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Nomogram predicting the cardiovascular disease mortality for older patients with colorectal cancer:A real-world population-based study

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World Journal of Cardiology 2024年第8期16卷 458-468页

作者： Jia-Yu Tan shuo-Hao shen Department of Medical Ultrasound The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250000Shandong ProvinceChina Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Cardio-oncology has received increasing attention especially among older patients with colorectal cancer(CRC).Cardiovascular disease(CVD)-specific mortality is the second-most frequent cause of *** risk factors for CVDspecific mortality among older patients with CRC are still poorly *** To identify the prognostic factors and construct a nomogram-based model to predict the CVD-specific mortality among older patients with *** The data on older patients diagnosed with CRC were retrieved from The Surveillance,Epidemiology,and End Results database from 2004 to *** prognostic factors and a nomogram-based model predicting the CVD-specific mortality were assessed using least absolute shrinkage and selection operator and Cox *** A total of 141251 eligible patients with CRC were enrolled,of which 41459 patients died of CRC and 12651 patients died of *** age at diagnosis,sex,marital status,year of diagnosis,surgery,and chemotherapy were independent prognostic factors associated with CVD-specific mortality among older patients with *** used these variables to develop a model to predict CVD-specific *** calibration curves for CVD-specific mortality probabilities showed that the model was in good agreement with actual *** C-index value of the model in the training cohort and testing cohort for predicting CVD-specific mortality was 0.728 and 0.734,*** The proposed nomogram-based model for CVD-specific mortality can be used for accurate prognostic prediction among older patients with *** model is a potentially useful tool for clinicians to identify high-risk patients and develop personalized treatment plans.

关键词： Older patients Colorectal cancer Cardio-oncology Nomogram Outcome

Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis)

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Zoological Research 2017年第4期38卷 180-190页

作者： Li-Ping Jiang Qiu-shuo shen Cui-Ping Yang Yong-Bin Chen Key Laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of Zoology Chinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences

Basal cell carcinoma （BCC） is the most common skin cancer worldwide, with incidence rates continuing to increase. Ultraviolet radiation is the major environmental risk factor and dysregulation of the Hedgehog （Hh） signaling pathway has been identified in most BCCs. The treatment of locally advanced and metastatic BBCs is still a challenge and requires a better animal model than the widely used rodents for drug development and testing. Chinese tree shrews （Tupaia belangeri chinensis） are closely related to primates, bearing many physiological and biochemical advantages over rodents for characterizing human diseases. Here, we successfully established a Chinese tree shrew BCC model by infecting tail skins with lentiviral SmoA1, an active form of Smoothened （Smo） used to constitutively activate the Hh signaling pathway. The pathological characteristics were verified by immunohistochemical analysis. Interestingly, BCC progress was greatly enhanced by the combined usage of lenUviral SmoA1 and shRNA targeting Chinese tree shrew p53. This work provides a useful animal model for further BCC studies and future

关键词： Chinese lree shrew Basal cell carcinoma Hedgehog

Cost-benefit comparison of carbon capture,utilization,and storage retrofitted to different thermal power plants in China based on real options approach

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Advances in Climate Change Research 2020年第4期11卷 415-428页

作者： FAN Jing-Li shen shuo XU Mao YANG Yang YANG Lin ZHANG Xian Center for Sustainable Development and Energy Policy Research(SDEP) School of Energy&Mining EngineeringChina University of Mining&TechnologyBeijing(CUMTB)Beijing100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyBeijing100083China School of Management and Economics Beijing Institute of TechnologyBeijing100081China Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing100081China School of Economics and Management China University of GeosciencesBeijing100083China The Administrative Centre for China's Agenda 21(ACCA21) Ministry of Science and Technology(MOST)Beijing100038China

A trinomial tree model based on a real options approach was developed to evaluate the investment decisions on carbon capture,utilization,and storage(CCUS)retrofitted to the three main types of thermal power plants in China under the same power generation and CO2 emissions *** plant types included pulverized coal(PC),integrated gasification combined cycle(IGCC),and natural gas combined cycle(NGCC)*** take into account a subsidy policy consistent with the 45Q tax credit of the U.S.,as well as uncertainty factors,such as carbon price,technological progress,CO_(2) geological storage paths,oil price,and electricity *** results showed that the investment benefit of ordinary NGCC power plants is 93.04 million *** provides greater economic advantages than the other two plant types as their investment benefit is negative if the captured CO_(2) was used for enhanced water recovery(EWR),even if 45Q subsidies are *** with NGCC+CCUS power plants,PC+CCUS and IGCC+CCUS power plants have more advantages in terms of economic benefits and emission *** 45Q subsidy policy reduced the critical carbon price,which determines the decision to invest or not,by 30.14 USDt^(-1) for the PC and IGCC power plants and by 15.24 USDt^(-1) for the NGCC power ***,only when the subsidy reaches at least 71.84 USDt^(-1) and the period limit is canceled can all three types of power plants be motivated to invest in CCUS and used the capture CO_(2) for ***,the government should focus on the application of CCUS in coal-fired power plants(in addition to developing gas power generation),especially when CO_(2) is used for enhanced oil recovery(EOR).The government could introduce fiscal policies,such as 45Q or stronger,to stimulate CCUS technology development in China.

关键词： Carbon dioxide remove CCUS Real option Government subsidy Thermal power plants

Robotic-assisted low anterior resection for rectal cancer shows similar clinical efficacy to laparoscopic surgery: A propensity score matched study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1558-1570页

作者： shen-Xiang Long Xin-Ning Wang Shu-Bo Tian Yu-Fang Bi shen-shuo Gao Yu Wang Xiao-Bo Guo Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Nursing The People’s Hospital of Zhangqiu AreaJinan 250200Shandong ProvinceChina Medical Center for Gastrointestinal Surgery Weifang People’s HospitalWeifang 261000Shandong ProvinceChina

BACKGROUND Rectal cancer ranks as the second leading cause of cancer-related mortality worldwide,necessitating surgical resection as the sole treatment *** the years,there has been a growing adoption of minimally invasive surgical techni-ques such as robotic and laparoscopic *** surgery represents an innovative modality that effectively addresses the limitations associated with traditional laparoscopic *** previous studies have reported favo-rable perioperative outcomes for robot-assisted radical resection in rectal cancer patients,further evidence regarding its oncological safety is still *** To conduct a comparative analysis of perioperative and oncological outcomes between robot-assisted and laparoscopic-assisted low anterior resection(LALAR)*** The clinical data of 125 patients who underwent robot-assisted low anterior resection(RALAR)and 279 patients who underwent LALAR resection at Shandong Provincial Hospital Affiliated to Shandong First Medical University from December 2019 to November 2022 were retrospectively *** performing a 1:1 propensity score matching,the patients were divided into two groups:The RALAR group and the LALAR group(111 cases in each group).Subsequently,a comparison was made between the short-term outcomes within 30 d after surgery and the 3-year survival outcomes of these two *** Compared to the LALAR group,the RALAR group exhibited a significantly earlier time to first flatus[2(2-2)d vs 3(3-3)d,P=0.000],as well as a shorter time to first fluid diet[4(3-4)d vs 5(4-6)d,P=0.001].Additionally,the RALAR group demonstrated reduced postoperative indwelling catheter time[2(1-3)d vs 4(3-5)d,P=0.000]and decreased length of hospital stay after surgery[5(5-7)d vs 7(6-8)d,P=0.009].Moreover,there was an observed increase in total cost of hospitalization for the RALAR group compared to the LALAR group[10777(10780-11850)dollars vs 10550(8766-11715)dollars,P=0.012].No signi

关键词： Rectal cancer Robotic surgical procedures Laparoscopy Low anterior resection Clinical efficacy

Role of transcribed ultraconserved regions in gastric cancer and therapeutic perspectives

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World Journal of Gastroenterology 2022年第25期28卷 2900-2909页

作者： shen-shuo Gao Zhi-Kai Zhang Xu-Bin Wang Yan Ma Guo-Qing Yin Xiao-Bo Guo Department of Gastrointestinal Surgery Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Anus and Intestine Surgery Qingzhou Hospital Affiliated to Shandong First Medical UniversityQingzhou 262500Shandong ProvinceChina

Gastric cancer(GC)is the fourth leading cause of cancer-related *** occurrence and development of GC is a complex process involving multiple biological *** traditional regulation modulates molecular functions related to the occurrence and development of GC,the comprehensive mechanisms remain *** region(UCR)refers to a genome sequence that is completely conserved in the homologous regions of the human,rat and mouse genomes,with 100%identity,without any insertions or deletions,and often located in fragile sites and tumour-related *** transcribed UCR(T-UCR)is transcribed from the UCR and is a new type of long noncoding *** studies have found that the expression level of T-UCRs changes during the occurrence and development of GC,revealing a new mechanism underlying ***,this article aims to review the relevant research on T-UCRs in GC,as well as the function of T-UCRs and their regulatory role in the occurrence and development of GC,to provide new strategies for GC diagnosis and treatment.

关键词： Transcribed ultraconserved region Gastric cancer Development Function Therapeutic perspectives

海洋真菌Neosartorya fischeri 1008F_1的次级代谢产物抑菌及抗肿瘤活性的研究

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海洋科学 2014年第11期38卷 35-40页

作者：沈硕青海省农林科学院生物技术研究所青海西宁810016 教育部青藏高原生物技术重点实验室青海西宁810016

通过抑菌及抗肿瘤活性实验,明确海洋真菌Neosartorya fischeri 1008F1次级代谢产物中的活性有效组分。应用对峙培养法和生长速率法,对菌株的抑菌活性进行测定。应用MTT法,对菌株的抗肿瘤活性进行测定。应用凝胶(Sephadex LH-20)柱层析... 详细信息

通过抑菌及抗肿瘤活性实验,明确海洋真菌Neosartorya fischeri 1008F1次级代谢产物中的活性有效组分。应用对峙培养法和生长速率法,对菌株的抑菌活性进行测定。应用MTT法,对菌株的抗肿瘤活性进行测定。应用凝胶(Sephadex LH-20)柱层析的方法,对菌株发酵产物的提取物进行分离。结果发现,海洋真菌Neosartorya fischeri 1008F1的水溶性提取物对番茄早疫菌(Alternaria solani)具有一定的抑制活性。菌株的粗提物浸膏经Sephadex LH-20柱梯度洗脱后,得到的组分B、C、D、E和F。在0.5 g/L的供试浓度下,组分B、C和D对胃癌细胞SGC-7901的抑制率均高于80%,而组分B、C、D、E和F对肝癌细胞BEL-7404的抑制率均高于70%。

关键词：海洋真菌Neosartorya fischeri 次级代谢产物抑菌活性抗肿瘤活性

中度嗜盐菌S61生防因子分析及其对马铃薯干腐病的防效

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南方农业学报 2021年第10期52卷 2619-2631页

作者：沈硕青海大学农林科学院/青海省马铃薯育种重点实验室/青藏高原生物技术教育部重点实验室西宁810016

【目的】测定中度嗜盐菌S61对马铃薯干腐病病原菌的抑菌活性及对干腐病的防效,为马铃薯干腐病的生物防治及绿色防控提供科学依据。【方法】以来源于青海察尔汗盐湖的1株中度嗜盐菌S61为材料,采用形态学、生理生化特征及分子生物学方法... 详细信息

【目的】测定中度嗜盐菌S61对马铃薯干腐病病原菌的抑菌活性及对干腐病的防效,为马铃薯干腐病的生物防治及绿色防控提供科学依据。【方法】以来源于青海察尔汗盐湖的1株中度嗜盐菌S61为材料,采用形态学、生理生化特征及分子生物学方法对菌株S61进行鉴定。通过对峙培养法和马铃薯活体试验,进行菌株S61及其发酵液有机溶剂萃取物抑制马铃薯干腐病病原菌活性测定及对储藏期马铃薯安全性评价。采用平板透明圈法和排油圈法,分别测定菌株S61发酵液分泌抑菌蛋白和产生脂肽类物质的能力。【结果】结合菌株S61的形态特征、生理生化特征和系统发育进化树分析结果,将菌株S61鉴定为特氏盐芽孢杆菌(Halobacillus trueperi)。其发酵液能产生蛋白酶、淀粉酶和纤维素酶,并能产生脂肽类物质。菌株S61及其有机溶剂萃取物对3株马铃薯干腐病病原菌(青9A-4-13、青9A-5-2和65B-2-6)均有不同程度的抑菌活性,其中对青9A-4-13的抑菌活性最强,对峙培养7 d后的抑制率为55.67%。菌株S61发酵液不同浓度(1、5、10和20 mg/mL)正丁醇萃取物对青9A-4-13的抑菌活性最高,抑制率分别为61.50%、63.00%、64.00%和66.00%。菌株S61发酵液及其正丁醇萃取物对马铃薯储藏安全。【结论】中度嗜盐菌S61在体外和马铃薯活体上均对干腐病病原真菌具有抑制作用,其发酵产物的正丁醇萃取物活性最高,并存在生防因子,能产生一些具有抑菌活性的次级代谢产物,具有较好的马铃薯干腐病生物防治潜力。

关键词：中度嗜盐菌生防因子马铃薯干腐病防效安全性评价

软土地区基坑开挖诱发邻近盾构隧道水平位移的简化算法

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湖南大学学报（自然科学版） 2021年第3期48卷 153-163页

作者：徐日庆申硕董梅程康浙江大学滨海和城市岩土工程研究中心浙江杭州310058 浙江省城市地下空间开发工程技术研究中心浙江杭州310058 中铁十一局集团有限公司湖北武汉430061

为探究软土地区基坑开挖对于邻近隧道水平位移的影响,首先,分析了软土地区基坑开挖卸载引起盾构隧道水平位移的变形机理;其次,收集了国内软土地区邻近地铁盾构隧道开挖基坑的工程实例,利用随机森林算法对影响隧道最大水平位移的因素进... 详细信息

为探究软土地区基坑开挖对于邻近隧道水平位移的影响,首先,分析了软土地区基坑开挖卸载引起盾构隧道水平位移的变形机理;其次,收集了国内软土地区邻近地铁盾构隧道开挖基坑的工程实例,利用随机森林算法对影响隧道最大水平位移的因素进行了重要度排序,并对影响因素进行了统计分析,提出一相对简便且方便广大工程从业人员使用的半经验公式,可直接用于隧道在邻近基坑开挖下的最大水平位移的预测.通过与所收集到文献中已发表的工程实际案例实测数据的对比,对经验公式进行了验证,验证了所提公式的准确性与适用性.参数分析表明:隧道最大水平位移随基坑开挖体量的增大近似呈对数增大,增速逐渐放缓.隧道水平位移受基坑围护结构水平位移影响较大,两者之间近似呈线性正相关.隧道最大水平位移与基坑隧道间距离呈负相关关系,当距离小于两倍开挖深度时,基坑开挖对隧道的影响较大.基于提出的公式,对基坑开挖对隧道的影响范围进行了分区,结果可为类似工程提供一定的理论指导.

关键词：岩土工程基坑盾构隧道水平位移

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青海高原地区春小麦品种田间化感作用评价

植物保护 2021年第5期47卷 198-203,209页

作者：李玮沈硕青海大学农林科学院西宁810016 农业农村部西宁作物有害生物科学观测实验站西宁810016 青海省农业有害生物综合治理重点实验室西宁810016

为明确青海高原地区不同春小麦品种对麦田主要危害杂草旱雀麦Bromus tectorum的化感作用,本研究通过田间一致性试验对青海高原地区的20个春小麦品种(系)进行化感作用评价,筛选出强化感作用品种。分别于春小麦3~5叶期和成熟期调查受体旱... 详细信息

为明确青海高原地区不同春小麦品种对麦田主要危害杂草旱雀麦Bromus tectorum的化感作用,本研究通过田间一致性试验对青海高原地区的20个春小麦品种(系)进行化感作用评价,筛选出强化感作用品种。分别于春小麦3~5叶期和成熟期调查受体旱雀麦的生长性状,转化为化感作用指数,并结合聚类分析,将20个小麦品种按化感作用的强弱分为强、中、弱3类。结果表明,20个春小麦品种(系)对受体旱雀麦的田间生长均具有化感抑制作用,其中‘青春38号’‘黑丝麦1号’‘通麦2号’和‘互麦11号’为田间化感作用较强的春小麦品种。该研究为青海高原地区春小麦化感抑草品种选育提供了新资源,同时为青海高原地区化学农药减量和生态环境保护提供了新策略。

关键词：青海高原春小麦品种化感作用田间评价