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Equilibrium Strategies in an Unobservable On-off Fluid Queue

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 324-336页

作者： Xiu-li XU Shuo wang School of Science Yanshan UniversityQinhuangdao 060004China

This paper considers an on-off fluid queue model.The on and off states of the system appear alternately,and the sojourn times at these two different states are independent,and each one follows an exponential distribution.The fluid flows into the system buffer with some strategies to wait for the system service under the first-come first-served discipline.Here the system can process the fluid in the buffer only when the system is on state.With given utility functions such as an expected average social profit,and an individual expected profit,the equilibrium strategies are characterized under both the fully unobservable case and the partially observable case.

关键词： fluid model on-off equilibrium strategies optimal benefit

Enrichment of anammox biomass during mainstream wastewater treatment driven by achievement of partial denitrification through the addition of bio-carriers

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Journal of Environmental Sciences 2024年第3期137卷 181-194页

作者： Yuqing Ma Bo wang Xiaodi Li Shuo wang Wen wang Yongzhen Peng National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China

Anammox is widely considered as the most cost-effective and sustainable process for nitrogen removal.However,how to achieve the enrichment of anammox biomass remains a challenge for its large-scale application,especially in mainstream wastewater treatment.In this study,the feasibility of enrichment of anammox biomass was explored through the realization of partial denitrification and the addition of bio-carriers.By using ordinary activated sludge,a sequencing batch reactor(SBR)followed by an up-fow anaerobic sludge bed(UASB)was operated at 25±2℃ for 214 days.The long-term operation was divided into five phases,in which SBR and UASB were started-up in Phases I and II,respectively.By eliminating oxygen and adjusting the infow ratios in Phases III-V,advanced nitrogen removal was achieved with the effuent total nitrogen being 4.7 mg/L and the nitrogen removal efficiency being 90.5%in Phase V.Both in-situ and ex-situ activity tests demonstrated the occurrence of partial denitrification and anammox.Moreover,16S rRNA high-throughput sequencing analysis revealed that Candidatus Brocadia was enriched from below the detection limit to in biofilms(0.4%in SBR,2.2%in UASB)and the foc sludge(0.2%in SBR,1.3%in UASB),while Thauera was mainly detected in the foc sludge(8.1%in SBR,8.8%in UASB),which might play a key role in partial denitrification.Overall,this study provides a novel strategy to enrich anammox biomass driven by rapid achievement of partial denitrification through the addition of bio-carriers,which will improve large-scale application of anammox processes in mainstream wastewater treatment.

关键词： Enrichment Anammox biomass Bio-carriers Partial denitrification Mainstream wastewater

Stabilizing sodium metal anode through facile construction of organicmetal interface

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Journal of Energy Chemistry 2022年第3期31卷 133-139,I0005页

作者： Jiaolong Zhang Shuo wang Wenhui wang Baohua Li School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808GuangdongChina International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060GuangdongChina School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhen 518055GuangdongChina Shenzhen Key Laboratory on Power Battery Safety and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate School(SIGS)Shenzhen 518055GuangdongChina

Implementation of sodium metal anode is highly desired for sodium batteries due to its high theoretical capacity and low redox potential.Unfortunately,formation of unstable solid electrolyte interphase(SEI)and uncontrollable growth of dendrites during charge/discharge cycles greatly hinder the practical application of sodium metal anode.In this study,an organic-metal artificial layer made of PVdF and Bi was constructed to protect Cu current collector via a facile coating method,leading to smooth and dense sodium plating/stripping,which in retern enables stable cycling and high coulombic efficiency(CE).At 1 mA cm^(−2),PB@Cu current collector presents extended lifetime of~2500 h with high sodium utilization of 50%,which is approximately six times higher than Cu current collector.PB@Cu electrode also displays high average CE of 99.92%and 99.95%over 2500 and 1300 cycles at 1 and 2 mA cm^(−2) respectively,which is in sharp contrast to the low and tremendously fluctuant CE gained from bare Cu electrode.Moreover,stable capacity of>90 mAh g^(−1) over 150 cycles is realized for PB@Cu-based full cell assembled with NVP cathode at a low negative-positive capacity ratio of~3.5,which is significantly higher than 37.2 mAh g^(−1) obtained from NVP/Cu at 150th cycle.The superior electrochemical performance of PB@Cu current collector is revealed to originate from the alloyed Na_(3)Bi phase with high sodium conductivity and robust mechanical strength as well as the formation of NaF-rich SEI with fast sodium ion migration,which enable dendrite-free morphology during plating/stripping cycles.

关键词： Sodium metal anode Organic-metal artificial layer Bi PVdF Solid electrolyte interphase

High-frequency spinal cord stimulation produces longlasting analgesic effects by restoring lysosomal function and autophagic flux in the spinal dorsal horn

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Neural Regeneration Research 2022年第2期17卷 370-377页

作者： Zhi-Bin wang Yong-Da Liu Shuo wang Ping Zhao Department of Anesthesiology and Pain Management Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

High-frequency spinal cord stimulation(HF-SCS) has been established as an effective therapy for neuropathic pain. However, the analgesic mechanisms involved in HF-SCS remain to be clarified. In our study, adult rat neuropathic pain was induced by spinal nerve ligation. Two days after modeling, the rats were subjected to 4 hours of HF-SCS(motor threshold 50%, frequency 10,000 Hz, and pulse width 0.024 ms) in the dorsal horn of the spinal cord. The results revealed that the tactile allodynia of spinal nerve-injured rats was markedly alleviated by HFSCS, and the effects were sustained for 3 hours after the stimulation had ceased. HF-SCS restored lysosomal function, increased the levels of lysosome-associated membrane protein 2(LAMP2) and the mature form of cathepsin D(matu-CTSD), and alleviated the abnormally elevated levels of microtubule-associated protein 1 A/B-light chain 3(LC3)-II and sequestosome 1(P62) in spinal nerve-injured rats. HF-SCS also mostly restored the immunoreactivity of LAMP2, which was localized in neurons in the superficial layers of the spinal dorsal horn in spinal nerve-injured rats. In addition, intraperitoneal administration of 15 mg/kg chloroquine for 60 minutes reversed the expression of the aforementioned proteins and shortened the timing of the analgesic effects of HF-SCS. These findings suggest that HF-SCS may exhibit longlasting analgesic effects on neuropathic pain in rats through improving lysosomal dysfunction and alleviating autophagic flux. This study was approved by the Laboratory Animal Ethics Committee of China Medical University, Shenyang, China(approval No. 2017 PS196 K) on March 1, 2017.

关键词： autolysosome dorsal horn of spinal cord dysfunction electrical stimulation high-frequency spinal cord stimulation neuropathic pain spinal nerve ligation

Methods for monitoring cancer cell pyroptosis

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Cancer Biology & Medicine 2022年第4期19卷 398-414页

作者： Shuo wang Yuantong Liu Lu Zhang Zhijun Sun The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of EducationSchool and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral Maxillofacial-Head Neck Oncology School and Hospital of StomatologyWuhan UniversityWuhan 430079China

Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins.The main features of pyroptosis are altered membrane permeability,cell swelling,membrane rupture,and the ability to mobilize a strong immune response.The relationship between pyroptosis and cancer has become a popular topic in immunological research.Multiple strategies for inducing pyroptosis in cancer cells have been developed for cancer therapy,including chemotherapy,small molecule drugs,and nanomedicines.In this review,we systematically discuss recent advances in research on the mechanisms of pyroptosis,and compare pyroptosis with apoptosis and necroptosis from several aspects.The development of various experimental systems has accompanied rapid progress in this field,but little consensus on monitoring pyroptosis is currently available.We focus on techniques commonly used to monitor pyroptosis,and describe future techniques that may be used to increase our knowledge in this field.Overall,the advancement of pyroptosis detection methods will help researchers to better investigate the relationships between pyroptosis and various cancers,and should provide insights into the use of these promising tools for cancer treatments.

关键词： Pyroptosis gasdermin caspase cancer immunotherapy cell death

Identifying the crystal structure of T 1 precipitates in Al-Li-Cu alloys by ab initio calculations and HAADF-STEM imaging

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Journal of Materials Science & Technology 2023年第2期133卷 41-57页

作者： Shuo wang Xianghai Yang Junsheng wang Chi Zhang Chengpeng Xue School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

Controversial experimental reports on the crystal structure of T 1 precipitates in Al-Li-Cu alloys have ex-isted for a long time,and all of them can be classified into five models.To clarify its ground-state atomic structure,herein,we have combined high-throughput first-principles calculations and CALPHAD,as well as aberration-corrected HAADF-STEM experiments.Employing the special quasi-random structure(SQS)and supercell approximation(SPA)methods to simulate the local disorder on Al-Cu sub-lattices,we find that none of the present models can satisfy the phase stability in Al-Li-Cu ternary system based on temperature-dependent convex hull analysis.Using the cluster expansion(CE)formulas,structural predic-tions derived from the five-frame models were performed.Subsequently,by introducing the vibrational contribution to the free energy at aging temperatures,we proposed a novel ground-state T 1 structure that maintains a coherent relationship with Al-matrix at theAl orientation.The underlying phase transition between the variants of T 1 precipitates was further discussed.By means of ab initio molecular dynamics(AIMD)simulations,we resolved the controversy regarding the number of atomic layers con-stituting the T 1 phase and acknowledged the existence of Al-Li corrugated layers.The root cause of this structural distortion is triggered by atomic forces and bondings.Our work can have an positive impact on the novel fourth generation of Al-Cu-Li alloy designs by engineering the T 1 strengthening phase.

关键词： Al-Cu-Li alloys T 1 precipitates Cluster expansion First-principle calculations ab initio molecular dynamics HAADF-STEM

Integrated Computational Materials Engineering for the Development and Design of High Modulus Al Alloys

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Journal of Beijing Institute of Technology 2023年第4期32卷 443-462页

作者： Chengpeng Xue Xinghai Yang Shuo wang Junsheng wang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

Integrated computational materials engineering(ICME)is to integrate multi-scale computational simulations and key experimental methods such as macroscopic,mesoscopic,and microscopic into the whole process of Al alloys design and development,which enables the design and development of Al alloys to upgrade from traditional empirical to the integration of compositionprocess-structure-mechanical property,thus greatly accelerating its development speed and reducing its development cost.This study combines calculation of phase diagram(CALPHAD),Finite element calculations,first principle calculations,and microstructure characterization methods to predict and regulate the formation and structure of composite precipitates from the design of highmodulus Al alloy compositions and optimize the casting process parameters to inhibit the formation of micropore defects in the casting process,and the final tensile strength of Al alloys reaches420 MPa and Young's modulus reaches more than 88 GPa,which achieves the design goal of the high strength and modulus Al alloys,and establishes a new mode of the design and development of the strength/modulus Al alloys.

关键词： integrated computational materials engineering(ICME) high modulus Al alloys

A novel motion coordination method for variable-sized multi-mobile robots

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Frontiers of Information Technology & Electronic Engineering 2023年第4期24卷 521-535页

作者： Zichao XING Xingkai wang Shuo wang Weimin WU Ruifen HU State Key Laboratory of Industrial Control Technology Institute of Cyber-Systems and ControlZhejiang UniversityHangzhou 310027China

Multi-mobile robot systems(MMRSs)are widely used for transportation in industrial scenes such as manufacturing and warehousing.In an MMRS,motion coordination is important as collisions and deadlocks may lead to losses or system stagnation.However,in some scenarios,robot sizes are different when loaded and unloaded,which means that the robots are variable-sized,making motion coordination more difficult.The methods based on zone control need to first divide the environment into disjoint zones,and then allocate the zones statically or dynamically for motion coordination.The zone-control-based methods are not accurate enough for variable-sized multi-mobile robots and reduce the efficiency of the system.This paper describes a motion coordination method based on glued nodes,which can dynamically avoid collisions and deadlocks according to the roadmap structure and the real-time paths of robots.Dynamic features make this method directly applicable to various scenarios,instead of dividing a roadmap into disjoint zones.The proposed method has been applied to many industrial projects,and this study is based on some manufacturing projects for experiments.Theoretical analysis and experimental results show that the proposed algorithm is effective and efficient.

关键词： Multi-mobile robot system Collision avoidance Deadlock avoidance Glued nodes Motion coordination

Preparation, characterization and antibacterial property of naringin loaded PLGA nanospheres

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Progress in Natural Science:Materials International 2022年第4期32卷 498-503页

作者： Shuo wang Tianren Xue Baolong Niu Liqiao Wei Huifang wang Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education Taiyuan University of Technology College of Materials Science and Engineering Taiyuan University of Technology

Naringin is a predominant flavanone in grapefruit and shows a variety of biological effects such as antioxidative,anticancer, anti-inflammatory and antibacterial activity. However, its application in pharmaceutical field is limited by low water solubility, poor bioavailability and instability. To overcome the problem, naringin has been encapsulated in poly(lactic-co-glycolic acid)(PLGA) polymer by emulsion-diffusion-evaporation method in this work. Moreover, naringin loaded PLGA nanospheres were characterized by scanning electron microscope(SEM),dynamic light scatter method(DLS), fourier transform infrared(FTIR) spectra, UV–vis spectra and fluorescence spectra of DNA-EB competition displacement. The mean diameter of PLGA nanospheres and NRG/PLGA nanospheres was 123 ± 25 nm and 137 ± 30 nm, respectively. The drug encapsulation efficiency was 86.4% while the drug loading rate was 22.3%. The fluorescence spectra of the competitive DNA-binding experiments revealed that the functional activity of naringin was retained after loaded in PLGA. It is revealed that the initial burst effect happened in the initial 24 h and followed by sustained release lasting for 10 days. Moreover, the nanospheres exhibited strong antibacterial activity, and 99.9% of E. coli and S. aureus were killed when treated with naringin loaded PLGA nanospheres at the concentration of 0.2 mg mL-1within 24 h. Furthermore, the viable cells remained only 48% when the concentration of NRG/PLGA nanospheres was 32 μg m L-1and NRG/PLGA nanospheres was important for inhibition of cancer cells. It is concluded that the stable naringin loaded PLGA nanospheres could have potential application in food industry and nanomedicine field.

关键词： Naringin PLGA Nanospheres Sustained release Antibacterial activity