Al-Li by tracing the size and bonding evolution of Li-rich precipitates

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Journal of Materials Science & Technology 2023年第14期145卷 125-135页

作者： Chengpeng Xue Yuxuan Zhang shuo wang Guangyuan Tian Xinghai Yang Yubin Ke Zhenhua Xie Junsheng wang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China China Spallation Neutron Source Dongguan BranchInstitute of High Energy PhysicsChinese Academy of SciencesDongguan 523803China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

For decades,it has been well accepted that every 1 wt.%Li addition to Al will reduce Al alloy’s density by 3%and increase its Young’s modulus by 6%.However,the fundamental mechanism of modulus improve-ments stays controversial though all studies agreed that the contribution of such a substantial boosting comes from Li-rich clusters either in solid solution or precipitations.In this study,we experimentally produce nano-sized Li-rich clusters by non-equilibrium solidification using centrifugal casting and trace their evolutions as a function of subsequent heat treatments.High-resolution transmission electron mi-croscopy(HRTEM)reveals a further decrease in the lattice constants of Li-rich regions from the as-cast(0.406 nm),solid solution(0.405 nm)to the aged state(0.401 nm),while Young’s modulus of the Al-Li al-loy reaches 89.16 GPa.Small-angle neutron scattering(SANS)experiments and first-principle calculations based on density functional theory have shown both the bond strength around precipitates and the size of those Li-rich region dominate Young’s modulus.At the beginning,it is volumetric compression due to Li addition that increases modulus,tightening the Al-Al potential curves.In the end,it is the Al-Al and Al-Li valence bonds in Al 3 Li at large size and high-volume fraction which increase its second derivative of internal energy and thus Young’s modulus.

关键词： Al-Li alloy Young’s modulus SANS HRTEM DFT Precipitate kinetics

Instability of solution-processed perovskite films:origin and mitigation strategies

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Materials Futures 2023年第1期2卷 26-59页

作者： shuo wang Ming-Hua Li Yan Jiang Jin-Song Hu Beijing National Laboratory for Molecular Sciences(BNLMS) Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Perovskite solar cells(PSCs)are promising next-generation photovoltaics due to their unique optoelectronic properties and rapid rise in power conversion efficiency.However,the instability of perovskite materials and devices is a serious obstacle hindering technology commercialization.The quality of perovskite films,which is an important prerequisite for long-term stable PSCs,is determined by the quality of the precursor solution and the post-deposition treatment performed after perovskite formation.Herein,we review the origin of instability of solution-processed PSCs from the perspectives of the precursor solutions and the perovskite films.In addition,we summarize the recent strategies for improving the stability of the perovskite films.Finally,we pinpoint possible approaches to further advance their long-term stability.

关键词： stability perovskite solar cells precursor solution perovskite films degradation

Analysis of longitude profiled rolling process of Cu/Al cladded sheet and evaluation of outlet warpage

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Journal of Iron and Steel Research(International) 2022年第6期29卷 973-982页

作者： Jing-na Sun Chi Chen shuo wang Guan-nan Liu Hua-gui Huang National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004HebeiChina Xinxiang Aviation Industry(Group)Co. Ltd.Xinxiang 453000HenanChina Harbin Dongan Engine Co. Ltd.Harbin 150060HeilongjiangChina

Longitude profiled cladded sheet is obtained by rolling bimetal cladded sheet with variable gauge rolling technology.The longitude profiled rolling process of Cu/Al cladded sheets was studied by finite element method and experiments.The rolling force rises with the increase in reduction,and a sudden change appears at the end of the thickness variation zone.The thickness ratio of copper layer is enlarged after rolling owing to its relatively large deformation resistance and continues to rise with the increase in reduction rate.Lower elongation of copper side leads to the warpage of exit metal to copper side,which further hinders the deformation of copper.The influence of asymmetric rolling parameters indicates that increasing the work roll diameter ratio,speed radio,and friction coefficient on Al side can reduce the warpage when the reduction rate is below a certain value depending on the thickness ratio and other rolling parameters.Comparison of experiments and simulation results showed good agreement and verified the finite element model.

关键词： Longitude profiled rolling Cladded sheet Rolling force Layer thickness ratio Outlet warpage Asymmetric rolling