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Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

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Protein & Cell 2024年第2期15卷 121-134页

作者： Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang shuo song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China State Key Laboratory of Vaccines for Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China Xiang An Biomedicine Laboratory Xiamen 361102China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalSchool of MedicineSouthem University of Science and TechnologyShenzhen 518112China The Second Affliated Hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China Research Unit of Frontier Technology of Structural Vaccinology Chinese Academy of Medical SciencesXiamen 361102China

Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or *** rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus ***,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron ***-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric *** antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant ***,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines.

关键词： SARS-CoV-2 broad neutralizing antibody rearrangement synergistic neutralization

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再生砂粉基发泡混凝土性能研究

混凝土 2024年第4期 152-156页

作者：宋硕曹剑李秋义青岛理工大学土木工程学院山东青岛266033 山东中建西部建设有限公司山东青岛266108 青岛农业大学建筑工程学院山东青岛266019

利用筑垃圾破碎后筛分出的再生砂粉细骨料制备设计密度等级为A11的发泡混凝土,研究了再生砂粉及泡沫掺量等因素对发泡混凝土力学性能、干密度及导热系数等性能的影响规律。研究结果表明,随着再生砂粉掺量的增加,发泡混凝土干密度在1086.... 详细信息

利用筑垃圾破碎后筛分出的再生砂粉细骨料制备设计密度等级为A11的发泡混凝土,研究了再生砂粉及泡沫掺量等因素对发泡混凝土力学性能、干密度及导热系数等性能的影响规律。研究结果表明,随着再生砂粉掺量的增加,发泡混凝土干密度在1086.1~1172.3 kg/m^(3),抗压强度等级从FC5下降到FC2,导热系数均≤0.27 W/(m·K);再生砂粉基发泡混凝土的抗压强度、干密度和导热系数随泡沫掺量的增加均呈现下降趋势。其中干密度等级从A13减小到A9,当泡沫掺量在7%时,抗压强度仅为0.6 MPa;对比分析再生砂粉取代率和泡沫掺量对发泡混凝土吸水率的影响规律,其吸水率均随着两者掺量的增加而增大,但泡沫掺量对其影响更为显著;此外,通过强度-成本比率,确定密度等级为A11的再生砂粉基发泡混凝土,即再生砂粉取代率为20%时,单位成本下获得的RSPFC抗压强度最高。

关键词：再生砂粉发泡混凝土物理性能导热系数强度-成本比率

简单退火和多重热处理对激光熔覆成形Ti-5321合金断裂韧性的影响

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稀有金属材料与工程 2024年第4期53卷 970-977页

作者：刘国政赵永庆贾蔚菊张艳宋硕毛成亮周伟东北大学辽宁沈阳110819 西北有色金属研究院陕西西安710016

为满足航空航天领域对快速制备高强韧复杂钛合金零件的需求,采用激光熔覆成形新型高强韧Ti-5321(Ti-5Al-3Mo-3V-2Zr-2Cr-1Nb-1Fe)合金,具有成形快、效率高、成形构件性能良好等优势。通过对Ti-5321合金进行简单退火和多重热处理(β相区... 详细信息

为满足航空航天领域对快速制备高强韧复杂钛合金零件的需求,采用激光熔覆成形新型高强韧Ti-5321(Ti-5Al-3Mo-3V-2Zr-2Cr-1Nb-1Fe)合金,具有成形快、效率高、成形构件性能良好等优势。通过对Ti-5321合金进行简单退火和多重热处理(β相区固熔缓冷加时效,BASCA),揭示了其显微组织的演变规律,并探究不同组织对断裂韧性的影响。结果表明:简单退火后,合金呈细长针片状α交织成的网篮组织,其抗拉伸强度为1102 MPa,断裂韧性为68.1 MPa·m^(1/2)。经BASCA热处理后,细长针片状α相全部转变为粗大的片层α相和超细针状α相,且合金的抗拉伸强度提高至1309 MPa,而断裂韧性降低至45.5 MPa·m^(1/2)。BASCA热处理能够提高合金强度,但会降低合金韧性。这是由于网篮组织中细长的针片状α相能够大大增加裂纹扩展阻力,增大裂纹扩展路径曲折程度,从而提高合金的韧性。而BASCA热处理组织中大片层α相具有一定的方向性,裂纹只有在穿过不同β晶粒的大片层α相时才会发生偏转;且裂纹扩展主要发生在超细针状α相中,而超细针状α相尺寸过于细小,不能阻碍裂纹的发展或使裂纹偏转,因此经BASCA热处理后合金的韧性变差。

关键词：激光熔覆成形 Ti-5321合金多重热处理断裂韧性

基于MOD16的银川地表蒸散量时空特征及影响因素分析

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北京林业大学学报 2024年第7期46卷 18-26页

作者：宋硕赵婉凝李少然王亚飞岳天泽贾黎明刘虎省部共建森林培育与保护教育部重点实验室北京林业大学北京100083 林学实验教学中心北京林业大学北京100083 银川市中山公园宁夏银川750000

【目的】阐明2000—2020年银川市地表蒸散量变化及其主要影响因素,为以水定市、以水定林提供理论依据。【方法】基于MODIS蒸散产品MOD16,气温、降水量和归一化植被指数(NDVI),运用slope线性趋势、相关分析等方法,并采用MOD16A3数据进行... 详细信息

【目的】阐明2000—2020年银川市地表蒸散量变化及其主要影响因素,为以水定市、以水定林提供理论依据。【方法】基于MODIS蒸散产品MOD16,气温、降水量和归一化植被指数(NDVI),运用slope线性趋势、相关分析等方法,并采用MOD16A3数据进行作物缺水指数的计算,对银川市2000—2020年蒸散量时空变化特征、不同土地利用类型蒸散量差异及其影响因素进行分析。【结果】(1)2000—2020年银川市蒸散量在201.2~344.2 mm之间,多年均值为273.4 mm;在空间分布上,整体上呈围绕建成区的中部区域较高,西部贺兰山区域和东部区域较低的分布特征。(2)2000—2020年银川市蒸散量呈增加趋势,倾向率为5.093 mm/a,蒸散量增加的区域面积占比最高,为88.30%,可见银川市大部分区域蒸散量变化趋势是增加的,显著增加的区域主要分布在围绕建成区的部分中部区域。蒸散量减少的区域面积占比为2.44%,年蒸散量基本不变的区域面积占比为9.26%。(3)与2000年相比,2020年的耕地、林地、草地、灌木地、湿地、水体、人造地表、裸地的相对变化率为−6.73%、0.33%、−8.34%、−14.87%、21.95%、9.05%、230.45%、−2.08%。银川市蒸散量空间分布受土地利用类型影响显著,多年平均蒸散量由大到小依次为耕地(322.9 mm)、水体(268.5 mm)、人造地表(256.9 mm)、林地(240.0 mm)、湿地(220.3 mm)、灌木地(216.7 mm)、草地(201.9 mm)、裸地(196.4 mm)。(4)对银川市2000—2020年蒸散量与气温、降水量、NDVI(2000—2019年)的相关分析表明,银川市蒸散量与气温、降水量和NDVI均呈显著正相关。【结论】2000—2020年,气温、降水量、NDVI都是影响银川市年均蒸散量上升的驱动因素,其中NDVI是最主要影响因子。本研究以期为银川市水资源的合理高效利用,银川市生态需水量研究和生态环境规划提供理论支撑。

关键词：银川 MOD16 蒸散量土地利用时空变化 NDVI 作物缺水指数

小型化S波段瓦式有源相控阵天线系统的设计研究

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遥测遥控 2024年第4期45卷 57-65页

作者：侯雪风林昱兵宋硕李刚李志强北京遥测技术研究所北京100076

基于运载火箭天基遥测传输的需求和箭载平台对重量、空间及能量消耗的严格限制,本文设计了一种小型轻量化、高集成、低能耗的S波段瓦式有源相控阵天线系统。该系统包括天线阵列模块、发射组件阵列模块、功分网络模块、波束控制器及电源... 详细信息

基于运载火箭天基遥测传输的需求和箭载平台对重量、空间及能量消耗的严格限制,本文设计了一种小型轻量化、高集成、低能耗的S波段瓦式有源相控阵天线系统。该系统包括天线阵列模块、发射组件阵列模块、功分网络模块、波束控制器及电源单元模块。本文阐述了该系统的工作原理、组成架构,并根据要求设计了天线阵列、发射组件、高可靠电源单元以及波束控制器等几种关键电路。经暗室实测,本系统中所研制的天线系统样机其波束宽度、轴比、方位面俯仰面±60°波束扫描范围内的ERIP等指标达到设计要求,与目前市场上同频段功能相似的砖式相控阵天线系统相比,其体积减小45%,重量缩减25%,能耗降低15%,更贴合箭载相控阵天线从体积、重量、经济上的应用需求,同时也为相关领域的相控阵天线系统研制提供了指导。

关键词：有源相控阵天线瓦式垂直互联 SIP 故障单元定位

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基于轮廓测量的牙膏磨损性测定法的研发概述

日用化学品科学 2024年第3期47卷 67-72页

作者：孙东方宋硕 Eva Schneiderman 王莉江施裔磊黑龙江省轻工科学研究院全国口腔护理用品标准化技术委员会牙膏分技术委员会黑龙江哈尔滨150010 北京宝洁技术有限公司北京101312 P&G Mason Business Center Mason OH 45040 上海美加净日化有限公司上海200333

牙膏中的磨料是提供牙膏清洁力的主要成分之一。恰当的磨料种类选择以及添加量的设定可以为消费者提供良好的牙齿清洁效果,甚至达到较佳的外源性色斑的去除而美白牙齿。然而,不当的磨料添加会导致过度磨损牙齿,从而引起安全性问题。因此... 详细信息

牙膏中的磨料是提供牙膏清洁力的主要成分之一。恰当的磨料种类选择以及添加量的设定可以为消费者提供良好的牙齿清洁效果,甚至达到较佳的外源性色斑的去除而美白牙齿。然而,不当的磨料添加会导致过度磨损牙齿,从而引起安全性问题。因此,制定方便有效的牙膏磨损性测定法一直是业界的需求。然而,由于实验条件等限制,国际上惯用的示踪法(RDA)无法在国内实施。本文介绍了一种优化后的基于轮廓仪测量法开发的RDA替代方法Radioactive Dentin Abrasivity–Profilometry Equivalent (简称RDA-PE),并对RDA-PE方法的建立、方法学验证以及与RDA方法间的关系进行了简要的介绍.。同时,对RDA-PE方法用于测定牙膏产品摩擦型性能的可行性进行了讨论。

关键词：牙膏磨损性示踪法轮廓测量法

Bird specimen number linked with species trait and climate niche breadth

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Avian Research 2024年第1期15卷 108-115页

作者： Xiaoyu Duan Xiongwei Huang Jingya Zhang shuo Lv Gang song Yanping Wang Gang Feng Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau&Inner Mongolia Key Laboratory of Grassland Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot010020China Key Laboratory of Marine Biotechnology of Fujian Province Institute of OceanologyCollege of Marine SciencesFujian Agriculture and Forestry UniversityFuzhou350002China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing100101China Laboratory of Island Biogeography and Conservation Biology College of Life SciencesNanjing Normal UniversityNanjing210023China

Biological specimens are fundamental for taxonomy and flora/fauna *** importantly,they also play crucial roles in recording environmental impacts on morphology and behavior,which is vital for biodiversity research and ***,there are few systematic studies on the patterns and drivers of bird specimen number at regional *** study is the first attempt to examine the relationships between bird specimen number and species traits as well as climate niche breadth in China,aiming to answer two questions:1)how do species’temperature niche breadth and precipitation niche breadth influence specimen number?2)which trait is most associated with bird specimen number?The associations between bird specimen number and explanatory variables were examined using ordinary least squares,generalized linear models,phylogenetic generalized linear mixed models,and multiple *** results showed that Muscicapidae was the family with the highest specimen number,and Passeriformes was the order with the highest specimen *** specimen number significantly increased with larger temperature niche breadth and precipitation niche *** number was also positively associated with geographic range size,habitat specificity,hunting vulnerability and clutch size,but negatively associated with body *** findings suggest that future bird specimen collection should pay more attention to birds with limited ecological niches,large body sizes,and small clutch *** research enhances the use of bird specimen data to study and preserve biodiversity.

关键词： Biodiversity conservation Biological specimens Bird traits Scientific collection Specimen number Temperature and precipitation

Association between Gene Polymorphisms and SNP-SNP Interactions of the Matrix Metalloproteinase 2 Signaling Pathway and the Risk of Vascular Senescence

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Biomedical and Environmental Sciences 2024年第2期37卷 146-156页

作者： LIAO Zhen Yu YANG shuo HU song LIU Jia MAO Yong Jun SUN Shu Qin Department of Geriatrics the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina

Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sectional study,between May and November 2022,peripheral venous blood of151 VS patients(case group)and 233 volunteers(control group)were *** SNPs were identified in five genes encoding the components of the MMP-2 signaling pathway,assessed through carotid-femoral pulse wave velocity(cf PWV),and analyzed using multivariate logistic *** multigene influence on the risk of VS was assessed using multifactor dimensionality reduction(MDR)and generalized multifactor dimensionality regression(GMDR)*** Within the multivariate logistic regression models,four SNPs were screened to have significant associations with VS:chemokine(C-C motif)ligand 2(CCL2)rs4586,MMP2 rs14070,MMP2rs7201,and MMP2 *** of the T/C genotype of MMP2 rs14070 had a 2.17-fold increased risk of developing VS compared with those of the C/C genotype,and those of the T/T genotype had a19.375-fold increased ***2 rs4586 and MMP-2 rs14070 exhibited the most significant *** CCL2 rs4586,MMP-2 rs14070,MMP-2 rs7201,and MMP-2 rs1053605 polymorphisms were significantly associated with the risk of VS.

关键词： Vascular senescence Pulse wave velocity(PWV) Single nucleotide polymorphism(SNP) Matrix metalloproteinase 2(MMP-2) Extracellular matrix(ECM) Structural degradation Multifactor dimensionality reduction(MDR)

A functional hydrogenase mimic that catalyzes robust H_(2) evolution spontaneously in aqueous environment

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Nano Research 2024年第5期17卷 3942-3949页

作者： Ningning song Zhanjun Guo shuo Wang Yongli Li Yunpeng Liu Meishuai Zou Minmin Liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Although great progress has been made in improving hydrogen production,highly efficient catalysts,which are able to produce hydrogen in a fast and steady way at ambient temperature and pressure,are still in large ***,we report a[NiCo]-based hydrogenase mimic,NiCo_(2)O_(4) nanozyme,that can catalyze robust hydrogen evolution spontaneously in water without external energy input at room *** hydrogenase nanozyme facilitates water splitting reaction by forming a three-center Ni-OH-Co bond analogous to the[NiFe]-hydrogenase reaction by using aluminum as electron donor,and realizes hydrogen evolution with a high production rate of 915 L·h^(-1) per gram of nanozymes,which is hundreds of times higher than most of the natural hydrogenase or hydrogenase ***,the NiCo_(2)O_(4) nanozyme can robustly disrupt the adhesive oxidized layer of aluminum and enable the full consumption of electrons from *** contrast to the often-expensive synthetic catalysts that rely on rare elements and consume high energy,we envision that this NiCo_(2)O_(4) nanozyme can potentially provide an upgrade for current hydrogen evolution,accelerate the development of scale-up hydrogen production,and generate a clean energy future.

关键词： hydrogenase mimic nanozyme hydrogen evolution reaction aluminum activation water-splitting