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Non-coding RNAs in acute ischemic stroke:from brain to periphery

Neural Regeneration Research 2025年第1期20卷 116-129页

作者： shuo li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang li-shuo Zheng Yu-Tao Zheng Yi-Wei Dong liping Huang Xiaoping Wang Wei Jiang liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 504-514页

作者： Lou Zhang shuo li Fu Tang Jingkai Zhang Yuetong Kang Hean Zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology Beijing

Silver nanoparticles(Ag NPs) have attracted attention in the field of biomaterials due to their excellent antibacterial ***, the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work, Ag NPs(31.2 nm in diameter) were prepared using the extract of straw, an agricultural waste, as the reducing and stabilizing agent. Experimental analysis revealed that the straw extract contained lignin, the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag NPs. The surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their aggregation. After the prepared Ag NPs were added to the precursor solution of acrylamide, free radical polymerization was triggered without the need for extra heating or light irradiation, resulting in the rapid formation of an Ag NP–polyacrylamide composite hydrogel. The inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag NPs. The prepared hydrogel may have potential applications in the fabrication of biomedical materials, such as antibacterial dressings.

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Medium-Mn steels for hot forming application in the automotive industry

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 741-753页

作者： shuo-shuo li Hai-wen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Advanced high-strength steels have been widely used to improve the crashworthiness and lightweight of *** from the popular cold stamping,hot forming of boron-alloyed manganese steels,such as 22MnB5,could produce ultra-high-strength steel parts without springback and with accurate control of ***,hot-formed medium-Mn steels could have many advantages,including better mechanical properties and lower production cost,over hot-formed *** paper reviews the hot forming process in the automotive industry,hot-formed steel grades,and medium-Mn steel grades and their application in hot forming in *** particular,the adaptabilities of medium-Mn steels and the presently popular 22MnB5 into hot forming were compared *** research should focus on the technological issues encountered in hot forming of medium-Mn steels to promote their commercialization.

关键词： medium-Mn transformation-induced plasticity steel hot forming mechanical properties retained austenite baking

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Campus Bus Network Design and Evaluation Based on the Route Property

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Tsinghua Science and Technology 2017年第5期22卷 539-550页

作者： Jishiyu Ding shuo Feng li li Yi Zhang the Department of Automation Tsinghua University

A campus bus network design and evaluation, taking Tsinghua University as an example, is investigated in this paper. To minimize the total cost for both passengers and operator, the campus bus system planning in a sequential approach is discussed, including the route network design, headway （i.e., the inverse of service frequency） optimization, and system evaluation. The improved genetic algorithm is proposed to optimize the route network based on the route property, and the impacts of the fluctuation of passenger demand and average traveling time are analyzed. The identity proportion in the headway optimization is then introduced with full consideration of its impacts. Based on the actual variety of passenger demand, a non-fixed schedule demonstrates its efficiency. VISSIM is finally adopted to simulate the campus bus system and a comprehensive evaluation system for the campus bus is developed. Compared with the current bus network and the one without considering the route property, the evaluation of the proposed approach shows an improvement of 18.7% and 10.1%, respectively. Moreover, the sequential approach shows an efficiency significance for the development of public transit systems passengers and operator. mprovement over the alternative method. It is of great n large industrial parks to decrease the total cost for both

关键词： genetic algorithm transit network design route property identity proportion transit system evaluation

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Synthesis and Growth Mechanism of Carbon Filaments by Chemical Vapor Deposition without Catalyst

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Journal of Materials Science & Technology 2009年第2期25卷 259-263页

作者： Shuhe liu Feng li shuo Bai Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Carbon filaments with diameter from several to hundreds deposition of methane without catalyst. The morphology micrometers were synthesized by chemical vapor microstructure and mechanical properties of the carbon filament were investigated by scanning electronic microscopy, optical microscopy, X-ray diffraction and mechanical testing. The results show that the carbon filament is inverted cone shape and grows up along the gas flow direction. The stem of it is formed of annular carbon layers arranged in a tree ring structure while the head is made up of concentrical layers. The tensile strength of the carbon filament is increased after graphitization for the restructuring and growing large of graphene. The growth mechanism of carbon filament was proposed according to the results of two series of experiments with different deposition time and intermittent deposition cycles.

关键词： Carbon filaments Pyrolytic carbon Synthesis Chemical vapor deposition Mechanical property

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Event-Triggered L1-Gain Control of Nonlinear Positive Switched Systems

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Journal of Systems Science & Complexity 2021年第3期34卷 873-898页

作者： ZHANG Junfeng liU Laiyou li shuo DENG Xuanjin School of Automation Hangzhou Dianzi UniversityHangzhou 310018China Inria University of LilleCNRSUMR9189-CRIStALF-59000 LilleFrance

This paper is concerned with the event-triggered L1-gain control of a class of nonlinear positive switched ***,an event-triggering condition in the form of 1-norm is presented for the *** virtue of the event-triggering strategy,the original system is transformed into an interval uncertain *** event-triggered L1-gain controller is designed by decomposing the controller gain matrix into the sum of nonnegative and non-positive *** the design controller,the resulting closed-loop systems are positive and L1-gain *** obtained approach is developed for the systems subject to input *** presented conditions are solvable in terms of linear ***,two examples are provided to verify the effectiveness of the design.

关键词： Event-triggered control input saturation linear programming nonlinear positive switched systems

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Emerging Two‑dimensional Materials Constructed Nanofuidic Fiber:Properties,Preparation and Applications

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Advanced Fiber Materials 2022年第2期4卷 129-144页

作者： shuo li Yaogang li Yuanlong Shao Hongzhi Wang Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province College of EnergySUDA-BGI Collaborative Innovation CenterSoochow Institute for Energy and Materials Innovations(SIEMIS)Soochow UniversitySuzhou 215006People’s Republic of China State Key Laboratory for Modifcation of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University ShanghaiShanghai 201620People’s Republic of China Beijing Graphene Institute(BGI) Beijing 100095People’s Republic of China

By virtue of ultra-fexibility and non-inductive feature,fbrous electrode is an ideal platform for constructing wearable electronics and implantable electrodes for medical therapy.2D nanofuidic channels with tailored ion transport dynamics enable minimized charge transfer resistance and efcient ion transport ***,combining the nanofuidic ion transport features and fbrous electrode advantages,2D nanofuidic fber electrode presents a series of extra advantages of unidirectional efcient ion transport and great *** this minireview,we frst elaborate the architecture characteristics of the emerging 2D nanofuidic fbers and highlight the intriguing features,such as tunable interlayer spacing,efcient ion transport and modifable channel *** strategies for constructing 2D nanofuidic fbers have been systematically enumerated,including solvent volatilizing regulation,confnement triggered alignment,and fow-driven *** addition,the promising applications of 2D nanofuidic fbers have been also summarized as ***,we analyze the challenges and perspectives of fbrous 2D nanofuidic construction,ion transport mechanism study and potential application extension.

关键词： Two-dimensional nanofuidic fber Nanofuidic channel Ion transport

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Immobilization of Hemoglobin on Cobalt Nanoparticles-modified Indium Tin Oxide Electrode： Direct Electrochemistry and Electrocatalytic Activity

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Chemical Research in Chinese Universities 2013年第3期29卷 563-567页

作者： li shuo-qi HU Jing-bo College of Materials Science and Engineering Shandong University of Science and Technology Qingdao 266590 P. R. China College of Chemistry Beijing Normal University Beijing 100875 P. R. China

A cobalt nanoparticles-attached indium tin oxide（CoNPs/ITO） electrode was applied to the immobilization of hemoglobin（Hb） and an Hb modified CoNPs/ITO electrode（Hb/CoNPs/ITO） was prepared. The direct electron transfer of Hb was shown by the well-behaved voltammetric responses for Hb/CoNPs/ITO electrode and the effects of scan rate and pH value were observed. Based on the catalytic activity of Hb immobilized on the CoNPs/ITO electrode toward the reduction of H2O2, a mediator-free H2O2 sensor was developed. A linear relationship existed between the catalytic current and the H2O2 concentration in a range of 1.0--100.0 μmol/L with a detection limit （S/N=3） of 0.2μmol/L.

关键词： Cobalt nanopartiele Indium tin oxide electrode Direct electron transfer Hemoglobin Electrocatalysis Hydrogen peroxide

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A New Acylated Flavonoid from Anaphalis aureo-punctata

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Chinese Chemical Letters 2003年第1期14卷 66-67页

作者： Yan Qi WU shuo li Ya li Yu li National Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000

A new acylated flavonoid glycoside, 3-O-kaempferol-3-O-acetyl-6-O-(p-coumaroyl)-- D-glucopyranoside 1 was isolated from the whole plant of Anaphalis aureo-punctata. The structure was established by spectral methods.

关键词： Anaphalis aureo-punctata flavonoid 3-O-kaempferol-3-O-acetyl-6-O-(p-coumaroyl)- -D-glucopyranoside.

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