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Multi-modal imaging for dynamic visualization of osteogenesis and implant degradation in 3D bioprinted scaffolds

Bioactive Materials 2024年第7期37卷 119-131页

作者： Qian Feng Kanwal Fatima Ai Yang chenglin Li shuo chen Guang Yang Xiaojun Zhou Chuanglong He State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Biological Science and Medical EngineeringDonghua UniversityShanghai201620China

In situ monitoring of bone regeneration enables timely diagnosis and intervention by acquiring vital biological ***,an existing gap exists in the availability of effective methodologies for continuous and dynamic monitoring of the bone tissue regeneration process,encompassing the concurrent visualization of bone formation and implant ***,we present an integrated scaffold designed to facilitate real-time monitoring of both bone formation and implant degradation during the repair of bone ***(Lap),CyP-loaded mesoporous silica(CyP@MSNs)and ultrasmall superparamagnetic iron oxide nanoparticles(USPIO@SiO2)were incorporated into a bioink containing bone marrow mesenchymal stem cells(BMSCs)to fabricate functional scaffolds denoted as C@M/GLU using 3D bioprinting *** both in vivo and in vitro experiments,the composite scaffold has demonstrated a significant enhancement of bone regeneration through the controlled release of silicon(Si)and magnesium(Mg)*** near-infrared fluorescence(NIR-FL)imaging,the composite scaffold facilitates the monitoring of alkaline phosphate(ALP)expression,providing an accurate reflection of the scaffold’s initial osteogenic ***,the degradation of scaffolds was monitored by tracking the changes in the magnetic resonance(MR)signals at various time *** findings indicate that the designed scaffold holds potential as an in situ bone implant for combined visualization of osteogenesis and implant degradation throughout the bone repair process.

关键词： In situ monitoring 3D bioprinting Magnetic resonance imaging Near-infrared fluorescence Implant degradation Bone regeneration

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Electrochemically enhanced adsorption of PFOA and PFOS on multiwalled carbon nanotubes in continuous flow mode

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Chinese Science Bulletin 2014年第23期59卷 2890-2897页

作者： Shuangyu Wang Xiaona Li Yaobin Zhang Xie Quan shuo chen Hongtao Yu Huimin Zhao Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) School of Environmental Science and TechnologyDalian University of Technology

It is important to develop efficient technologies on removal of perfluorooctanoic acid(PFOA)and perfluorooctane sulfonate(PFOS)from water due to their wide distribution and potential threat to human *** this work,a durable and convenient electrosorption device was designed in continuous flow mode to investigate the adsorption of PFOX(X=A and S)on multiwalled carbon nanotubes(MWNTs)from water under electrochemical *** electrosorption experiments were conducted under different influent and electrolyte concentrations,hydraulic retention time(HRT)and electrode distance to optimize the *** results showed that the highest removal efficiencies toward both PFOA and PFOS could come up to 90%at 1 *** with open circuit(OC)adsorption under the same conditions,the removal efficiencies were improved by 4.9 times(PFOA)and 4.2 times(PFOS)*** addition,the MWNTs electrode was found to be *** findings provide an efficient method to remove PFOX from water by electrosorption in continuous flow mode.

关键词：多壁碳纳米管电化学吸附 PFOS PFOA 水力停留时间流模式碳纳米管电极电解质浓度

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Boron-promoted reductive deoxygenation coupling reaction of sulfonyl chlorides for the C(sp3)-S bond construction

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Chinese Chemical Letters 2022年第12期33卷 5101-5105页

作者： shuo chen Qingru Wen Yanqing Zhu Yanru Ji Yu Pu Zhengli Liu Yun He Zhang Feng Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing UniversityChongqing 401331China Medical Imaging Key Laboratory of Sichuan Province North Sichuan Medical CollegeNanchong 637000China

Herein,we report a borane-promoted reductive deoxygenation coupling reaction to synthesize *** reaction features excellent functional group compatibility,high efficiency,broad substrate scope,and application in late-stage functionalization of *** mechanistic studies suggest diaryl sulfides are the intermediates of this ***,the real active aryl sulfide anions may be generated in situ with the aid of B2pin2 and react with alkyl tosylates through a concerted SN2 pathway.

关键词： C-S bond formation Reductive deoxygenation coupling Borane Organosulfur compounds Green chemistry

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Defining a Subgroup Treatable for Laparoscopic Surgery in Poorly Differentiated Early Gastric Cancer:the Role of Lymph Node Metastasis

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Clinical oncology and cancer researeh 2012年第1期9卷 54-56页

作者： Zhi-bin Huo shuo-po chen Hua Li Dian-chao Wu Department of Surgical Oncology Affiliated Xingtai People Hospital of Hebei Medial University Department of Surgical Urology Affiliated Xingtai People Hospital of Hebei Medial University Department of Surgical Oncology Affiliated Xingtai People Hospital of Hebei Medial University

Objective The present study aims to identify the clinicopathologic factors predictive of lymph node metastasis(LNM) in poorly differentiated early gastric cancer(EGC) and to expand the possibility of using laparoscopic surgery for the treatment of poorly differentiated EGC. Methods Data from 70 cases of poorly differentiated EGC treated with surgery were *** association between clinicopathologic factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. Results Univariate analysis showed that tumor size,depth of invasion,and lymphatic vessel involvement(LVI) were the significant and independent risk factors for LNM(all P<0.05).The LNM rates were 6.9%,45.5%,and 60.0%,*** was no LNM in 25 patients without the above three risk factors. Conclusions Laparoscopic surgery is a sufficient treatment for intramucosal poorly differentiated EGC if the tumor is less than or equal to 2.0 cm in size and when LVI is absent upon postoperative histological examination.

关键词： gastric cancer lymph nodes metastasis laparoscopy

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Biodegradation of Benzo[a]pyrene by Arthrobacter oxydans B4

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Pedosphere 2012年第4期22卷 554-561页

作者： PENG Hui YIN Hua DENG Jun YE Jin-Shao chen shuo-Na HE Bao-Yan ZHANG Na Department of Environmental Engineering Jinan UniversityGuangzhou 510632(China) Key Laboratory of Water//Soil Toxic Pollutants Control and Bioremediation of Guangdong Higher Education Institutes Jinan UniversityGuangzhou 510632(China)

A bacterial strain, Arthrobacter oxydans （B4）, capable of degrading benzo[a]pyrene （BaP） in water body, was isolated from a polycyclic aromatic hydrocarbons-contaminated site. Effects of different factors, such as reaction time, pH value, temperature and organic nutrients, on BaP biodegradation by the strain B4 were studied. After 5 d treatment, the concentration of BaP in mineral salts medium was reduced to 0.318 mg L-1, compared to the initial concentration of 1.000 mg L-1. There was a process of acid formation during the degradation with pH falling from initial 7.01 to 4.61 at 5 d, so keeping the water body under slightly alkaline condition was propitious to BaP degradation. Strain B4 efficiently degraded BaP at 20 to 37 ~C with addition of organic nutrients. The biodegradation and transformation of BaP mainly occurred on cell surfaces, and extracellular secretions played an important role in these processes. Fourier transform infrared spectroscopy and gas chromatograph-mass spectrometer analyses of metabolites showed that ring cleavage occurred in the BaP degradation process and the resulting metabolically utilizable substrates were generated as sole carbon sources for B4 growth. Furthermore, mineralization extent of metabolites was verified by determining the total organic carbon and inorganic carbon in the degradation system.

关键词： degradation mechanism metabolites microbial transformation polycyclic aromatic hydrocarbon

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Simple and cost-effective methods for precise analysis of trace element abundances in geological materials with ICP-MS

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Science Bulletin 2017年第4期62卷 277-289页

作者： shuo chen Xiaohong Wang Yaoling Niu Pu Sun Meng Duan Yuanyuan Xiao Pengyuan Guo Hongmei Gong Guodong Wang Qiqi Xue Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China University of Chinese Academy of Sciences Beijing 100049China Department of Earth Sciences Durham UniversityDurham DH1 3LEUK School of Earth Science and Mineral Resources China University of GeosciencesBeijing 100083China

Inductively coupled plasma mass spectrometry （ICP-MS） is the most commonly used technique to deter- mine the abundances of trace elements in a wide range of geological materials. However, incomplete sample digestion, isobaric interferences and instrumental drift remain obvious problems that must be overcome in order to obtain precise and accurate results, For this reason, we have done many experi- ments and developed a set of simple, cost-effective and practical methods widely applicable for precise and rapid determination of trace element abundances in geological materials using ICP-MS. Commonly used high-pressure digestion technique is indeed effective in decomposing refractory phases, but this inevitably produces fluoride complexes that create new problems. We demonstrate that the fluoride complexes formed during high-pressure digestion can be readily re-dissolved using high-pressure vessel at 190 ℃ for only 2 h for 50 mg sample. In the case of isobaric interferences, although oxide （e.g., MO^＋/M^＋） and hydroxide （e.g., MO^＋/M^＋） productivity is variable between runs, the （MO^＋/M^＋）/（CeO^＋/Ce^＋） and （MOH^＋/M^＋）/（CeO^＋/Ce^＋） ratios remain constant, making isobaric interference correction for all other elements of interest straightforward, for which we provide an easy-to-use off-line procedure. We also show that mass-time-intensity drift curve is smooth as recognized previously, for which the correction can be readily done by analyzing a quality-control （QC） solution and using off-line Excel VBA procedure without internal standards. With these methods, we can produce data in reasonable agreement with rec- ommended values of international rock reference standards with a relative error of 〈8% and precision generally better than 5%. Importantly, compared to the widely used analytical practice, we can effectively save 〉60% of time （e.g., 〈24 h vs. 〉60 h）.

关键词： Inductively coupled plasma mass spectrometry High-pressure digestion Oxide and hydroxide interferences Instrumental drift Correction methods Trace elements

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Potassium doping for grain boundary passivation and defect suppression enables highly-efficient kesterite solar cells

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Chinese Chemical Letters 2024年第11期35卷 565-570页

作者： Yingfen Li Zhiqi Wang Yunhai Zhao Dajun Luo Xueliang Zhang Jun Zhao Zhenghua Su shuo chen Guangxing Liang College of Materials and Energy Engineering Guizhou Institute of TechnologyGuiyang 550003China Shenzhen Key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

The complicated and diverse deep defects,voids,and grain boundary in the CZTSSe absorber are the main reasons for carrier recombination and efficiency *** further improvement of the open-circuit voltage and fill factor so as to increase the efficiency of CZTSSe device is *** this work,we obtained K-doped CZTSSe absorber by a simple solution *** medium-sized K atoms,which combine the advantages of light and heavy alkali metals,are able to enter the grain interior as well as segregate at grain *** K-Se liquid phase can improve the absorber *** find that the accumulation of the wide bandgap compound K_(2)Sn_(2)S_(5)at grain boundary can increase the contact potential difference of grain boundary,form more effective hole barriers,and enhance the charge separation *** the same time,K doping passivates the interface as well as bulk defects and suppresses the non-radiative *** improved crystallinity,enhanced charge transport capability and reduced defect density due to K doping result in a significant enhancement of the carrier lifetime,leading to 13.04%device *** study provides a new idea for simultaneous realization of grain boundary passivation and defect suppression in inorganic kesterite solar cells.

关键词： Kesterite Solar cell Chemical doping Defect Efficiency

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分子动力学模拟中氦分子势函数的应用

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化工学报 2012年第7期63卷 1995-2000页

作者：陈煜陈硕上海工程技术大学机械工程学院热能与动力工程系上海201620 同济大学航空航天与力学学院上海200092

为了能够在关于氦的分子动力学的模拟中准确地使用其势函数,并确定其量纲1分子间相互作用力,通过对比分析可用于氦的势函数的数学形式和使用条件,指出虽然标准Lennard-Jones(LJ-12-6)势函数的物理意义清晰、形式简化、应用广泛,但对于... 详细信息

为了能够在关于氦的分子动力学的模拟中准确地使用其势函数,并确定其量纲1分子间相互作用力,通过对比分析可用于氦的势函数的数学形式和使用条件,指出虽然标准Lennard-Jones(LJ-12-6)势函数的物理意义清晰、形式简化、应用广泛,但对于氦而言,分子间的排斥力不再适宜采用原子中心间距r的-12次方的形式,而更适合采用指数形式的排斥项。在具有指数形式排斥项的势函数中,EXP-6势函数较好地反映了液氦原子间的多体相互作用,其吸引项是van der Waals吸引力的主要组成部分;Bruch-McGee组合半经验势函数多具有分段函数的形式,在模拟过程中转变为分子间作用力的过程和最终的形式较复杂;而Tang-Toennies势函数更适合于描述低密度氦气的性质。通过将势函数的物理参数量纲1化,确定量纲1分子间相互作用力,目的是可以在随后的分子动力学模拟中依使用条件采用。

关键词：氦分子动力学势能函数分子间相互作用

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Serum microRNA-221 as a biomarker for diabetic retinopathy in patients associated with type 2 diabetes

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1889-1894页

作者： He-Nan Liu Xun Li Na Wu Meng-Meng Tong shuo chen Shan-Shan Zhu Wei Qian Xiao-Long chen Department of Ophthalmology Shengjing Hospital China Medical University Department of Endocrinology Shengjing Hospital China Medical University Sino-Dutch Biomedical and Information Engineering School Northeastern University Department of Electrical and Computer Engineering College of Engineering University of Texas at El Paso

AIM: To investigate the candidate microRNA(miRNA), miR-221 as a novel biomarker for diabetic retinopathy(DR) in patients associated with type 2 diabetes(T2D).METHODS: The subjects involved were divided into four groups: healthy control(HC), no diabetic retinopathy(NDR), non-proliferative diabetic retinopathy(NPDR) and proliferative diabetic retinopathy(PDR) group. Serum miR-221 was validated by real-time quantitative reversetranscription polymerase chain reaction(qRT-PCR). Also, serum angiotensin II(Ang II) and vascular endothelial growth factor(VEGF) were examined by enzyme-linked immunosorbent assay. In addition, receiver operating characteristic(ROC) curve was performed to explore the diagnostic accuracy of miR-221, Ang Ⅱ and VEGF for DR in patients with T2D. Spearman’s rank correlation coefficient was executed to estimate the correlations of serum miR-221 with metabolic parameters and serum markers in patients with ***: Primarily, serum miR-221, Ang Ⅱ and VEGF were increased significantly in T2D patients compared to HC participant respectively, and progressive up-regulated in NDR, NPDR and PDR groups(P<0.001). Additionally, miR-221 in serum was remarkably positively correlatedwith metabolic parameters such as glycated hemoglobin(r=0.310, P=0.002) and homeostasis model assessment for insulin resistance(r=0.413, P<0.001), as well as serum markers for instance Ang Ⅱ(r=0.667, P<0.001) and VEGF(r=0.499, P<0.001). Furthermore, serum miR-221(AUC, 0.894; 95%CI, 0.833-0.955; P<0.001), Ang Ⅱ(AUC, 0.888; 95%CI, 0.828-0.949; P<0.001) and VEGF(AUC, 0.785; 95%CI, 0.695-0.875; P<0.001) had evidently diagnostic efficiency in DR, and miR-221 is the most effective among ***: Serum miR-221 as a potential biomarker could be related to not only occurrence but also progression for DR in patients with T2D. However, a prospective clinical trial is warranted.

关键词： microRNA-221 biomarker diabetic retinopathy type 2 diabetes

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Tumor necrosis factor a accelerates Hep-2 cells proliferation by suppressing TRPP2 expression

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Science China(Life Sciences) 2017年第11期60卷 1251-1259页

作者： Jing Wu Jizheng Guo Yunyun Yang Feifei Jiang shuo chen Kaile Wu Bing Shen Yehai Liu Juan Du Department of Otorhinolaryngology Head and Neck Surgerythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China School of Basic Medical Sciences Anhui Medical UniversityHefei 230022China Department of Pediatrics The People's Hospital of BozhouHefei 236800China

TRPP2, a Ca2＋-permeable non-selective cation channel, has been shown to negatively regulate cell cycle, but the mechanism underlying this regulation is unknown. Tumor necrosis factor a （TNF-a） is a proinflammatory cytokine extensively involved in immune system regulation, cell proliferation and cell survival. However, the effects and mechanisms for the role of TNF-a in laryngeal cancer remain unclear. Here, we demonstrated using western blot analyses and intracellular Ca〉 concentration measurements that TNF-a treatment suppressed both TRPP2 expression and ATP-induced Ca2＋ release in a laryngeal cancer cell line （Hep-2）. Knockdown of TRPP2 by a specific siRNA significantly decreased ATP-induced Ca2＋ release and abolished the effect of TNF-a on the ATP-induced Ca2＋ release. TNF-a treatment also enhanced Hep-2 cell proliferation and growth, as determined using cell counting and flow cytometry cell cycle assays. Moreover, TNF-a treatment down-regulated phosphorylated protein kinase R-like endoplasmic reticulum kinase （p-PERK） and phosphorylated eukaryotic translation initiation factor （p-elF2c0 expression levels, without affecting PERK and elF2ct expression levels in Hep-2 cells. We concluded that suppressing TRPP2 expression and TRPP2-mediated Ca2＋ signaling may be one mechanism underlying TNF〈t-enhanced Hep-2 cell proliferation. These results offer new insights into the mechanisms of TNF-a-mediated laryngeal cancer cell proliferation, and provide evidences showing a potential role of TNF-a in the development of laryngeal cancer.

关键词： tumor necrosis factor a TRPP2 human laryngeal squamous cell carcinoma proliferation protein kinase R-likeendoplasmic reticulum kinase eukaryotic translation initiation factor

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