检索结果-南通市图书馆

Journal of Environmental Sciences 2024年第4期138卷 709-718页

作者： shuo Hu Jianghao Zhang Xueyan Chen Xiaoxiao qin Jinshui Yao Changbin Zhang School of Materials Science&Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Formaldehyde(HCHO)is a common indoor pollutant that is detrimental to human health.Its efficient removal has become an urgent demand to reduce the public health risk.In this work,Ag-MnO_(x)-based catalysts were prepared and activated under different atmosphere(i.e.,air,hydrogen(H_(2))and carbon monoxide(CO))for efficient oxidation of HCHO.The catalyst activated with CO(Ag/Mn-CO)displayed the highest activity among the tested samples with 90% conversion at 100℃ under a gas space velocity of 75,000 mL/(g_(cat)·hr).Complementary characterizations demonstrate that CO reduction treatment resulted in synergically regulated content of surface oxygen on support to adsorb/activate HCHO and size of Ag particle to dissociate oxygen to oxidize the adsorbed HCHO.In contrast,other catalysts lack for either abundant surface oxygen species or metallic silver with the appropriate particle size,so that the integrate activity is limited by one specific reaction step.This study contributes to elucidating the mechanisms regulating the oxidation activity of Ag-based catalysts.

关键词： HCHO oxidation Ag-MnO_(x)-based catalyst Activation condition Synergic regulation Surface oxygen Oxidized Ag

Effect of fluid shear stress on the internalization of kidney-targeted delivery systems in renal tubular epithelial cells

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2020年第4期10卷 680-692页

作者： Yingying Xu Shuo Qin Yining Niu Tao Gong Zhirong Zhang Yao Fu Key Laboratory of Drug-Targeting and Drug Delivery Systems of Ministry of Education and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Renal tubular epithelial cells(RTECs)are important target cells for the development of kidney-targeted drug delivery systems.Under physiological conditions,RTECs are under constant fluid shear stress(FSS)from original urine in the renal tubule and respond to changes of FSS by altering their morphology and receptor expression patterns,which may affect reabsorption and cellular uptake.Using a microfluidic system,controlled shear stress was applied to proximal tubule epithelial cell line HK-2.Next,2-glucosamine,bovine serum albumin,and albumin nanoparticles were selected as representative carriers to perform cell uptake studies in HK-2 cells using the microfluidic platform system with controlled FSS.FSS is proven to impact the morphology of HK-2 cells and upregulate the levels of megalin and clathrin,which then led to enhanced cellular uptake efficiencies of energy-driven carrier systems such as macromolecular and albumin nanoparticles in HK-2 cells.To further investigate the effects of FSS on endocytic behavior mediated by related receptors,a mice model of acute kidney injury with reduced fluid shear stress was established.Consistent with in vitro findings,in vivo studies have also shown reduced fluid shear stress down-regulated the levels of megalin receptors,thereby reducing the renal distribution of albumin nanoparticles.

关键词： Fluid shear stress Kidney-targeted drug delivery HK-2 cells Acute kidney injury

Identification of new diagnostic targets for hepatitis B virus‐induced liver fibrosis

在线全文

学校读者我要写书评

暂无评论

iLABMED

iLABMED 2024年第1期2卷 27-37页

作者： Ying Wang Shuo Qin Meng Yang Xiaoling Wang Department of Clinical Laboratory Shanxi Hospital of Traditional Chinese MedicineTaiyuanShanxi ProvinceChina Academy of Medical Sciences Shanxi Medical UniversityTaiyuanShanxi ProvinceChina

Background:Liver fibrosis is a transitional stage from hepatitis to cirrhosis,and hepatitis B virus(HBV)is the most common cause of liver disease.Transcriptome sequencing technology and bioinformatics analysis are increasingly being used to screen diagnostic targets for liver fibrosis.Methods:The GSE171294 dataset of HBV-induced liver fibrosis tissue and normal tissue was obtained from the Gene Expression Omnibus(GEO)public database and used to screen for differentially expressed mRNAs using R software.mRNAs with|log fold change|>1 and p<0.05 were considered to be differentially expressed.A heat map was drawn to visualize the expression patterns of the differentially expressed mRNAs.To screen for candidate target mRNAs,the differentially expressed mRNAs were annotated by Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment analysis.Finally,a protein-protein interaction(PPI)network was constructed to analyze the relationships between the differen-tially expressed mRNAs.Results:A total of 243 differentially expressed mRNAs were identified(p<0.05);129 were up-regulated and 114 were down-regulated.The up-regulated and down-regulated mRNAs were significantly enriched in 16 and 8 KEGG pathways,respectively.The enriched KEGG pathways included Sal-monella infection,Protein processing in the endoplasmic reticulum,IL-17 signaling pathway,and Aldosterone synthesis and secretion.The enriched GO terms were related mainly to cell proliferation,apoptosis,endoplasmic reticulum complex assembly,and myosin synthesis.The PPI network con-tained 161 nodes and 120 pairs of interactions.The top 10 key nodes were CAV1,CD4,NR3C1,PDIA3,EZR,IRF4,SOX9,HSP90AB1,CD40,and SEC13.Conclusions:Bioinformatics analysis of the transcriptome sequencing data in the GSE171294 dataset identified CD4,NR3C1,and EZR and other genes at key nodes as new targets for the treatment of liver fibrosis caused by HBV.These results provide new insights for HBV‐induced liver fibrosis research and clinical treatment.

关键词： expression profiles HBV liver fibrosis transcriptome sequencing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

北京鲁迅博物馆藏鲁迅著译版本述略

鲁迅研究月刊 2023年第7期 82-92,96页

作者：秦硕北京鲁迅博物馆(北京新文化运动纪念馆)文物资料保管部 100034

本文从北京鲁迅博物馆馆藏数千种“鲁迅著译版本”中择取一些较具代表性的藏品,析为“图书”类著译版本及“遗物”类著译版本两部分概述之。“图书”部分分为“全集”“著作”“译作”“外文”四大类;“遗物”部分分为“文稿、信稿及日... 详细信息

本文从北京鲁迅博物馆馆藏数千种“鲁迅著译版本”中择取一些较具代表性的藏品,析为“图书”类著译版本及“遗物”类著译版本两部分概述之。“图书”部分分为“全集”“著作”“译作”“外文”四大类;“遗物”部分分为“文稿、信稿及日记”“诗稿”“译稿”“鲁迅题赠许广平著译签名本”“油印本《生理学》讲义”“《中国小说史略》五种”六大类。

关键词：鲁迅著译版本出版物遗物史料

Coded Multicasting for Content Delivery over Predictable Time-Varying Satellite Communication Networks

在线全文

学校读者我要写书评

暂无评论

China Communications 2023年第6期20卷 339-367页

作者： Fan Xu shuo Shao Meixia Tao qin Huang Qifa Yan Xiaohu Tang Peng Cheng Laboratory ShenzhenGuangdong 518000China Department of Electronic Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Electronics and Information Engineering BeiHang UniversityBeijing 100191China School of Information Science and Technology Southwest Jiaotong UniversityChengduSichuan 611756China

With the development of astronautic technology, communication satellites now have a tremendous gain in both quantity and quality, and have already shown their capability on multi-functional converged communication other than telecommunication. Under this circumstance, increasing the transmission efficiency of satellite communication network becomes a top priority. In this paper, we focus on content delivery service on satellite networks, where each ground station may have prefetched some file fragments. We cast this problem into a coded caching framework so as to exploit the coded multicast gain for minimizing the satellite communication load. We first propose an optimization-based coded multicast scheme by considering the special property that the satellite network topology is predictable and timevariant. Then, a greedy based fast algorithm is proposed, which can tremendously reduce the computation complexity with a small loss in optimality. Simulation experiments conducted on two Walker constellation satellite networks show that our proposed coded multicast method can efficiently reduce the communication load of satellite networks.

关键词： satellite communication content delivery coded multicast greedy algorithm

Study on mechanism of increased allergenicity induced by Ara h 3 from roasted peanut using bone marrow-derived dendritic cells

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2023年第3期12卷 755-764页

作者： Minjia Wang shuo Wang Xiaodong Sun Zhirui Deng Bing Niu qin Chen School of Life Sciences Shanghai UniversityShanghai 200444China Medical School Shanghai UniversityShanghai 200444China

Little information was so far available about allergenic mechanism of the roasted peanut allergens during initial stages of allergy.The purpose of this study was to determine the influence of roasting(150℃,20 min)on biochemical and biological properties of Ara h 3,a major peanut allergen.Allergenicity of roasted peanut emulsion to mice,differences in uptakes between Ara h 3 purified from raw peanuts(named as Ara h 3-Raw)and that purified from roasted peanuts(named as Ara h 3-Roasted)by bone marrow-derived dendritic cells(BMDCs)and the implication of cell surface receptors involving in uptake,and changes in glycosylation and structure of Ara h 3 after roasting were analyzed in this study.This study suggested that roasting increased allergenicity of peanut to BALB/c mice.Maillard reaction and structural changes of Ara h 3 induced by roasting significantly altered the uptake of Ara h 3-Roasted by BMDCs,and modified Ara h 3 fate in processes involved in immunogenicity and hyper allergenicity,indicating that food processing pattern can change food allergenicity.

关键词： Roasted peanut Ara h 3 Bone marrow-derived dendritic cells(BMDCs) Allergenicity Maillard reactions

Two-layer formation-containment fault-tolerant control of fixed-wing UAV swarm for dynamic target tracking

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2023年第6期34卷 1375-1396页

作者： qin Boyu ZHANG Dong TANG shuo XU Yang School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Shaanxi Aerospace Flight Vehicle Design Key Laboratory Xi’an 710072China School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072China

This paper tackles the formation-containment control problem of fixed-wing unmanned aerial vehicle(UAV)swarm with model uncertainties for dynamic target tracking in three-dimensional space in the faulty case of UAVs’actuator and sensor.The fixed-wing UAV swarm under consideration is organized as a“multi-leader-multi-follower”structure,in which only several leaders can obtain the dynamic target information while others only receive the neighbors’information through the communication network.To simultaneously realize the formation,containment,and dynamic target tracking,a two-layer control framework is adopted to decouple the problem into two subproblems:reference trajectory generation and trajectory tracking.In the upper layer,a distributed finite-time estimator(DFTE)is proposed to generate each UAV’s reference trajectory in accordance with the control objective.Subsequently,a distributed composite robust fault-tolerant trajectory tracking controller is developed in the lower layer,where a novel adaptive extended super-twisting(AESTW)algorithm with a finite-time extended state observer(FTESO)is involved in solving the robust trajectory tracking control problem under model uncertainties,actuator,and sensor faults.The proposed controller simultaneously guarantees rapidness and enhances the system’s robustness with fewer chattering effects.Finally,corresponding simulations are carried out to demonstrate the effectiveness and competitiveness of the proposed two-layer fault-tolerant cooperative control scheme.

关键词： fixed-wing unmanned aerial vehicle(UAV)swarm two-layer control formation-containment dynamic target tracking

Open-source dataset of vehicle state for an electric vehicle on a low-adhesion road

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2022年第3期65卷 258-259页

作者： shuo CAI Haitao DING Yunfeng HU Lin ZHANG qin LI Hong CHEN State Key Laboratory of Automotive Simulation and Control Jilin University Department of Control Science and Engineering Jilin University School of Automotive Studies Tongji University Collaborative Innovation Center of Electric Vehicles in Beijing Beijing Institute of Technology GAC R&D Center

This study demonstrates and opens for academic research six sets of electric vehicle data collected during experiments on a low-adhesion road. The 11-dimensional data were collected from a small, single-motor SUV with front-wheel drive.Experimental data collected for vehicles on low-adhesion roads are crucial for research on system dynamics modeling,stability control system design, and vehicle state estimation. Indeed, all vehicle control systems must be validated on low-adhesion roads, including vehicle models,

关键词： vehicle experimental data dynamics modeling state estimation control system design low adhesion road

Largely Improved Stretch Ductility and β-Form Room-temperature Durability of Poly(vinylidene fluoride) by Incorporating Aliphatic Polyketone

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2018年第11期36卷 1277-1285页

作者： Shui-qin Pu shuo Guo Ke Wang Qiang Fu College of Polymer Science and Engineering Sichuan University State Key Laboratory of Polymer Materials Engineering

In this study, we attempt to prepare a new blending system of poly（vinylidene fluoride）（PVDF） and aliphatic polyketone （POK） by melt compounding, The latter is a promising engineering plastic with comprehensive mechanical performances. When POK acted as minor phase to homogeneously disperse in and intimately contact with PVDF matrix, the brittle tensile behavior of neat PVDF transferred into a remarkably flexible manner （the elongation at break increased for 20 times）, and more interestingly, the room- temperature durability of β-form PVDF in the uniaxially drawn blend film was obviously better than that in the neat PVDF film. Fourier transform infrared spectroscopy revealed that specific dipole interaction existed between CF2 group of PVDF and C=O group of POK. The intermolecular dipolar interaction induced good compatibility in the PVDF/POK blends, as evidently proved by fine two-phase morphology and decreased melting points of POK crystals. Therefore, the good compatibility and interracial enhancement are responsible for the improvement of the stretch ductility and β-form room-temperature durability of the PVDF/POK blends.

关键词： Blend Aliphatic polyketone Dipole interaction Stretch ductility Uniaxially drawn β-PVDF

Degradation and mineralization of aniline by O_3/Fenton process enhanced using high-gravity technology

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2018年第7期26卷 1444-1450页

作者： Yuejiao qin Shuai Luo shuo Geng Weizhou Jiao Youzhi Liu Shanxi Province Key Laboratory of Higee-Oriented Chemical Engineering North University of China Department of Civil and Environmental Engineering Virginia Polytechnic Institute and State University

The degradation and mineralization of aniline(AN) using ozone combined with Fenton reagent(O_3/Fenton) in a rotating packed bed(RPB) was proposed in this study, and the process(RPB-O_3/Fenton) was compared with conventional O_3/Fenton in a stirred tank reactor(STR-O_3/Fenton) or single ozonation in an RPB(RPB-O_3). Effects of high gravity factor, H_2O_2 dosage, H_2O_2 dosing method and initial p H on the AN mineralization efficiency were investigated in the RPB-O_3/Fenton process. In addition, the behavior of Fe(II) was monitored at different H2 O2 dosing methods and p H values. Finally, the optimal operation conditions were determined with high gravity factor of100, initial pH of 5, Fe(II) concentration of 0.8 mmol·L^(-1) and H_2O_2 dosage of 2.5 ml. Under these conditions, for aniline wastewater at the volume of 1 L and concentration of 200 mg·L^(-1), a fast and thorough decay of AN was conducted in 10 min, and the TOC removal efficiency reached 89% in 60 min. The main intermediates of p-benzoquinone, nitrobenzene, maleic acid and oxalic acid were identified by liquid chromatography/mass spectroscopy(LC/MS), and the degradation pathways of AN in RPB-O_3/Fenton system were proposed based on experimental evidence. It could be envisioned that high-gravity technology combined with O_3/Fenton processes would be promising in the rapid and efficient mineralization of wastewater.

关键词：矿化作用苯胺废水技术 Fenton H2O2 作用效率操作条件移动效率